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Home > SCOP hierarchy > Phosphohistidine domain superfamily

Phosphohistidine domain superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Alpha and beta proteins (a/b) [ 51349] (147)
Fold:	The "swivelling" beta/beta/alpha domain [ 52008] (10)
Superfamily:	Phosphohistidine domain [ 52009] (2)
Families:	Pyruvate phosphate dikinase, central domain [ 52010]
	N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system [ 52013]

Superfamily statistics

	Genomes (2,754)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,609	53,563	12
Proteins	6,608	53,514	12

Functional annotation

General category	Regulation
Detailed category	Kinases/phosphatases

Document: Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Phosphotransferases with a nitrogenous group as ac	0	Informative	Direct
Enzyme Commission (EC)	Pyruvate kinase	0	Highly Informative	Direct
Enzyme Commission (EC)	Phosphoenolpyruvate--protein phosphotransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	Pyruvate, phosphate dikinase	0.000000008653	Highly Informative	Direct
Enzyme Commission (EC)	Pyruvate, water dikinase	0.000000734	Highly Informative	Direct

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	Least Informative	Direct
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0.8459	Moderately Informative	Inherited
Enzyme Commission (EC)	Phosphotransferases with a nitrogenous group as acceptor	0	Highly Informative	Direct
Enzyme Commission (EC)	Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase	0.00000000005753	Highly Informative	Direct
Enzyme Commission (EC)	Phosphoenolpyruvate--glycerone phosphotransferase	0.000000002221	Highly Informative	Direct

Document: EC annotation of SCOP domains

InterPro annotation

Cross references IPR008279 SSF52009 Protein matches

Abstract A number of enzymes that catalyze the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) via a phospho-histidine intermediate have been shown to be structurally related [ PubMed 7686067, PubMed 8973315, PubMed 2176881, PubMed 1557039]. All these enzymes share the same catalytic mechanism: they bind PEP and transfer the phosphoryl group from it to a histidine residue. This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it [ PubMed 12083528]. It is often found associated with the pyruvate phosphate dikinase, PEP/pyruvate-binding domain at its N-terminus.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Phosphohistidine domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Phosphohistidine domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) · Internal database links ]