PA domain superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: The "swivelling" beta/beta/alpha domain [ 52008] (10)
• Superfamily: PA domain [ 52025]
• Families: PA domain [ 52026] (2)

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Superfamily statistics

	Genomes (1,120)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,319	27,474	5
Proteins	6,283	27,401	5

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Functional annotation

• General category: Processes_IC
• Detailed category: Proteases

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.04271	--	DIRECT
Enzyme Commission (EC)	Glutamate carboxypeptidase II	0	2.259	--	DIRECT
Enzyme Commission (EC)	C5a peptidase	0.00000000000002234	2.259	--	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	0.5513	Least Informative	DIRECT
Enzyme Commission (EC)	Serine endopeptidases	0.3108	0.9917	Moderately Informative	INHERITED FROM: C5a peptidase
Enzyme Commission (EC)	Metallocarboxypeptidases	0	1.782	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of anatomical entity	0	0.2157	--	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0	0.5805	Least Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: lethal || development variant || organism development variant

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.2018	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.4182	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system || plant cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acyltransferases	0	0.8446	--	DIRECT
Enzyme Commission (EC)	Glutamate carboxypeptidase II	0	2.651	--	DIRECT
Enzyme Commission (EC)	C5a peptidase	0.00000000000005087	2.651	--	DIRECT
Enzyme Commission (EC)	Lactocepin	0.000000000009213	2.651	--	DIRECT
Enzyme Commission (EC)	Mannosyl-oligosaccharide 1,2-alpha-mannosidase	0.0000000005895	2.651	--	DIRECT
Enzyme Commission (EC)	Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds	0.01726	1.228	--	INHERITED FROM: Mannosyl-oligosaccharide 1,2-alpha-mannosidase
Enzyme Commission (EC)	Transferases	0.09218	0.3035	--	INHERITED FROM: Aminoacyltransferases || Acyltransferases || RING-type E3 ubiquitin transferase
Enzyme Commission (EC)	Hydrolases	0.00000001484	0.3541	Least Informative	DIRECT
Enzyme Commission (EC)	Aminoacyltransferases	0	1.166	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	0.8949	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosylases	0.4925	1.094	Moderately Informative	INHERITED FROM: Mannosyl-oligosaccharide 1,2-alpha-mannosidase
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0	1.384	Informative	DIRECT
Enzyme Commission (EC)	Serine endopeptidases	0.384	1.35	Informative	INHERITED FROM: Lactocepin || C5a peptidase
Enzyme Commission (EC)	Metallocarboxypeptidases	0	2.049	Highly Informative	DIRECT

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