Hemopexin-like domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: 4-bladed beta-propeller [ 50922]
• Superfamily: Hemopexin-like domain [ 50923]
• Family: Hemopexin-like domain [ 50924] (5)

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Family statistics

	Genomes (131)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,546	3,664	11
Proteins	1,484	3,510	10

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Interstitial collagenase	0.0000003007	2.264	--	DIRECT
Enzyme Commission (EC)	Membrane-type matrix metalloproteinase-1	0.000001338	2.264	--	DIRECT
Enzyme Commission (EC)	Stromelysin 1	0.000005852	2.264	--	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	0.5709	Least Informative	DIRECT
Enzyme Commission (EC)	Metalloendopeptidases	0	1.326	Informative	DIRECT
Enzyme Commission (EC)	Gelatinase B	0.000005852	2.139	Highly Informative	DIRECT
Enzyme Commission (EC)	Gelatinase A	0.000005852	2.139	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	tooth disease	0.00000001053	1.399	--	DIRECT
Disease Ontology (DO)	lymph node disease	0.0000005567	1.668	--	DIRECT
Disease Ontology (DO)	prostate cancer	0.0000008597	1.735	--	DIRECT
Disease Ontology (DO)	refractive error	0.000007987	1.911	--	DIRECT
Disease Ontology (DO)	reproductive organ cancer	0.00001165	1.367	--	DIRECT
Disease Ontology (DO)	ovary epithelial cancer	0.00001208	1.735	--	DIRECT
Disease Ontology (DO)	ovarian cancer	0.00001452	1.735	--	DIRECT
Disease Ontology (DO)	mouth disease	0.00002597	1.399	--	DIRECT
Disease Ontology (DO)	carcinoma	0.00003742	1.098	--	DIRECT
Disease Ontology (DO)	lung disease	0.00004538	1.258	--	DIRECT
Disease Ontology (DO)	intrinsic cardiomyopathy	0.00005094	1.735	--	DIRECT
Disease Ontology (DO)	arteriosclerotic cardiovascular disease	0.00006763	1.367	--	DIRECT
Disease Ontology (DO)	reproductive system disease	0.0002498	1.399	--	DIRECT
Disease Ontology (DO)	lymphatic system disease	0.0004438	1.668	--	DIRECT
Disease Ontology (DO)	endometrial carcinoma	0.0005019	1.735	--	DIRECT
Disease Ontology (DO)	primary bacterial infectious disease	0.0005252	1.212	--	DIRECT
Disease Ontology (DO)	endometrial cancer	0.00056	1.735	--	DIRECT
Disease Ontology (DO)	aortic disease	0.0005876	1.814	--	DIRECT
Disease Ontology (DO)	bone marrow cancer	0.0007253	1.399	--	DIRECT
Disease Ontology (DO)	bone inflammation disease	0.0008238	1.309	--	DIRECT
Disease Ontology (DO)	astrocytoma	0.001051	1.735	--	INHERITED FROM: adult astrocytic tumour
Disease Ontology (DO)	lipid metabolism disorder	0.001147	1.61	--	INHERITED FROM: familial hyperlipidemia
Disease Ontology (DO)	rheumatic disease	0.001161	1.513	--	INHERITED FROM: scleroderma
Disease Ontology (DO)	oral cavity cancer	0.001768	2.036	--	INHERITED FROM: salivary gland adenoid cystic carcinoma
Disease Ontology (DO)	respiratory system disease	0.00209	0.9334	--	INHERITED FROM: bronchiectasis || lower respiratory tract disease || lung disease
Disease Ontology (DO)	connective tissue cancer	0.003093	1.367	--	INHERITED FROM: chondrosarcoma
Disease Ontology (DO)	central nervous system cancer	0.00551	1.668	--	INHERITED FROM: meningioma
Disease Ontology (DO)	collagen disease	0.006001	1.472	--	INHERITED FROM: scleroderma
Disease Ontology (DO)	cardiovascular system disease	0.006814	0.7889	--	INHERITED FROM: aortic disease || atherosclerosis || abdominal aortic aneurysm || arteriosclerotic cardiovascular disease || intrinsic cardiomyopathy
Disease Ontology (DO)	arteriosclerosis	0.01167	1.367	--	INHERITED FROM: atherosclerosis || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	bacterial infectious disease	0.01346	1.191	--	INHERITED FROM: primary bacterial infectious disease
Disease Ontology (DO)	immune system disease	0.01604	0.8411	--	INHERITED FROM: Kawasaki disease || lymphatic system disease || lymph node disease || scleroderma
Disease Ontology (DO)	musculoskeletal system disease	0.01725	0.89	--	INHERITED FROM: scleroderma || arthritis || bone inflammation disease
Disease Ontology (DO)	cardiomyopathy	0.01866	1.735	--	INHERITED FROM: intrinsic cardiomyopathy
Disease Ontology (DO)	cancer	0.0412	0.2555	--	INHERITED FROM: ovarian cancer || adult astrocytic tumour || salivary gland adenoid cystic carcinoma || endometrial cancer || carcinoma || prostate cancer || ovary epithelial cancer || reproductive organ cancer || myeloid neoplasm || chondrosarcoma || endometrial carcinoma || meningioma || integumentary system cancer || bone marrow cancer
Disease Ontology (DO)	musculoskeletal system cancer	0.0475	1.283	--	INHERITED FROM: chondrosarcoma
Disease Ontology (DO)	disease of cellular proliferation	0.04943	0.2322	--	INHERITED FROM: ovary epithelial cancer || carcinoma || endometrial cancer || ovarian cancer || adult astrocytic tumour || integumentary system cancer || endometrial carcinoma || reproductive organ cancer || prostate cancer || salivary gland adenoid cystic carcinoma || bone marrow cancer || meningioma || chondrosarcoma || myeloid neoplasm
Disease Ontology (DO)	eye and adnexa disease	0.05227	1.472	--	INHERITED FROM: myopia || refractive error
Disease Ontology (DO)	sensory system disease	0.1144	1.399	--	INHERITED FROM: refractive error || myopia
Disease Ontology (DO)	uterine cancer	0.1179	1.735	--	INHERITED FROM: endometrial carcinoma || endometrial cancer
Disease Ontology (DO)	inherited metabolic disorder	0.1195	1.337	--	INHERITED FROM: familial hyperlipidemia
Disease Ontology (DO)	disease of anatomical entity	0.1307	0.2414	--	INHERITED FROM: atherosclerosis || tooth disease || mouth disease || bronchiectasis || arthritis || intrinsic cardiomyopathy || scleroderma || female reproductive system disease || refractive error || reproductive system disease || abdominal aortic aneurysm || lymph node disease || lymphatic system disease || bone inflammation disease || myopia || lower respiratory tract disease || aortic disease || arteriosclerotic cardiovascular disease || lung disease || Kawasaki disease
Disease Ontology (DO)	bone disease	0.2322	1.171	--	INHERITED FROM: bone inflammation disease || arthritis
Disease Ontology (DO)	vascular disease	0.3153	0.832	--	INHERITED FROM: arteriosclerotic cardiovascular disease || abdominal aortic aneurysm || atherosclerosis || aortic disease
Disease Ontology (DO)	bronchial disease	0.3618	1.133	--	INHERITED FROM: bronchiectasis
Disease Ontology (DO)	immune system cancer	0.7026	0.89	--	INHERITED FROM: myeloid neoplasm || bone marrow cancer
Disease Ontology (DO)	hypersensitivity reaction disease	0.7679	0.8505	--	INHERITED FROM: scleroderma
Disease Ontology (DO)	salivary gland carcinoma	1	2.036	--	INHERITED FROM: salivary gland adenoid cystic carcinoma
Disease Ontology (DO)	lymphadenitis	1	1.668	--	INHERITED FROM: Kawasaki disease
Disease Ontology (DO)	aortic aneurysm	1	1.911	--	INHERITED FROM: abdominal aortic aneurysm
Disease Ontology (DO)	salivary gland cancer	1	2.036	--	INHERITED FROM: salivary gland adenoid cystic carcinoma
Disease Ontology (DO)	organ system cancer	0.02074	0.4879	Least Informative	INHERITED FROM: bone marrow cancer || integumentary system cancer || meningioma || endometrial carcinoma || myeloid neoplasm || chondrosarcoma || ovary epithelial cancer || reproductive organ cancer || prostate cancer || endometrial cancer || salivary gland adenoid cystic carcinoma || ovarian cancer
Disease Ontology (DO)	nervous system disease	0.4217	0.7279	Least Informative	INHERITED FROM: myopia || refractive error
Disease Ontology (DO)	lower respiratory tract disease	0.0006939	0.9947	Moderately Informative	DIRECT
Disease Ontology (DO)	gastrointestinal system disease	0.00128	0.8797	Moderately Informative	INHERITED FROM: tooth disease || mouth disease
Disease Ontology (DO)	artery disease	0.001395	0.9817	Moderately Informative	INHERITED FROM: aortic disease || atherosclerosis || abdominal aortic aneurysm || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	cell type cancer	0.001417	0.9112	Moderately Informative	INHERITED FROM: adult astrocytic tumour || carcinoma
Disease Ontology (DO)	connective tissue disease	0.003036	1.022	Moderately Informative	INHERITED FROM: bone inflammation disease || arthritis || scleroderma
Disease Ontology (DO)	disease by infectious agent	0.01337	0.8142	Moderately Informative	INHERITED FROM: primary bacterial infectious disease
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.01719	0.8797	Moderately Informative	INHERITED FROM: scleroderma
Disease Ontology (DO)	disease of metabolism	0.1494	0.9817	Moderately Informative	INHERITED FROM: familial hyperlipidemia
Disease Ontology (DO)	gastrointestinal system cancer	0.1609	1.151	Moderately Informative	INHERITED FROM: salivary gland adenoid cystic carcinoma
Disease Ontology (DO)	hematologic cancer	0.1667	0.89	Moderately Informative	INHERITED FROM: myeloid neoplasm || bone marrow cancer
Disease Ontology (DO)	nervous system cancer	0.2193	1.191	Moderately Informative	INHERITED FROM: meningioma
Disease Ontology (DO)	Kawasaki disease	0.0000003525	1.668	Informative	DIRECT
Disease Ontology (DO)	female reproductive system disease	0.000008105	1.472	Informative	DIRECT
Disease Ontology (DO)	atherosclerosis	0.00006609	1.367	Informative	DIRECT
Disease Ontology (DO)	scleroderma	0.0001053	1.513	Informative	DIRECT
Disease Ontology (DO)	meningioma	0.0005504	1.668	Informative	DIRECT
Disease Ontology (DO)	arthritis	0.0005708	1.472	Informative	DIRECT
Disease Ontology (DO)	myeloid neoplasm	0.0006438	1.399	Informative	DIRECT
Disease Ontology (DO)	familial hyperlipidemia	0.0007858	1.61	Informative	DIRECT
Disease Ontology (DO)	heart disease	0.0346	1.472	Informative	INHERITED FROM: intrinsic cardiomyopathy
Disease Ontology (DO)	malignant glioma	0.04333	1.61	Informative	INHERITED FROM: adult astrocytic tumour
Disease Ontology (DO)	male reproductive organ cancer	0.05004	1.61	Informative	INHERITED FROM: prostate cancer
Disease Ontology (DO)	eye disease	0.05034	1.472	Informative	INHERITED FROM: myopia || refractive error
Disease Ontology (DO)	female reproductive organ cancer	0.9101	1.472	Informative	INHERITED FROM: ovarian cancer || endometrial cancer || ovary epithelial cancer || endometrial carcinoma
Disease Ontology (DO)	chondrosarcoma	0.0000005567	2.036	Highly Informative	DIRECT
Disease Ontology (DO)	myopia	0.000002084	1.911	Highly Informative	DIRECT
Disease Ontology (DO)	adult astrocytic tumour	0.000004942	2.036	Highly Informative	DIRECT
Disease Ontology (DO)	abdominal aortic aneurysm	0.000005137	1.911	Highly Informative	DIRECT
Disease Ontology (DO)	bronchiectasis	0.00008823	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	salivary gland adenoid cystic carcinoma	0.0001065	2.036	Highly Informative	DIRECT
Disease Ontology (DO)	integumentary system cancer	0.0002515	1.814	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Arthropathy	0.00002909	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal mitral valve morphology	0.0004238	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal atrioventricular valve morphology	0.0008169	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the femoral neck or head region	0.001436	1.86	--	INHERITED FROM: Abnormality of the femoral neck
Phenotypic Abnormality (PA)	Abnormality of the metaphysis	0.01068	1.763	--	INHERITED FROM: Metaphyseal widening
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.09014	0.8289	--	INHERITED FROM: Abnormality of the femoral neck || Metaphyseal widening
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system morphology	0.09168	0.8391	--	INHERITED FROM: Abnormal atrioventricular valve morphology || Abnormal mitral valve morphology
Phenotypic Abnormality (PA)	Abnormality of limb bone	0.1079	0.9572	--	INHERITED FROM: Metaphyseal widening || Abnormality of the femoral neck
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.1545	0.4712	--	INHERITED FROM: Arthritis || Arthropathy || Metaphyseal widening || Abnormality of the femoral neck
Phenotypic Abnormality (PA)	Abnormality of femur morphology	0.1741	1.86	--	INHERITED FROM: Abnormality of the femoral neck
Phenotypic Abnormality (PA)	Abnormality of limbs	0.08065	0.6429	Least Informative	INHERITED FROM: Metaphyseal widening || Abnormality of the femoral neck
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.4041	0.5179	Least Informative	INHERITED FROM: Abnormal atrioventricular valve morphology || Abnormal mitral valve morphology
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.8358	0.513	Least Informative	INHERITED FROM: Abnormality of the femoral neck || Arthritis || Arthropathy || Metaphyseal widening
Phenotypic Abnormality (PA)	Abnormal heart morphology	0.03912	0.9183	Moderately Informative	INHERITED FROM: Abnormal atrioventricular valve morphology || Abnormal mitral valve morphology
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0.06751	0.9572	Moderately Informative	INHERITED FROM: Metaphyseal widening || Abnormality of the femoral neck
Phenotypic Abnormality (PA)	Abnormal joint morphology	0.09242	1.101	Moderately Informative	INHERITED FROM: Arthropathy || Arthritis
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.2848	0.9309	Moderately Informative	INHERITED FROM: Abnormality of the femoral neck
Phenotypic Abnormality (PA)	Abnormal lower limb bone morphology	0.002051	1.508	Informative	INHERITED FROM: Abnormality of the femoral neck
Phenotypic Abnormality (PA)	Abnormal heart valve morphology	0.04986	1.421	Informative	INHERITED FROM: Abnormal atrioventricular valve morphology || Abnormal mitral valve morphology
Phenotypic Abnormality (PA)	Abnormality of long bone morphology	0.1726	1.462	Informative	INHERITED FROM: Metaphyseal widening
Phenotypic Abnormality (PA)	Metaphyseal widening	0.0001143	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Arthritis	0.0004726	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the femoral neck	0.0009143	1.985	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	overexpanded pulmonary alveoli	0.00005335	2.126	--	DIRECT
Mammalian Phenotype (MP)	decreased tumor growth/size	0.0002291	2.126	--	DIRECT
Mammalian Phenotype (MP)	small maxilla	0.0002921	2.126	--	DIRECT
Mammalian Phenotype (MP)	aneurysm	0.0005026	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal hindlimb stylopod morphology	0.000867	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal viscerocranium morphology	0.006645	1.399	--	INHERITED FROM: small maxilla
Mammalian Phenotype (MP)	joint inflammation	0.009893	1.825	--	INHERITED FROM: arthritis
Mammalian Phenotype (MP)	abnormal aorta morphology	0.01438	1.562	--	INHERITED FROM: aortic aneurysm
Mammalian Phenotype (MP)	abnormal pulmonary acinus morphology	0.01726	1.825	--	INHERITED FROM: overexpanded pulmonary alveoli
Mammalian Phenotype (MP)	abnormal cranium morphology	0.01995	1.205	--	INHERITED FROM: small maxilla
Mammalian Phenotype (MP)	abnormal response to infection	0.0213	1.112	--	INHERITED FROM: altered susceptibility to infection || altered susceptibility to bacterial infection
Mammalian Phenotype (MP)	abnormal craniofacial bone morphology	0.0214	1.205	--	INHERITED FROM: small maxilla
Mammalian Phenotype (MP)	abnormal appendicular skeleton morphology	0.02165	1.373	--	INHERITED FROM: abnormal femur morphology
Mammalian Phenotype (MP)	abnormal skeleton physiology	0.02552	1.302	--	INHERITED FROM: arthritis
Mammalian Phenotype (MP)	abnormal limb morphology	0.03153	1.281	--	INHERITED FROM: abnormal hindlimb stylopod morphology || abnormal femur morphology
Mammalian Phenotype (MP)	skeleton phenotype	0.04689	0.8038	--	INHERITED FROM: small maxilla || arthritis || abnormal trabecular bone morphology || abnormal femur morphology
Mammalian Phenotype (MP)	abnormal immune system physiology	0.05116	0.6789	--	INHERITED FROM: altered susceptibility to infection || arthritis || altered susceptibility to bacterial infection
Mammalian Phenotype (MP)	abnormal hindlimb morphology	0.1032	1.825	--	INHERITED FROM: abnormal femur morphology || abnormal hindlimb stylopod morphology
Mammalian Phenotype (MP)	craniofacial phenotype	0.104	1.047	--	INHERITED FROM: small maxilla
Mammalian Phenotype (MP)	abnormal respiratory system morphology	0.1194	1.072	--	INHERITED FROM: overexpanded pulmonary alveoli
Mammalian Phenotype (MP)	abnormal vascular development	0.1232	1.223	--	INHERITED FROM: decreased angiogenesis
Mammalian Phenotype (MP)	abnormal lung morphology	0.1908	1.205	--	INHERITED FROM: overexpanded pulmonary alveoli
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.2046	0.3626	--	INHERITED FROM: abnormal response to injury
Mammalian Phenotype (MP)	abnormal pulmonary alveolar system morphology	0.2448	1.758	--	INHERITED FROM: overexpanded pulmonary alveoli
Mammalian Phenotype (MP)	abnormal artery morphology	0.3534	1.302	--	INHERITED FROM: aortic aneurysm
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.5148	0.7902	--	INHERITED FROM: aortic aneurysm || aneurysm || decreased angiogenesis
Mammalian Phenotype (MP)	abnormal limb long bone morphology	0.6514	1.649	--	INHERITED FROM: abnormal femur morphology
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.6835	0.8323	--	INHERITED FROM: abnormal trabecular bone morphology || abnormal femur morphology || small maxilla
Mammalian Phenotype (MP)	increased inflammatory response	0.89	1.059	--	INHERITED FROM: arthritis
Mammalian Phenotype (MP)	immune system phenotype	0.02562	0.5462	Least Informative	INHERITED FROM: altered susceptibility to bacterial infection || arthritis || altered susceptibility to infection
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.1227	0.6737	Least Informative	INHERITED FROM: decreased angiogenesis || aortic aneurysm || aneurysm
Mammalian Phenotype (MP)	altered susceptibility to infection	0.0005	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	neoplasm	0.02639	1.035	Moderately Informative	INHERITED FROM: decreased tumor growth/size
Mammalian Phenotype (MP)	abnormal inflammatory response	0.04212	1.023	Moderately Informative	INHERITED FROM: arthritis
Mammalian Phenotype (MP)	respiratory system phenotype	0.04811	0.9404	Moderately Informative	INHERITED FROM: overexpanded pulmonary alveoli
Mammalian Phenotype (MP)	limbs/digits/tail phenotype	0.07029	1.188	Moderately Informative	INHERITED FROM: abnormal femur morphology || abnormal hindlimb stylopod morphology
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.1009	1.023	Moderately Informative	INHERITED FROM: decreased angiogenesis || aortic aneurysm
Mammalian Phenotype (MP)	abnormal craniofacial morphology	0.1029	1.047	Moderately Informative	INHERITED FROM: small maxilla
Mammalian Phenotype (MP)	abnormal bone structure	0.1661	1.241	Moderately Informative	INHERITED FROM: abnormal trabecular bone morphology
Mammalian Phenotype (MP)	abnormal cardiovascular development	0.2147	1.059	Moderately Informative	INHERITED FROM: decreased angiogenesis
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0.5761	1.001	Moderately Informative	INHERITED FROM: small maxilla
Mammalian Phenotype (MP)	altered susceptibility to bacterial infection	0.0000266	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal trabecular bone morphology	0.0005017	1.489	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal response to injury	0.0008284	1.261	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal long bone morphology	0.001991	1.489	Informative	INHERITED FROM: abnormal femur morphology
Mammalian Phenotype (MP)	abnormal jaw morphology	0.003935	1.427	Informative	INHERITED FROM: small maxilla
Mammalian Phenotype (MP)	abnormal angiogenesis	0.01415	1.427	Informative	INHERITED FROM: decreased angiogenesis
Mammalian Phenotype (MP)	abnormal systemic artery morphology	0.0204	1.489	Informative	INHERITED FROM: aortic aneurysm
Mammalian Phenotype (MP)	altered tumor pathology	0.05139	1.562	Informative	INHERITED FROM: decreased tumor growth/size
Mammalian Phenotype (MP)	abnormal limb bone morphology	0.1848	1.649	Informative	INHERITED FROM: abnormal femur morphology
Mammalian Phenotype (MP)	aortic aneurysm	0.00001966	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased angiogenesis	0.0001211	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	arthritis	0.0004332	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal femur morphology	0.0007762	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal tumor morphology	0.001423	1.904	Highly Informative	INHERITED FROM: decreased tumor growth/size
Mammalian Phenotype (MP)	abnormal pulmonary alveolus morphology	0.01127	1.904	Highly Informative	INHERITED FROM: overexpanded pulmonary alveoli
Mammalian Phenotype (MP)	abnormal maxilla morphology	0.1577	2.001	Highly Informative	INHERITED FROM: small maxilla

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	basement membrane remodeling variant	0.0000006487	1.225	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: pericellular component development variant || hermaphrodite fertility variant || reproductive system physiology variant || lethal || basement membrane remodeling variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	pericellular component development variant	0.000002116	1.178	Moderately Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: skeletal system || anatomical system || anatomical cluster || anatomical group || whole organism
Zebrafish Anatomy (ZA)	anatomical cluster	0	0.7389	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	skeletal system	0.0002624	1.517	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	fibroblast	0.0000004565	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	mesodermal cell	0.00000126	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.6641	0.1131	--	INHERITED FROM: fibroblast || mesodermal cell || notochord
Xenopus ANatomical entity (XAN)	cell	0.8684	0.8608	--	INHERITED FROM: fibroblast || mesodermal cell
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: mesodermal cell || fibroblast || notochord
Xenopus ANatomical entity (XAN)	primary germ layer	1	0.6748	--	INHERITED FROM: fibroblast || mesodermal cell
Xenopus ANatomical entity (XAN)	tissue	0.3138	0.4672	Least Informative	INHERITED FROM: notochord || mesodermal cell || fibroblast
Xenopus ANatomical entity (XAN)	embryo	0.8676	0.5979	Least Informative	INHERITED FROM: mesodermal cell || fibroblast
Xenopus ANatomical entity (XAN)	notochord	0.0001142	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	mesoderm	0.07257	1.285	Informative	INHERITED FROM: fibroblast || mesodermal cell
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Interstitial collagenase	0.0000005525	2.753	--	DIRECT
Enzyme Commission (EC)	Membrane-type matrix metalloproteinase-1	0.000002302	2.753	--	DIRECT
Enzyme Commission (EC)	Stromelysin 1	0.000009376	2.753	--	DIRECT
Enzyme Commission (EC)	Gelatinase A	0.000009376	2.628	--	DIRECT
Enzyme Commission (EC)	Gelatinase B	0.000009376	2.628	--	DIRECT
Enzyme Commission (EC)	Macrophage elastase	0.0001496	2.753	--	DIRECT
Enzyme Commission (EC)	Stromelysin 2	0.000582	2.753	--	DIRECT
Enzyme Commission (EC)	Neutrophil collagenase	0.000582	2.753	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	1.004	Moderately Informative	DIRECT
Enzyme Commission (EC)	Metalloendopeptidases	0	1.753	Highly Informative	DIRECT

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