alpha-Amylases, C-terminal beta-sheet domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Glycosyl hydrolase domain [ 51010]
• Superfamily: Glycosyl hydrolase domain [ 51011] (5)
• Family: alpha-Amylases, C-terminal beta-sheet domain [ 51012] (22)

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Family statistics

	Genomes (716)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,120	6,531	137
Proteins	1,120	6,515	137

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	1,4-alpha-glucan branching enzyme	0	2.264	--	DIRECT
Enzyme Commission (EC)	Glycosylases	0	0.8221	--	DIRECT
Enzyme Commission (EC)	Alpha-amylase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Hydrolases	3.476e-16	0.01852	--	DIRECT
Enzyme Commission (EC)	Alpha-galactosidase	0.00000000000002238	2.44	--	DIRECT
Enzyme Commission (EC)	Oligo-1,6-glucosidase	0.000000003446	2.44	--	DIRECT
Enzyme Commission (EC)	Isoamylase	0.000002478	2.44	--	DIRECT
Enzyme Commission (EC)	Alpha-N-acetylgalactosaminidase	0.0000338	2.44	--	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0	0.993	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosidases, i.e. enzymes hydrolyzing O- and S-gl	0	0.8899	Moderately Informative	DIRECT
Enzyme Commission (EC)	Hexosyltransferases	0	1.264	Informative	DIRECT
Enzyme Commission (EC)	Cyclomaltodextrin glucanotransferase	0.0000000004006	2.139	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of metabolism	0	0.9817	Moderately Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the urinary system	0	0.8496	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Sensory neuropathy	0	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4712	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skin	0	0.722	--	DIRECT
Phenotypic Abnormality (PA)	Cardiomyopathy	0	1.559	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0	0.533	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0	0.7142	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of fluid regulation	0	1.508	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0	0.7722	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.6915	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0	0.6631	--	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0	0.7381	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system morphology	0	0.8391	--	DIRECT
Phenotypic Abnormality (PA)	Cognitive impairment	0	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0	0.6051	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the integument	0	0.6235	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0	0.5179	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0	0.5486	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.5433	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.513	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.4756	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0	0.5759	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Behavioral abnormality	0	1.082	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal peripheral nervous system morphology	0	1.232	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal heart morphology	0	0.9183	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Localized skin lesion	0	1.161	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0	0.8092	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal homeostasis	0	0.7903	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of movement	0	1.064	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Edema	0	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal myocardium morphology	0	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Peripheral neuropathy	0	1.421	Informative	DIRECT
Phenotypic Abnormality (PA)	Paresthesia	0	1.763	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0	0.3626	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood homeostasis	0	0.6893	--	DIRECT
Mammalian Phenotype (MP)	abnormal homeostasis	0	0.4926	Least Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || retarded heterochronic variations || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || organism physiology variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || general pace of development variant || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || trunk region || organism subdivision
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6447	--	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7127	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	cauline leaf	0	0.6042	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence meristem	0	0.6337	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina base	0	0.6245	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.5171	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.5117	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.4893	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.4728	--	DIRECT
Plant ANatomical entity (PAN)	cotyledon	0	0.6432	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.5999	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.4385	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.4282	--	DIRECT
Plant ANatomical entity (PAN)	lamina	0	0.6199	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.437	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || sporophyll || calyx || flower || lamina || collective plant structure || plant embryo || leaf || shoot internode || phyllome || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || megasporophyll || cauline leaf || reproductive shoot system || leaf apex || leaf lamina base || collective leaf structure || stem internode || shoot system || portion of plant tissue || stomatal complex || plant organ || portion of meristem tissue || stem || whole plant || inflorescence meristem || epidermis || inflorescence || cardinal part of multi-tissue plant structure || gynoecium || vascular leaf || sepal || epidermal cell || leaf lamina || shoot epidermal cell || corolla || plant axis || collective phyllome structure || petal || plant cell || carpel || seed || shoot epidermis || phyllome apex || cotyledon || stamen || shoot axis || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: calyx || flower || sporophyll || inflorescence meristem || inflorescence || perianth || stem || leaf || phyllome || shoot internode || sepal || vascular leaf || gynoecium || petal || reproductive shoot system || leaf apex || carpel || collective phyllome structure || guard cell || megasporophyll || cauline leaf || microsporophyll || leaf lamina || shoot epidermal cell || corolla || androecium || stomatal complex || phyllome apex || cotyledon || stamen || stem internode || shoot axis || shoot system || leaf lamina base || collective leaf structure || shoot epidermis
Plant ANatomical entity (PAN)	phyllome lamina	1	0.6199	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	organ lamina	1	0.6199	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	shoot internode	0	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0	0.4978	Least Informative	DIRECT
Plant ANatomical entity (PAN)	seed	0	0.5189	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0	0.5892	Least Informative	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.437	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.5117	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.4728	Least Informative	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.4893	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.4777	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.4859	Least Informative	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.5153	Least Informative	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.5082	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf lamina	0	0.6199	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.46	Least Informative	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.5956	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3245	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.3879	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.3879	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	leaf production stage	1	0.3272	--	INHERITED FROM: LP.02 two leaves visible stage || LP.10 ten leaves visible stage || LP.04 four leaves visible stage || LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || LP.06 six leaves visible stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || LP.12 twelve leaves visible stage || LP.04 four leaves visible stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || E expanded cotyledon stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || C globular stage || 1 main shoot growth stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.3895	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.4752	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.4603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.4234	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.3479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.4268	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hexosyltransferases	0	1.65	--	DIRECT
Enzyme Commission (EC)	1,4-alpha-glucan branching enzyme	0	2.531	--	DIRECT
Enzyme Commission (EC)	Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds	0	1.225	--	DIRECT
Enzyme Commission (EC)	Alpha-amylase	0	2.385	--	DIRECT
Enzyme Commission (EC)	Alpha-galactosidase	0	2.531	--	DIRECT
Enzyme Commission (EC)	Cyclomaltodextrin glucanotransferase	0.0000000000393	2.628	--	DIRECT
Enzyme Commission (EC)	Isoamylase	0.000000005939	2.753	--	DIRECT
Enzyme Commission (EC)	Oligo-1,6-glucosidase	0.0000001854	2.531	--	DIRECT
Enzyme Commission (EC)	Neopullulanase	0.00001011	2.753	--	DIRECT
Enzyme Commission (EC)	Alpha-N-acetylgalactosaminidase	0.00002171	2.753	--	DIRECT
Enzyme Commission (EC)	Glucan 1,6-alpha-glucosidase	0.00006483	2.929	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Glycosylases	0	1.154	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0	1.378	Informative	DIRECT

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