Class I aldolase family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: TIM beta/alpha-barrel [ 51350] (33)
• Superfamily: Aldolase [ 51569] (8)
• Family: Class I aldolase [ 51570] (12)

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Family statistics

	Genomes (3,205)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	14,707	104,049	70
Proteins	14,692	104,014	70

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Dihydrodipicolinate synthase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Transferring aldehyde or ketone residues	0	1.787	--	DIRECT
Enzyme Commission (EC)	N-acetylneuraminate lyase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Deoxyribose-phosphate aldolase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Transaldolase	0	2.741	--	DIRECT
Enzyme Commission (EC)	5-dehydro-4-deoxyglucarate dehydratase	0	2.741	--	DIRECT
Enzyme Commission (EC)	4-hydroxy-2-oxoglutarate aldolase	0.00000000002435	2.741	--	DIRECT
Enzyme Commission (EC)	Carbon-carbon lyases	0.000000005623	0.9151	--	DIRECT
Enzyme Commission (EC)	Carbon-oxygen lyases	0.000001643	0.8221	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	1	0.2728	--	INHERITED FROM: Shikimate kinase
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	0.004784	1.185	--	INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Transaldolase || Shikimate kinase || Transferring aldehyde or ketone residues || 3-phosphoshikimate 1-carboxyvinyltransferase
Enzyme Commission (EC)	Transketolases and transaldolases	1	1.787	--	INHERITED FROM: Transaldolase
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.3836	0.935	--	INHERITED FROM: Shikimate dehydrogenase
Enzyme Commission (EC)	Lyases	0	0.4956	Least Informative	DIRECT
Enzyme Commission (EC)	Oxidoreductases	1	0.3212	Least Informative	INHERITED FROM: Shikimate dehydrogenase
Enzyme Commission (EC)	Hydro-lyases	0	0.9853	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	0.08728	0.8381	Moderately Informative	INHERITED FROM: Shikimate kinase
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	1	1.185	Moderately Informative	INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.2465	0.9853	Moderately Informative	INHERITED FROM: Shikimate dehydrogenase
Enzyme Commission (EC)	Aldehyde-lyases	0	1.662	Informative	DIRECT
Enzyme Commission (EC)	Acting on phosphates	1	1.595	Informative	INHERITED FROM: 3-dehydroquinate synthase
Enzyme Commission (EC)	Oxo-acid-lyases	0.1093	1.741	Informative	INHERITED FROM: N-acetylneuraminate lyase || 4-hydroxy-2-oxoglutarate aldolase
Enzyme Commission (EC)	Shikimate kinase	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Shikimate dehydrogenase	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	3-phosphoshikimate 1-carboxyvinyltransferase	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	3-dehydroquinate synthase	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	3-dehydroquinate dehydratase	0	1.896	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.2218	--	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || organism physiology variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	pronephric kidney	0.000356	1.824	--	DIRECT
Xenopus ANatomical entity (XAN)	coelom	0.000356	1.661	--	DIRECT
Xenopus ANatomical entity (XAN)	embryonic kidney	0.000356	1.719	--	DIRECT
Xenopus ANatomical entity (XAN)	heart	0.0003631	1.689	--	DIRECT
Xenopus ANatomical entity (XAN)	kidney	0.02739	1.564	--	INHERITED FROM: embryonic kidney || pronephric kidney
Xenopus ANatomical entity (XAN)	trunk region	0.3285	0.388	--	INHERITED FROM: heart || pronephric kidney || coelom
Xenopus ANatomical entity (XAN)	anatomical region	0.7795	0.1803	--	INHERITED FROM: heart || tail region || tail || coelom || pronephric kidney
Xenopus ANatomical entity (XAN)	compound organ	0.8435	0.2177	--	INHERITED FROM: heart || embryonic kidney || pronephric kidney
Xenopus ANatomical entity (XAN)	organism subdivision	0.987	0.1679	--	INHERITED FROM: heart || tail || coelom || pronephric kidney
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: pronephric kidney || embryonic kidney || heart
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: tail region || pronephric kidney || anatomical group || multicellular anatomical structure || tail || tissue || coelom || heart || anatomical space || embryonic kidney || primordium
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0.1086	0.7159	Least Informative	INHERITED FROM: heart
Xenopus ANatomical entity (XAN)	embryo	0.314	0.5979	Least Informative	INHERITED FROM: primordium || pronephric kidney || coelom
Xenopus ANatomical entity (XAN)	trunk	0.3278	0.3894	Least Informative	INHERITED FROM: heart || pronephric kidney || coelom
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.5895	0.2685	Least Informative	INHERITED FROM: heart || embryonic kidney || pronephric kidney
Xenopus ANatomical entity (XAN)	urogenital system	0.7201	0.4777	Least Informative	INHERITED FROM: embryonic kidney || pronephric kidney
Xenopus ANatomical entity (XAN)	tail region	0.0008639	1.242	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0.03816	0.8828	Moderately Informative	INHERITED FROM: heart
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.07145	1.066	Moderately Informative	INHERITED FROM: pronephric kidney
Xenopus ANatomical entity (XAN)	embryonic structure	0.1206	1.149	Moderately Informative	INHERITED FROM: primordium
Xenopus ANatomical entity (XAN)	tail	0.0004972	1.334	Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical space	0.0009149	1.503	Informative	DIRECT
Xenopus ANatomical entity (XAN)	cardiovascular system	0.001749	1.586	Informative	INHERITED FROM: heart
Xenopus ANatomical entity (XAN)	urinary system	0.03516	1.523	Informative	INHERITED FROM: embryonic kidney || pronephric kidney
Xenopus ANatomical entity (XAN)	primordium	0.0001524	1.751	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6447	--	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7127	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	cauline leaf	0	0.6042	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence meristem	0	0.6337	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina base	0	0.6245	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.5171	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.4893	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.4728	--	DIRECT
Plant ANatomical entity (PAN)	cotyledon	0	0.6432	--	DIRECT
Plant ANatomical entity (PAN)	petiole	0	0.6385	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.5999	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.4385	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.4282	--	DIRECT
Plant ANatomical entity (PAN)	lamina	0	0.6199	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.437	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || sporophyll || calyx || flower || lamina || collective plant structure || plant embryo || leaf || phyllome || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || cauline leaf || reproductive shoot system || shoot apex || leaf apex || leaf lamina base || collective leaf structure || shoot system || portion of plant tissue || stomatal complex || plant organ || portion of meristem tissue || stem || whole plant || inflorescence meristem || epidermis || inflorescence || cardinal part of multi-tissue plant structure || petiole || stalk || vascular leaf || sepal || epidermal cell || leaf lamina || shoot epidermal cell || corolla || plant axis || collective phyllome structure || petal || plant cell || shoot epidermis || phyllome apex || cotyledon || stamen || shoot axis || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: calyx || flower || sporophyll || inflorescence meristem || inflorescence || perianth || stem || leaf || phyllome || sepal || vascular leaf || petiole || petal || reproductive shoot system || shoot apex || leaf apex || collective phyllome structure || guard cell || cauline leaf || microsporophyll || leaf lamina || shoot epidermal cell || corolla || androecium || stomatal complex || phyllome apex || cotyledon || stamen || shoot axis || shoot system || leaf lamina base || collective leaf structure || shoot epidermis
Plant ANatomical entity (PAN)	phyllome lamina	1	0.6199	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	organ lamina	1	0.6199	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	shoot apex	0	0.481	Least Informative	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0	0.4978	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0	0.5892	Least Informative	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.437	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.4728	Least Informative	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.4893	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.4777	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.4859	Least Informative	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.5153	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf lamina	0	0.6199	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.46	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stalk	0	0.6176	Least Informative	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.5956	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3245	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.3879	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.3879	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	leaf production stage	1	0.3272	--	INHERITED FROM: LP.02 two leaves visible stage || LP.10 ten leaves visible stage || LP.04 four leaves visible stage || LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || LP.06 six leaves visible stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || LP.12 twelve leaves visible stage || LP.04 four leaves visible stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || C globular stage || 1 main shoot growth stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.3895	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.4752	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.4603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.4234	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.3479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.4268	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	seed development stage	0.0001592	1.304	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Shikimate dehydrogenase	0	2.452	--	DIRECT
Enzyme Commission (EC)	Transferring aldehyde or ketonic groups	0	2.151	--	DIRECT
Enzyme Commission (EC)	Transaldolase	0	3.23	--	DIRECT
Enzyme Commission (EC)	3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase	0	3.23	--	DIRECT
Enzyme Commission (EC)	3-phosphoshikimate 1-carboxyvinyltransferase	0	2.452	--	DIRECT
Enzyme Commission (EC)	Shikimate kinase	0	2.452	--	DIRECT
Enzyme Commission (EC)	Carbon-carbon lyases	0	1.305	--	DIRECT
Enzyme Commission (EC)	Deoxyribose-phosphate aldolase	0	3.23	--	DIRECT
Enzyme Commission (EC)	N-acetylneuraminate lyase	0	3.23	--	DIRECT
Enzyme Commission (EC)	3-dehydroquinate dehydratase	0	2.385	--	DIRECT
Enzyme Commission (EC)	5-dehydro-4-deoxyglucarate dehydratase	0	3.23	--	DIRECT
Enzyme Commission (EC)	3-dehydroquinate synthase	0	2.452	--	DIRECT
Enzyme Commission (EC)	Amine-lyases	0	2.753	--	DIRECT
Enzyme Commission (EC)	4-hydroxy-tetrahydrodipicolinate synthase	0	3.23	--	DIRECT
Enzyme Commission (EC)	4-hydroxy-2-oxoglutarate aldolase	0.000000000007615	3.23	--	DIRECT
Enzyme Commission (EC)	2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase	0.0006729	3.23	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.1893	1.372	--	INHERITED FROM: Shikimate dehydrogenase
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	1	1.567	--	INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase
Enzyme Commission (EC)	Transferring phosphorus-containing groups	1	0.7021	--	INHERITED FROM: Shikimate kinase
Enzyme Commission (EC)	Carbon-oxygen lyases	1	1.208	--	INHERITED FROM: 5-dehydro-4-deoxyglucarate dehydratase || 3-dehydroquinate synthase || 3-dehydroquinate dehydratase || Hydro-lyases
Enzyme Commission (EC)	Oxidoreductases	1	0.7328	Least Informative	INHERITED FROM: Shikimate dehydrogenase
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Shikimate kinase || 3-phosphoshikimate 1-carboxyvinyltransferase || 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase || Transaldolase || 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase || Transferring aldehyde or ketonic groups
Enzyme Commission (EC)	Lyases	0	0.8775	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0.08786	1.238	Moderately Informative	INHERITED FROM: Shikimate kinase
Enzyme Commission (EC)	Acyltransferases	1	1.034	Moderately Informative	INHERITED FROM: 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
Enzyme Commission (EC)	Hydro-lyases	0	1.385	Informative	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	0.002062	1.558	Informative	INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.1102	1.437	Informative	INHERITED FROM: Shikimate dehydrogenase
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	1	1.321	Informative	INHERITED FROM: 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
Enzyme Commission (EC)	Aldehyde-lyases	0	1.999	Highly Informative	DIRECT
Enzyme Commission (EC)	Carbon-nitrogen lyases	0	1.907	Highly Informative	DIRECT
Enzyme Commission (EC)	Acting on phosphates	0.00144	2.026	Highly Informative	INHERITED FROM: 3-dehydroquinate synthase
Enzyme Commission (EC)	Oxo-acid-lyases	0.4965	2.084	Highly Informative	INHERITED FROM: N-acetylneuraminate lyase || 4-hydroxy-2-oxoglutarate aldolase
Enzyme Commission (EC)	Transketolases and transaldolases	1	2.151	Highly Informative	INHERITED FROM: 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase || Transaldolase

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Post-translational modification	Lyase	0	0.7782	Moderately Informative	DIRECT

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