Single hybrid motif superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Barrel-sandwich hybrid [ 51229] (4)
• Superfamily: Single hybrid motif [ 51230]
• Families: Biotinyl/lipoyl-carrier proteins and domains [ 51231] (6)

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Superfamily statistics

	Genomes (3,196)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	23,011	162,963	16
Proteins	21,233	150,010	16

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Functional annotation

• General category: Metabolism
• Detailed category: Coenzyme metabolism and transport

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acyltransferases	0	0.8117	--	DIRECT
Enzyme Commission (EC)	Forming carbon-carbon bonds	0	1.715	--	DIRECT
Enzyme Commission (EC)	Transferases	0.00000004218	0	--	DIRECT
Enzyme Commission (EC)	Propionyl-CoA carboxylase	0.0005857	2.259	--	DIRECT
Enzyme Commission (EC)	Ligases	0.000000000001568	0.6568	Least Informative	DIRECT
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	0.9165	Moderately Informative	DIRECT
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	0.1167	0.9067	Moderately Informative	INHERITED FROM: Biotin carboxylase || Other carbon--nitrogen ligases
Enzyme Commission (EC)	Other carbon--nitrogen ligases	0	1.329	Informative	DIRECT
Enzyme Commission (EC)	Ligases that form carbon-carbon bonds	1	1.715	Informative	INHERITED FROM: Pyruvate carboxylase || Methylcrotonoyl-CoA carboxylase || Propionyl-CoA carboxylase
Enzyme Commission (EC)	Biotin carboxylase	0	1.861	Highly Informative	DIRECT
Enzyme Commission (EC)	Dihydrolipoyllysine-residue succinyltransferase	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Dihydrolipoyllysine-residue acetyltransferase	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Pyruvate carboxylase	4.713e-16	1.782	Highly Informative	DIRECT
Enzyme Commission (EC)	Dihydrolipoyllysine-residue (2-methylpropanoyl)tra	0.0000000000521	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Methylcrotonoyl-CoA carboxylase	0.000001983	1.958	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	autoimmune disease of urogenital tract	0.000005828	1.769	--	DIRECT
Disease Ontology (DO)	liver cirrhosis	0.0003789	1.672	--	DIRECT
Disease Ontology (DO)	hepatobiliary disease	0.01194	1.468	--	INHERITED FROM: primary biliary cirrhosis || liver cirrhosis
Disease Ontology (DO)	hypersensitivity reaction disease	0.0237	0.827	--	INHERITED FROM: primary biliary cirrhosis || autoimmune disease of urogenital tract
Disease Ontology (DO)	immune system disease	0.03865	0.78	--	INHERITED FROM: autoimmune disease of urogenital tract || primary biliary cirrhosis
Disease Ontology (DO)	disease of anatomical entity	0.5233	0.2157	--	INHERITED FROM: liver cirrhosis || primary biliary cirrhosis || autoimmune disease of urogenital tract
Disease Ontology (DO)	disease of metabolism	0.0001052	1.029	Moderately Informative	DIRECT
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.01674	0.8526	Moderately Informative	INHERITED FROM: primary biliary cirrhosis || autoimmune disease of urogenital tract
Disease Ontology (DO)	gastrointestinal system disease	0.04212	0.8526	Moderately Informative	INHERITED FROM: primary biliary cirrhosis || liver cirrhosis
Disease Ontology (DO)	liver disease	0.01052	1.468	Informative	INHERITED FROM: liver cirrhosis || primary biliary cirrhosis
Disease Ontology (DO)	primary biliary cirrhosis	0.000005828	1.769	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal circulating carboxylic acid concentration	0.00003332	1.452	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal blood glucose concentration	0.0008359	1.561	--	DIRECT
Phenotypic Abnormality (PA)	Muscular hypotonia	0.0009042	1.23	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0.01193	0.7631	--	INHERITED FROM: Muscular hypotonia
Phenotypic Abnormality (PA)	Abnormal glucose homeostasis	0.1545	1.365	--	INHERITED FROM: Hypoglycemia || Abnormal blood glucose concentration
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.1947	0.2543	--	INHERITED FROM: Psychomotor retardation || Lethargy
Phenotypic Abnormality (PA)	Abnormal homeostasis	0.2692	0.7631	--	INHERITED FROM: Abnormal blood glucose concentration || Acidosis || Abnormality of acid-base homeostasis || Hypoglycemia
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.01316	0.5315	Least Informative	INHERITED FROM: Abnormal blood glucose concentration || Abnormal circulating carboxylic acid concentration || Acidosis || Abnormality of serum amino acid level || Abnormality of acid-base homeostasis || Hypoglycemia
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.02832	0.6004	Least Informative	INHERITED FROM: Muscular hypotonia
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.1281	0.4022	Least Informative	INHERITED FROM: Lethargy || Psychomotor retardation
Phenotypic Abnormality (PA)	Abnormality of acid-base homeostasis	0.00001632	1.128	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle tone	0.003153	1.045	Moderately Informative	INHERITED FROM: Muscular hypotonia
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0.01683	0.8268	Moderately Informative	INHERITED FROM: Lethargy
Phenotypic Abnormality (PA)	Behavioral abnormality	0.02001	1.176	Moderately Informative	INHERITED FROM: Psychomotor retardation
Phenotypic Abnormality (PA)	Abnormal circulating metabolite concentration	0.02213	0.9294	Moderately Informative	INHERITED FROM: Abnormal circulating carboxylic acid concentration || Abnormality of serum amino acid level
Phenotypic Abnormality (PA)	Abnormality of serum amino acid level	0.00000001487	1.503	Informative	DIRECT
Phenotypic Abnormality (PA)	Acidosis	0.000009128	1.293	Informative	DIRECT
Phenotypic Abnormality (PA)	Hypoglycemia	0.0005388	1.561	Informative	DIRECT
Phenotypic Abnormality (PA)	Reduced consciousness/confusion	0.01814	1.365	Informative	INHERITED FROM: Lethargy
Phenotypic Abnormality (PA)	Lethargy	0.00011	1.804	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Psychomotor retardation	0.0006357	2.106	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.4022	--	DIRECT
Worm Phenotype (WP)	slow growth	0	0.5903	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.5373	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0.005447	0.7938	--	INHERITED FROM: transgene expression increased || level of transgene expression variant
Worm Phenotype (WP)	gene expression variant	0.01347	0.6038	--	INHERITED FROM: transgene expression increased || level of transgene expression variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || retarded heterochronic variations || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || organism physiology variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || general pace of development variant || fertility variant || organ system physiology variant || maternal sterile || organism development variant || level of transgene expression variant || fertility reduced || transgene expression increased
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	general pace of development variant	0	0.5708	Least Informative	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.5373	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.06973	0.4572	Least Informative	INHERITED FROM: transgene expression increased || level of transgene expression variant
Worm Phenotype (WP)	level of transgene expression variant	0.00007662	1.151	Moderately Informative	DIRECT
Worm Phenotype (WP)	transgene expression increased	0.000001443	1.531	Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.2018	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	visual system	0	1.485	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.2245	--	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5472	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || eye || sensory system || anatomical group || whole organism || visual system || organism subdivision || compound organ || cavitated compound organ || head || nervous system
Zebrafish Anatomy (ZA)	nervous system	0	0.6911	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	compound organ	0	0.4571	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	organism subdivision	0	0.6264	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	sensory system	0	1.097	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	head	0	1.008	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	eye	0	1.485	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	genital system	0	0.5909	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: urogenital system || genital system
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: urogenital system || genital system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || anatomical region || organism subdivision
Xenopus ANatomical entity (XAN)	urogenital system	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.3033	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	cauline leaf	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	shoot apex	0	0.5633	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0	0.5969	--	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.5246	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.4713	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.6087	--	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.5448	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.6058	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3881	--	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.55	--	DIRECT
Plant ANatomical entity (PAN)	branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.4141	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	stalk	0.00008132	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina base	0.00009723	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0.0001028	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	lamina	0.000104	0.7057	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0.0001078	0.7448	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0.0008264	0.6028	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0.0009143	0.6495	--	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0.02005	0.7531	--	INHERITED FROM: pollen
Plant ANatomical entity (PAN)	androecium	0.05075	0.594	--	INHERITED FROM: stamen
Plant ANatomical entity (PAN)	cardinal organ part	0.05686	0.51	--	INHERITED FROM: stem internode || stalk || leaf lamina base
Plant ANatomical entity (PAN)	leaf lamina	0.07424	0.7057	--	INHERITED FROM: leaf lamina base
Plant ANatomical entity (PAN)	shoot internode	0.1083	0.6463	--	INHERITED FROM: stem internode
Plant ANatomical entity (PAN)	stem	0.5344	0.577	--	INHERITED FROM: stem internode
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || sporophyll || calyx || inflorescence axis || flower || lamina || collective plant structure || plant embryo || leaf || phyllome || pollen sac || multi-tissue plant structure || guard cell || megasporophyll || cauline leaf || reproductive shoot system || shoot apex || leaf lamina base || branch || collective leaf structure || stem internode || inflorescence branch || shoot system || portion of plant tissue || stomatal complex || plant organ || whole plant || epidermis || inflorescence || stalk || gynoecium || vascular leaf || sepal || microsporangium || epidermal cell || shoot epidermal cell || corolla || pollen || plant axis || collective phyllome structure || petal || plant cell || carpel || seed || shoot epidermis || stamen || shoot axis || pedicel
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: inflorescence axis || calyx || flower || sporophyll || inflorescence || perianth || leaf || phyllome || sepal || vascular leaf || gynoecium || petal || reproductive shoot system || shoot apex || carpel || collective phyllome structure || guard cell || megasporophyll || cauline leaf || pollen || pollen sac || shoot epidermal cell || corolla || pedicel || stomatal complex || stamen || stem internode || inflorescence branch || shoot axis || shoot system || leaf lamina base || collective leaf structure || branch || shoot epidermis
Plant ANatomical entity (PAN)	phyllome lamina	1	0.7057	--	INHERITED FROM: leaf lamina base
Plant ANatomical entity (PAN)	organ lamina	1	0.7057	--	INHERITED FROM: leaf lamina base
Plant ANatomical entity (PAN)	whole plant	0	0.4218	Least Informative	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	seed	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.4337	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.5969	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.4648	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.4735	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.5053	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0.001949	0.7407	Least Informative	INHERITED FROM: pollen || pollen sac || microsporangium
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0.003587	0.5029	Least Informative	INHERITED FROM: lamina || stalk || leaf lamina base || stem internode
Plant ANatomical entity (PAN)	microsporophyll	0.7119	0.5029	Least Informative	INHERITED FROM: pollen sac || pollen || stamen
Plant ANatomical entity (PAN)	pollen	0.0001023	0.7531	Moderately Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1968	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.2036	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2833	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || E expanded cotyledon stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || plant embryo stage || leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: E expanded cotyledon stage || sporophyte vegetative stage || C globular stage || leaf production stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.353	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.4088	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3937	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.3729	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.4338	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	seed development stage	0.0008019	1.256	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acyltransferases	0	0.8446	--	DIRECT
Enzyme Commission (EC)	Dihydrolipoyllysine-residue acetyltransferase	0	2.475	--	DIRECT
Enzyme Commission (EC)	Dihydrolipoyllysine-residue succinyltransferase	0	2.35	--	DIRECT
Enzyme Commission (EC)	Biotin carboxylase	0	2.253	--	DIRECT
Enzyme Commission (EC)	Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase	5.111e-16	2.475	--	DIRECT
Enzyme Commission (EC)	Linked to decarboxylation	0.000000001927	2.475	--	DIRECT
Enzyme Commission (EC)	Transferases	0.0000001684	0.3035	--	DIRECT
Enzyme Commission (EC)	Catalysing the translocation of inorganic cations	0.0000003093	1.776	--	DIRECT
Enzyme Commission (EC)	Translocases	0.0431	1.339	--	INHERITED FROM: Catalysing the translocation of inorganic cations || Linked to decarboxylation
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	1.181	--	INHERITED FROM: Urea carboxylase || Biotin carboxylase || Other carbon--nitrogen ligases
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	1.119	Moderately Informative	DIRECT
Enzyme Commission (EC)	Ligases	0.00000000000001436	0.9606	Moderately Informative	DIRECT
Enzyme Commission (EC)	Other carbon--nitrogen ligases	0.00000000001264	1.505	Informative	DIRECT
Enzyme Commission (EC)	Forming carbon-carbon bonds	0	1.998	Highly Informative	DIRECT
Enzyme Commission (EC)	Urea carboxylase	0.000000006046	2.174	Highly Informative	DIRECT

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Domain	Lipoyl	0	0.9542	Moderately Informative	DIRECT

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InterPro annotation

• Cross references: IPR011053 SSF51230 Protein matches
• Abstract:

  The single hybrid motif has a beta-barrel sandwich hybrid fold, consisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in biotinyl/lipoyl-carrier proteins and domains, where the biotin and lipoic acid moieties act as covalently attached coenzyme cofactors in enzymes that catalyse metabolic reactions. For example, this motif can be found in the biotinyl domain of Escherichia coli acetyl-CoA carboxylase [8747466], protein H of the glycine cleavage system in Pisum sativum (Garden pea) [10806386], the ipoyl domain of dihydrolipoamide acetyltransferase, which is a component of the pyruvate dehydrogenase complex [10913250], the lipoyl domain of the 2-oxoglutarate dehydrogenase complex [8950276], and the lipoyl domain f the mitochondrial branched-chain alpha-ketoacid dehydrogenase.

InterPro database

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