Single strand DNA-binding domain, SSB family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: OB-fold [ 50198] (16)
• Superfamily: Nucleic acid-binding proteins [ 50249] (16)
• Family: Single strand DNA-binding domain, SSB [ 50263] (12)

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Family statistics

	Genomes (1,874)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	4,597	23,300	59
Proteins	3,506	20,336	40

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	autosomal dominant disease	0.0002506	1.399	--	DIRECT
Disease Ontology (DO)	autosomal genetic disease	0.001703	1.133	--	INHERITED FROM: hereditary breast ovarian cancer syndrome || autosomal dominant disease
Disease Ontology (DO)	monogenic disease	0.001983	1.115	--	INHERITED FROM: autosomal dominant disease || hereditary breast ovarian cancer syndrome
Disease Ontology (DO)	genetic disease	0.0031	1.066	Moderately Informative	INHERITED FROM: hereditary breast ovarian cancer syndrome || autosomal dominant disease
Disease Ontology (DO)	hereditary breast ovarian cancer syndrome	0.00006591	1.513	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal chromosome morphology	0.000002181	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal chromosome stability	0.000007922	1.825	--	DIRECT
Mammalian Phenotype (MP)	decreased germ cell number	0.00009647	1.562	--	DIRECT
Mammalian Phenotype (MP)	abnormal male germ cell morphology	0.0001691	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal testis size	0.0002018	1.649	--	DIRECT
Mammalian Phenotype (MP)	small gonad	0.000219	1.649	--	DIRECT
Mammalian Phenotype (MP)	increased lymphoma incidence	0.0002981	1.649	--	DIRECT
Mammalian Phenotype (MP)	abnormal sex determination	0.0003207	1.348	--	DIRECT
Mammalian Phenotype (MP)	abnormal male germ cell apoptosis	0.0004259	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal gametogenesis	0.0007174	1.324	--	DIRECT
Mammalian Phenotype (MP)	abnormal male reproductive gland morphology	0.0007862	1.427	--	DIRECT
Mammalian Phenotype (MP)	abnormal internal male genitalia morphology	0.0009566	1.373	--	DIRECT
Mammalian Phenotype (MP)	abnormal male reproductive system morphology	0.001058	1.348	--	INHERITED FROM: abnormal internal male genitalia morphology || small testis || abnormal testis morphology || abnormal testis size
Mammalian Phenotype (MP)	abnormal sex gland morphology	0.001636	1.141	--	INHERITED FROM: abnormal testis size || small testis || abnormal testis morphology || abnormal male reproductive gland morphology
Mammalian Phenotype (MP)	abnormal cell physiology	0.004988	0.6209	--	INHERITED FROM: abnormal chromosome stability || abnormal male germ cell apoptosis || chromosomal instability
Mammalian Phenotype (MP)	abnormal cell morphology	0.004997	1.324	--	INHERITED FROM: decreased male germ cell number || abnormal chromosome morphology || abnormal male germ cell morphology || decreased germ cell number
Mammalian Phenotype (MP)	increased classified tumor incidence	0.005084	1.324	--	INHERITED FROM: increased lymphoma incidence
Mammalian Phenotype (MP)	abnormal classified tumor incidence	0.005257	1.324	--	INHERITED FROM: increased lymphoma incidence
Mammalian Phenotype (MP)	increased organ/body region tumor incidence	0.006185	1.223	--	INHERITED FROM: increased lymphoma incidence || increased hemolymphoid system tumor incidence
Mammalian Phenotype (MP)	abnormal organ/body region tumor incidence	0.006645	1.223	--	INHERITED FROM: increased hemolymphoid system tumor incidence || increased lymphoma incidence
Mammalian Phenotype (MP)	abnormal apoptosis	0.00777	1.023	--	INHERITED FROM: abnormal male germ cell apoptosis
Mammalian Phenotype (MP)	increased tumor incidence	0.009847	1.172	--	INHERITED FROM: increased lymphoma incidence || increased hemolymphoid system tumor incidence
Mammalian Phenotype (MP)	abnormal tumor incidence	0.01418	1.141	--	INHERITED FROM: increased lymphoma incidence || increased hemolymphoid system tumor incidence
Mammalian Phenotype (MP)	altered tumor susceptibility	0.01488	1.141	--	INHERITED FROM: increased lymphoma incidence || increased hemolymphoid system tumor incidence
Mammalian Phenotype (MP)	reproductive system phenotype	0.0287	0.8397	--	INHERITED FROM: abnormal sex determination || decreased male germ cell number || abnormal internal male genitalia morphology || abnormal male germ cell morphology || abnormal male germ cell apoptosis || abnormal testis morphology || small gonad || abnormal spermatogenesis || small testis || decreased germ cell number || abnormal gametogenesis || abnormal testis size || abnormal primary sex determination || abnormal male reproductive gland morphology
Mammalian Phenotype (MP)	abnormal gland morphology	0.03683	0.7519	--	INHERITED FROM: abnormal testis size || small testis || abnormal male reproductive gland morphology || abnormal testis morphology
Mammalian Phenotype (MP)	abnormal male genitalia morphology	1	1.348	--	INHERITED FROM: abnormal internal male genitalia morphology || abnormal testis morphology || small testis || abnormal testis size
Mammalian Phenotype (MP)	cellular phenotype	0.009722	0.5387	Least Informative	INHERITED FROM: abnormal chromosome morphology || chromosomal instability || abnormal male germ cell morphology || abnormal male germ cell apoptosis || abnormal chromosome stability || decreased male germ cell number || decreased germ cell number
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.04769	0.6947	Least Informative	INHERITED FROM: abnormal male reproductive gland morphology || abnormal testis size || small testis || abnormal testis morphology
Mammalian Phenotype (MP)	abnormal reproductive system morphology	0.006077	0.9404	Moderately Informative	INHERITED FROM: decreased germ cell number || abnormal gametogenesis || small testis || abnormal testis size || abnormal primary sex determination || abnormal male reproductive gland morphology || abnormal sex determination || abnormal internal male genitalia morphology || abnormal male germ cell morphology || decreased male germ cell number || small gonad || abnormal testis morphology || abnormal spermatogenesis
Mammalian Phenotype (MP)	abnormal reproductive system physiology	0.01442	1.012	Moderately Informative	INHERITED FROM: abnormal male germ cell apoptosis
Mammalian Phenotype (MP)	neoplasm	0.01966	1.035	Moderately Informative	INHERITED FROM: increased hemolymphoid system tumor incidence || increased lymphoma incidence
Mammalian Phenotype (MP)	abnormal cell death	0.1763	0.9904	Moderately Informative	INHERITED FROM: abnormal male germ cell apoptosis
Mammalian Phenotype (MP)	abnormal primary sex determination	0.0002488	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal spermatogenesis	0.0002944	1.489	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal testis morphology	0.0004741	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	increased hemolymphoid system tumor incidence	0.0005729	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal male reproductive system physiology	0.001534	1.7	Informative	INHERITED FROM: abnormal male germ cell apoptosis
Mammalian Phenotype (MP)	abnormal germ cell morphology	0.0857	1.524	Informative	INHERITED FROM: decreased male germ cell number || decreased germ cell number || abnormal male germ cell morphology
Mammalian Phenotype (MP)	chromosomal instability	0.0000001877	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased male germ cell number	0.00005479	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	small testis	0.0001545	1.758	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cell nucleus morphology	0.01198	1.825	Highly Informative	INHERITED FROM: abnormal chromosome morphology

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	gametogenesis variant	0.001047	1.013	--	INHERITED FROM: germ cell development variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: retarded heterochronic variations || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || organism physiology variant || germ cell development variant || development variant || developmental timing variant || embryonic development variant || embryonic lethal || fertility variant || cell cycle variant || organ system physiology variant || organism development variant || fertility reduced
Worm Phenotype (WP)	cell physiology variant	0.01888	0.5955	Least Informative	INHERITED FROM: cell cycle variant
Worm Phenotype (WP)	cell development variant	0.03259	0.6752	Least Informative	INHERITED FROM: germ cell development variant
Worm Phenotype (WP)	cell cycle variant	0.0008287	1.225	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0.0009531	1.013	Moderately Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	mitotic cell cycle	0.0007939	1.444	--	DIRECT
Yeast Phenotype (YP)	cell cycle progression	0.0005015	1.444	Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	lethal	0	0.678	--	DIRECT
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	increased mortality during development	0	0.6148	--	DIRECT
Fly Phenotype (FP)	increased mortality	0	0.5343	Least Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	embryonic/larval nervous system	0	0.7171	--	DIRECT
Fly Anatomy (FA)	embryonic/larval central nervous system	0	1.275	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || nervous system || embryonic/larval nervous system || embryonic/larval central nervous system || larva || organ system subdivision || central nervous system || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || central nervous system || organ system subdivision || embryonic/larval central nervous system || larva || embryonic/larval nervous system || organism || nervous system
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.6333	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	central nervous system	0	1.009	Moderately Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: cell || anatomical system || anatomical cluster || anatomical group || portion of tissue || whole organism || organism subdivision || compound organ || cavitated compound organ
Zebrafish Anatomy (ZA)	organism subdivision	0	0.614	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	anatomical cluster	0	0.7389	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5123	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cell	0	0.6388	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	portion of tissue	0	0.7637	Moderately Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system || plant cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || corolla development stage || plant organ development stage

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Post-translational modification	DNA-binding	0	1.255	Informative	DIRECT

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