Interleukin-1 (IL-1) family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: beta-Trefoil [ 50352] (8)
• Superfamily: Cytokine [ 50353] (2)
• Family: Interleukin-1 (IL-1) [ 50362] (5)

---

Family statistics

	Genomes (44)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	227	592	17
Proteins	227	592	17

---

Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	gingivitis	0.000000000599	2.513	--	DIRECT
Disease Ontology (DO)	gingival disease	0.000000004823	2.513	--	DIRECT
Disease Ontology (DO)	skin disease	0.0000000378	1.022	--	DIRECT
Disease Ontology (DO)	silicosis	0.0000001515	2.513	--	DIRECT
Disease Ontology (DO)	Plasmodium falciparum malaria	0.0000001515	2.513	--	DIRECT
Disease Ontology (DO)	bullous pemphigoid	0.0000008149	1.61	--	DIRECT
Disease Ontology (DO)	periodontitis	0.000002132	1.559	--	DIRECT
Disease Ontology (DO)	open-angle glaucoma	0.000005133	2.212	--	DIRECT
Disease Ontology (DO)	tooth disease	0.000005731	1.399	--	DIRECT
Disease Ontology (DO)	sudden infant death syndrome	0.000007933	2.513	--	DIRECT
Disease Ontology (DO)	spondyloarthropathy	0.0000179	1.814	--	DIRECT
Disease Ontology (DO)	nephritis	0.00002256	1.309	--	DIRECT
Disease Ontology (DO)	primary bacterial infectious disease	0.00003468	1.212	--	DIRECT
Disease Ontology (DO)	malaria	0.00004112	1.735	--	DIRECT
Disease Ontology (DO)	hepatitis C	0.00004159	2.513	--	DIRECT
Disease Ontology (DO)	glaucoma	0.00004267	2.212	--	DIRECT
Disease Ontology (DO)	bacterial infectious disease	0.00006101	1.191	--	DIRECT
Disease Ontology (DO)	myocardial infarction	0.00008076	1.559	--	DIRECT
Disease Ontology (DO)	contact dermatitis	0.00008959	2.513	--	DIRECT
Disease Ontology (DO)	parasitic protozoa infectious disease	0.00009547	1.735	--	DIRECT
Disease Ontology (DO)	obesity	0.0001627	1.61	--	DIRECT
Disease Ontology (DO)	arteriosclerotic cardiovascular disease	0.0001773	1.367	--	DIRECT
Disease Ontology (DO)	nutrition disease	0.0001925	1.559	--	DIRECT
Disease Ontology (DO)	arteriosclerosis	0.0001985	1.367	--	DIRECT
Disease Ontology (DO)	bone inflammation disease	0.0002396	1.309	--	DIRECT
Disease Ontology (DO)	blood coagulation disease	0.0002962	1.258	--	DIRECT
Disease Ontology (DO)	brain disease	0.0004285	1.258	--	DIRECT
Disease Ontology (DO)	lung disease	0.000503	1.258	--	DIRECT
Disease Ontology (DO)	hypersensitivity reaction disease	0.0005953	0.8505	--	DIRECT
Disease Ontology (DO)	bone disease	0.0006318	1.171	--	DIRECT
Disease Ontology (DO)	kidney disease	0.000662	1.066	--	DIRECT
Disease Ontology (DO)	pancreatic cancer	0.0006975	1.668	--	DIRECT
Disease Ontology (DO)	stomach disease	0.001313	1.814	--	INHERITED FROM: gastritis
Disease Ontology (DO)	mouth disease	0.001388	1.399	--	INHERITED FROM: periodontitis || gingival disease || gingivitis || periodontal disease || tooth disease
Disease Ontology (DO)	viral infectious disease	0.004949	1.212	--	INHERITED FROM: hepatitis C
Disease Ontology (DO)	pneumoconiosis	0.00666	2.513	--	INHERITED FROM: silicosis
Disease Ontology (DO)	reproductive system disease	0.006989	1.399	--	INHERITED FROM: female reproductive system disease || endometriosis
Disease Ontology (DO)	eye and adnexa disease	0.008372	1.472	--	INHERITED FROM: open-angle glaucoma || glaucoma || primary open angle glaucoma
Disease Ontology (DO)	acquired metabolic disease	0.01321	1.191	--	INHERITED FROM: nutrition disease || overnutrition || obesity
Disease Ontology (DO)	collagen disease	0.01384	1.472	--	INHERITED FROM: scleroderma
Disease Ontology (DO)	vascular disease	0.01447	0.832	--	INHERITED FROM: arteriosclerotic cardiovascular disease || coronary artery disease || myocardial infarction || arteriosclerosis || Behcet's disease || atherosclerosis
Disease Ontology (DO)	immune system disease	0.01596	0.8411	--	INHERITED FROM: bullous pemphigoid || autoimmune disease of skin and connective tissue || hypersensitivity reaction type II disease || hypersensitivity reaction disease || scleroderma
Disease Ontology (DO)	central nervous system disease	0.02081	0.8698	--	INHERITED FROM: brain disease
Disease Ontology (DO)	respiratory system disease	0.02155	0.9334	--	INHERITED FROM: interstitial lung disease || silicosis || obstructive lung disease || lung disease
Disease Ontology (DO)	bone marrow cancer	0.0239	1.399	--	INHERITED FROM: multiple myeloma
Disease Ontology (DO)	immune system cancer	0.02685	0.89	--	INHERITED FROM: multiple myeloma
Disease Ontology (DO)	rheumatic disease	0.03622	1.513	--	INHERITED FROM: scleroderma
Disease Ontology (DO)	musculoskeletal system disease	0.03901	0.89	--	INHERITED FROM: scleroderma || spondylitis || arthritis || bone disease || spondyloarthropathy || bone inflammation disease || rheumatoid arthritis
Disease Ontology (DO)	sensory system disease	0.0409	1.399	--	INHERITED FROM: primary open angle glaucoma || open-angle glaucoma || glaucoma
Disease Ontology (DO)	cardiovascular system disease	0.159	0.7889	--	INHERITED FROM: heart disease || atherosclerosis || Behcet's disease || arteriosclerotic cardiovascular disease || myocardial infarction || coronary artery disease || arteriosclerosis
Disease Ontology (DO)	hepatobiliary disease	0.1929	1.472	--	INHERITED FROM: hepatitis
Disease Ontology (DO)	dermatitis	0.2061	1.283	--	INHERITED FROM: contact dermatitis
Disease Ontology (DO)	cancer	0.8662	0.2555	--	INHERITED FROM: pancreatic cancer || multiple myeloma
Disease Ontology (DO)	disease of cellular proliferation	0.883	0.2322	--	INHERITED FROM: multiple myeloma || pancreatic cancer
Disease Ontology (DO)	nervous system disease	0.3436	0.7279	Least Informative	INHERITED FROM: primary open angle glaucoma || brain disease || glaucoma || open-angle glaucoma
Disease Ontology (DO)	organ system cancer	0.3783	0.4879	Least Informative	INHERITED FROM: multiple myeloma || pancreatic cancer
Disease Ontology (DO)	integumentary system disease	0.000003431	0.9817	Moderately Informative	DIRECT
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.0003004	0.8797	Moderately Informative	DIRECT
Disease Ontology (DO)	connective tissue disease	0.001827	1.022	Moderately Informative	INHERITED FROM: rheumatoid arthritis || bone inflammation disease || spondyloarthropathy || bone disease || arthritis || spondylitis || scleroderma
Disease Ontology (DO)	lower respiratory tract disease	0.002453	0.9947	Moderately Informative	INHERITED FROM: interstitial lung disease || silicosis || obstructive lung disease || lung disease
Disease Ontology (DO)	urinary system disease	0.006206	1.051	Moderately Informative	INHERITED FROM: kidney disease || glomerulonephritis || nephritis
Disease Ontology (DO)	artery disease	0.008548	0.9817	Moderately Informative	INHERITED FROM: atherosclerosis || arteriosclerosis || coronary artery disease || myocardial infarction || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	gastrointestinal system disease	0.01925	0.8797	Moderately Informative	INHERITED FROM: periodontal disease || periodontitis || gastritis || tooth disease || gingival disease || peptic ulcer disease || hepatitis || gingivitis
Disease Ontology (DO)	disease of metabolism	0.02335	0.9817	Moderately Informative	INHERITED FROM: nutrition disease || obesity || overnutrition
Disease Ontology (DO)	hematopoietic system disease	0.02566	1.051	Moderately Informative	INHERITED FROM: blood coagulation disease || hemorrhagic disease || purpura
Disease Ontology (DO)	hematologic cancer	0.02601	0.89	Moderately Informative	INHERITED FROM: multiple myeloma
Disease Ontology (DO)	disease by infectious agent	0.0292	0.8142	Moderately Informative	INHERITED FROM: primary bacterial infectious disease || bacterial infectious disease || malaria || Plasmodium falciparum malaria || parasitic protozoa infectious disease || hepatitis C
Disease Ontology (DO)	syndrome	0.06032	1.151	Moderately Informative	INHERITED FROM: polycystic ovary syndrome || sudden infant death syndrome
Disease Ontology (DO)	periodontal disease	0.000003543	1.513	Informative	DIRECT
Disease Ontology (DO)	glomerulonephritis	0.000004624	1.513	Informative	DIRECT
Disease Ontology (DO)	interstitial lung disease	0.00001233	1.668	Informative	DIRECT
Disease Ontology (DO)	hemorrhagic disease	0.0001354	1.513	Informative	DIRECT
Disease Ontology (DO)	atherosclerosis	0.0001749	1.367	Informative	DIRECT
Disease Ontology (DO)	overnutrition	0.0001749	1.559	Informative	DIRECT
Disease Ontology (DO)	arthritis	0.0001792	1.472	Informative	DIRECT
Disease Ontology (DO)	coronary artery disease	0.0001874	1.472	Informative	DIRECT
Disease Ontology (DO)	female reproductive system disease	0.0001925	1.472	Informative	DIRECT
Disease Ontology (DO)	scleroderma	0.0002352	1.513	Informative	DIRECT
Disease Ontology (DO)	autoimmune disease of skin and connective tissue	0.000394	1.472	Informative	DIRECT
Disease Ontology (DO)	heart disease	0.0007959	1.472	Informative	DIRECT
Disease Ontology (DO)	parasitic infectious disease	0.001308	1.61	Informative	INHERITED FROM: Plasmodium falciparum malaria || parasitic protozoa infectious disease || malaria
Disease Ontology (DO)	vasculitis	0.001389	1.668	Informative	INHERITED FROM: Behcet's disease
Disease Ontology (DO)	liver disease	0.001873	1.513	Informative	INHERITED FROM: hepatitis
Disease Ontology (DO)	myeloid neoplasm	0.00288	1.399	Informative	INHERITED FROM: multiple myeloma
Disease Ontology (DO)	endocrine gland cancer	0.003724	1.337	Informative	INHERITED FROM: pancreatic cancer
Disease Ontology (DO)	arthropathy	0.008016	1.735	Informative	INHERITED FROM: spondyloarthropathy || spondylitis
Disease Ontology (DO)	eye disease	0.00805	1.472	Informative	INHERITED FROM: glaucoma || open-angle glaucoma || primary open angle glaucoma
Disease Ontology (DO)	primary open angle glaucoma	0.000002785	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	polycystic ovary syndrome	0.000006566	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	gastritis	0.00001042	1.911	Highly Informative	DIRECT
Disease Ontology (DO)	spondylitis	0.00001112	2.036	Highly Informative	DIRECT
Disease Ontology (DO)	purpura	0.0000179	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	Behcet's disease	0.00002219	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	obstructive lung disease	0.00002607	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	rheumatoid arthritis	0.00005233	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	endometriosis	0.00006832	2.036	Highly Informative	DIRECT
Disease Ontology (DO)	peptic ulcer disease	0.0004018	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	hepatitis	0.0004701	1.911	Highly Informative	DIRECT
Disease Ontology (DO)	multiple myeloma	0.000731	1.814	Highly Informative	DIRECT

---

Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the mouth	0	0.7065	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal oral morphology	0	0.7381	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.533	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0	0.5759	Least Informative	DIRECT

---

Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal immune system physiology	0	0.6789	--	DIRECT
Mammalian Phenotype (MP)	increased inflammatory response	0	1.059	--	DIRECT
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0	0.7902	--	DIRECT
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0	0.3626	--	DIRECT
Mammalian Phenotype (MP)	abnormal interleukin level	0.00000177	1.562	--	DIRECT
Mammalian Phenotype (MP)	abnormal interleukin-1 secretion	0.000002151	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating cytokine level	0.000002798	1.373	--	DIRECT
Mammalian Phenotype (MP)	abnormal cytokine level	0.000009234	1.348	--	DIRECT
Mammalian Phenotype (MP)	abnormal intercellular signaling peptide or protein level	0.00001062	1.324	--	DIRECT
Mammalian Phenotype (MP)	decreased susceptibility to autoimmune disorder	0.00003726	1.758	--	DIRECT
Mammalian Phenotype (MP)	increased neutrophil cell number	0.00004376	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal cytokine secretion	0.0000599	1.085	--	DIRECT
Mammalian Phenotype (MP)	abnormal neutrophil morphology	0.0002191	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating protein level	0.0002422	1.205	--	DIRECT
Mammalian Phenotype (MP)	skin inflammation	0.0003194	2.302	--	DIRECT
Mammalian Phenotype (MP)	autoimmune response	0.0003912	1.324	--	DIRECT
Mammalian Phenotype (MP)	abnormal self tolerance	0.000399	1.324	--	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.002483	0.9129	--	INHERITED FROM: increased neutrophil cell number || increased granulocyte number || abnormal neutrophil cell number
Mammalian Phenotype (MP)	abnormal phagocyte morphology	0.00291	1.281	--	INHERITED FROM: increased neutrophil cell number || abnormal neutrophil morphology || abnormal neutrophil cell number
Mammalian Phenotype (MP)	integument phenotype	0.003251	0.797	--	INHERITED FROM: skin inflammation || abnormal skin physiology
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.003958	0.8108	--	INHERITED FROM: increased granulocyte number || increased neutrophil cell number || abnormal neutrophil cell number || abnormal neutrophil morphology || abnormal granulocyte morphology
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.004083	0.8038	--	INHERITED FROM: increased neutrophil cell number || increased granulocyte number || abnormal granulocyte morphology || abnormal neutrophil morphology || abnormal neutrophil cell number
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.004272	0.8473	--	INHERITED FROM: abnormal neutrophil cell number || increased neutrophil cell number || increased granulocyte number
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.01104	0.7167	--	INHERITED FROM: abnormal neutrophil morphology || abnormal neutrophil cell number || increased neutrophil cell number || abnormal granulocyte morphology || increased granulocyte number
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.01814	0.6893	--	INHERITED FROM: abnormal circulating interleukin level || abnormal circulating cytokine level || abnormal circulating protein level
Mammalian Phenotype (MP)	abnormal immune tolerance	0.02494	1.324	--	INHERITED FROM: autoimmune response || abnormal self tolerance || altered susceptibility to autoimmune disorder || decreased susceptibility to autoimmune disorder
Mammalian Phenotype (MP)	abnormal granulocyte number	0.02571	1.758	--	INHERITED FROM: increased neutrophil cell number || abnormal neutrophil cell number || increased granulocyte number
Mammalian Phenotype (MP)	abnormal response to infection	0.06474	1.112	--	INHERITED FROM: decreased susceptibility to infection || altered susceptibility to bacterial infection
Mammalian Phenotype (MP)	abnormal myeloid leukocyte morphology	0.07219	1.223	--	INHERITED FROM: abnormal neutrophil morphology || increased neutrophil cell number || abnormal neutrophil cell number || increased granulocyte number || abnormal granulocyte morphology
Mammalian Phenotype (MP)	abnormal interferon secretion	0.1273	1.373	--	INHERITED FROM: abnormal interferon-gamma secretion
Mammalian Phenotype (MP)	increased leukocyte cell number	0.2388	1.241	--	INHERITED FROM: increased granulocyte number || increased neutrophil cell number
Mammalian Phenotype (MP)	abnormal immune system morphology	0.3282	0.7223	--	INHERITED FROM: abnormal neutrophil morphology || abnormal neutrophil cell number || increased neutrophil cell number || abnormal granulocyte morphology || increased granulocyte number
Mammalian Phenotype (MP)	abnormal interleukin secretion	0.4287	1.188	--	INHERITED FROM: abnormal interleukin-1 beta secretion || abnormal interleukin-1 secretion
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.637	0.6686	--	INHERITED FROM: increased neutrophil cell number || abnormal neutrophil morphology || abnormal neutrophil cell number || increased granulocyte number || abnormal granulocyte morphology
Mammalian Phenotype (MP)	cardiovascular system phenotype	0	0.6737	Least Informative	DIRECT
Mammalian Phenotype (MP)	immune system phenotype	0	0.5462	Least Informative	DIRECT
Mammalian Phenotype (MP)	hematopoietic system phenotype	0	0.5945	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal homeostasis	0.6476	0.4926	Least Informative	INHERITED FROM: abnormal cytokine level || abnormal protein level || abnormal interleukin level || abnormal circulating interleukin level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || abnormal circulating protein level || abnormal body temperature homeostasis
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0	1.023	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal inflammatory response	0	1.023	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal protein level	0.0003989	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	altered susceptibility to infection	0.001034	1.112	Moderately Informative	INHERITED FROM: decreased susceptibility to infection || altered susceptibility to bacterial infection
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.07857	1.001	Moderately Informative	INHERITED FROM: abnormal interleukin level || abnormal interleukin-1 beta secretion || abnormal cytokine secretion || abnormal interferon-gamma secretion || abnormal interleukin-1 secretion || abnormal cytokine level || abnormal circulating cytokine level || abnormal circulating interleukin level
Mammalian Phenotype (MP)	increased hematopoietic cell number	0.2975	1.188	Moderately Informative	INHERITED FROM: increased neutrophil cell number || increased granulocyte number
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.3273	0.9904	Moderately Informative	INHERITED FROM: increased granulocyte number || abnormal neutrophil morphology || abnormal neutrophil cell number || increased neutrophil cell number || abnormal granulocyte morphology
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.4112	0.9129	Moderately Informative	INHERITED FROM: increased granulocyte number || abnormal neutrophil cell number || abnormal neutrophil morphology || abnormal granulocyte morphology || increased neutrophil cell number
Mammalian Phenotype (MP)	abnormal circulating interleukin level	0.0000008244	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal skin physiology	0.000002992	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal interferon-gamma secretion	0.0001088	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	altered susceptibility to autoimmune disorder	0.0001844	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	altered susceptibility to bacterial infection	0.0002245	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal granulocyte morphology	0.0009754	1.7	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal interleukin-1 beta secretion	0.000001675	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal body temperature homeostasis	0.000002078	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased susceptibility to infection	0.00002741	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal neutrophil cell number	0.0001844	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased granulocyte number	0.0002017	2.001	Highly Informative	DIRECT

---