Mammalian PLC family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: TIM beta/alpha-barrel [ 51350] (33)
• Superfamily: PLC-like phosphodiesterases [ 51695] (3)
• Family: Mammalian PLC [ 51696] (2)

---

Family statistics

	Genomes (463)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,764	8,219	3
Proteins	2,748	8,175	3

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	1.379	Informative	DIRECT
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	1.896	Highly Informative	DIRECT

---

Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT

---

Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal platelet aggregation	0.0001223	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal platelet activation	0.000146	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal platelet physiology	0.001797	1.7	--	INHERITED FROM: abnormal platelet activation || decreased platelet aggregation || abnormal platelet aggregation
Mammalian Phenotype (MP)	abnormal hemostasis	0.00374	1.399	--	INHERITED FROM: abnormal platelet activation || abnormal platelet aggregation || decreased platelet aggregation
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.04542	0.8789	--	INHERITED FROM: decreased platelet aggregation || abnormal platelet aggregation || abnormal platelet activation
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.07024	0.8789	--	INHERITED FROM: abnormal platelet activation || abnormal platelet aggregation || decreased platelet aggregation
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.3313	0.3626	--	INHERITED FROM: decreased platelet aggregation || abnormal platelet aggregation || abnormal calcium ion homeostasis || abnormal platelet activation
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.6203	0.6893	--	INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation || abnormal platelet activation
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.2059	0.5945	Least Informative	INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation || abnormal platelet activation
Mammalian Phenotype (MP)	abnormal homeostasis	0.5414	0.4926	Least Informative	INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation || abnormal calcium ion homeostasis || abnormal platelet activation
Mammalian Phenotype (MP)	abnormal blood coagulation	0.003634	1.399	Informative	INHERITED FROM: decreased platelet aggregation || abnormal platelet aggregation || abnormal platelet activation
Mammalian Phenotype (MP)	abnormal ion homeostasis	0.004023	1.524	Informative	INHERITED FROM: abnormal calcium ion homeostasis
Mammalian Phenotype (MP)	abnormal calcium ion homeostasis	0.00001557	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased platelet aggregation	0.00004045	2.001	Highly Informative	DIRECT

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	posterior body wall contraction defecation cycle variant	0	2.292	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.773	--	DIRECT
Worm Phenotype (WP)	behavior variant	0	0.6859	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0	0.7558	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0	1.306	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic physiology variant	0	1.426	--	DIRECT
Worm Phenotype (WP)	germ cell morphology variant	0	1.156	--	DIRECT
Worm Phenotype (WP)	somatic gonad physiology variant	0	2.292	--	DIRECT
Worm Phenotype (WP)	somatic sheath physiology variant	0	2.292	--	DIRECT
Worm Phenotype (WP)	gonad sheath contractions variant	0	2.292	--	DIRECT
Worm Phenotype (WP)	gonad sheath contraction rate reduced	0	2.292	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	cellular osmotic stress response variant	0	2.167	--	DIRECT
Worm Phenotype (WP)	spicule insertion defective	0.000000000525	2.769	--	DIRECT
Worm Phenotype (WP)	RNAi response variant	0.0000000005433	1.769	--	DIRECT
Worm Phenotype (WP)	post hermaphrodite contact variant	0.0000002914	2.167	--	DIRECT
Worm Phenotype (WP)	male mating defective	0.000004534	2.167	--	DIRECT
Worm Phenotype (WP)	protein subcellular localization variant	0.00008833	1.513	--	DIRECT
Worm Phenotype (WP)	response to injury variant	0.0001399	2.292	--	DIRECT
Worm Phenotype (WP)	copulation variant	0.001703	1.866	--	INHERITED FROM: male mating defective || post hermaphrodite contact variant || spicule insertion defective || male mating variant
Worm Phenotype (WP)	sexually dimorphic behavior variant	0.001703	1.866	--	INHERITED FROM: male mating defective || post hermaphrodite contact variant || spicule insertion defective || male mating variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || male mating defective || organism metabolism processing variant || RNAi response variant || ovulation variant || gonad sheath contraction rate reduced || organism osmotic stress response variant || reproductive system physiology variant || transgene expression variant || male mating variant || gene expression variant || organism homeostasis metabolism variant || lethal || cellular osmotic stress response variant || organism physiology variant || somatic sheath physiology variant || muscle cell physiology variant || protein subcellular localization variant || sexually dimorphic physiology variant || organism stress response variant || cell homeostasis metabolism variant || development variant || posterior body wall contraction defecation cycle variant || organism pathogen response variant || somatic gonad physiology variant || defecation contraction variant || cell physiology variant || hermaphrodite sterile || organism environmental stimulus response variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || spicule insertion defective || behavior variant || muscle system physiology variant || post hermaphrodite contact variant || gonad sheath contractions variant || organ system physiology variant || organism behavior variant || maternal sterile || cell stress response variant || organism development variant || response to injury variant || hermaphrodite physiology variant || defecation variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	male behavior variant	1	1.866	--	INHERITED FROM: male mating variant || post hermaphrodite contact variant || spicule insertion defective || male mating defective
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	organism stress response variant	0	0.9693	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell homeostasis metabolism variant	0	1.036	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell type morphology variant	0	0.8878	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0.001022	1.125	Moderately Informative	INHERITED FROM: protein subcellular localization variant
Worm Phenotype (WP)	cell stress response variant	0	1.538	Informative	DIRECT
Worm Phenotype (WP)	defecation variant	0	1.689	Informative	DIRECT
Worm Phenotype (WP)	hermaphrodite physiology variant	0	1.446	Informative	DIRECT
Worm Phenotype (WP)	muscle cell physiology variant	0	1.426	Informative	DIRECT
Worm Phenotype (WP)	organism pathogen response variant	0	1.468	Informative	DIRECT
Worm Phenotype (WP)	oocyte morphology variant	0	1.292	Informative	DIRECT
Worm Phenotype (WP)	pattern protein expression variant	0.1674	1.49	Informative	INHERITED FROM: protein subcellular localization variant
Worm Phenotype (WP)	defecation contraction variant	0	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	ovulation variant	0	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	endomitotic oocytes	0	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	organism osmotic stress response variant	0	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	male mating variant	0.00001998	1.866	Highly Informative	DIRECT

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism || compound organ || cavitated compound organ
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5123	Least Informative	DIRECT

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage 29 and 30	0.000005428	2.307	--	DIRECT
Xenopus DEvelopment stage (XDE)	late tailbud stage	0.1179	1.638	--	INHERITED FROM: NF stage 29 and 30
Xenopus DEvelopment stage (XDE)	embryonic stage	0.02689	1.006	Moderately Informative	INHERITED FROM: NF stage 29 and 30
Xenopus DEvelopment stage (XDE)	tailbud stage	0.6405	1.554	Informative	INHERITED FROM: NF stage 29 and 30

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system || plant cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	2.275	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	1.753	Highly Informative	DIRECT

---