FAD/NAD(P)-binding domain superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: FAD/NAD(P)-binding domain [ 51904]
• Superfamily: FAD/NAD(P)-binding domain [ 51905] (8)
• Families:
  • C-terminal domain of adrenodoxin reductase-like [ 51906] (5)
  • FAD-linked reductases, N-terminal domain [ 51913] (18)
  • GDI-like N domain [ 51931] (2)
  • Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain [ 51934] (5)
  • FAD/NAD-linked reductases, N-terminal and central domains [ 51943] (15)
  • Thi4-like [ 141942]
  • GidA-like [ 141946]
  • HI0933 N-terminal domain-like [ 159436] (2)

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Superfamily statistics

	Genomes (3,261)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	142,279	1,022,522	171
Proteins	127,014	925,947	156

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Functional annotation

• General category: General
• Detailed category: Small molecule binding

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Ribose 1,5-bisphosphate isomerase	0	2.56	--	DIRECT
Enzyme Commission (EC)	(FADH(2)-oxidizing)	0	2.56	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.861	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH(2) group of donors	0	1.281	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0	2.259	--	DIRECT
Enzyme Commission (EC)	NAD(P)(+) transhydrogenase (B-specific)	0	2.259	--	DIRECT
Enzyme Commission (EC)	Protoporphyrinogen oxidase	0	2.259	--	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0	2.259	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	4.713e-16	1.782	--	DIRECT
Enzyme Commission (EC)	Thioredoxin-disulfide reductase	0.00000000000001464	2.56	--	DIRECT
Enzyme Commission (EC)	Tryptophan 2-monooxygenase	0.00000000000007259	2.259	--	DIRECT
Enzyme Commission (EC)	Diapolycopene oxygenase	0.00000000000007259	2.56	--	DIRECT
Enzyme Commission (EC)	L-amino-acid oxidase	0.0000000000001608	2.259	--	DIRECT
Enzyme Commission (EC)	4,4'-diapophytoene desaturase	0.000000000002442	2.56	--	DIRECT
Enzyme Commission (EC)	(R)-mandelonitrile lyase	0.000000000002442	2.259	--	DIRECT
Enzyme Commission (EC)	Kynurenine 3-monooxygenase	0.00000000000881	2.56	--	DIRECT
Enzyme Commission (EC)	CoB--CoM heterodisulfide reductase	0.00000000001033	2.083	--	DIRECT
Enzyme Commission (EC)	Dihydrolipoyl dehydrogenase	0.00000000004275	2.259	--	DIRECT
Enzyme Commission (EC)	Geranylgeranyl diphosphate reductase	0.00000000008148	2.56	--	DIRECT
Enzyme Commission (EC)	Prolycopene isomerase	0.00000000008148	2.56	--	DIRECT
Enzyme Commission (EC)	9,9'-di-cis-zeta-carotene desaturase	0.000000000108	2.56	--	DIRECT
Enzyme Commission (EC)	Monoamine oxidase	0.0000000001593	2.259	--	DIRECT
Enzyme Commission (EC)	Monodehydroascorbate reductase (NADH)	0.00000001145	2.259	--	DIRECT
Enzyme Commission (EC)	Flavin-containing monooxygenase	0.00000008443	2.56	--	DIRECT
Enzyme Commission (EC)	NADH dehydrogenase	0.0000004082	1.657	--	DIRECT
Enzyme Commission (EC)	Lycopene beta-cyclase	0.0000004083	2.259	--	DIRECT
Enzyme Commission (EC)	Prenylcysteine oxidase	0.000003039	2.56	--	DIRECT
Enzyme Commission (EC)	Glutathione-disulfide reductase	0.000004101	2.259	--	DIRECT
Enzyme Commission (EC)	3-(3-hydroxy-phenyl)propanoic acid hydroxylase	0.000005223	2.56	--	DIRECT
Enzyme Commission (EC)	With a quinone or related compound as acceptor	0.000088	1.782	--	DIRECT
Enzyme Commission (EC)	Choline dehydrogenase	0.0002235	2.259	--	DIRECT
Enzyme Commission (EC)	Squalene monooxygenase	0.0003842	2.56	--	DIRECT
Enzyme Commission (EC)	Intramolecular lyases	0.007618	1.606	--	INHERITED FROM: Lycopene beta-cyclase
Enzyme Commission (EC)	Cis-trans-isomerases	1	1.414	--	INHERITED FROM: Prolycopene isomerase
Enzyme Commission (EC)	Cis-trans Isomerases	1	1.414	--	INHERITED FROM: Prolycopene isomerase
Enzyme Commission (EC)	Carbon-carbon lyases	1	0.8275	--	INHERITED FROM: (R)-mandelonitrile lyase
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: tRNA (5-methylaminomethyl-2-thiouridylate)-methylt || Transferring one-carbon groups || Methyltransferases || (FADH(2)-oxidizing)
Enzyme Commission (EC)	With oxygen as acceptor	0.8825	1.782	--	INHERITED FROM: Prenylcysteine oxidase
Enzyme Commission (EC)	Acting on other nitrogenous compounds as donors	1	1.329	--	INHERITED FROM: Nitrite reductase (NAD(P)H)
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0.001592	1.384	--	INHERITED FROM: Monodehydroascorbate reductase (NADH)
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	1	1.198	--	INHERITED FROM: Geranylgeranyl diphosphate reductase
Enzyme Commission (EC)	Acting on the CH-OH group of donors	1	0.8787	--	INHERITED FROM: With a quinone or similar compound as acceptor || With other acceptors || With oxygen as acceptor || Choline dehydrogenase
Enzyme Commission (EC)	Transferring one-carbon groups	0	0.7211	Least Informative	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.2975	Least Informative	DIRECT
Enzyme Commission (EC)	Isomerases	1	0.5914	Least Informative	INHERITED FROM: Ribose 1,5-bisphosphate isomerase || Prolycopene isomerase || Lycopene beta-cyclase
Enzyme Commission (EC)	Lyases	1	0.4169	Least Informative	INHERITED FROM: (R)-mandelonitrile lyase
Enzyme Commission (EC)	Methyltransferases	0	0.8609	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on a sulfur group of donors	0	1.198	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0.0000000000001853	1.016	Moderately Informative	DIRECT
Enzyme Commission (EC)	Intramolecular oxidoreductases	0.9013	1.069	Moderately Informative	INHERITED FROM: Ribose 1,5-bisphosphate isomerase
Enzyme Commission (EC)	Acting on NADH or NADPH	1	1.145	Moderately Informative	INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Monodehydroascorbate reductase (NADH) || NADH dehydrogenase || NAD(P)(+) transhydrogenase (B-specific)
Enzyme Commission (EC)	Acting on the CH-NH group of donors	1	1.198	Moderately Informative	INHERITED FROM: With a quinone or similar compound as acceptor || With oxygen as acceptor
Enzyme Commission (EC)	Acting on the CH-CH group of donors	1	1.055	Moderately Informative	INHERITED FROM: With a flavin as acceptor || With a quinone or related compound as acceptor || 4,4'-diapophytoene desaturase || Geranylgeranyl diphosphate reductase || Succinate dehydrogenase (ubiquinone) || 9,9'-di-cis-zeta-carotene desaturase || With other acceptors || Succinate dehydrogenase || Protoporphyrinogen oxidase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.519	Informative	DIRECT
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation	0	1.56	Informative	DIRECT
Enzyme Commission (EC)	Acting on iron-sulfur proteins as donors	0	1.657	Informative	DIRECT
Enzyme Commission (EC)	With other acceptors	7.054e-16	1.657	Informative	DIRECT
Enzyme Commission (EC)	Intramolecular lyases	1	1.606	Informative	INHERITED FROM: Lycopene beta-cyclase
Enzyme Commission (EC)	Interconverting aldoses and ketoses, and related c	0.7028	1.384	Informative	INHERITED FROM: Ribose 1,5-bisphosphate isomerase
Enzyme Commission (EC)	Aldehyde-lyases	0.7665	1.56	Informative	INHERITED FROM: (R)-mandelonitrile lyase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.4281	1.519	Informative	INHERITED FROM: Nitrite reductase (NAD(P)H)
Enzyme Commission (EC)	With other acceptors	1	1.384	Informative	INHERITED FROM: NADH dehydrogenase
Enzyme Commission (EC)	With oxygen as acceptor	0.01735	1.657	Informative	INHERITED FROM: L-aspartate oxidase || L-amino-acid oxidase || Monoamine oxidase
Enzyme Commission (EC)	Oxidizing metal ions	0.117	1.657	Informative	INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Mercury(II) reductase
Enzyme Commission (EC)	Miscellaneous (requires further characterization)	1	1.715	Informative	INHERITED FROM: Diapolycopene oxygenase
Enzyme Commission (EC)	Acting on single donors with incorporation of mole	1	1.481	Informative	INHERITED FROM: With incorporation of one atom of oxygen || Tryptophan 2-monooxygenase
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.782	Highly Informative	DIRECT
Enzyme Commission (EC)	tRNA (5-methylaminomethyl-2-thiouridylate)-methylt	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	With other acceptors	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Mercury(II) reductase	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	L-aspartate oxidase	2.368e-16	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	7.054e-16	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Succinate dehydrogenase (ubiquinone)	0.00000000000724	1.861	Highly Informative	DIRECT
Enzyme Commission (EC)	Nitrite reductase (NAD(P)H)	0.00000000003923	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	With incorporation of one atom of oxygen	0.000000007326	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	With a flavin as acceptor	0.00002146	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Succinate dehydrogenase	0.0001822	1.861	Highly Informative	DIRECT
Enzyme Commission (EC)	With other, known, acceptors	0.08055	1.958	Highly Informative	INHERITED FROM: CoB--CoM heterodisulfide reductase
Enzyme Commission (EC)	With oxygen as acceptor	0.4925	1.782	Highly Informative	INHERITED FROM: Protoporphyrinogen oxidase

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Hypertrophic cardiomyopathy	0.0007851	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal myocardium morphology	0.02531	1.929	--	INHERITED FROM: Hypertrophic cardiomyopathy
Phenotypic Abnormality (PA)	Abnormal heart morphology	0.4353	1.106	--	INHERITED FROM: Hypertrophic cardiomyopathy
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.8977	0.6284	Least Informative	INHERITED FROM: Hypertrophic cardiomyopathy
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system morphology	0.6623	0.9441	Moderately Informative	INHERITED FROM: Hypertrophic cardiomyopathy
Phenotypic Abnormality (PA)	Cardiomyopathy	0.01903	1.929	Highly Informative	INHERITED FROM: Hypertrophic cardiomyopathy

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal mitochondrial inner membrane morphology	0.000435	2.508	--	DIRECT
Mammalian Phenotype (MP)	increased dopamine level	0.0004737	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal dopamine level	0.007043	2.207	--	INHERITED FROM: increased dopamine level
Mammalian Phenotype (MP)	abnormal mitochondrion morphology	0.01378	2.508	--	INHERITED FROM: abnormal mitochondrial inner membrane morphology
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.4468	0.3617	--	INHERITED FROM: increased dopamine level
Mammalian Phenotype (MP)	nervous system phenotype	0.773	0.5166	Least Informative	INHERITED FROM: increased dopamine level
Mammalian Phenotype (MP)	abnormal homeostasis	0.7952	0.495	Least Informative	INHERITED FROM: increased dopamine level
Mammalian Phenotype (MP)	cellular phenotype	0.8672	0.5301	Least Informative	INHERITED FROM: abnormal mitochondrial inner membrane morphology
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.698	0.8744	Moderately Informative	INHERITED FROM: increased dopamine level
Mammalian Phenotype (MP)	abnormal cell morphology	0.7078	1.229	Moderately Informative	INHERITED FROM: abnormal mitochondrial inner membrane morphology
Mammalian Phenotype (MP)	abnormal catecholamine level	0.01797	1.906	Highly Informative	INHERITED FROM: increased dopamine level

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	ATP levels reduced	0.00002175	2.407	--	DIRECT
Worm Phenotype (WP)	ATP levels variant	0.000135	2.407	--	DIRECT
Worm Phenotype (WP)	organism toxic chemical response variant	0.0002867	1.929	--	DIRECT
Worm Phenotype (WP)	organism oxidative stress response variant	0.0004761	1.862	--	DIRECT
Worm Phenotype (WP)	chemical response variant	0.3843	0.8045	--	INHERITED FROM: organism toxic chemical response variant
Worm Phenotype (WP)	organism physiology variant	0.5317	0.1405	--	INHERITED FROM: ATP levels reduced || organism toxic chemical response variant || life span variant || pesticide response variant || organism oxidative stress response variant || ATP levels variant
Worm Phenotype (WP)	behavior variant	0.6845	0.632	--	INHERITED FROM: fewer eggs laid
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.9495	0.1501	--	INHERITED FROM: ATP levels reduced || organism toxic chemical response variant || pesticide response variant || ATP levels variant || organism oxidative stress response variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: pesticide response variant || ATP levels variant || reproductive system physiology variant || ATP levels reduced || lethal || fewer eggs laid || life span variant || development variant || organism oxidative stress response variant || embryonic development variant || organism toxic chemical response variant || embryonic lethal || fertility variant || organ system physiology variant || organism development variant || fertility reduced
Worm Phenotype (WP)	organism metabolism processing variant	0.1026	0.4572	Least Informative	INHERITED FROM: ATP levels variant || ATP levels reduced
Worm Phenotype (WP)	organism environmental stimulus response variant	0.5525	0.5677	Least Informative	INHERITED FROM: pesticide response variant || organism toxic chemical response variant || organism oxidative stress response variant
Worm Phenotype (WP)	organism behavior variant	0.6728	0.632	Least Informative	INHERITED FROM: fewer eggs laid
Worm Phenotype (WP)	organism stress response variant	0.3181	0.8325	Moderately Informative	INHERITED FROM: organism oxidative stress response variant
Worm Phenotype (WP)	life span variant	0.00005586	1.276	Informative	DIRECT
Worm Phenotype (WP)	pesticide response variant	0.0007215	1.708	Informative	DIRECT
Worm Phenotype (WP)	egg laying variant	0.1288	1.452	Informative	INHERITED FROM: fewer eggs laid
Worm Phenotype (WP)	fewer eggs laid	0.000003593	2.106	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical group

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: multicellular anatomical structure

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	With oxygen as acceptor	0	2.35	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0	2.253	--	DIRECT
Enzyme Commission (EC)	Squalene monooxygenase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Mercury(II) reductase	0	2.475	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.174	--	DIRECT
Enzyme Commission (EC)	Betaine-aldehyde dehydrogenase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Protoporphyrinogen oxidase	0	2.651	--	DIRECT
Enzyme Commission (EC)	2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase	0	2.952	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0	2.475	--	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0	2.35	--	DIRECT
Enzyme Commission (EC)	Electron-transferring-flavoprotein dehydrogenase	0	2.475	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.651	--	DIRECT
Enzyme Commission (EC)	Methyltransferases	0	1.181	--	DIRECT
Enzyme Commission (EC)	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase	0	2.475	--	DIRECT
Enzyme Commission (EC)	(NAD(P)H-oxidizing)	0	2.952	--	DIRECT
Enzyme Commission (EC)	Sulfide-dependent adenosine diphosphate thiazole synthase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Cysteine-dependent adenosine diphosphate thiazole synthase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Zeaxanthin epoxidase	0.000000000000002269	2.651	--	DIRECT
Enzyme Commission (EC)	L-aspartate oxidase	0.000000000000004014	2.475	--	DIRECT
Enzyme Commission (EC)	L-amino-acid oxidase	0.000000000000009956	2.651	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.00000000000001778	2.174	--	DIRECT
Enzyme Commission (EC)	(R)-mandelonitrile lyase	0.0000000000002127	2.651	--	DIRECT
Enzyme Commission (EC)	Dihydrolipoyl dehydrogenase	0.000000000006486	2.651	--	DIRECT
Enzyme Commission (EC)	Thioredoxin-disulfide reductase	0.000000000008722	2.952	--	DIRECT
Enzyme Commission (EC)	NADH:ubiquinone reductase (non-electrogenic)	0.000000000009774	2.651	--	DIRECT
Enzyme Commission (EC)	Renalase	0.00000000008414	2.952	--	DIRECT
Enzyme Commission (EC)	Prolycopene isomerase	0.00000000008414	2.952	--	DIRECT
Enzyme Commission (EC)	Geranylgeranyl diphosphate reductase	0.0000000001498	2.952	--	DIRECT
Enzyme Commission (EC)	Nitrite reductase (NAD(P)H)	0.0000000002449	2.35	--	DIRECT
Enzyme Commission (EC)	Albendazole monooxygenase (sufoxide-forming)	0.0000000003146	2.952	--	DIRECT
Enzyme Commission (EC)	Succinate dehydrogenase (quinone)	0.000000001155	2.253	--	DIRECT
Enzyme Commission (EC)	Monoamine oxidase	0.000000002026	2.651	--	DIRECT
Enzyme Commission (EC)	Monodehydroascorbate reductase (NADH)	0.000000002646	2.651	--	DIRECT
Enzyme Commission (EC)	Intramolecular lyases	0.000000006223	1.952	--	DIRECT
Enzyme Commission (EC)	With a flavin as acceptor	0.000000009578	2.35	--	DIRECT
Enzyme Commission (EC)	Fumarate reductase (quinol)	0.0000000449	2.35	--	DIRECT
Enzyme Commission (EC)	Lycopene beta-cyclase	0.0000000476	2.651	--	DIRECT
Enzyme Commission (EC)	With a flavin as acceptor	0.00000009479	2.952	--	DIRECT
Enzyme Commission (EC)	Bacterial sulfide:quinone reductase	0.00000009479	2.952	--	DIRECT
Enzyme Commission (EC)	Oleate hydratase	0.00000009479	2.952	--	DIRECT
Enzyme Commission (EC)	2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (NAD(P)H)	0.0000001911	2.952	--	DIRECT
Enzyme Commission (EC)	Fumarate reductase (NADH)	0.0000001911	2.651	--	DIRECT
Enzyme Commission (EC)	Prenylcysteine oxidase	0.0000004361	2.952	--	DIRECT
Enzyme Commission (EC)	9,9'-di-cis-zeta-carotene desaturase	0.0000005014	2.952	--	DIRECT
Enzyme Commission (EC)	Glutamate synthase (NADH)	0.0000006907	2.253	--	DIRECT
Enzyme Commission (EC)	Ferredoxin:CoB-CoM heterodisulfide reductase	0.000001404	2.475	--	DIRECT
Enzyme Commission (EC)	15-cis-phytoene desaturase	0.000001644	2.952	--	DIRECT
Enzyme Commission (EC)	Glutathione-disulfide reductase	0.0000026	2.651	--	DIRECT
Enzyme Commission (EC)	Choline dehydrogenase	0.000005704	2.651	--	DIRECT
Enzyme Commission (EC)	Tryptophan 2-monooxygenase	0.00001869	2.651	--	DIRECT
Enzyme Commission (EC)	Kynurenine 3-monooxygenase	0.00006599	2.952	--	DIRECT
Enzyme Commission (EC)	Lycopene epsilon-cyclase	0.0001148	2.952	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0.0001663	2.952	--	DIRECT
Enzyme Commission (EC)	Glycine oxidase	0.0002246	2.475	--	DIRECT
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0.000466	2.952	--	DIRECT
Enzyme Commission (EC)	Steroid Delta-isomerase	0.0004829	2.475	--	DIRECT
Enzyme Commission (EC)	CoA-disulfide reductase	0.0009582	2.651	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-CH group of donors	0.02713	1.35	--	INHERITED FROM: With a quinone or related compound as acceptor || 15-cis-phytoene desaturase || 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (NAD(P)H) || 9,9'-di-cis-zeta-carotene desaturase || Succinate dehydrogenase (quinone) || 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase || With other acceptors || Fumarate reductase (quinol) || Geranylgeranyl diphosphate reductase || Protoporphyrinogen oxidase || Fumarate reductase (NADH)
Enzyme Commission (EC)	With an iron-sulfur protein as acceptor	0.0956	2.475	--	INHERITED FROM: 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase
Enzyme Commission (EC)	With oxygen as acceptor	0.09893	2.253	--	INHERITED FROM: Renalase
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0.9774	2.253	--	INHERITED FROM: Bacterial sulfide:quinone reductase
Enzyme Commission (EC)	With other acceptors	1	1.838	--	INHERITED FROM: NADH dehydrogenase
Enzyme Commission (EC)	Transferases	1	0.3035	--	INHERITED FROM: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase || Cysteine-dependent adenosine diphosphate thiazole synthase || Transferring one-carbon groups || Pentosyltransferases || (NAD(P)H-oxidizing) || Methyltransferases || Sulfide-dependent adenosine diphosphate thiazole synthase
Enzyme Commission (EC)	Hydro-lyases	1	1.166	--	INHERITED FROM: Oleate hydratase
Enzyme Commission (EC)	Cis-trans-isomerases	1	1.806	--	INHERITED FROM: Prolycopene isomerase
Enzyme Commission (EC)	Cis-trans isomerases	1	1.806	--	INHERITED FROM: Prolycopene isomerase
Enzyme Commission (EC)	Oxidoreductases	0	0.6234	Least Informative	DIRECT
Enzyme Commission (EC)	Lyases	1	0.6918	Least Informative	INHERITED FROM: (R)-mandelonitrile lyase || Oleate hydratase
Enzyme Commission (EC)	Transferring one-carbon groups	0	1.054	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0.8658	1.204	Moderately Informative	INHERITED FROM: Sulfide-dependent adenosine diphosphate thiazole synthase || Cysteine-dependent adenosine diphosphate thiazole synthase || Pentosyltransferases
Enzyme Commission (EC)	Acting on the CH-OH group of donors	1	1.228	Moderately Informative	INHERITED FROM: With other acceptors || With a quinone or similar compound as acceptor || Choline dehydrogenase || With oxygen as acceptor
Enzyme Commission (EC)	Carbon-carbon lyases	1	1.101	Moderately Informative	INHERITED FROM: (R)-mandelonitrile lyase
Enzyme Commission (EC)	Carbon-oxygen lyases	1	1.012	Moderately Informative	INHERITED FROM: Oleate hydratase
Enzyme Commission (EC)	Isomerases	1	0.8446	Moderately Informative	INHERITED FROM: Other intramolecular oxidoreductases || Prolycopene isomerase || Intramolecular lyases || Steroid Delta-isomerase || Lycopene epsilon-cyclase || Lycopene beta-cyclase
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0	1.308	Informative	DIRECT
Enzyme Commission (EC)	Acting on NADH or NADPH	0	1.59	Informative	DIRECT
Enzyme Commission (EC)	Acting on a sulfur group of donors	0	1.489	Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH(2) group of donors	0.0000001826	1.59	Informative	DIRECT
Enzyme Commission (EC)	Pentosyltransferases	0.000008355	1.447	Informative	DIRECT
Enzyme Commission (EC)	Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated	1	1.673	Informative	INHERITED FROM: Tryptophan 2-monooxygenase || With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase
Enzyme Commission (EC)	Acting on CH or CH(2) groups	1	1.475	Informative	INHERITED FROM: With a flavin as acceptor
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	1	1.42	Informative	INHERITED FROM: Betaine-aldehyde dehydrogenase || With NAD(+) or NADP(+) as acceptor
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	1	1.505	Informative	INHERITED FROM: 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (NAD(P)H) || Fumarate reductase (NADH) || Geranylgeranyl diphosphate reductase
Enzyme Commission (EC)	Acting on the CH-NH group of donors	1	1.505	Informative	INHERITED FROM: With a quinone or similar compound as acceptor || Electron-transferring-flavoprotein dehydrogenase || With oxygen as acceptor || With a flavin as acceptor
Enzyme Commission (EC)	Acting on other nitrogenous compounds as donors	1	1.609	Informative	INHERITED FROM: Nitrite reductase (NAD(P)H)
Enzyme Commission (EC)	Intramolecular oxidoreductases	1	1.35	Informative	INHERITED FROM: Other intramolecular oxidoreductases || Steroid Delta-isomerase
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0	2.107	Highly Informative	DIRECT
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation of one atom of oxygen	0	1.806	Highly Informative	DIRECT
Enzyme Commission (EC)	Acting on iron-sulfur proteins as donors	0	2.049	Highly Informative	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0	1.91	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.91	Highly Informative	DIRECT
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0.00000000008101	2.107	Highly Informative	DIRECT
Enzyme Commission (EC)	With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase	0.0000000001703	2.174	Highly Informative	DIRECT
Enzyme Commission (EC)	With a quinone or related compound as acceptor	0.000000004187	2.107	Highly Informative	DIRECT
Enzyme Commission (EC)	NADH dehydrogenase	0.00000004741	1.873	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.000005743	1.806	Highly Informative	DIRECT
Enzyme Commission (EC)	Other intramolecular oxidoreductases	0.0009231	1.998	Highly Informative	DIRECT
Enzyme Commission (EC)	Oxidizing metal ions	0.2173	1.998	Highly Informative	INHERITED FROM: Mercury(II) reductase || With NAD(+) or NADP(+) as acceptor
Enzyme Commission (EC)	Aldehyde-lyases	0.7142	1.838	Highly Informative	INHERITED FROM: (R)-mandelonitrile lyase
Enzyme Commission (EC)	With oxygen as acceptor	0.82	2.174	Highly Informative	INHERITED FROM: Protoporphyrinogen oxidase
Enzyme Commission (EC)	Transposing C=C bonds	0.8572	1.776	Highly Informative	INHERITED FROM: Steroid Delta-isomerase
Enzyme Commission (EC)	With an iron-sulfur protein as acceptor	0.8607	2.174	Highly Informative	INHERITED FROM: Ferredoxin:CoB-CoM heterodisulfide reductase
Enzyme Commission (EC)	With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	0.873	2.049	Highly Informative	INHERITED FROM: Zeaxanthin epoxidase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.8872	1.873	Highly Informative	INHERITED FROM: Nitrite reductase (NAD(P)H)
Enzyme Commission (EC)	With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1	1.91	Highly Informative	INHERITED FROM: Squalene monooxygenase || Albendazole monooxygenase (sufoxide-forming)
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	1	1.91	Highly Informative	INHERITED FROM: Glutamate synthase (NADH)
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	1	2.174	Highly Informative	INHERITED FROM: NADH:ubiquinone reductase (non-electrogenic) || Monodehydroascorbate reductase (NADH)
Enzyme Commission (EC)	With oxygen as acceptor	1	2.049	Highly Informative	INHERITED FROM: Prenylcysteine oxidase
Enzyme Commission (EC)	Intramolecular lyases	1	1.952	Highly Informative	INHERITED FROM: Lycopene epsilon-cyclase || Lycopene beta-cyclase

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