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Pleckstrin-homology domain (PH domain) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Family:   Pleckstrin-homology domain (PH domain) [ 50730] (47)

Family statistics
Genomes (147) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,356 22,474 73
Proteins 7,148 21,855 73

Enzyme Commission (EC)

show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000001836Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.4013Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3308Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.0000001585InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000000000001037Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0.00000006708Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the ear0.8045Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.2532InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the inner ear0.006079Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.06415Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1491Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3945Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.915Least InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.02019Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.0663Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.07199Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.125Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1701Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.1828Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.4337Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.6307Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.00003008InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.00009182InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0.05308InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland physiology0.06567InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.1379InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.5911InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-2 secretion0.00006608Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.000109Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage B cell morphology0.01019Highly InformativeInherited
Mammalian Phenotype (MP)decreased immature B cell number0.1725Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000002744Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000007837Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00005522Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0001213Least InformativeDirect
Worm Phenotype (WP)cell development variant0.01382Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0000003356Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0000003529Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.000004733Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0001776Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.009697Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.04256Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.0492Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.05527Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.1138Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0000000003342InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0000003186InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000009306InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.00004774InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000143InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0001435InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0003092InformativeDirect
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.002233InformativeInherited
Worm Phenotype (WP)body posture variant0.00241InformativeInherited
Worm Phenotype (WP)egg laying variant0.003651InformativeInherited
Worm Phenotype (WP)endocytic transport defect0.003863InformativeInherited
Worm Phenotype (WP)cell number increased0.005085InformativeInherited
Worm Phenotype (WP)chemical resistant0.005549InformativeInherited
Worm Phenotype (WP)cell component localization variant0.01234InformativeInherited
Worm Phenotype (WP)hermaphrodite physiology variant0.01416InformativeInherited
Worm Phenotype (WP)defecation variant0.01438InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.02738InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.05494InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.06644InformativeInherited
Worm Phenotype (WP)drug resistant0.09947InformativeInherited
Worm Phenotype (WP)chemosensory response variant0.1255InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.5564InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)growth rate variant0.0000001283Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.00001528Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.00003292Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.00004222Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00004946Highly InformativeDirect
Worm Phenotype (WP)coelomocyte endocytosis defective0.00006374Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00007872Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0001403Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.000393Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.000939Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.002066Highly InformativeInherited
Worm Phenotype (WP)protein phosphorylation variant0.002097Highly InformativeInherited
Worm Phenotype (WP)tail morphology variant0.00407Highly InformativeInherited
Worm Phenotype (WP)egg laying response to drug variant0.03441Highly InformativeInherited
Worm Phenotype (WP)serotonin response variant0.05766Highly InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.1217Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases3.693e-16Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.00003228Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.00000000001524Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.04578Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.239InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000000000001101Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 129 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a PH domain-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]