PH domain-like superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: PH domain-like barrel [ 50728] (2)
• Superfamily: PH domain-like [ 50729] (13)
• Families:
  • Pleckstrin-homology domain (PH domain) [ 50730] (47)
  • Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  • Ran-binding domain [ 50764] (4)
  • Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  • Dcp1 [ 101836]
  • Third domain of FERM [ 50776] (8)
  • PreBEACH PH-like domain [ 82146] (2)
  • GRAM domain [ 101839]
  • TFIIH domain [ 110272] (2)
  • SSRP1-like [ 141436]
  • Necap1 N-terminal domain-like [ 141439]
  • VPS36 N-terminal domain-like [ 141442]
  • BPHL domain [ 159216] (2)

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Superfamily statistics

	Genomes (922)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	75,120	226,141	146
Proteins	66,982	203,244	145

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Functional annotation

• General category: Regulation
• Detailed category: Signal transduction

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Dynamin GTPase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Protein-tyrosine kinases	0	1.281	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2175	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-3-phosphatase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Sterol 3-beta-glucosyltransferase	0	2.56	--	DIRECT
Enzyme Commission (EC)	[Beta-adrenergic-receptor] kinase	0.00000000000006766	2.259	--	DIRECT
Enzyme Commission (EC)	Hexosyltransferases	0.0000000000001244	1.217	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.00000000565	0.04271	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.4665	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	1	0.6408	Least Informative	INHERITED FROM: Dynamin GTPase || Acting on GTP; involved in cellular and subcellula
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	1.162	Moderately Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	0.8971	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0.05493	0.9165	Moderately Informative	INHERITED FROM: Phosphatidylinositol-3-phosphatase || Protein-tyrosine-phosphatase
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	1	0.8195	Moderately Informative	INHERITED FROM: Diacylglycerol kinase
Enzyme Commission (EC)	Glycosyltransferases	0.02837	0.9165	Moderately Informative	INHERITED FROM: Sterol 3-beta-glucosyltransferase || Hexosyltransferases
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	1.715	Informative	DIRECT
Enzyme Commission (EC)	Non-specific protein-tyrosine kinase	0	1.715	Informative	DIRECT
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0.00000004532	1.414	Informative	DIRECT
Enzyme Commission (EC)	Diacylglycerol kinase	0	1.782	Highly Informative	DIRECT
Enzyme Commission (EC)	Acting on GTP; involved in cellular and subcellula	0.00000000000001873	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	Protein kinase C	0.000003652	1.861	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	centronuclear myopathy	0.00065	2.371	--	DIRECT
Disease Ontology (DO)	muscular disease	0.916	1.417	--	INHERITED FROM: centronuclear myopathy
Disease Ontology (DO)	musculoskeletal system disease	1	0.9087	--	INHERITED FROM: centronuclear myopathy
Disease Ontology (DO)	myopathy	1	1.593	--	INHERITED FROM: centronuclear myopathy
Disease Ontology (DO)	disease of anatomical entity	1	0.2157	--	INHERITED FROM: centronuclear myopathy
Disease Ontology (DO)	muscle tissue disease	0.8863	1.468	Informative	INHERITED FROM: centronuclear myopathy

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Decreased nerve conduction velocity	0.0001765	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal nerve conduction velocity	0.000217	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of peripheral nerve conduction	0.0004371	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of peripheral nerves	0.005388	2.407	--	INHERITED FROM: Abnormality of peripheral nerve conduction || Decreased nerve conduction velocity || Abnormal nerve conduction velocity
Phenotypic Abnormality (PA)	Abnormality of peripheral nervous system electrophysiology	0.0219	2.407	--	INHERITED FROM: Abnormal nerve conduction velocity || Abnormality of peripheral nerve conduction || Decreased nerve conduction velocity
Phenotypic Abnormality (PA)	Abnormal peripheral nervous system morphology	0.03739	1.26	--	INHERITED FROM: Abnormality of peripheral nerve conduction || Decreased nerve conduction velocity || Abnormal nerve conduction velocity
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.8204	0.2543	--	INHERITED FROM: Abnormality of peripheral nerve conduction || Abnormal nerve conduction velocity || Decreased nerve conduction velocity
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.6096	0.4022	Least Informative	INHERITED FROM: Abnormal nerve conduction velocity || Decreased nerve conduction velocity || Abnormality of peripheral nerve conduction
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.7532	0.5677	Least Informative	INHERITED FROM: Abnormality of peripheral nerve conduction || Abnormal nerve conduction velocity || Decreased nerve conduction velocity
Phenotypic Abnormality (PA)	Abnormal nervous system electrophysiology	0.01652	1.503	Informative	INHERITED FROM: Abnormal nerve conduction velocity || Abnormality of peripheral nerve conduction || Decreased nerve conduction velocity

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal bronchioalveolar stem cell morphology	0.0007349	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal meninges morphology	0.0007481	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal platelet activation	0.0009743	1.809	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.01711	0.9168	--	INHERITED FROM: abnormal platelet activation
Mammalian Phenotype (MP)	abnormal platelet physiology	0.0296	1.809	--	INHERITED FROM: abnormal platelet activation
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.07142	0.9281	--	INHERITED FROM: abnormal platelet activation
Mammalian Phenotype (MP)	abnormal brain meninges morphology	0.1519	2.207	--	INHERITED FROM: abnormal brain pia mater morphology
Mammalian Phenotype (MP)	abnormal hemostasis	0.1934	1.394	--	INHERITED FROM: abnormal platelet activation
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.3275	0.7085	--	INHERITED FROM: abnormal platelet activation
Mammalian Phenotype (MP)	abnormal lung epithelium morphology	0.5413	2.207	--	INHERITED FROM: abnormal bronchioalveolar stem cell morphology
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.7257	0.3617	--	INHERITED FROM: abnormal platelet activation
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.7677	0.627	--	INHERITED FROM: abnormal brain pia mater morphology || abnormal meninges morphology
Mammalian Phenotype (MP)	abnormal respiratory system morphology	1	1.165	--	INHERITED FROM: abnormal bronchioalveolar stem cell morphology
Mammalian Phenotype (MP)	nervous system phenotype	0.1546	0.5166	Least Informative	INHERITED FROM: abnormal brain pia mater morphology || abnormal meninges morphology
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.3012	0.6505	Least Informative	INHERITED FROM: abnormal platelet activation
Mammalian Phenotype (MP)	abnormal homeostasis	0.4449	0.495	Least Informative	INHERITED FROM: abnormal platelet activation
Mammalian Phenotype (MP)	respiratory system phenotype	1	0.9893	Moderately Informative	INHERITED FROM: abnormal bronchioalveolar stem cell morphology
Mammalian Phenotype (MP)	abnormal blood coagulation	0.1397	1.394	Informative	INHERITED FROM: abnormal platelet activation
Mammalian Phenotype (MP)	abnormal lung morphology	1	1.332	Informative	INHERITED FROM: abnormal bronchioalveolar stem cell morphology
Mammalian Phenotype (MP)	abnormal brain pia mater morphology	0.00001073	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal respiratory epithelium morphology	0.9303	1.906	Highly Informative	INHERITED FROM: abnormal bronchioalveolar stem cell morphology

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0	1.276	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	mitochondria alignment variant	0.00000000000056	1.594	--	DIRECT
Worm Phenotype (WP)	gonad sheath contraction rate reduced	0.0000000004121	2.23	--	DIRECT
Worm Phenotype (WP)	bacterially unswollen	0.000000003268	2.106	--	DIRECT
Worm Phenotype (WP)	posterior body wall contraction defecation cycle variant	0.000000005312	2.407	--	DIRECT
Worm Phenotype (WP)	organ system development variant	0.00000001115	0.8099	--	DIRECT
Worm Phenotype (WP)	somatic gonad physiology variant	0.0000001212	2.106	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0.0000008618	0.9594	--	DIRECT
Worm Phenotype (WP)	muscle system morphology variant	0.000009886	1.385	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.00001282	0.1501	--	DIRECT
Worm Phenotype (WP)	muscle cell morphology variant	0.00001651	1.346	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0.00002159	0.1405	--	DIRECT
Worm Phenotype (WP)	coelomocyte physiology variant	0.00003875	1.862	--	DIRECT
Worm Phenotype (WP)	extra and ectopic cell	0.00004048	2.708	--	DIRECT
Worm Phenotype (WP)	somatic sheath physiology variant	0.00005123	2.106	--	DIRECT
Worm Phenotype (WP)	mitochondria spacing variant	0.00005332	1.594	--	DIRECT
Worm Phenotype (WP)	axon morphology variant	0.00005804	1.708	--	DIRECT
Worm Phenotype (WP)	intercellular junction variant	0.000147	2.708	--	DIRECT
Worm Phenotype (WP)	body size variant	0.0001562	1.202	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.0002013	0.632	--	DIRECT
Worm Phenotype (WP)	hermaphrodite physiology variant	0.0002274	1.365	--	DIRECT
Worm Phenotype (WP)	protein transport variant	0.0003952	2.407	--	DIRECT
Worm Phenotype (WP)	cell junction variant	0.0003991	2.407	--	DIRECT
Worm Phenotype (WP)	protein metabolism variant	0.0007933	1.23	--	DIRECT
Worm Phenotype (WP)	alimentary system physiology variant	0.0007983	2.708	--	DIRECT
Worm Phenotype (WP)	conflicting sensory integration variant	0.0008023	2.407	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic physiology variant	0.0009439	1.31	--	DIRECT
Worm Phenotype (WP)	ectopic cell	0.001588	2.708	--	INHERITED FROM: extra and ectopic cell
Worm Phenotype (WP)	locomotor coordination variant	0.004514	1.452	--	INHERITED FROM: body bend variant
Worm Phenotype (WP)	vesicle trafficking variant	0.006609	1.216	--	INHERITED FROM: endocytic transport variant || coelomocyte endocytosis defective
Worm Phenotype (WP)	acetylcholinesterase inhibitor response variant	0.007935	1.503	--	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	excretory secretory system development variant	0.01131	1.929	--	INHERITED FROM: extra excretory cells
Worm Phenotype (WP)	cell membrane morphology variant	0.02587	2.407	--	INHERITED FROM: intercellular junction variant || cell junction variant
Worm Phenotype (WP)	gene expression variant	0.02618	0.6038	--	INHERITED FROM: protein expression variant || drug induced gene expression variant || level of protein expression variant || protein phosphorylation variant
Worm Phenotype (WP)	neuronal outgrowth variant	0.02758	1.407	--	INHERITED FROM: axon outgrowth variant
Worm Phenotype (WP)	neurite morphology variant	0.03625	1.628	--	INHERITED FROM: axon morphology variant
Worm Phenotype (WP)	cell number variant	0.06161	1.327	--	INHERITED FROM: extra excretory cells || extra and ectopic cell
Worm Phenotype (WP)	cell death variant	0.07708	0.9441	--	INHERITED FROM: apoptosis variant || programmed cell death variant
Worm Phenotype (WP)	cell type morphology variant	0.09421	0.8211	--	INHERITED FROM: axon morphology variant || endomitotic oocytes || muscle cell morphology variant
Worm Phenotype (WP)	response to bacteria variant	0.1441	1.26	--	INHERITED FROM: bacterially unswollen
Worm Phenotype (WP)	chemical response variant	0.1967	0.8045	--	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	cell component morphology variant	0.2854	0.7833	--	INHERITED FROM: cell junction variant || intercellular junction variant || axon morphology variant || mitochondria spacing variant || actin organization biogenesis variant || mitochondria alignment variant || mitochondria morphology variant
Worm Phenotype (WP)	sinusoidal movement variant	0.3574	1.708	--	INHERITED FROM: body bend variant
Worm Phenotype (WP)	hermaphrodite fertility variant	0.5399	0.1278	--	INHERITED FROM: brood size variant
Worm Phenotype (WP)	organelle organization biogenesis variant	0.5593	1.23	--	INHERITED FROM: actin organization biogenesis variant
Worm Phenotype (WP)	organism morphology variant	0.6272	0.2011	--	INHERITED FROM: bacterially unswollen || body size variant || organism segment morphology variant || body region morphology variant
Worm Phenotype (WP)	locomotion variant	0.8898	1.045	--	INHERITED FROM: body bend variant || forward locomotion decreased
Worm Phenotype (WP)	growth variant	1	0.4022	--	INHERITED FROM: growth rate variant
Worm Phenotype (WP)	body morphology variant	1	1.164	--	INHERITED FROM: body size variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: level of protein expression variant || forward locomotion decreased || organism metabolism processing variant || ovulation variant || extra and ectopic cell || gonad sheath contraction rate reduced || reproductive system physiology variant || endocytic transport variant || organ system development variant || growth rate variant || organism homeostasis metabolism variant || body bend variant || alimentary system physiology variant || apoptosis variant || lethal || cellular osmotic stress response variant || aldicarb response variant || organism physiology variant || somatic sheath physiology variant || muscle cell physiology variant || extra excretory cells || pathogen resistance increased || sexually dimorphic physiology variant || actin organization biogenesis variant || protein transport variant || protein phosphorylation variant || development variant || posterior body wall contraction defecation cycle variant || organism pathogen response variant || coelomocyte endocytosis defective || coelomocyte physiology variant || somatic gonad physiology variant || defecation contraction variant || cell physiology variant || axon outgrowth variant || brood size variant || embryonic development variant || embryonic lethal || fertility variant || behavior variant || muscle system physiology variant || gonad sheath contractions variant || protein metabolism variant || bacterially unswollen || organ system physiology variant || conflicting sensory integration variant || protein expression variant || organism behavior variant || coelomic system physiology variant || organism development variant || programmed cell death variant || response to injury variant || hermaphrodite physiology variant || fertility reduced || cell development variant || drug induced gene expression variant
Worm Phenotype (WP)	excretory system development variant	1	2.009	--	INHERITED FROM: extra excretory cells
Worm Phenotype (WP)	cell physiology variant	0.0000000001094	0.5344	Least Informative	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.000000001954	0.7119	Least Informative	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.000000004186	0.6905	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.000007577	0.632	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.0001107	0.4572	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0.0001652	0.632	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.01518	0.5677	Least Informative	INHERITED FROM: conflicting sensory integration variant || pathogen resistance increased || bacterially unswollen || response to injury variant || organism pathogen response variant || cellular osmotic stress response variant || aldicarb response variant
Worm Phenotype (WP)	endocytic transport variant	0.00000002511	1.216	Moderately Informative	DIRECT
Worm Phenotype (WP)	apoptosis variant	0.0000002632	1	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0.000001283	1.117	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism segment morphology variant	0.000004652	1.064	Moderately Informative	DIRECT
Worm Phenotype (WP)	body region morphology variant	0.000005033	1.045	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism stress response variant	0.005304	0.8325	Moderately Informative	INHERITED FROM: bacterially unswollen || response to injury variant || cellular osmotic stress response variant || organism pathogen response variant || pathogen resistance increased
Worm Phenotype (WP)	metabolic pathway variant	0.005975	1.117	Moderately Informative	INHERITED FROM: protein phosphorylation variant || protein metabolism variant || protein transport variant
Worm Phenotype (WP)	movement variant	0.0112	1.026	Moderately Informative	INHERITED FROM: forward locomotion decreased || body bend variant
Worm Phenotype (WP)	neuron development variant	0.08967	1.245	Moderately Informative	INHERITED FROM: axon outgrowth variant
Worm Phenotype (WP)	drug response variant	0.2108	1.017	Moderately Informative	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	nervous system morphology variant	0.334	1.216	Moderately Informative	INHERITED FROM: axon morphology variant
Worm Phenotype (WP)	germ cell morphology variant	0.8485	1.064	Moderately Informative	INHERITED FROM: endomitotic oocytes
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.8573	0.9294	Moderately Informative	INHERITED FROM: protein metabolism variant || protein transport variant || response to injury variant || cellular osmotic stress response variant || protein phosphorylation variant
Worm Phenotype (WP)	cell organization biogenesis variant	0.8965	1.106	Moderately Informative	INHERITED FROM: actin organization biogenesis variant
Worm Phenotype (WP)	muscle cell physiology variant	0.000000000009172	1.385	Informative	DIRECT
Worm Phenotype (WP)	coelomic system physiology variant	0.000000009957	1.708	Informative	DIRECT
Worm Phenotype (WP)	brood size variant	0.000002028	1.628	Informative	DIRECT
Worm Phenotype (WP)	mitochondria morphology variant	0.000002028	1.477	Informative	DIRECT
Worm Phenotype (WP)	body bend variant	0.00003635	1.708	Informative	DIRECT
Worm Phenotype (WP)	axon outgrowth variant	0.00005957	1.407	Informative	DIRECT
Worm Phenotype (WP)	aldicarb response variant	0.00008826	1.503	Informative	DIRECT
Worm Phenotype (WP)	cell component localization variant	0.0004331	1.365	Informative	DIRECT
Worm Phenotype (WP)	organism pathogen response variant	0.0005802	1.365	Informative	DIRECT
Worm Phenotype (WP)	level of protein expression variant	0.0007146	1.666	Informative	DIRECT
Worm Phenotype (WP)	tail morphology variant	0.01084	1.666	Informative	INHERITED FROM: bacterially unswollen
Worm Phenotype (WP)	organism osmotic stress response variant	0.01888	1.708	Informative	INHERITED FROM: cellular osmotic stress response variant
Worm Phenotype (WP)	defecation variant	0.03384	1.628	Informative	INHERITED FROM: defecation contraction variant || posterior body wall contraction defecation cycle variant
Worm Phenotype (WP)	cell stress response variant	0.08282	1.407	Informative	INHERITED FROM: cellular osmotic stress response variant || response to injury variant
Worm Phenotype (WP)	neuron morphology variant	0.1513	1.594	Informative	INHERITED FROM: axon morphology variant
Worm Phenotype (WP)	forward locomotion variant	0.2731	1.628	Informative	INHERITED FROM: forward locomotion decreased
Worm Phenotype (WP)	cytoskeleton organization biogenesis variant	0.4564	1.561	Informative	INHERITED FROM: actin organization biogenesis variant
Worm Phenotype (WP)	cell number increased	0.4827	1.477	Informative	INHERITED FROM: extra and ectopic cell || extra excretory cells
Worm Phenotype (WP)	protein modification variant	0.5733	1.594	Informative	INHERITED FROM: protein phosphorylation variant
Worm Phenotype (WP)	oocyte morphology variant	0.761	1.276	Informative	INHERITED FROM: endomitotic oocytes
Worm Phenotype (WP)	endocytic transport defect	1	1.327	Informative	INHERITED FROM: coelomocyte endocytosis defective
Worm Phenotype (WP)	gonad sheath contractions variant	0.000000008015	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	cellular osmotic stress response variant	0.000000351	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	growth rate variant	0.00000389	1.753	Highly Informative	DIRECT
Worm Phenotype (WP)	ovulation variant	0.000009669	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	pathogen resistance increased	0.00004329	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	response to injury variant	0.0001117	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	endomitotic oocytes	0.0001407	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	actin organization biogenesis variant	0.0001695	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	extra excretory cells	0.0002153	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	protein phosphorylation variant	0.0004088	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	coelomocyte endocytosis defective	0.000546	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	defecation contraction variant	0.0006019	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	forward locomotion decreased	0.0006468	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	drug induced gene expression variant	0.0009227	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	membrane trafficking variant	0.001287	2.106	Highly Informative	INHERITED FROM: protein transport variant

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	actin cytoskeleton morphology	0.0006698	2.471	--	DIRECT
Yeast Phenotype (YP)	cytoskeleton morphology	0.01078	2.471	--	INHERITED FROM: actin cytoskeleton morphology
Yeast Phenotype (YP)	cellular morphology	0.5389	1.216	--	INHERITED FROM: actin cytoskeleton morphology
Yeast Phenotype (YP)	morphology	0.02795	1.11	Moderately Informative	INHERITED FROM: actin cytoskeleton morphology
Yeast Phenotype (YP)	subcellular morphology	0.3789	1.392	Informative	INHERITED FROM: actin cytoskeleton morphology

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	non-connected developing system	0.000807	1.339	--	DIRECT
Fly Anatomy (FA)	developing embryonic structure	0.003937	1.204	--	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	organ system	0.004664	0.2279	--	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	anatomical group	0.01351	0.7891	--	INHERITED FROM: embryonic foregut || non-connected developing system
Fly Anatomy (FA)	organism	0.2258	0.07918	--	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	digestive system	0.2319	1.426	--	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	alimentary canal	0.2978	1.426	--	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	gut	0.3094	1.426	--	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	foregut	0.3516	1.778	--	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	presumptive embryonic/larval digestive system	0.4111	1.903	--	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	developing material anatomical entity	0.4482	0.8487	--	INHERITED FROM: non-connected developing system || embryonic foregut
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: embryonic foregut || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || non-connected developing system || embryonic foregut
Fly Anatomy (FA)	organ system subdivision	0.01653	0.5673	Least Informative	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	multi-tissue structure	0.08276	0.7081	Least Informative	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	embryo	0.1778	0.9178	Moderately Informative	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	presumptive embryonic/larval system	0.05646	1.339	Informative	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	gut section	0.5295	1.426	Informative	INHERITED FROM: embryonic foregut
Fly Anatomy (FA)	embryonic foregut	0.0005364	2.079	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical group	0.03488	0.1442	--	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	compound organ	0.05098	0.24	--	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.2756	0.1217	--	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	head region	0.3307	0.5108	--	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	anatomical region	0.5859	0.193	--	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	organism subdivision	0.8149	0.1871	--	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	anatomical structure	0.9824	0	--	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	central nervous system	0.9951	0.6506	--	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	nervous system	0.07515	0.6341	Least Informative	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.2774	0.3033	Least Informative	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	head	0.4383	0.5108	Least Informative	INHERITED FROM: brain
Xenopus ANatomical entity (XAN)	brain	0.0002482	0.8635	Moderately Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	pollen sac	0.000341	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0.0003716	0.7448	--	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0.002827	0.7531	--	INHERITED FROM: pollen
Plant ANatomical entity (PAN)	plant cell	0.005622	0.1489	--	INHERITED FROM: pollen tube cell
Plant ANatomical entity (PAN)	sporophyll	0.02992	0.4713	--	INHERITED FROM: pollen || pollen sac
Plant ANatomical entity (PAN)	phyllome	0.1826	0.3809	--	INHERITED FROM: pollen sac || pollen
Plant ANatomical entity (PAN)	shoot system	0.2331	0.05747	--	INHERITED FROM: pollen sac || pollen
Plant ANatomical entity (PAN)	collective plant structure	0.6015	0.01577	--	INHERITED FROM: pollen sac || pollen
Plant ANatomical entity (PAN)	plant organ	0.6174	0.2816	--	INHERITED FROM: microsporangium || pollen sac || pollen || sporangium
Plant ANatomical entity (PAN)	multi-tissue plant structure	0.6598	0.2691	--	INHERITED FROM: microsporangium || pollen || pollen sac || sporangium
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: pollen sac || sporangium || microsporangium || pollen || pollen tube cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: pollen || pollen sac
Plant ANatomical entity (PAN)	sporangium	0.0003839	0.7407	Least Informative	DIRECT
Plant ANatomical entity (PAN)	whole plant	0.03634	0.4218	Least Informative	INHERITED FROM: pollen
Plant ANatomical entity (PAN)	microsporophyll	0.6566	0.5029	Least Informative	INHERITED FROM: pollen sac || pollen
Plant ANatomical entity (PAN)	pollen	0.0003383	0.7531	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	pollen tube cell	0.00001548	1.339	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	androecium development stage	0.00008874	1.135	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0.1342	0.0937	--	INHERITED FROM: androecium development stage || pollen development stage
Plant structure DEvelopment stage (PDE)	plant organ development stage	0.1753	0.08108	--	INHERITED FROM: androecium development stage || pollen development stage
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0.4096	0.0937	--	INHERITED FROM: androecium development stage || pollen development stage
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0.4665	0.0937	--	INHERITED FROM: androecium development stage || pollen development stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: flowering stage || pollen development stage || androecium development stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || flowering stage || pollen development stage || androecium development stage
Plant structure DEvelopment stage (PDE)	pollen development stage	0.00004521	1.135	Moderately Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Sterol 3-beta-glucosyltransferase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.7559	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-3-phosphatase	0	2.475	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase	0	2.475	--	DIRECT
Enzyme Commission (EC)	Dynamin GTPase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Transferases	0.00000000000000277	0.3035	--	DIRECT
Enzyme Commission (EC)	[Beta-adrenergic-receptor] kinase	0.00000000000005063	2.651	--	DIRECT
Enzyme Commission (EC)	Acting on GTP; involved in cellular and subcellular movement	0.00000000000007979	2.253	--	DIRECT
Enzyme Commission (EC)	Protein kinase C	0.000002995	2.253	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.5453	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.3541	Least Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.181	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0.000007383	1.174	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0.04169	1.204	Moderately Informative	INHERITED FROM: Hexosyltransferases || Sterol 3-beta-glucosyltransferase
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	1	1.119	Moderately Informative	INHERITED FROM: Diacylglycerol kinase (ATP)
Enzyme Commission (EC)	Acting on acid anhydrides	1	0.9562	Moderately Informative	INHERITED FROM: Dynamin GTPase || Acting on GTP; involved in cellular and subcellular movement
Enzyme Commission (EC)	Protein-tyrosine kinases	0	1.537	Informative	DIRECT
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	1.46	Informative	DIRECT
Enzyme Commission (EC)	Hexosyltransferases	0.0000000000003104	1.572	Informative	DIRECT
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0.0002048	1.63	Informative	DIRECT
Enzyme Commission (EC)	Diacylglycerol kinase (ATP)	0	2.174	Highly Informative	DIRECT
Enzyme Commission (EC)	Non-specific protein-tyrosine kinase	0	1.873	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	1.998	Highly Informative	DIRECT

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