Metallo-dependent hydrolases superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: TIM beta/alpha-barrel [ 51350] (33)
• Superfamily: Metallo-dependent hydrolases [ 51556] (18)
• Families:
  • Adenosine/AMP deaminase [ 51557] (2)
  • Dihydroorotase [ 63917]
  • Cytosine deaminase catalytic domain [ 69390]
  • alpha-subunit of urease, catalytic domain [ 51560]
  • Hydantoinase (dihydropyrimidinase), catalytic domain [ 75073] (5)
  • SAH/MTA deaminase-like [ 82258] (3)
  • Isoaspartyl dipeptidase, catalytic domain [ 89489]
  • N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain [ 82261]
  • D-aminoacylase, catalytic domain [ 82264]
  • TatD Mg-dependent DNase-like [ 82267] (4)
  • Phosphotriesterase-like [ 51564] (2)
  • Renal dipeptidase [ 75079]
  • Uronate isomerase-like [ 75082] (2)
  • Adenine deaminase-like [ 141816]
  • PP1699/LP2961-like [ 141819] (5)
  • DR0824-like [ 159397]
  • Imidazolonepropionase-like [ 159400] (3)
  • Zn-dependent arginine carboxypeptidase-like [ 159408] (3)

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Superfamily statistics

	Genomes (3,238)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	42,455	367,028	96
Proteins	42,166	365,733	96

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Functional annotation

• General category: Metabolism
• Detailed category: Other enzymes

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptid	0	0.8195	--	DIRECT
Enzyme Commission (EC)	Membrane dipeptidase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Adenine deaminase	0	2.259	--	DIRECT
Enzyme Commission (EC)	S-methyl-5'-thioadenosine deaminase	0	2.259	--	DIRECT
Enzyme Commission (EC)	S-adenosylhomocysteine deaminase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Glucuronate isomerase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.04271	--	DIRECT
Enzyme Commission (EC)	Adenosine deaminase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Aminocarboxymuconate-semialdehyde decarboxylase	0.000000000000006915	2.56	--	DIRECT
Enzyme Commission (EC)	N-acetylglucosamine-6-phosphate deacetylase	0.000000000141	2.259	--	DIRECT
Enzyme Commission (EC)	AMP deaminase	0.00000001551	2.56	--	DIRECT
Enzyme Commission (EC)	Guanine deaminase	0.000007749	2.259	--	DIRECT
Enzyme Commission (EC)	Imidazolonepropionase	0.00001966	2.259	--	DIRECT
Enzyme Commission (EC)	Carbon-carbon lyases	1	0.8275	--	INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase
Enzyme Commission (EC)	Isomerases	0.6788	0.5914	Least Informative	INHERITED FROM: Glucuronate isomerase || Interconverting aldoses and ketoses, and related c || Intramolecular oxidoreductases
Enzyme Commission (EC)	Lyases	1	0.4169	Least Informative	INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	1	0.5513	Least Informative	INHERITED FROM: Membrane dipeptidase || Dipeptidases
Enzyme Commission (EC)	Intramolecular oxidoreductases	0	1.069	Moderately Informative	DIRECT
Enzyme Commission (EC)	Carboxy-lyases	1	0.9578	Moderately Informative	INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase
Enzyme Commission (EC)	In linear amides	1	1.083	Moderately Informative	INHERITED FROM: Urease || N-acetylglucosamine-6-phosphate deacetylase
Enzyme Commission (EC)	Interconverting aldoses and ketoses, and related c	0	1.384	Informative	DIRECT
Enzyme Commission (EC)	In cyclic amides	0	1.657	Informative	DIRECT
Enzyme Commission (EC)	In cyclic amidines	1	1.384	Informative	INHERITED FROM: Guanine deaminase || Adenine deaminase || S-methyl-5'-thioadenosine deaminase || S-adenosylhomocysteine deaminase || AMP deaminase || Adenosine deaminase
Enzyme Commission (EC)	Urease	0	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	Dipeptidases	0	1.782	Highly Informative	DIRECT
Enzyme Commission (EC)	Dihydroorotase	0.0000002676	2.083	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.1924	--	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal nucleotide metabolism	0.0000001743	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal hippocampus pyramidal cell morphology	0.00005091	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal dendrite morphology	0.00009308	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal hippocampus layer morphology	0.0002104	1.906	--	DIRECT
Mammalian Phenotype (MP)	abnormal telencephalon morphology	0.01675	1.332	--	INHERITED FROM: abnormal hippocampus layer morphology || abnormal hippocampus pyramidal cell morphology || abnormal hippocampus pyramidal cell layer
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.02708	0.627	--	INHERITED FROM: abnormal hippocampus pyramidal cell layer || abnormal hippocampus layer morphology || abnormal dendrite morphology || abnormal hippocampus pyramidal cell morphology
Mammalian Phenotype (MP)	abnormal hippocampus morphology	0.1027	1.663	--	INHERITED FROM: abnormal hippocampus pyramidal cell morphology || abnormal hippocampus pyramidal cell layer || abnormal hippocampus layer morphology
Mammalian Phenotype (MP)	abnormal forebrain morphology	0.2261	1.253	--	INHERITED FROM: abnormal hippocampus layer morphology || abnormal hippocampus pyramidal cell morphology || abnormal hippocampus pyramidal cell layer
Mammalian Phenotype (MP)	abnormal temporal lobe morphology	0.2401	1.663	--	INHERITED FROM: abnormal hippocampus layer morphology || abnormal hippocampus pyramidal cell layer || abnormal hippocampus pyramidal cell morphology
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.8234	0.3617	--	INHERITED FROM: abnormal nucleotide metabolism
Mammalian Phenotype (MP)	nervous system phenotype	0.06746	0.5166	Least Informative	INHERITED FROM: abnormal hippocampus layer morphology || abnormal hippocampus pyramidal cell layer || abnormal hippocampus pyramidal cell morphology || abnormal dendrite morphology
Mammalian Phenotype (MP)	abnormal metabolism	0.0374	1.093	Moderately Informative	INHERITED FROM: abnormal nucleotide metabolism
Mammalian Phenotype (MP)	abnormal neuron morphology	0.292	0.9516	Moderately Informative	INHERITED FROM: abnormal hippocampus pyramidal cell morphology || abnormal dendrite morphology
Mammalian Phenotype (MP)	abnormal brain morphology	0.3665	1.11	Moderately Informative	INHERITED FROM: abnormal hippocampus layer morphology || abnormal hippocampus pyramidal cell morphology || abnormal hippocampus pyramidal cell layer
Mammalian Phenotype (MP)	abnormal cerebral hemisphere morphology	0.006415	1.605	Informative	INHERITED FROM: abnormal hippocampus pyramidal cell morphology || abnormal hippocampus pyramidal cell layer || abnormal hippocampus layer morphology
Mammalian Phenotype (MP)	abnormal limbic system morphology	0.08629	1.663	Informative	INHERITED FROM: abnormal hippocampus pyramidal cell layer || abnormal hippocampus pyramidal cell morphology || abnormal hippocampus layer morphology
Mammalian Phenotype (MP)	abnormal hippocampus pyramidal cell layer	0.0001101	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal hippocampus neuron morphology	0.002214	2.207	Highly Informative	INHERITED FROM: abnormal hippocampus pyramidal cell morphology
Mammalian Phenotype (MP)	abnormal neurite morphology	0.01538	1.906	Highly Informative	INHERITED FROM: abnormal dendrite morphology

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.3347	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.2245	--	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5472	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || multi-tissue structure || anatomical group || whole organism || organism subdivision || compound organ || cavitated compound organ || head || nervous system
Zebrafish Anatomy (ZA)	nervous system	0	0.6911	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	compound organ	0	0.4571	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	organism subdivision	0	0.6264	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0	0.6005	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	head	0	1.008	Moderately Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: anatomical group || multicellular anatomical structure || organism subdivision
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	cauline leaf	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	shoot apex	0	0.5633	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.6463	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina base	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	root	0	0.5579	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0	0.5969	--	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.5246	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.4713	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.6028	--	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.577	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.5448	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	petiole	0	0.7287	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina	0	0.7057	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.6495	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.51	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3881	--	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.55	--	DIRECT
Plant ANatomical entity (PAN)	lamina	0	0.7057	--	DIRECT
Plant ANatomical entity (PAN)	stalk	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.4141	--	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.7448	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || root || sporophyll || calyx || inflorescence axis || flower || lamina || collective plant structure || plant embryo || leaf || shoot internode || phyllome || pollen sac || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || cauline leaf || reproductive shoot system || shoot apex || leaf apex || leaf lamina base || branch || collective leaf structure || stem internode || inflorescence branch || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || portion of meristem tissue || stem || whole plant || inflorescence meristem || epidermis || root system || inflorescence || cardinal part of multi-tissue plant structure || petiole || stalk || vascular leaf || sepal || microsporangium || epidermal cell || leaf lamina || shoot epidermal cell || corolla || pollen || plant axis || collective phyllome structure || petal || plant cell || seed || shoot epidermis || phyllome apex || cotyledon || stamen || shoot axis || microgametophyte || pedicel || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: inflorescence axis || calyx || flower || sporophyll || inflorescence meristem || root system || inflorescence || root || perianth || stem || leaf || phyllome || shoot internode || sepal || vascular leaf || petiole || petal || reproductive shoot system || shoot apex || leaf apex || collective phyllome structure || guard cell || cauline leaf || pollen || microsporophyll || pollen sac || leaf lamina || shoot epidermal cell || corolla || pedicel || androecium || stomatal complex || phyllome apex || cotyledon || stamen || stem internode || inflorescence branch || shoot axis || shoot system || leaf lamina base || collective leaf structure || branch || shoot epidermis
Plant ANatomical entity (PAN)	phyllome lamina	1	0.7057	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	organ lamina	1	0.7057	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	whole plant	0	0.4218	Least Informative	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	seed	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0	0.6838	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.4337	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.5969	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.4648	Least Informative	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.5346	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.4735	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.5053	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.7407	Least Informative	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence meristem	0	0.7789	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	cotyledon	0	0.7615	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.7531	Moderately Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1968	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.2036	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2833	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.4754	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.4754	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || LP.12 twelve leaves visible stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || E expanded cotyledon stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || C globular stage || leaf production stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.478	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.353	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.4088	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3937	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.3729	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.5666	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.586	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.5603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.513	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.4338	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.5243	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Membrane dipeptidase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Urease	0	2.35	--	DIRECT
Enzyme Commission (EC)	In cyclic amides	0	1.806	--	DIRECT
Enzyme Commission (EC)	Adenine deaminase	0	2.651	--	DIRECT
Enzyme Commission (EC)	S-adenosylhomocysteine deaminase	0	2.651	--	DIRECT
Enzyme Commission (EC)	S-methyl-5'-thioadenosine deaminase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Adenosine deaminase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Glucuronate isomerase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Imidazolonepropionase	0.000000000000001518	2.651	--	DIRECT
Enzyme Commission (EC)	Aminocarboxymuconate-semialdehyde decarboxylase	0.000000000000004014	2.952	--	DIRECT
Enzyme Commission (EC)	N-acetylglucosamine-6-phosphate deacetylase	0.0000000000001813	2.651	--	DIRECT
Enzyme Commission (EC)	5'-deoxyadenosine deaminase	0.0000000002198	2.651	--	DIRECT
Enzyme Commission (EC)	AMP deaminase	0.00000001552	2.952	--	DIRECT
Enzyme Commission (EC)	Guanine deaminase	0.000002662	2.651	--	DIRECT
Enzyme Commission (EC)	Aminodeoxyfutalosine deaminase	0.0002225	2.952	--	DIRECT
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	1.181	--	INHERITED FROM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing)
Enzyme Commission (EC)	Hydrolases	0	0.3541	Least Informative	DIRECT
Enzyme Commission (EC)	Lyases	1	0.6918	Least Informative	INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptide bonds	0	1.094	Moderately Informative	DIRECT
Enzyme Commission (EC)	Isomerases	0.5691	0.8446	Moderately Informative	INHERITED FROM: Interconverting aldoses and ketoses || Glucuronate isomerase || Intramolecular oxidoreductases
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	1	0.8949	Moderately Informative	INHERITED FROM: Dipeptidases || Membrane dipeptidase
Enzyme Commission (EC)	Carbon-carbon lyases	1	1.101	Moderately Informative	INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase
Enzyme Commission (EC)	Ligases	1	0.9606	Moderately Informative	INHERITED FROM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing)
Enzyme Commission (EC)	Intramolecular oxidoreductases	0	1.35	Informative	DIRECT
Enzyme Commission (EC)	In cyclic amidines	0.4852	1.721	Informative	INHERITED FROM: S-methyl-5'-thioadenosine deaminase || Guanine deaminase || AMP deaminase || Aminodeoxyfutalosine deaminase || 5'-deoxyadenosine deaminase || Adenine deaminase || Adenosine deaminase || S-adenosylhomocysteine deaminase
Enzyme Commission (EC)	In linear amides	1	1.372	Informative	INHERITED FROM: N-acetylglucosamine-6-phosphate deacetylase || Urease
Enzyme Commission (EC)	Carboxy-lyases	1	1.253	Informative	INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase
Enzyme Commission (EC)	Carbon--nitrogen ligases with glutamine as amido-N-donor	1	1.651	Informative	INHERITED FROM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing)
Enzyme Commission (EC)	Dipeptidases	0	2.174	Highly Informative	DIRECT
Enzyme Commission (EC)	Dihydroorotase	0	2.174	Highly Informative	DIRECT
Enzyme Commission (EC)	Interconverting aldoses and ketoses	0	1.776	Highly Informative	DIRECT
Enzyme Commission (EC)	Carbamoyl-phosphate synthase (glutamine-hydrolyzing)	0.0007461	2.049	Highly Informative	DIRECT

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Post-translational modification	Isomerase	0	0.9853	Moderately Informative	DIRECT

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