Elongation factors family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Reductase/isomerase/elongation factor common domain [ 50412] (4)
• Superfamily: Translation proteins [ 50447] (6)
• Family: Elongation factors [ 50448] (10)

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Family statistics

	Genomes (3,262)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	12,710	110,666	36
Proteins	12,697	110,637	35

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Elongation factor 4	0	2.44	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.000008446	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Nucleotidyltransferases || Sulfate adenylyltransferase || Adenylyl-sulfate kinase || Transferring phosphorous-containing groups
Enzyme Commission (EC)	Nucleotidyltransferases	0	0.6958	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0	0.7283	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	1	0.8381	Moderately Informative	INHERITED FROM: Adenylyl-sulfate kinase
Enzyme Commission (EC)	Sulfate adenylyltransferase	0	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	Acting on GTP; involved in cellular and subcellula	0	2.139	Highly Informative	DIRECT
Enzyme Commission (EC)	Adenylyl-sulfate kinase	0.00000000000002154	1.963	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0	0.533	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0	0.6631	--	DIRECT
Phenotypic Abnormality (PA)	Decreased head circumference	0.0003288	1.348	--	DIRECT
Phenotypic Abnormality (PA)	Spasticity	0.0006524	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Upper motor neuron dysfunction	0.000893	1.286	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle tone	0.01417	0.8942	--	INHERITED FROM: Spasticity
Phenotypic Abnormality (PA)	Abnormal skull morphology	0.02243	0.8826	--	INHERITED FROM: Microcephaly || Decreased head circumference
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0.04339	0.6915	--	INHERITED FROM: Spasticity
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.05089	0.6771	--	INHERITED FROM: Microcephaly || Decreased head circumference
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0.1503	0.9572	--	INHERITED FROM: Abnormality of the cerebrum || Microcephaly
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.1545	0.4712	--	INHERITED FROM: Decreased head circumference || Microcephaly
Phenotypic Abnormality (PA)	Abnormality of the head	0.1662	0.4538	--	INHERITED FROM: Decreased head circumference || Microcephaly
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.1725	0.4454	--	INHERITED FROM: Decreased head circumference || Microcephaly
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the cerebrum	0.1787	1.184	--	INHERITED FROM: Microcephaly
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.4756	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.09083	0.5433	Least Informative	INHERITED FROM: Spasticity
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.129	0.513	Least Informative	INHERITED FROM: Microcephaly || Decreased head circumference
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0.0005977	0.971	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skull size	0.001737	1.101	Moderately Informative	INHERITED FROM: Microcephaly || Decreased head circumference
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia involving the central nervous system	0.03425	1.047	Moderately Informative	INHERITED FROM: Microcephaly
Phenotypic Abnormality (PA)	Abnormality of central motor function	0.07231	1.047	Moderately Informative	INHERITED FROM: Spasticity || Upper motor neuron dysfunction
Phenotypic Abnormality (PA)	Microcephaly	0.0003179	1.383	Informative	DIRECT
Phenotypic Abnormality (PA)	Hypertonia	0.06448	1.508	Informative	INHERITED FROM: Spasticity

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	protein phosphorylation increased	0.00000388	2.769	--	DIRECT
Worm Phenotype (WP)	pachytene region organization variant	0.000008163	1.727	--	DIRECT
Worm Phenotype (WP)	proteasome core activity variant	0.00001622	2.769	--	DIRECT
Worm Phenotype (WP)	meiotic progression prophase variant	0.00009569	1.407	--	DIRECT
Worm Phenotype (WP)	mRNA levels reduced	0.000186	2.468	--	DIRECT
Worm Phenotype (WP)	meiotic progression during oogenesis variant	0.0002188	1.321	--	DIRECT
Worm Phenotype (WP)	germ cell compartment morphology variant	0.0003204	1.354	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.0007495	1.087	--	DIRECT
Worm Phenotype (WP)	oogenesis variant	0.000776	1.237	--	DIRECT
Worm Phenotype (WP)	meiosis variant	0.002222	1.263	--	INHERITED FROM: pachytene progression during oogenesis variant || meiotic progression prophase variant || pachytene region organization variant || diplotene progression during oogenesis variant
Worm Phenotype (WP)	gonad morphology variant	0.00267	1.306	--	INHERITED FROM: pachytene region organization variant || rachis morphology variant
Worm Phenotype (WP)	mRNA expression variant	0.003836	1.814	--	INHERITED FROM: mRNA levels reduced || mRNA levels increased
Worm Phenotype (WP)	protein interaction variant	0.004128	1.078	--	INHERITED FROM: protein protein interaction variant || protein aggregation variant
Worm Phenotype (WP)	protein modification variant	0.006275	1.769	--	INHERITED FROM: protein phosphorylation increased || protein phosphorylation variant
Worm Phenotype (WP)	germ cell morphology variant	0.01282	1.156	--	INHERITED FROM: oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant
Worm Phenotype (WP)	gene expression variant	0.01836	0.6256	--	INHERITED FROM: protein phosphorylation increased || protein phosphorylation variant || mRNA levels reduced || mRNA levels increased
Worm Phenotype (WP)	metabolic pathway variant	0.02382	1.263	--	INHERITED FROM: proteasome core activity variant || protein phosphorylation variant || protein phosphorylation increased
Worm Phenotype (WP)	gametogenesis variant	0.03192	1.013	--	INHERITED FROM: pachytene progression during oogenesis variant || meiotic progression prophase variant || oogenesis variant || pachytene region organization variant || meiotic progression during oogenesis variant || diplotene progression during oogenesis variant
Worm Phenotype (WP)	cell component morphology variant	0.06814	0.8392	--	INHERITED FROM: nuclear appearance variant
Worm Phenotype (WP)	cell morphology variant	0.167	0.7558	--	INHERITED FROM: nuclear appearance variant || germ cell compartment morphology variant || oocytes small || oocyte morphology variant || germ cell compartment expansion variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.1925	0.1444	--	INHERITED FROM: mRNA levels increased || mRNA levels reduced || protein phosphorylation variant || proteasome core activity variant || protein phosphorylation increased || protein protein interaction variant || protein aggregation variant
Worm Phenotype (WP)	organism physiology variant	0.2094	0.1342	--	INHERITED FROM: mRNA levels reduced || mRNA levels increased || protein phosphorylation increased || protein phosphorylation variant || proteasome core activity variant || protein protein interaction variant || protein aggregation variant
Worm Phenotype (WP)	organ system morphology variant	0.3161	0.7516	--	INHERITED FROM: rachis morphology variant || pachytene region organization variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || meiotic progression during oogenesis variant || protein phosphorylation increased || protein protein interaction variant || reproductive system physiology variant || diplotene progression during oogenesis variant || oogenesis variant || proteasome core activity variant || lethal || protein phosphorylation variant || development variant || hermaphrodite sterile || mRNA levels reduced || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || protein aggregation variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || postembryonic development variant || organ system physiology variant || maternal sterile || mRNA levels increased || organism development variant || fertility reduced || pachytene region organization variant
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	cell physiology variant	0.03562	0.5955	Least Informative	INHERITED FROM: proteasome core activity variant || protein phosphorylation variant || diplotene progression during oogenesis variant || protein phosphorylation increased || pachytene progression during oogenesis variant || meiotic progression prophase variant || pachytene region organization variant
Worm Phenotype (WP)	organism metabolism processing variant	0.08045	0.4899	Least Informative	INHERITED FROM: proteasome core activity variant || protein phosphorylation variant || mRNA levels increased || mRNA levels reduced || protein aggregation variant || protein phosphorylation increased || protein protein interaction variant
Worm Phenotype (WP)	cell development variant	0.3731	0.6752	Least Informative	INHERITED FROM: meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || oogenesis variant || pachytene region organization variant
Worm Phenotype (WP)	protein protein interaction variant	0.0008831	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell differentiation variant	0.004005	1.167	Moderately Informative	INHERITED FROM: meiotic progression prophase variant || diplotene progression during oogenesis variant || meiotic progression during oogenesis variant || pachytene progression during oogenesis variant || oogenesis variant || pachytene region organization variant
Worm Phenotype (WP)	cell cycle variant	0.02654	1.225	Moderately Informative	INHERITED FROM: diplotene progression during oogenesis variant || pachytene region organization variant || meiotic progression prophase variant || pachytene progression during oogenesis variant
Worm Phenotype (WP)	germ cell development variant	0.02953	1.013	Moderately Informative	INHERITED FROM: meiotic progression during oogenesis variant || pachytene region organization variant || diplotene progression during oogenesis variant || oogenesis variant || pachytene progression during oogenesis variant || meiotic progression prophase variant
Worm Phenotype (WP)	reproductive system morphology variant	0.05067	1.078	Moderately Informative	INHERITED FROM: pachytene region organization variant || rachis morphology variant
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.09003	1.036	Moderately Informative	INHERITED FROM: protein phosphorylation increased || proteasome core activity variant || protein phosphorylation variant
Worm Phenotype (WP)	cell division variant	0.1333	1.036	Moderately Informative	INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || pachytene region organization variant || diplotene progression during oogenesis variant
Worm Phenotype (WP)	cell type morphology variant	0.2926	0.8878	Moderately Informative	INHERITED FROM: oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant
Worm Phenotype (WP)	protein expression variant	0.4859	1.125	Moderately Informative	INHERITED FROM: protein phosphorylation variant || protein phosphorylation increased
Worm Phenotype (WP)	pachytene progression during oogenesis variant	0.00001711	1.565	Informative	DIRECT
Worm Phenotype (WP)	diplotene progression during oogenesis variant	0.00001711	1.655	Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment expansion variant	0.00009969	1.468	Informative	DIRECT
Worm Phenotype (WP)	rachis morphology variant	0.0001081	1.623	Informative	DIRECT
Worm Phenotype (WP)	oocyte morphology variant	0.000895	1.292	Informative	DIRECT
Worm Phenotype (WP)	protein metabolism variant	0.01569	1.354	Informative	INHERITED FROM: protein phosphorylation variant || proteasome core activity variant || protein phosphorylation increased
Worm Phenotype (WP)	RNA expression variant	0.08643	1.565	Informative	INHERITED FROM: mRNA levels reduced || mRNA levels increased
Worm Phenotype (WP)	protein phosphorylation variant	0.0001442	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	nuclear appearance variant	0.0002224	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	mRNA levels increased	0.0004146	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	oocytes small	0.0008932	2.07	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	metabolism and growth	0.02229	0.5867	Least Informative	INHERITED FROM: vegetative growth
Yeast Phenotype (YP)	vegetative growth	0.00002667	1.24	Moderately Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || organism

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism || organism subdivision || compound organ || cavitated compound organ
Zebrafish Anatomy (ZA)	organism subdivision	0	0.614	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5123	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	primary oogonium	0.000000002914	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	primary spermatogonium	0.000000035	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	female organism	0.000003681	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	female genitalia	0.00001102	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	ovary	0.00002338	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0.006525	0.7647	--	INHERITED FROM: primary spermatogonium
Xenopus ANatomical entity (XAN)	male organism	0.006578	0.7647	--	INHERITED FROM: primary spermatogonium
Xenopus ANatomical entity (XAN)	gonad	0.02867	0.7579	--	INHERITED FROM: primary spermatogonium || ovary || primary oogonium
Xenopus ANatomical entity (XAN)	cell	0.03481	0.8608	--	INHERITED FROM: primary spermatogonium || primary oogonium
Xenopus ANatomical entity (XAN)	genital system	0.1034	0.5751	--	INHERITED FROM: primary oogonium || ovary || female genitalia || primary spermatogonium
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: female genitalia || primary oogonium || primary spermatogonium || ovary
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || primary spermatogonium || ovary || female organism || trunk region || organism subdivision || female genitalia || primary oogonium
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	urogenital system	0.2208	0.4777	Least Informative	INHERITED FROM: ovary || female genitalia || primary oogonium || primary spermatogonium
Xenopus ANatomical entity (XAN)	testis	0.006525	0.7647	Moderately Informative	INHERITED FROM: primary spermatogonium
Xenopus ANatomical entity (XAN)	germ cell	0.482	1.08	Moderately Informative	INHERITED FROM: primary spermatogonium || primary oogonium
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Sulfate adenylyltransferase	0	2.327	--	DIRECT
Enzyme Commission (EC)	Acting on GTP; involved in cellular and subcellular movement	0	2.531	--	DIRECT
Enzyme Commission (EC)	Adenylyl-sulfate kinase	0.00000000000001226	2.452	--	DIRECT
Enzyme Commission (EC)	Elongation factor 4	0.0000001472	2.929	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.0000029	0.7021	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Adenylyl-sulfate kinase || Nucleotidyltransferases || Transferring phosphorus-containing groups || Sulfate adenylyltransferase
Enzyme Commission (EC)	Nucleotidyltransferases	0	1.126	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0	1.133	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	1	1.238	Moderately Informative	INHERITED FROM: Adenylyl-sulfate kinase

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