Carbonic anhydrase superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Carbonic anhydrase [ 51068]
• Superfamily: Carbonic anhydrase [ 51069]
• Families: Carbonic anhydrase [ 51070]

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Superfamily statistics

	Genomes (756)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	4,108	13,298	72
Proteins	3,996	13,050	72

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Functional annotation

• General category: Metabolism
• Detailed category: Other enzymes

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Carbon-oxygen lyases	0	0.7274	--	DIRECT
Enzyme Commission (EC)	Carbonate dehydratase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Hydrolases	1	0.04271	--	INHERITED FROM: Protein-tyrosine-phosphatase
Enzyme Commission (EC)	Lyases	0	0.4169	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.4594	0.4665	Least Informative	INHERITED FROM: Protein-tyrosine-phosphatase
Enzyme Commission (EC)	Hydro-lyases	0	0.8523	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0.004856	0.9165	Moderately Informative	INHERITED FROM: Protein-tyrosine-phosphatase
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0.0000002434	1.414	Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.6421	0.3617	--	INHERITED FROM: abnormal pH regulation
Mammalian Phenotype (MP)	abnormal homeostasis	0.4904	0.495	Least Informative	INHERITED FROM: abnormal pH regulation
Mammalian Phenotype (MP)	abnormal pH regulation	0.00001829	2.207	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || organism physiology variant || life span variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || shortened life span || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	life span variant	0	1.276	Informative	DIRECT
Worm Phenotype (WP)	shortened life span	0	1.929	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	swim bladder	0.0007152	2.439	--	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0.7934	0.5472	--	INHERITED FROM: swim bladder
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical group || whole organism || swim bladder
Zebrafish Anatomy (ZA)	compound organ	0.8945	0.4571	Least Informative	INHERITED FROM: swim bladder
Zebrafish Anatomy (ZA)	anatomical cluster	0.692	0.883	Moderately Informative	INHERITED FROM: swim bladder
Zebrafish Anatomy (ZA)	pleuroperitoneal region	0.09523	1.661	Informative	INHERITED FROM: swim bladder

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: anatomical group || multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydro-lyases	0	1.166	--	DIRECT
Enzyme Commission (EC)	Carbonic anhydrase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.3769	0.7559	--	INHERITED FROM: Protein-tyrosine-phosphatase
Enzyme Commission (EC)	Lyases	0	0.6918	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	1	0.3541	Least Informative	INHERITED FROM: Protein-tyrosine-phosphatase
Enzyme Commission (EC)	Carbon-oxygen lyases	0	1.012	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0.001622	1.174	Moderately Informative	INHERITED FROM: Protein-tyrosine-phosphatase
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0.000000009897	1.63	Informative	DIRECT

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InterPro annotation

• Cross references: IPR001148 SSF51069 Protein matches
• Abstract:

  Synonym(s): Carbonic dehydratase, Carbonic anhydrase

  Carbonate dehydratase (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. Eight enzymatic and evolutionary related forms of carbonic anhydrase are currently known to exist in vertebrates: three cytosolic isozymes (CA-I, CA-II and CA-III); two membrane-bound forms (CA-IV and CA-VII); a mitochondrial form (CA-V); a secreted salivary form (CA-VI); and a yet uncharacterised isozyme.

InterPro database

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