Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: FAD/NAD(P)-binding domain [ 51904]
• Superfamily: FAD/NAD(P)-binding domain [ 51905] (8)
• Family: Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain [ 51934] (5)

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Family statistics

	Genomes (2,517)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	4,636	34,927	27
Proteins	4,635	34,922	27

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Succinate dehydrogenase (ubiquinone)	0	2.042	--	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0	1.741	--	DIRECT
Enzyme Commission (EC)	L-aspartate oxidase	0	2.264	--	DIRECT
Enzyme Commission (EC)	With other acceptors	5.205e-16	1.838	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-CH group of donors	0	1.185	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH(2) group of donors	0	1.399	Informative	DIRECT
Enzyme Commission (EC)	Succinate dehydrogenase	0	2.042	Highly Informative	DIRECT
Enzyme Commission (EC)	With a quinone or related compound as acceptor	0.00000965	1.963	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	ATP levels variant	0	2.468	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	behavior variant	0	0.6859	--	DIRECT
Worm Phenotype (WP)	ATP levels reduced	0	2.468	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	fewer eggs laid	0	2.292	--	DIRECT
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: organism metabolism processing variant || retarded heterochronic variations || ATP levels variant || reproductive system physiology variant || egg laying variant || ATP levels reduced || extended life span || organism homeostasis metabolism variant || lethal || organism physiology variant || fewer eggs laid || slow growth || life span variant || development variant || developmental timing variant || growth variant || embryonic development variant || embryonic lethal || general pace of development variant || fertility variant || behavior variant || organ system physiology variant || organism behavior variant || organism development variant || fertility reduced
Worm Phenotype (WP)	organism behavior variant	0	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	life span variant	0	1.321	Informative	DIRECT
Worm Phenotype (WP)	egg laying variant	0	1.513	Informative	DIRECT
Worm Phenotype (WP)	extended life span	0	1.814	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5867	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.4584	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: root || collective plant structure || multi-tissue plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || plant organ || epidermis || root system || epidermal cell || shoot epidermal cell || plant axis || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: root system || root || guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	root	0	0.4679	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	With a quinone or related compound as acceptor	0	2.385	--	DIRECT
Enzyme Commission (EC)	Urocanate reductase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH(2) group of donors	0	1.798	--	DIRECT
Enzyme Commission (EC)	L-aspartate oxidase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Succinate dehydrogenase (quinone)	0.000000000000001283	2.531	--	DIRECT
Enzyme Commission (EC)	Fumarate reductase (NADH)	0.000000000000503	2.929	--	DIRECT
Enzyme Commission (EC)	Fumarate reductase (quinol)	0.0000000006169	2.628	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0.0000005609	2.753	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-CH group of donors	0	1.586	Informative	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0	2.116	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	1	1.783	Highly Informative	INHERITED FROM: Fumarate reductase (NADH)

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