Tyrosine-dependent oxidoreductases family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: NAD(P)-binding Rossmann-fold domains [ 51734]
• Superfamily: NAD(P)-binding Rossmann-fold domains [ 51735] (12)
• Family: Tyrosine-dependent oxidoreductases [ 51751] (70)

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Family statistics

	Genomes (3,138)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	66,561	523,616	181
Proteins	65,421	514,456	180

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0	0.935	--	DIRECT
Enzyme Commission (EC)	UDP-4-amino-4-deoxy-L-arabinose formyltransferase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Enoyl-[acyl-carrier-protein] reductase (NADH)	0	2.264	--	DIRECT
Enzyme Commission (EC)	Steroid Delta-isomerase	0	2.741	--	DIRECT
Enzyme Commission (EC)	GDP-mannose 4,6-dehydratase	0	2.741	--	DIRECT
Enzyme Commission (EC)	UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic	0	2.264	--	DIRECT
Enzyme Commission (EC)	ADP-glyceromanno-heptose 6-epimerase	0	2.741	--	DIRECT
Enzyme Commission (EC)	3-beta-hydroxy-Delta(5)-steroid dehydrogenase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Acting on carbohydrates and derivatives	0	1.662	--	DIRECT
Enzyme Commission (EC)	dTDP-glucose 4,6-dehydratase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Carbonyl reductase (NADPH)	0	2.741	--	DIRECT
Enzyme Commission (EC)	Estradiol 17-beta-dehydrogenase	0	2.741	--	DIRECT
Enzyme Commission (EC)	UDP-glucuronate decarboxylase	0.0000000000000109	2.741	--	DIRECT
Enzyme Commission (EC)	Enoyl-CoA hydratase 2	0.00000000000004286	2.44	--	DIRECT
Enzyme Commission (EC)	3-dehydrosphinganine reductase	0.0000000000001226	2.741	--	DIRECT
Enzyme Commission (EC)	NADP-retinol dehydrogenase	0.0000000000001226	2.741	--	DIRECT
Enzyme Commission (EC)	3-hydroxybutyrate dehydrogenase	0.0000000000001226	2.741	--	DIRECT
Enzyme Commission (EC)	UDP-glucose 4-epimerase	0.000000000000162	2.741	--	DIRECT
Enzyme Commission (EC)	Dihydrokaempferol 4-reductase	0.0000000000006816	2.741	--	DIRECT
Enzyme Commission (EC)	Protochlorophyllide reductase	0.00000000001107	2.741	--	DIRECT
Enzyme Commission (EC)	Testosterone 17-beta-dehydrogenase	0.00000000002413	2.741	--	DIRECT
Enzyme Commission (EC)	GDP-L-fucose synthase	0.0000000001162	2.741	--	DIRECT
Enzyme Commission (EC)	6,7-dihydropteridine reductase	0.0000000002541	2.741	--	DIRECT
Enzyme Commission (EC)	All-trans-retinol dehydrogenase (NAD(+))	0.0000000006441	2.741	--	DIRECT
Enzyme Commission (EC)	Sterol-4-alpha-carboxylate 3-dehydrogenase (decarb	0.000000003575	2.741	--	DIRECT
Enzyme Commission (EC)	L-xylulose reductase	0.000000003575	2.741	--	DIRECT
Enzyme Commission (EC)	3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propan	0.000000004056	2.741	--	DIRECT
Enzyme Commission (EC)	2,4-dienoyl-CoA reductase (NADPH)	0.00000001047	2.741	--	DIRECT
Enzyme Commission (EC)	dTDP-4-dehydrorhamnose reductase	0.00000001986	2.741	--	DIRECT
Enzyme Commission (EC)	15-hydroxyprostaglandin dehydrogenase (NADP(+))	0.00000001986	2.741	--	DIRECT
Enzyme Commission (EC)	11-beta-hydroxysteroid dehydrogenase	0.00000001986	2.741	--	DIRECT
Enzyme Commission (EC)	Sepiapterin reductase	0.00000001986	2.741	--	DIRECT
Enzyme Commission (EC)	Dihydrofolate reductase	0.00000003467	2.264	--	DIRECT
Enzyme Commission (EC)	Prostaglandin-E(2) 9-reductase	0.00000005327	2.741	--	DIRECT
Enzyme Commission (EC)	Acetoacetyl-CoA reductase	0.0000006154	2.741	--	DIRECT
Enzyme Commission (EC)	15-hydroxyprostaglandin dehydrogenase (NAD(+))	0.0000006154	2.741	--	DIRECT
Enzyme Commission (EC)	3-hydroxy-2-methylbutyryl-CoA dehydrogenase	0.000003437	2.741	--	DIRECT
Enzyme Commission (EC)	Diacetyl reductase ((S)-acetoin forming)	0.000003437	2.741	--	DIRECT
Enzyme Commission (EC)	Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	0.000005592	2.741	--	DIRECT
Enzyme Commission (EC)	3-keto-steroid reductase	0.000009524	2.741	--	DIRECT
Enzyme Commission (EC)	Glucose 1-dehydrogenase	0.0001761	2.44	--	DIRECT
Enzyme Commission (EC)	Carbon-oxygen lyases	0.1661	0.8221	--	INHERITED FROM: Enoyl-CoA hydratase 2 || dTDP-glucose 4,6-dehydratase || GDP-mannose 4,6-dehydratase || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat
Enzyme Commission (EC)	Carbon-carbon lyases	1	0.9151	--	INHERITED FROM: UDP-glucuronate decarboxylase
Enzyme Commission (EC)	Hydrolases	1	0.01852	--	INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase
Enzyme Commission (EC)	Acyltransferases	0.8807	0.8778	--	INHERITED FROM: Fatty-acid synthase || [Acyl-carrier-protein] S-malonyltransferase || [Acyl-carrier-protein] S-acetyltransferase || Beta-ketoacyl-acyl-carrier-protein synthase I
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: [Acyl-carrier-protein] S-malonyltransferase || Beta-ketoacyl-acyl-carrier-protein synthase I || UDP-4-amino-4-deoxy-L-arabinose formyltransferase || [Acyl-carrier-protein] S-acetyltransferase || Fatty-acid synthase || Hydroxymethyl-, formyl- and related transferases
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0.9531	1.279	--	INHERITED FROM: 6,7-dihydropteridine reductase || Dihydrofolate reductase || With NAD(+) or NADP(+) as acceptor
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Isomerases	0	0.6881	Least Informative	DIRECT
Enzyme Commission (EC)	Lyases	1	0.4956	Least Informative	INHERITED FROM: Enoyl-CoA hydratase 2 || dTDP-glucose 4,6-dehydratase || GDP-mannose 4,6-dehydratase || UDP-glucuronate decarboxylase || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat
Enzyme Commission (EC)	Acting on ester bonds	1	0.5107	Least Informative	INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase
Enzyme Commission (EC)	Transferring one-carbon groups	0.2912	0.72	Least Informative	INHERITED FROM: UDP-4-amino-4-deoxy-L-arabinose formyltransferase || Hydroxymethyl-, formyl- and related transferases
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	0.9853	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-CH group of donors	0.00000000000009433	1.185	Moderately Informative	DIRECT
Enzyme Commission (EC)	Intramolecular oxidoreductases	1	1.118	Moderately Informative	INHERITED FROM: Steroid Delta-isomerase || Transposing C==C bonds
Enzyme Commission (EC)	Hydro-lyases	0.001489	0.9853	Moderately Informative	INHERITED FROM: Enoyl-CoA hydratase 2 || dTDP-glucose 4,6-dehydratase || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat || GDP-mannose 4,6-dehydratase
Enzyme Commission (EC)	Carboxy-lyases	1	1.06	Moderately Informative	INHERITED FROM: UDP-glucuronate decarboxylase
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.4637	1.001	Moderately Informative	INHERITED FROM: Fatty-acid synthase || [Acyl-carrier-protein] S-malonyltransferase || [Acyl-carrier-protein] S-acetyltransferase || Beta-ketoacyl-acyl-carrier-protein synthase I
Enzyme Commission (EC)	Racemases and epimerases	0	1.379	Informative	DIRECT
Enzyme Commission (EC)	Hydroxymethyl-, formyl- and related transferases	0	1.537	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.399	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.000000004136	1.511	Informative	DIRECT
Enzyme Commission (EC)	Thiolester hydrolases	0.01624	1.595	Informative	INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase
Enzyme Commission (EC)	Alcohol dehydrogenase	0	2.139	Highly Informative	DIRECT
Enzyme Commission (EC)	3-oxoacyl-[acyl-carrier-protein] reductase	0	2.042	Highly Informative	DIRECT
Enzyme Commission (EC)	Transposing C==C bonds	0.000000000000002579	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	Beta-ketoacyl-acyl-carrier-protein synthase I	0.0000000000001536	1.787	Highly Informative	DIRECT
Enzyme Commission (EC)	Fatty-acid synthase	0.000000000005635	1.896	Highly Informative	DIRECT
Enzyme Commission (EC)	[Acyl-carrier-protein] S-acetyltransferase	0.00000000004633	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	Oleoyl-[acyl-carrier-protein] hydrolase	0.0000000001359	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat	0.0000000004285	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	[Acyl-carrier-protein] S-malonyltransferase	0.00000006016	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s	0.000004149	1.896	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	syndrome	0.3364	1.151	Moderately Informative	INHERITED FROM: polycystic ovary syndrome
Disease Ontology (DO)	polycystic ovary syndrome	0.000332	1.814	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
	Variable expressivity	0	0.04347	--	DIRECT
	Phenotypic variability	1	0	--	INHERITED FROM: Variable expressivity
Phenotypic Abnormality (PA)	Palmoplantar hyperkeratosis	0.0001727	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Gynecomastia	0.0006822	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the plantar skin of foot	0.005225	2.161	--	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Abnormality of the adrenal glands	0.0097	1.763	--	INHERITED FROM: Adrenal insufficiency
Phenotypic Abnormality (PA)	Abnormality of the skin of the palm	0.01223	1.763	--	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Abnormal breast morphology	0.04756	1.763	--	INHERITED FROM: Gynecomastia
Phenotypic Abnormality (PA)	Abnormality of the breast	0.04878	1.763	--	INHERITED FROM: Gynecomastia
Phenotypic Abnormality (PA)	Abnormality of the pituitary gland	0.05467	1.617	--	INHERITED FROM: Hyperpituitarism
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.08626	0.2371	--	INHERITED FROM: Hyperpituitarism
Phenotypic Abnormality (PA)	Thickened skin	0.0867	1.684	--	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.1107	0.6631	--	INHERITED FROM: Hyperpituitarism
Phenotypic Abnormality (PA)	Abnormality of the foot	0.1713	1.082	--	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Abnormality of the hypothalamus-pituitary axis	0.1913	1.617	--	INHERITED FROM: Hyperpituitarism
Phenotypic Abnormality (PA)	Abnormality of the skin	0.1999	0.722	--	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Abnormality of adrenal physiology	0.2423	1.763	--	INHERITED FROM: Adrenal insufficiency
Phenotypic Abnormality (PA)	Hyperkeratosis	0.2729	1.763	--	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.4131	0.533	--	INHERITED FROM: Hyperpituitarism
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.4142	0.9183	--	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.523	0.7722	--	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Abnormality of the integument	0.09588	0.6235	Least Informative	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Abnormality of limbs	0.4788	0.6429	Least Informative	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.497	0.4756	Least Informative	INHERITED FROM: Hyperpituitarism
Phenotypic Abnormality (PA)	Abnormality of the endocrine system	0.0224	0.9183	Moderately Informative	INHERITED FROM: Hyperpituitarism || Adrenal insufficiency
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.3048	0.9309	Moderately Informative	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Abnormality of the hand	0.3437	1.031	Moderately Informative	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Epidermal thickening	0.01715	1.684	Informative	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Abnormality of the anterior pituitary	0.01943	1.617	Informative	INHERITED FROM: Hyperpituitarism
Phenotypic Abnormality (PA)	Abnormality of the palm	0.03183	1.617	Informative	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Regional abnormality of skin	0.1005	1.508	Informative	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Adrenal insufficiency	0.0004073	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Hyperpituitarism	0.0004659	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Palmar hyperkeratosis	0.0027	2.161	Highly Informative	INHERITED FROM: Palmoplantar hyperkeratosis
Phenotypic Abnormality (PA)	Plantar hyperkeratosis	0.003998	2.161	Highly Informative	INHERITED FROM: Palmoplantar hyperkeratosis

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	delayed dark adaptation	0.0000005735	2.603	--	DIRECT
Mammalian Phenotype (MP)	vision/eye phenotype	0.0956	0.8789	--	INHERITED FROM: delayed dark adaptation
Mammalian Phenotype (MP)	abnormal eye physiology	0.163	1.649	Informative	INHERITED FROM: delayed dark adaptation

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: lethal || development variant || organism development variant

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	vacuolar morphology	0.0006373	2.444	--	DIRECT
Yeast Phenotype (YP)	cellular morphology	0.3731	1.24	--	INHERITED FROM: vacuolar morphology
Yeast Phenotype (YP)	morphology	0.6388	1.143	Moderately Informative	INHERITED FROM: vacuolar morphology
Yeast Phenotype (YP)	subcellular morphology	0.1599	1.541	Informative	INHERITED FROM: vacuolar morphology
Yeast Phenotype (YP)	endomembrane system morphology	0.05845	2.143	Highly Informative	INHERITED FROM: vacuolar morphology

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || organism

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0.9747	0.1408	--	INHERITED FROM: alimentary system || anatomical cluster
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: alimentary system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: alimentary system || anatomical cluster
Xenopus ANatomical entity (XAN)	anatomical cluster	0.0004053	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0.0002467	0.8739	Moderately Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	seed development stage	0.0003589	1.304	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0	1.372	--	DIRECT
Enzyme Commission (EC)	3-oxoacyl-[acyl-carrier-protein] reductase	0	2.385	--	DIRECT
Enzyme Commission (EC)	UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating)	0	2.753	--	DIRECT
Enzyme Commission (EC)	Very-long-chain 3-oxoacyl-CoA reductase	0	3.23	--	DIRECT
Enzyme Commission (EC)	17-beta-estradiol 17-dehydrogenase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Enoyl-[acyl-carrier-protein] reductase (NADH)	0	2.753	--	DIRECT
Enzyme Commission (EC)	Dihydromonapterin reductase	0	3.23	--	DIRECT
Enzyme Commission (EC)	UDP-4-amino-4-deoxy-L-arabinose formyltransferase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Beta-ketoacyl-[acyl-carrier-protein] synthase I	0	2.275	--	DIRECT
Enzyme Commission (EC)	UDP-glucuronate decarboxylase	0	3.23	--	DIRECT
Enzyme Commission (EC)	dTDP-glucose 4,6-dehydratase	0	3.23	--	DIRECT
Enzyme Commission (EC)	GDP-mannose 4,6-dehydratase	0	3.23	--	DIRECT
Enzyme Commission (EC)	ADP-glyceromanno-heptose 6-epimerase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Steroid Delta-isomerase	0	2.929	--	DIRECT
Enzyme Commission (EC)	UDP-glucose 4-epimerase	5.532e-16	3.23	--	DIRECT
Enzyme Commission (EC)	Reducing C-O-C group as acceptor	0.000000000000001463	3.23	--	DIRECT
Enzyme Commission (EC)	3-beta-hydroxy-Delta(5)-steroid dehydrogenase	0.000000000000003636	3.23	--	DIRECT
Enzyme Commission (EC)	NADP-retinol dehydrogenase	0.0000000000001279	2.929	--	DIRECT
Enzyme Commission (EC)	Carbonyl reductase (NADPH)	0.000000000000157	3.23	--	DIRECT
Enzyme Commission (EC)	Enoyl-CoA hydratase 2	0.000000000000422	2.753	--	DIRECT
Enzyme Commission (EC)	Alcohol dehydrogenase	0.0000000000006375	2.753	--	DIRECT
Enzyme Commission (EC)	3-beta-hydroxysteroid 3-dehydrogenase	0.0000000000006416	3.23	--	DIRECT
Enzyme Commission (EC)	3-dehydrosphinganine reductase	0.000000000001038	3.23	--	DIRECT
Enzyme Commission (EC)	6-methylsalicylic acid synthase	0.000000000003107	2.628	--	DIRECT
Enzyme Commission (EC)	3-hydroxybutyrate dehydrogenase	0.00000000001725	3.23	--	DIRECT
Enzyme Commission (EC)	Fatty-acid synthase system	0.00000000002274	2.327	--	DIRECT
Enzyme Commission (EC)	Protochlorophyllide reductase	0.00000000003876	3.23	--	DIRECT
Enzyme Commission (EC)	Dihydroflavanol 4-reductase	0.00000000007015	3.23	--	DIRECT
Enzyme Commission (EC)	6,7-dihydropteridine reductase	0.000000000259	3.23	--	DIRECT
Enzyme Commission (EC)	Flavanone 4-reductase	0.0000000002853	3.23	--	DIRECT
Enzyme Commission (EC)	GDP-L-fucose synthase	0.0000000002853	3.23	--	DIRECT
Enzyme Commission (EC)	3-alpha(or 20-beta)-hydroxysteroid dehydrogenase	0.0000000002853	3.23	--	DIRECT
Enzyme Commission (EC)	[Acyl-carrier-protein] S-acetyltransferase	0.0000000008717	2.275	--	DIRECT
Enzyme Commission (EC)	2,4-dienoyl-CoA reductase (NADPH)	0.000000001624	3.23	--	DIRECT
Enzyme Commission (EC)	Oleoyl-[acyl-carrier-protein] hydrolase	0.000000003984	2.23	--	DIRECT
Enzyme Commission (EC)	3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))	0.000000007011	3.23	--	DIRECT
Enzyme Commission (EC)	Cinnamoyl-CoA reductase	0.000000007672	3.23	--	DIRECT
Enzyme Commission (EC)	UDP-sulfoquinovose synthase	0.000000007672	3.23	--	DIRECT
Enzyme Commission (EC)	3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase	0.00000001022	3.23	--	DIRECT
Enzyme Commission (EC)	2-methylbutanoate polyketide synthase	0.00000001109	2.531	--	DIRECT
Enzyme Commission (EC)	6-deoxyerythronolide-B synthase	0.00000001109	2.628	--	DIRECT
Enzyme Commission (EC)	L-xylulose reductase	0.00000001933	3.23	--	DIRECT
Enzyme Commission (EC)	dTDP-4-dehydrorhamnose reductase	0.00000001933	3.23	--	DIRECT
Enzyme Commission (EC)	All-trans-retinol dehydrogenase (NAD(+))	0.00000002199	2.753	--	DIRECT
Enzyme Commission (EC)	Lovastatin nonaketide synthase	0.00000003447	2.628	--	DIRECT
Enzyme Commission (EC)	10-deoxymethynolide syntase	0.00000003447	2.628	--	DIRECT
Enzyme Commission (EC)	Narbonolide synthase	0.00000003447	2.628	--	DIRECT
Enzyme Commission (EC)	Dihydrofolate reductase	0.00000003891	2.628	--	DIRECT
Enzyme Commission (EC)	hydratase	0.00000003918	2.753	--	DIRECT
Enzyme Commission (EC)	UDP-N-acetylglucosamine 4,6-dehydratase (inverting)	0.00000003918	3.23	--	DIRECT
Enzyme Commission (EC)	UDP-glucose 4,6-dehydratase	0.00000003918	3.23	--	DIRECT
Enzyme Commission (EC)	11-beta-hydroxysteroid dehydrogenase	0.00000007894	3.23	--	DIRECT
Enzyme Commission (EC)	(decarboxylating)	0.00000007894	3.23	--	DIRECT
Enzyme Commission (EC)	3-beta-(or 20-alpha)-hydroxysteroid dehydrogenase	0.00000007894	3.23	--	DIRECT
Enzyme Commission (EC)	3(or 17)-alpha-hydroxysteroid dehydrogenase	0.0000001169	3.23	--	DIRECT
Enzyme Commission (EC)	Acting on carbon-sulfur bonds	0.0000002151	2.929	--	DIRECT
Enzyme Commission (EC)	Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)	0.0000003222	3.23	--	DIRECT
Enzyme Commission (EC)	15-hydroxyprostaglandin dehydrogenase (NADP(+))	0.0000003222	3.23	--	DIRECT
Enzyme Commission (EC)	[Acyl-carrier-protein] S-malonyltransferase	0.0000003822	2.327	--	DIRECT
Enzyme Commission (EC)	Prostaglandin-E(2) 9-reductase	0.0000008384	3.23	--	DIRECT
Enzyme Commission (EC)	Chanoclavine-I dehydrogenase	0.000001319	3.23	--	DIRECT
Enzyme Commission (EC)	(3R)-hydroxyacyl-CoA dehydrogenase	0.000001319	2.753	--	DIRECT
Enzyme Commission (EC)	Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)	0.000002448	2.327	--	DIRECT
Enzyme Commission (EC)	Flavin reductase (NADPH)	0.000002777	3.23	--	DIRECT
Enzyme Commission (EC)	15-hydroxyprostaglandin dehydrogenase (NAD(+))	0.000005404	3.23	--	DIRECT
Enzyme Commission (EC)	Diacetyl reductase ((S)-acetoin forming)	0.000005404	3.23	--	DIRECT
Enzyme Commission (EC)	11-cis-retinol dehydrogenase	0.000005404	3.23	--	DIRECT
Enzyme Commission (EC)	Acetoacetyl-CoA reductase	0.000005404	3.23	--	DIRECT
Enzyme Commission (EC)	3-hydroxy acid dehydrogenase	0.000005404	3.23	--	DIRECT
Enzyme Commission (EC)	3(or 17)-beta-hydroxysteroid dehydrogenase	0.000005404	3.23	--	DIRECT
Enzyme Commission (EC)	Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	0.000009482	3.23	--	DIRECT
Enzyme Commission (EC)	Mannitol 2-dehydrogenase (NADP(+))	0.00002217	3.23	--	DIRECT
Enzyme Commission (EC)	3-hydroxy-2-methylbutyryl-CoA dehydrogenase	0.00002217	3.23	--	DIRECT
Enzyme Commission (EC)	Trans-2-enoyl-CoA reductase (NADPH)	0.00003671	3.23	--	DIRECT
Enzyme Commission (EC)	2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase	0.00009156	3.23	--	DIRECT
Enzyme Commission (EC)	Chlorophyll(ide) b reductase	0.00009156	3.23	--	DIRECT
Enzyme Commission (EC)	Benzil reductase ((S)-benzoin forming)	0.00009156	3.23	--	DIRECT
Enzyme Commission (EC)	Galactitol 2-dehydrogenase	0.0003783	3.23	--	DIRECT
Enzyme Commission (EC)	Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase	0.0003783	3.23	--	DIRECT
Enzyme Commission (EC)	Uronate dehydrogenase	0.0003783	3.23	--	DIRECT
Enzyme Commission (EC)	Tropinone reductase II	0.0003783	3.23	--	DIRECT
Enzyme Commission (EC)	D-arabinitol 2-dehydrogenase	0.0003783	3.23	--	DIRECT
Enzyme Commission (EC)	Sulfoacetaldehyde reductase	0.0003783	3.23	--	DIRECT
Enzyme Commission (EC)	1-deoxy-11-beta-hydroxypentalenate dehydrogenase	0.0003783	3.23	--	DIRECT
Enzyme Commission (EC)	CDP-abequose synthase	0.0003783	3.23	--	DIRECT
Enzyme Commission (EC)	Dihydroanticapsin 7-dehydrogenase	0.0003783	3.23	--	DIRECT
Enzyme Commission (EC)	2-alkyl-3-oxoalkanoate reductase	0.0003783	3.23	--	DIRECT
Enzyme Commission (EC)	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase	0.0005453	3.23	--	DIRECT
Enzyme Commission (EC)	Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase	0.0005453	3.23	--	DIRECT
Enzyme Commission (EC)	2'-hydroxyisoflavone reductase	0.0005453	3.23	--	DIRECT
Enzyme Commission (EC)	Carbon-oxygen lyases	0.1505	1.208	--	INHERITED FROM: hydratase || dTDP-glucose 4,6-dehydratase || UDP-N-acetylglucosamine 4,6-dehydratase (inverting) || UDP-glucose 4,6-dehydratase || GDP-mannose 4,6-dehydratase || Hydro-lyases || Enoyl-CoA hydratase 2
Enzyme Commission (EC)	Acting on carbon-sulfur bonds	1	2.929	--	INHERITED FROM: UDP-sulfoquinovose synthase
Enzyme Commission (EC)	Carbon-carbon lyases	1	1.305	--	INHERITED FROM: UDP-glucuronate decarboxylase
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Lovastatin nonaketide synthase || Fatty-acid synthase system || 10-deoxymethynolide syntase || UDP-4-amino-4-deoxy-L-arabinose formyltransferase || Hydroxymethyl-, formyl- and related transferases || [Acyl-carrier-protein] S-malonyltransferase || [Acyl-carrier-protein] S-acetyltransferase || 2-methylbutanoate polyketide synthase || Beta-ketoacyl-[acyl-carrier-protein] synthase I || 6-deoxyerythronolide-B synthase || 6-methylsalicylic acid synthase || Narbonolide synthase
Enzyme Commission (EC)	Hydrolases	1	0.4043	Least Informative	INHERITED FROM: Acting on carbon-sulfur bonds || Oleoyl-[acyl-carrier-protein] hydrolase || UDP-sulfoquinovose synthase
Enzyme Commission (EC)	Isomerases	0	1.026	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	1	1.161	Moderately Informative	INHERITED FROM: UDP-4-amino-4-deoxy-L-arabinose formyltransferase || Hydroxymethyl-, formyl- and related transferases
Enzyme Commission (EC)	Acyltransferases	1	1.034	Moderately Informative	INHERITED FROM: 6-deoxyerythronolide-B synthase || 10-deoxymethynolide syntase || 2-methylbutanoate polyketide synthase || Lovastatin nonaketide synthase || Beta-ketoacyl-[acyl-carrier-protein] synthase I || Fatty-acid synthase system || [Acyl-carrier-protein] S-acetyltransferase || [Acyl-carrier-protein] S-malonyltransferase || 6-methylsalicylic acid synthase || Narbonolide synthase
Enzyme Commission (EC)	Acting on ester bonds	1	0.8756	Moderately Informative	INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase
Enzyme Commission (EC)	Lyases	1	0.8775	Moderately Informative	INHERITED FROM: dTDP-glucose 4,6-dehydratase || hydratase || Enoyl-CoA hydratase 2 || GDP-mannose 4,6-dehydratase || UDP-N-acetylglucosamine 4,6-dehydratase (inverting) || UDP-glucose 4,6-dehydratase || Hydro-lyases || UDP-glucuronate decarboxylase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.437	Informative	DIRECT
Enzyme Commission (EC)	Racemases and epimerases	0	1.711	Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-CH group of donors	0.000001134	1.586	Informative	DIRECT
Enzyme Commission (EC)	Hydro-lyases	0.0003585	1.385	Informative	DIRECT
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.2029	1.321	Informative	INHERITED FROM: Lovastatin nonaketide synthase || 2-methylbutanoate polyketide synthase || 10-deoxymethynolide syntase || 6-deoxyerythronolide-B synthase || 6-methylsalicylic acid synthase || Narbonolide synthase || [Acyl-carrier-protein] S-malonyltransferase || Fatty-acid synthase system || Beta-ketoacyl-[acyl-carrier-protein] synthase I || [Acyl-carrier-protein] S-acetyltransferase
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	1	1.65	Informative	INHERITED FROM: Cinnamoyl-CoA reductase
Enzyme Commission (EC)	Acting on the CH-NH group of donors	1	1.686	Informative	INHERITED FROM: 6,7-dihydropteridine reductase || Flavin reductase (NADPH) || Dihydrofolate reductase || Dihydromonapterin reductase || With NAD(+) or NADP(+) as acceptor
Enzyme Commission (EC)	Carboxy-lyases	1	1.474	Informative	INHERITED FROM: UDP-glucuronate decarboxylase
Enzyme Commission (EC)	Intramolecular oxidoreductases	1	1.505	Informative	INHERITED FROM: Transposing C=C bonds || Steroid Delta-isomerase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.783	Highly Informative	DIRECT
Enzyme Commission (EC)	Hydroxymethyl-, formyl- and related transferases	0	1.999	Highly Informative	DIRECT
Enzyme Commission (EC)	Acting on carbohydrates and derivatives	0	2.084	Highly Informative	DIRECT
Enzyme Commission (EC)	Transposing C=C bonds	0.0000000000195	2.116	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.00000009384	1.907	Highly Informative	DIRECT
Enzyme Commission (EC)	Thiolester hydrolases	0.0431	1.951	Highly Informative	INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	1	2.054	Highly Informative	INHERITED FROM: Cinnamoyl-CoA reductase

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Post-translational modification	Oxidoreductase	0	0.9542	Moderately Informative	DIRECT

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