Hedgehog/intein (Hint) domain superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Hedgehog/intein (Hint) domain [ 51293]
• Superfamily: Hedgehog/intein (Hint) domain [ 51294] (2)
• Families:
  • Hedgehog C-terminal (Hog) autoprocessing domain [ 51295]
  • Intein (protein splicing domain) [ 51298] (4)

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Superfamily statistics

	Genomes (882)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,765	20,894	9
Proteins	2,613	19,917	9

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Functional annotation

• General category: Regulation
• Detailed category: Signal transduction

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Other isomerases	0	1.446	--	DIRECT
Enzyme Commission (EC)	DNA helicase	0.00000000000004362	1.162	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.00000008607	0.2175	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.007242	0.04271	--	INHERITED FROM: H(+)-transporting two-sector ATPase || DNA helicase || Acting on acid anhydrides
Enzyme Commission (EC)	Transferases	0.06771	0	--	INHERITED FROM: Nucleotidyltransferases || DNA-directed DNA polymerase || Transferring phosphorous-containing groups
Enzyme Commission (EC)	Nucleotidyltransferases	0.00000000001853	0.6105	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0.00000000002567	0.6408	Least Informative	DIRECT
Enzyme Commission (EC)	Isomerases	0.0007016	0.5914	Least Informative	DIRECT
Enzyme Commission (EC)	DNA-directed DNA polymerase	0	1.238	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides; involved in cellular an	0.003052	0.8971	Moderately Informative	INHERITED FROM: DNA helicase
Enzyme Commission (EC)	Acting on acid anhydrides; catalyzing transmembran	0.5033	1.481	Informative	INHERITED FROM: H(+)-transporting two-sector ATPase
Enzyme Commission (EC)	H(+)-transporting two-sector ATPase	0.0000003949	1.861	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the foot	0	1.106	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limbs	0	0.6431	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0	0.9152	Moderately Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal nervous system morphology	0	0.627	--	DIRECT
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0	0.8003	--	DIRECT
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0	0.9281	--	DIRECT
Mammalian Phenotype (MP)	nervous system phenotype	0	0.5166	Least Informative	DIRECT
Mammalian Phenotype (MP)	cellular phenotype	0	0.5301	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal digestive system morphology	0	1.031	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal gland morphology	0	0.8644	Moderately Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.3347	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	growth variant	0	0.4022	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	slow growth	0	0.5903	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.5677	--	DIRECT
Worm Phenotype (WP)	multiple alae	0	2.407	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.5677	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.5373	--	DIRECT
Worm Phenotype (WP)	alae secretion variant	0.000000000000009842	2.407	--	DIRECT
Worm Phenotype (WP)	intestinal vacuole	0.00000000000006911	2.407	--	DIRECT
Worm Phenotype (WP)	cuticle morphology variant	0.0000000000003183	1.753	--	DIRECT
Worm Phenotype (WP)	tail development variant	0.000000000001923	2.23	--	DIRECT
Worm Phenotype (WP)	organism segment development variant	0.000000000001932	2.23	--	DIRECT
Worm Phenotype (WP)	body region development variant	0.00000000001543	2.23	--	DIRECT
Worm Phenotype (WP)	intestinal morphology variant	0.00000000008763	2.23	--	DIRECT
Worm Phenotype (WP)	body length variant	0.000000002073	1.346	--	DIRECT
Worm Phenotype (WP)	body width variant	0.000000004932	1.245	--	DIRECT
Worm Phenotype (WP)	body size variant	0.00000001327	1.202	--	DIRECT
Worm Phenotype (WP)	body morphology variant	0.00000002766	1.164	--	DIRECT
Worm Phenotype (WP)	locomotion variant	0.00004039	1.045	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.001665	0.632	--	INHERITED FROM: movement variant || locomotion variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: pericellular component development variant || hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || epithelial system physiology variant || movement variant || lethal || male tail development variant || larval development variant || molt variant || organism physiology variant || slow growth || cell secretion variant || development variant || alae secretion variant || developmental timing variant || organism segment development variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || tail development variant || pericellular component physiology variant || body region development variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || locomotion variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	general pace of development variant	0	0.5708	Least Informative	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.5007	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.6947	Least Informative	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.5677	Least Informative	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.5373	Least Informative	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.000201	0.7119	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0.001582	0.632	Least Informative	INHERITED FROM: movement variant || locomotion variant
Worm Phenotype (WP)	cell physiology variant	0.009057	0.5344	Least Informative	INHERITED FROM: alae secretion variant || cell secretion variant
Worm Phenotype (WP)	pericellular component development variant	0.00000001771	1.216	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism segment morphology variant	0.0000001139	1.064	Moderately Informative	DIRECT
Worm Phenotype (WP)	body region morphology variant	0.0000001177	1.045	Moderately Informative	DIRECT
Worm Phenotype (WP)	movement variant	0.0000486	1.026	Moderately Informative	DIRECT
Worm Phenotype (WP)	pericellular component morphology variant	0.000000000000943	1.666	Informative	DIRECT
Worm Phenotype (WP)	small	0.00000000001294	1.594	Informative	DIRECT
Worm Phenotype (WP)	molt variant	0	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	male tail development variant	0.000000000001626	2.23	Highly Informative	DIRECT
Worm Phenotype (WP)	pericellular component physiology variant	0.000000000003263	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	epithelial system physiology variant	0.0000000005414	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	cell secretion variant	0.000000001074	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	body vacuole	0.00000001621	2.23	Highly Informative	DIRECT
Worm Phenotype (WP)	alimentary system morphology variant	0.0000008517	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	alae morphology variant	0.09202	1.929	Highly Informative	INHERITED FROM: multiple alae

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Exodeoxyribonuclease I	0	2.475	--	DIRECT
Enzyme Commission (EC)	Enzymes altering nucleic acid conformation	0	1.806	--	DIRECT
Enzyme Commission (EC)	3'-phosphate/5'-hydroxy nucleic acid ligase	0.00000000000009377	2.475	--	DIRECT
Enzyme Commission (EC)	Acting on ATP; involved in cellular and subcellular movement	0.000000000001444	1.196	--	DIRECT
Enzyme Commission (EC)	Ribonucleoside-diphosphate reductase	0.00000001061	2.174	--	DIRECT
Enzyme Commission (EC)	H(+)-transporting two-sector ATPase	0.000000517	2.253	--	DIRECT
Enzyme Commission (EC)	Forming phosphoric ester bonds	0.000005536	1.952	--	DIRECT
Enzyme Commission (EC)	Translocases	0.0002493	1.339	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.32	0.7559	--	INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoesters || Exodeoxyribonuclease I
Enzyme Commission (EC)	Transferases	0.3289	0.3035	--	INHERITED FROM: DNA-directed DNA polymerase || Nucleotidyltransferases || Transferring phosphorus-containing groups
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.0000006691	0.5453	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0.001094	0.3541	Least Informative	INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoesters || DNA helicase || Acting on ATP; involved in cellular and subcellular movement || Acting on acid anhydrides || Exodeoxyribonuclease I
Enzyme Commission (EC)	Oxidoreductases	1	0.6234	Least Informative	INHERITED FROM: With a disulfide as acceptor || Ribonucleoside-diphosphate reductase || Acting on CH or CH(2) groups
Enzyme Commission (EC)	Nucleotidyltransferases	0.00000000002264	0.9432	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0.00000149	0.9562	Moderately Informative	DIRECT
Enzyme Commission (EC)	Isomerases	0.001608	0.8446	Moderately Informative	INHERITED FROM: Enzymes altering nucleic acid conformation || Isomerases altering macromolecular conformation
Enzyme Commission (EC)	Ligases	0.9895	0.9606	Moderately Informative	INHERITED FROM: Forming phosphoric ester bonds || 3'-phosphate/5'-hydroxy nucleic acid ligase
Enzyme Commission (EC)	DNA-directed DNA polymerase	0	1.59	Informative	DIRECT
Enzyme Commission (EC)	Isomerases altering macromolecular conformation	0	1.651	Informative	DIRECT
Enzyme Commission (EC)	DNA helicase	5.111e-16	1.475	Informative	DIRECT
Enzyme Commission (EC)	Catalysing the translocation of hydrons	0.000001474	1.505	Informative	DIRECT
Enzyme Commission (EC)	Acting on CH or CH(2) groups	0.0000856	1.475	Informative	DIRECT
Enzyme Commission (EC)	Exodeoxyribonucleases producing 5'-phosphomonoesters	0.00000000000005111	1.91	Highly Informative	DIRECT
Enzyme Commission (EC)	With a disulfide as acceptor	0.00000001577	2.107	Highly Informative	DIRECT
Enzyme Commission (EC)	Hydron translocation linked to the hydrolysis of a nucleoside triphosphate	0.000000593	2.049	Highly Informative	DIRECT
Enzyme Commission (EC)	Forming phosphoric ester bonds	1	1.952	Highly Informative	INHERITED FROM: 3'-phosphate/5'-hydroxy nucleic acid ligase

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