beta-Roll superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Single-stranded right-handed beta-helix [ 51125] (8)
• Superfamily: beta-Roll [ 51120]
• Families: Serralysin-like metalloprotease, C-terminal domain [ 51121]

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Superfamily statistics

	Genomes (710)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	8,048	84,294	13
Proteins	3,086	32,866	13

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Functional annotation

• General category: Processes_IC
• Detailed category: Proteases

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Serralysin	0	2.56	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.000000002927	0.04271	--	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0.000000001008	0.5513	Least Informative	DIRECT
Enzyme Commission (EC)	Metalloendopeptidases	0	1.356	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Serralysin	0	2.952	--	DIRECT
Enzyme Commission (EC)	Mannuronan 5-epimerase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.000004884	0.3541	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0.000000001853	0.8949	Moderately Informative	DIRECT
Enzyme Commission (EC)	Isomerases	0.00009486	0.8446	Moderately Informative	DIRECT
Enzyme Commission (EC)	Metalloendopeptidases	0	1.673	Informative	DIRECT
Enzyme Commission (EC)	Racemases and epimerases	0.0000000001399	1.447	Informative	DIRECT
Enzyme Commission (EC)	Acting on carbohydrates and derivatives	0.00000000000001339	1.776	Highly Informative	DIRECT

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InterPro annotation

• Cross references: IPR011049 SSF51120 Protein matches
• Abstract:

  Serralysin is a bacterial Zn-endopeptidase that acts as a virulence factor to cause tissue damage and anaphylactic response [12072965]. Many Zn-endopeptidases contain the metal binding motif HexxHxxGxxH; in addition to these coordinated histidine residues, serralysin contains a coordinated tyrosine residue that is unique to the astacin-like Zn enzymes. The Zn-endopeptidases containing the histidine motif are structurally similar to one another, containing an N-terminal catalytic domain that belongs to the zincin family, and a C-terminal beta-helix metal-binding domain. These peptidase include the astacin family, snake venom Zn-endopeptidases, the extracellular metalloproteases from Serratia sp., Pseudomonas sp. and Erwinia sp., and the matrixins.

InterPro database

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