Galactose oxidase, central domain superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: 7-bladed beta-propeller [ 50964] (14)
• Superfamily: Galactose oxidase, central domain [ 50965]
• Families: Galactose oxidase, central domain [ 50966]

---

Superfamily statistics

	Genomes (748)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	7,334	34,965	6
Proteins	6,953	33,218	6

---

Functional annotation

• General category: Metabolism
• Detailed category: Carbohydrate metabolism and transport

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.4022	--	DIRECT
Worm Phenotype (WP)	slow growth	0	0.5903	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.5373	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.3347	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.5677	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.7582	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.5677	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	general pace of development variant	0	0.5708	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.6947	Least Informative	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.5373	Least Informative	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.5007	Least Informative	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.5677	Least Informative	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.7582	Moderately Informative	DIRECT

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase	0	2.475	--	DIRECT
Enzyme Commission (EC)	methoxycarbonyltransferase	0	2.35	--	DIRECT
Enzyme Commission (EC)	Aldehyde oxidase	0.000000000000001518	2.651	--	DIRECT
Enzyme Commission (EC)	Guanylate kinase	0.00000004493	2.651	--	DIRECT
Enzyme Commission (EC)	Methyltransferases	0.0000002344	1.181	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0.0000007709	0.8446	--	DIRECT
Enzyme Commission (EC)	Transferases	0.02773	0.3035	--	INHERITED FROM: Guanylate kinase || Transferring groups other than amino-acyl groups || Phosphotransferases with a phosphate group as acceptor || Transferring one-carbon groups || Acyltransferases || Methyltransferases || methoxycarbonyltransferase || tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
Enzyme Commission (EC)	Oxidoreductases	0.002727	0.6234	Least Informative	INHERITED FROM: Acting on the aldehyde or oxo group of donors || With oxygen as acceptor || Aldehyde oxidase
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.8163	0.5453	Least Informative	INHERITED FROM: Guanylate kinase || Phosphotransferases with a phosphate group as acceptor
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.000000005881	1.119	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	0.00002736	1.054	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with a phosphate group as acceptor	0.0004758	1.59	Informative	DIRECT
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0.000761	1.42	Informative	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0.000000000000008975	1.998	Highly Informative	DIRECT

---

InterPro annotation

• Cross references: IPR011043 SSF50965 Protein matches
• Abstract:

  This entry represents a beta-propeller domain found in galactose oxidase and in Kelch repeat-containing proteins.

  The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; neuraminidase hydrolyses sialic acid residues from glycoproteins; and kelch may have a cytoskeletal function, as it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila [7593276]. Nevertheless, based on the location of the kelch pattern in the catalytic unit in galactose oxidase, functionally important residues have been predicted in glyoxal oxidase [8126718].

  Galactose oxidase is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehyde [11698678]. The protein contains an unusual covalent thioether bond between a tyrosine and a cysteine that forms during its maturation [12418174]. Galactose oxidase is a three-domain protein: the N-terminal domain forms a jelly-roll sandwich, the central domain forms a seven 4-bladed beta-propeller, and the C-terminal domain has an immunoglobulin-like fold.

InterPro database

---