Anticodon-binding domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: OB-fold [ 50198] (16)
• Superfamily: Nucleic acid-binding proteins [ 50249] (16)
• Family: Anticodon-binding domain [ 50250] (2)

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Family statistics

	Genomes (1,452)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,394	16,515	10
Proteins	2,394	16,515	10

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Asparagine--tRNA ligase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Aspartate--tRNA ligase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Lysine--tRNA ligase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Lysyltransferase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Forming carbon-oxygen bonds	0	1.25	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Lysyltransferase || Aminoacyltransferases
Enzyme Commission (EC)	Acyltransferases	1	0.8778	--	INHERITED FROM: Lysyltransferase || Aminoacyltransferases
Enzyme Commission (EC)	Ligases	0	0.7455	Least Informative	DIRECT
Enzyme Commission (EC)	Ligases forming aminoacyl-tRNA and related compoun	0	1.25	Moderately Informative	DIRECT
Enzyme Commission (EC)	Aminoacyltransferases	0.000000000004217	1.662	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.2218	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.6915	--	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0	0.7381	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.5433	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.4756	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental delay	0	0.9853	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of movement	0	1.064	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal reflex	0	1.508	Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	pachytene region organization variant	0.0000009653	1.727	--	DIRECT
Worm Phenotype (WP)	meiotic progression prophase variant	0.000005528	1.407	--	DIRECT
Worm Phenotype (WP)	meiotic progression during oogenesis variant	0.00001009	1.321	--	DIRECT
Worm Phenotype (WP)	response to bacteria variant	0.00001229	1.426	--	DIRECT
Worm Phenotype (WP)	germ cell compartment morphology variant	0.00001336	1.354	--	DIRECT
Worm Phenotype (WP)	oogenesis variant	0.0000259	1.237	--	DIRECT
Worm Phenotype (WP)	meiosis variant	0.00005795	1.263	--	DIRECT
Worm Phenotype (WP)	gonad morphology variant	0.00006683	1.306	--	DIRECT
Worm Phenotype (WP)	feeding behavior variant	0.00006838	1.25	--	DIRECT
Worm Phenotype (WP)	germ cell morphology variant	0.000238	1.156	--	DIRECT
Worm Phenotype (WP)	gametogenesis variant	0.0005227	1.013	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0.002723	0.8392	--	INHERITED FROM: cell organization biogenesis variant
Worm Phenotype (WP)	organ system morphology variant	0.005747	0.7516	--	INHERITED FROM: rachis morphology variant || diplotene region organization variant || reproductive system morphology variant || gonad morphology variant || pachytene region organization variant
Worm Phenotype (WP)	cell morphology variant	0.006115	0.7558	--	INHERITED FROM: germ cell compartment morphology variant || germ cell morphology variant || oocyte number decreased || oocyte morphology variant || germ cell compartment expansion variant || cell organization biogenesis variant
Worm Phenotype (WP)	behavior variant	0.01835	0.6859	--	INHERITED FROM: avoids bacterial lawn || feeding behavior variant
Worm Phenotype (WP)	transgene expression variant	0.01959	0.773	--	INHERITED FROM: transgene expression increased
Worm Phenotype (WP)	gene expression variant	0.03294	0.6256	--	INHERITED FROM: transgene expression increased
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || meiotic progression during oogenesis variant || developmental growth variant || retarded heterochronic variations || response to bacteria variant || reproductive system physiology variant || diplotene progression during oogenesis variant || oogenesis variant || organism homeostasis metabolism variant || oocyte number decreased || avoids bacterial lawn || lethal || larval development variant || diplotene region organization variant || organism physiology variant || meiosis variant || germ cell development variant || germ cell differentiation variant || slow growth || cell division variant || cell differentiation variant || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || gametogenesis variant || cell cycle variant || feeding behavior variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced || transgene expression increased || pachytene region organization variant
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.00718	0.6752	Least Informative	INHERITED FROM: germ cell differentiation variant || cell differentiation variant || gametogenesis variant || meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || meiosis variant || diplotene region organization variant || oocyte number decreased || pachytene progression during oogenesis variant || meiotic progression prophase variant || oogenesis variant || pachytene region organization variant || germ cell development variant
Worm Phenotype (WP)	cell physiology variant	0.01484	0.5955	Least Informative	INHERITED FROM: meiosis variant || diplotene progression during oogenesis variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || cell division variant || pachytene region organization variant || cell cycle variant || diplotene region organization variant
Worm Phenotype (WP)	organism behavior variant	0.01807	0.6859	Least Informative	INHERITED FROM: avoids bacterial lawn || feeding behavior variant
Worm Phenotype (WP)	organism environmental stimulus response variant	0.01977	0.6614	Least Informative	INHERITED FROM: avoids bacterial lawn || response to bacteria variant
Worm Phenotype (WP)	organism metabolism processing variant	0.08473	0.4899	Least Informative	INHERITED FROM: transgene expression increased
Worm Phenotype (WP)	germ cell differentiation variant	0.00009214	1.167	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell cycle variant	0.0000975	1.225	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell organization biogenesis variant	0.000151	1.135	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell division variant	0.000394	1.036	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0.0004882	1.013	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system morphology variant	0.0007974	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell type morphology variant	0.002022	0.8878	Moderately Informative	INHERITED FROM: germ cell morphology variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased
Worm Phenotype (WP)	level of transgene expression variant	0.002061	1.125	Moderately Informative	INHERITED FROM: transgene expression increased
Worm Phenotype (WP)	pachytene progression during oogenesis variant	0.000001623	1.565	Informative	DIRECT
Worm Phenotype (WP)	diplotene progression during oogenesis variant	0.000001623	1.655	Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment expansion variant	0.000005692	1.468	Informative	DIRECT
Worm Phenotype (WP)	rachis morphology variant	0.000006035	1.623	Informative	DIRECT
Worm Phenotype (WP)	avoids bacterial lawn	0.000008527	1.49	Informative	DIRECT
Worm Phenotype (WP)	oocyte morphology variant	0.00002885	1.292	Informative	DIRECT
Worm Phenotype (WP)	transgene expression increased	0.0002585	1.426	Informative	DIRECT
Worm Phenotype (WP)	cell differentiation variant	0.00000001027	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	diplotene region organization variant	0.000000287	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	oocyte number decreased	0.000001591	1.924	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	genital system	0	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: urogenital system || genital system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || tail region || genital system || anatomical group || multicellular anatomical structure || tail || anatomical region || organism subdivision
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tail region	0	1.242	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	tail	0	1.334	Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6447	--	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7127	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.6705	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: sporophyll || collective plant structure || phyllome || pollen sac || multi-tissue plant structure || microsporophyll || guard cell || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || whole plant || epidermis || microsporangium || epidermal cell || shoot epidermal cell || pollen || plant cell || shoot epidermis || microgametophyte
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: sporophyll || phyllome || guard cell || pollen || microsporophyll || pollen sac || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.6679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.673	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Lysyltransferase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Aspartate--tRNA ligase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Asparagine--tRNA ligase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Aspartate--tRNA(Asn) ligase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Lysine--tRNA ligase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Lysyltransferase
Enzyme Commission (EC)	Ligases	0	1.14	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acyltransferases	1	1.034	Moderately Informative	INHERITED FROM: Lysyltransferase
Enzyme Commission (EC)	Forming carbon-oxygen bonds	0	1.738	Informative	DIRECT
Enzyme Commission (EC)	Aminoacyltransferases	0.008094	1.391	Informative	INHERITED FROM: Lysyltransferase
Enzyme Commission (EC)	Ligases forming aminoacyl-tRNA and related compounds	0	1.753	Highly Informative	DIRECT

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