Pleckstrin-homology domain (PH domain) family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: PH domain-like barrel [ 50728] (2)
• Superfamily: PH domain-like [ 50729] (13)
• Family: Pleckstrin-homology domain (PH domain) [ 50730] (47)

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Family statistics

	Genomes (147)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	7,356	22,474	73
Proteins	7,148	21,855	73

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Dynamin GTPase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Sterol 3-beta-glucosyltransferase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Transferases	5.205e-16	0	--	DIRECT
Enzyme Commission (EC)	[Beta-adrenergic-receptor] kinase	0.000000000000001381	2.44	--	DIRECT
Enzyme Commission (EC)	Protein-tyrosine kinases	0.000006997	1.361	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.0002753	0.01852	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.000000000001836	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0.4013	0.7283	Least Informative	INHERITED FROM: Dynamin GTPase || Acting on GTP; involved in cellular and subcellula
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.042	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	1	0.8381	Moderately Informative	INHERITED FROM: Diacylglycerol kinase
Enzyme Commission (EC)	Glycosyltransferases	0.3308	0.993	Moderately Informative	INHERITED FROM: Sterol 3-beta-glucosyltransferase || Hexosyltransferases
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	1.379	Informative	DIRECT
Enzyme Commission (EC)	Hexosyltransferases	0.0000001585	1.264	Informative	DIRECT
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	1.896	Highly Informative	DIRECT
Enzyme Commission (EC)	Diacylglycerol kinase	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Acting on GTP; involved in cellular and subcellula	0	2.139	Highly Informative	DIRECT
Enzyme Commission (EC)	Non-specific protein-tyrosine kinase	0.000000000000001037	1.787	Highly Informative	DIRECT
Enzyme Commission (EC)	Protein kinase C	0.00000006708	1.963	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Aplasia of the semicircular canal	0.0005921	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the semicircular canal	0.001277	2.161	--	INHERITED FROM: Aplasia of the semicircular canal
Phenotypic Abnormality (PA)	Morphological abnormality of the vestibule of the inner ear	0.1009	2.161	--	INHERITED FROM: Aplasia of the semicircular canal
Phenotypic Abnormality (PA)	Abnormal ear morphology	0.7405	1.047	--	INHERITED FROM: Aplasia of the semicircular canal
Phenotypic Abnormality (PA)	Abnormality of the ear	0.8045	0.9572	Moderately Informative	INHERITED FROM: Aplasia of the semicircular canal
Phenotypic Abnormality (PA)	Abnormality of the inner ear	0.2532	1.508	Informative	INHERITED FROM: Aplasia of the semicircular canal
Phenotypic Abnormality (PA)	Morphological abnormality of the inner ear	0.006079	1.985	Highly Informative	INHERITED FROM: Aplasia of the semicircular canal

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased transitional stage B cell number	0.00002274	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal adrenal gland secretion	0.0001241	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.0001945	0.8789	--	DIRECT
Mammalian Phenotype (MP)	abnormal platelet aggregation	0.0007475	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.000842	0.9219	--	DIRECT
Mammalian Phenotype (MP)	abnormal platelet activation	0.001002	1.7	--	INHERITED FROM: decreased platelet aggregation || abnormal platelet aggregation
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.00125	0.9219	--	INHERITED FROM: abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal interleukin-2 secretion	0.00187	1.758	--	INHERITED FROM: decreased interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.002285	0.8789	--	INHERITED FROM: abnormal platelet aggregation || abnormal B cell proliferation || abnormal blood cell physiology || decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.002478	0.9219	--	INHERITED FROM: abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal adrenal gland physiology	0.002802	2.603	--	INHERITED FROM: abnormal adrenal gland secretion
Mammalian Phenotype (MP)	abnormal mature B cell morphology	0.004114	1.281	--	INHERITED FROM: abnormal B-1 B cell number || decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.009424	0.7167	--	INHERITED FROM: decreased transitional stage B cell number || abnormal B-1 B cell number
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.009554	1.072	--	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal B-1 B cell morphology	0.01431	1.649	--	INHERITED FROM: abnormal B-1 B cell number
Mammalian Phenotype (MP)	abnormal B cell activation	0.01787	1.562	--	INHERITED FROM: abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.02721	0.8473	--	INHERITED FROM: abnormal B-1 B cell number || decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.02954	0.8038	--	INHERITED FROM: abnormal B-1 B cell number || decreased transitional stage B cell number
Mammalian Phenotype (MP)	decreased leukocyte cell number	0.0328	1.156	--	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.03408	0.9129	--	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.03932	1.156	--	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal platelet physiology	0.04731	1.7	--	INHERITED FROM: decreased platelet aggregation || abnormal platelet aggregation
Mammalian Phenotype (MP)	abnormal B cell number	0.05083	1.348	--	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal immune system physiology	0.05159	0.6789	--	INHERITED FROM: abnormal cell-mediated immunity || decreased interleukin-2 secretion || abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal hemostasis	0.07097	1.399	--	INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0.07316	1.156	--	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.07492	1.112	--	INHERITED FROM: abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.1047	0.9404	--	INHERITED FROM: abnormal B-1 B cell number || decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal B cell physiology	0.1201	1.172	--	INHERITED FROM: abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.1699	1.205	--	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal immature B cell morphology	0.1781	1.7	--	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal immature B cell number	0.1895	1.7	--	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.2244	1.072	--	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal gland physiology	0.2879	1.324	--	INHERITED FROM: abnormal adrenal gland secretion
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.3292	0.6686	--	INHERITED FROM: decreased transitional stage B cell number || abnormal B-1 B cell number
Mammalian Phenotype (MP)	abnormal immune system morphology	0.3512	0.7223	--	INHERITED FROM: decreased transitional stage B cell number || abnormal B-1 B cell number
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.4011	0.6893	--	INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal interleukin secretion	0.4283	1.188	--	INHERITED FROM: decreased interleukin-2 secretion
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.4641	0.3626	--	INHERITED FROM: decreased platelet aggregation || abnormal platelet aggregation
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.5294	0.8473	--	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.559	0.8108	--	INHERITED FROM: abnormal B-1 B cell number || decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal cytokine secretion	0.8625	1.085	--	INHERITED FROM: decreased interleukin-2 secretion
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.06415	0.5945	Least Informative	INHERITED FROM: abnormal B-1 B cell number || abnormal blood cell physiology || abnormal B cell proliferation || abnormal platelet aggregation || decreased platelet aggregation || decreased transitional stage B cell number
Mammalian Phenotype (MP)	immune system phenotype	0.1491	0.5462	Least Informative	INHERITED FROM: abnormal B cell proliferation || decreased interleukin-2 secretion || abnormal B-1 B cell number || abnormal cell-mediated immunity || decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal homeostasis	0.3945	0.4926	Least Informative	INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.915	0.6947	Least Informative	INHERITED FROM: abnormal adrenal gland secretion
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.02019	1.072	Moderately Informative	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal B cell morphology	0.0663	1.156	Moderately Informative	INHERITED FROM: decreased transitional stage B cell number || abnormal B-1 B cell number
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0.07199	1.023	Moderately Informative	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.125	1.059	Moderately Informative	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.1701	1.001	Moderately Informative	INHERITED FROM: decreased interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.1828	1.098	Moderately Informative	INHERITED FROM: decreased transitional stage B cell number || abnormal B-1 B cell number
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.2218	0.9129	Moderately Informative	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.4337	0.9219	Moderately Informative	INHERITED FROM: abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.6307	1.098	Moderately Informative	INHERITED FROM: abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal B cell proliferation	0.00003008	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal B-1 B cell number	0.00009182	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal blood coagulation	0.05308	1.399	Informative	INHERITED FROM: decreased platelet aggregation || abnormal platelet aggregation
Mammalian Phenotype (MP)	abnormal endocrine gland physiology	0.06567	1.603	Informative	INHERITED FROM: abnormal adrenal gland secretion
Mammalian Phenotype (MP)	decreased B cell number	0.1379	1.562	Informative	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal B cell differentiation	0.5911	1.373	Informative	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	decreased interleukin-2 secretion	0.00006608	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased platelet aggregation	0.000109	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal transitional stage B cell morphology	0.01019	2.001	Highly Informative	INHERITED FROM: decreased transitional stage B cell number
Mammalian Phenotype (MP)	decreased immature B cell number	0.1725	2.001	Highly Informative	INHERITED FROM: decreased transitional stage B cell number

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0.0000000005112	1.306	--	DIRECT
Worm Phenotype (WP)	posterior body wall contraction defecation cycle variant	0.0000000005453	2.292	--	DIRECT
Worm Phenotype (WP)	striated muscle morphology variant	0.0000000008115	1.407	--	DIRECT
Worm Phenotype (WP)	bacterially unswollen	0.000000002372	2.468	--	DIRECT
Worm Phenotype (WP)	gonad sheath contraction rate reduced	0.00000001024	2.292	--	DIRECT
Worm Phenotype (WP)	gonad sheath contractions variant	0.00000006453	2.292	--	DIRECT
Worm Phenotype (WP)	protein subcellular localization variant	0.0000002912	1.513	--	DIRECT
Worm Phenotype (WP)	somatic gonad physiology variant	0.0000005104	2.292	--	DIRECT
Worm Phenotype (WP)	body bend variant	0.0000005228	1.623	--	DIRECT
Worm Phenotype (WP)	aldicarb response variant	0.0000007124	1.655	--	DIRECT
Worm Phenotype (WP)	coiling variant	0.00000188	1.769	--	DIRECT
Worm Phenotype (WP)	coelomic system physiology variant	0.000002888	1.814	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.000003191	0.7516	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.000004281	0.7558	--	DIRECT
Worm Phenotype (WP)	cellular osmotic stress response variant	0.000006993	2.167	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.000008505	0.6859	--	DIRECT
Worm Phenotype (WP)	mitochondria alignment variant	0.000008563	1.623	--	DIRECT
Worm Phenotype (WP)	muscle system morphology variant	0.00001925	1.407	--	DIRECT
Worm Phenotype (WP)	somatic sheath physiology variant	0.00003012	2.292	--	DIRECT
Worm Phenotype (WP)	diacetyl chemotaxis variant	0.00003061	2.468	--	DIRECT
Worm Phenotype (WP)	body size variant	0.00003657	1.189	--	DIRECT
Worm Phenotype (WP)	AWA odorant chemotaxis variant	0.00005174	2.468	--	DIRECT
Worm Phenotype (WP)	egg laying imipramine resistant	0.00007337	2.769	--	DIRECT
Worm Phenotype (WP)	conflicting sensory integration variant	0.0001003	2.468	--	DIRECT
Worm Phenotype (WP)	muscle cell morphology variant	0.000133	1.337	--	DIRECT
Worm Phenotype (WP)	pathogen resistance increased	0.0002201	2.292	--	DIRECT
Worm Phenotype (WP)	protein phosphorylation reduced	0.0002459	2.292	--	DIRECT
Worm Phenotype (WP)	muscle arm development variant	0.0002657	1.866	--	DIRECT
Worm Phenotype (WP)	body wall cell development variant	0.0004097	1.814	--	DIRECT
Worm Phenotype (WP)	egg laying serotonin variant	0.0004685	2.468	--	DIRECT
Worm Phenotype (WP)	coelomocyte physiology variant	0.000483	1.924	--	DIRECT
Worm Phenotype (WP)	dauer development variant	0.0007621	1.769	--	DIRECT
Worm Phenotype (WP)	positive chemotaxis variant	0.001971	1.689	--	INHERITED FROM: diacetyl chemotaxis variant || AWA odorant chemotaxis variant
Worm Phenotype (WP)	muscle cell development variant	0.002867	1.814	--	INHERITED FROM: muscle arm development variant || body wall cell development variant
Worm Phenotype (WP)	excretory secretory system development variant	0.003365	1.924	--	INHERITED FROM: extra excretory cells
Worm Phenotype (WP)	metabolic pathway variant	0.003697	1.263	--	INHERITED FROM: protein degradation variant || protein phosphorylation reduced
Worm Phenotype (WP)	endocytic transport variant	0.004393	1.354	--	INHERITED FROM: coelomocyte endocytosis defective
Worm Phenotype (WP)	inhibitor of serotonin uptake variant	0.005214	2.769	--	INHERITED FROM: egg laying imipramine resistant
Worm Phenotype (WP)	larval physiology variant	0.01046	1.593	--	INHERITED FROM: dauer development variant
Worm Phenotype (WP)	imipramine resistant	0.01486	2.769	--	INHERITED FROM: egg laying imipramine resistant
Worm Phenotype (WP)	cell number variant	0.01719	1.371	--	INHERITED FROM: extra excretory cells
Worm Phenotype (WP)	neuron development variant	0.01747	1.321	--	INHERITED FROM: axon outgrowth variant
Worm Phenotype (WP)	chemosensory behavior variant	0.01969	1.49	--	INHERITED FROM: AWA odorant chemotaxis variant || diacetyl chemotaxis variant
Worm Phenotype (WP)	neuronal outgrowth variant	0.02153	1.565	--	INHERITED FROM: axon outgrowth variant
Worm Phenotype (WP)	sexually dimorphic physiology variant	0.02583	1.426	--	INHERITED FROM: somatic sheath physiology variant || gonad sheath contraction rate reduced || gonad sheath contractions variant
Worm Phenotype (WP)	neurite morphology variant	0.03457	1.866	--	INHERITED FROM: axon morphology variant
Worm Phenotype (WP)	postembryonic development variant	0.03589	0.269	--	INHERITED FROM: dauer development variant
Worm Phenotype (WP)	response to bacteria variant	0.04496	1.426	--	INHERITED FROM: bacterially unswollen
Worm Phenotype (WP)	neuron morphology variant	0.07217	1.866	--	INHERITED FROM: axon morphology variant
Worm Phenotype (WP)	drug response variant	0.1036	1.135	--	INHERITED FROM: egg laying serotonin variant || aldicarb response variant || egg laying imipramine resistant
Worm Phenotype (WP)	gene expression variant	0.1541	0.6256	--	INHERITED FROM: protein subcellular localization variant || protein expression variant || drug induced gene expression variant || protein phosphorylation reduced
Worm Phenotype (WP)	mitochondria spacing variant	0.1569	1.623	--	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	nervous system morphology variant	0.2338	1.321	--	INHERITED FROM: axon morphology variant
Worm Phenotype (WP)	larval development variant	0.2353	0.4322	--	INHERITED FROM: dauer development variant
Worm Phenotype (WP)	sinusoidal movement variant	0.2752	1.623	--	INHERITED FROM: body bend variant
Worm Phenotype (WP)	vesicle trafficking variant	0.2944	1.354	--	INHERITED FROM: coelomocyte endocytosis defective
Worm Phenotype (WP)	odorant chemosensory response variant	0.3197	1.814	--	INHERITED FROM: diacetyl chemotaxis variant || AWA odorant chemotaxis variant
Worm Phenotype (WP)	cell component morphology variant	0.3853	0.8392	--	INHERITED FROM: axon morphology variant || mitochondria alignment variant || mitochondria morphology variant
Worm Phenotype (WP)	protein modification variant	0.4565	1.769	--	INHERITED FROM: protein phosphorylation reduced
Worm Phenotype (WP)	organism morphology variant	0.7156	0.1372	--	INHERITED FROM: bacterially unswollen || body size variant || organism segment morphology variant || body region morphology variant
Worm Phenotype (WP)	locomotion variant	0.7577	1.053	--	INHERITED FROM: body bend variant || locomotor coordination variant || forward locomotion decreased
Worm Phenotype (WP)	growth variant	0.82	0.3438	--	INHERITED FROM: growth rate variant
Worm Phenotype (WP)	chemotaxis variant	0.8411	1.513	--	INHERITED FROM: diacetyl chemotaxis variant || AWA odorant chemotaxis variant
Worm Phenotype (WP)	germ cell morphology variant	0.8604	1.156	--	INHERITED FROM: endomitotic oocytes
Worm Phenotype (WP)	body morphology variant	1	1.145	--	INHERITED FROM: body size variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || forward locomotion decreased || organism metabolism processing variant || muscle arm development variant || ovulation variant || gonad sheath contraction rate reduced || reproductive system physiology variant || protein phosphorylation reduced || organ system development variant || growth rate variant || organism homeostasis metabolism variant || body bend variant || protein degradation variant || lethal || cellular osmotic stress response variant || aldicarb response variant || organism physiology variant || somatic sheath physiology variant || AWA odorant chemotaxis variant || muscle cell physiology variant || extra excretory cells || pathogen resistance increased || protein subcellular localization variant || development variant || egg laying serotonin variant || posterior body wall contraction defecation cycle variant || organism pathogen response variant || coelomocyte endocytosis defective || coelomocyte physiology variant || somatic gonad physiology variant || defecation contraction variant || cell physiology variant || hermaphrodite sterile || organism environmental stimulus response variant || hermaphrodite fertility reduced || diacetyl chemotaxis variant || axon outgrowth variant || embryonic development variant || embryonic lethal || egg laying imipramine resistant || fertility variant || behavior variant || muscle system physiology variant || coiling variant || gonad sheath contractions variant || body wall cell development variant || locomotor coordination variant || bacterially unswollen || dauer development variant || organ system physiology variant || conflicting sensory integration variant || protein expression variant || organism behavior variant || maternal sterile || cell stress response variant || coelomic system physiology variant || organism development variant || fertility reduced || drug induced gene expression variant
Worm Phenotype (WP)	excretory system development variant	1	1.99	--	INHERITED FROM: extra excretory cells
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.446	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	cell physiology variant	0.000002744	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0.000007837	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.00005522	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.0001213	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.01382	0.6752	Least Informative	INHERITED FROM: body wall cell development variant || muscle arm development variant || axon outgrowth variant
Worm Phenotype (WP)	organism segment morphology variant	0.0000003356	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	body region morphology variant	0.0000003529	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	organ system development variant	0.000004733	0.9113	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0.0001776	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism stress response variant	0.009697	0.9693	Moderately Informative	INHERITED FROM: bacterially unswollen || cellular osmotic stress response variant || organism pathogen response variant || cell stress response variant || pathogen resistance increased
Worm Phenotype (WP)	movement variant	0.04256	1.02	Moderately Informative	INHERITED FROM: locomotor coordination variant || forward locomotion decreased || body bend variant
Worm Phenotype (WP)	cell type morphology variant	0.0492	0.8878	Moderately Informative	INHERITED FROM: striated muscle morphology variant || axon morphology variant || body wall muscle sarcomere morphology variant || endomitotic oocytes || muscle cell morphology variant
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.05527	1.036	Moderately Informative	INHERITED FROM: cellular osmotic stress response variant || protein degradation variant || cell stress response variant || protein phosphorylation reduced
Worm Phenotype (WP)	chemical response variant	0.1138	0.9053	Moderately Informative	INHERITED FROM: diacetyl chemotaxis variant || AWA odorant chemotaxis variant || aldicarb response variant || egg laying imipramine resistant || egg laying serotonin variant
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0.0000000003342	1.446	Informative	DIRECT
Worm Phenotype (WP)	muscle cell physiology variant	0.0000003186	1.426	Informative	DIRECT
Worm Phenotype (WP)	mitochondria morphology variant	0.000009306	1.513	Informative	DIRECT
Worm Phenotype (WP)	organism pathogen response variant	0.00004774	1.468	Informative	DIRECT
Worm Phenotype (WP)	axon outgrowth variant	0.000143	1.565	Informative	DIRECT
Worm Phenotype (WP)	locomotor coordination variant	0.0001435	1.446	Informative	DIRECT
Worm Phenotype (WP)	cell stress response variant	0.0003092	1.538	Informative	DIRECT
Worm Phenotype (WP)	acetylcholinesterase inhibitor response variant	0.002233	1.623	Informative	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	body posture variant	0.00241	1.513	Informative	INHERITED FROM: coiling variant
Worm Phenotype (WP)	egg laying variant	0.003651	1.513	Informative	INHERITED FROM: egg laying imipramine resistant || egg laying serotonin variant
Worm Phenotype (WP)	endocytic transport defect	0.003863	1.407	Informative	INHERITED FROM: coelomocyte endocytosis defective
Worm Phenotype (WP)	cell number increased	0.005085	1.446	Informative	INHERITED FROM: extra excretory cells
Worm Phenotype (WP)	chemical resistant	0.005549	1.593	Informative	INHERITED FROM: egg laying imipramine resistant
Worm Phenotype (WP)	cell component localization variant	0.01234	1.388	Informative	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	hermaphrodite physiology variant	0.01416	1.446	Informative	INHERITED FROM: somatic sheath physiology variant || gonad sheath contraction rate reduced || gonad sheath contractions variant
Worm Phenotype (WP)	defecation variant	0.01438	1.689	Informative	INHERITED FROM: defecation contraction variant || posterior body wall contraction defecation cycle variant
Worm Phenotype (WP)	protein metabolism variant	0.02738	1.354	Informative	INHERITED FROM: protein phosphorylation reduced || protein degradation variant
Worm Phenotype (WP)	pattern protein expression variant	0.05494	1.49	Informative	INHERITED FROM: protein subcellular localization variant
Worm Phenotype (WP)	forward locomotion variant	0.06644	1.623	Informative	INHERITED FROM: forward locomotion decreased
Worm Phenotype (WP)	drug resistant	0.09947	1.689	Informative	INHERITED FROM: egg laying imipramine resistant
Worm Phenotype (WP)	chemosensory response variant	0.1255	1.49	Informative	INHERITED FROM: AWA odorant chemotaxis variant || diacetyl chemotaxis variant
Worm Phenotype (WP)	oocyte morphology variant	0.5564	1.292	Informative	INHERITED FROM: endomitotic oocytes
Worm Phenotype (WP)	dauer larva physiology variant	1	1.593	Informative	INHERITED FROM: dauer development variant
Worm Phenotype (WP)	growth rate variant	0.0000001283	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	drug induced gene expression variant	0.00001528	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	endomitotic oocytes	0.00003292	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	ovulation variant	0.00004222	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	forward locomotion decreased	0.00004946	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	coelomocyte endocytosis defective	0.00006374	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	protein degradation variant	0.00007872	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	defecation contraction variant	0.0001403	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	axon morphology variant	0.000393	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	extra excretory cells	0.000939	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	organism osmotic stress response variant	0.002066	1.866	Highly Informative	INHERITED FROM: cellular osmotic stress response variant
Worm Phenotype (WP)	protein phosphorylation variant	0.002097	2.07	Highly Informative	INHERITED FROM: protein phosphorylation reduced
Worm Phenotype (WP)	tail morphology variant	0.00407	1.866	Highly Informative	INHERITED FROM: bacterially unswollen
Worm Phenotype (WP)	egg laying response to drug variant	0.03441	2.167	Highly Informative	INHERITED FROM: egg laying imipramine resistant || egg laying serotonin variant
Worm Phenotype (WP)	serotonin response variant	0.05766	2.167	Highly Informative	INHERITED FROM: egg laying serotonin variant
Worm Phenotype (WP)	odorant positive chemotaxis variant	0.1217	1.924	Highly Informative	INHERITED FROM: AWA odorant chemotaxis variant || diacetyl chemotaxis variant

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || organism

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Sterol 3-beta-glucosyltransferase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Diacylglycerol kinase (ATP)	0	2.452	--	DIRECT
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	2.275	--	DIRECT
Enzyme Commission (EC)	Acting on GTP; involved in cellular and subcellular movement	0	2.531	--	DIRECT
Enzyme Commission (EC)	Dynamin GTPase	0	3.23	--	DIRECT
Enzyme Commission (EC)	[Beta-adrenergic-receptor] kinase	7.357e-16	2.929	--	DIRECT
Enzyme Commission (EC)	Hexosyltransferases	0.00000001178	1.65	--	DIRECT
Enzyme Commission (EC)	Protein kinase C	0.00000003551	2.452	--	DIRECT
Enzyme Commission (EC)	Protein-tyrosine kinases	0.000008448	1.767	--	DIRECT
Enzyme Commission (EC)	Transferases	3.693e-16	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0.00003228	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.00000000001524	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0.04578	1.133	Moderately Informative	INHERITED FROM: Dynamin GTPase || Acting on GTP; involved in cellular and subcellular movement
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	1	1.238	Moderately Informative	INHERITED FROM: Diacylglycerol kinase (ATP)
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.437	Informative	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0.239	1.378	Informative	INHERITED FROM: Hexosyltransferases || Sterol 3-beta-glucosyltransferase
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	1.753	Highly Informative	DIRECT
Enzyme Commission (EC)	Non-specific protein-tyrosine kinase	0.000000000000001101	2.084	Highly Informative	DIRECT

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