RNI-like superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Alpha and beta proteins (a/b) [ 51349] (147)
Fold:	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:	RNI-like [ 52047] (3)
Families:	28-residue LRR [ 52048] (2)
	Rna1p (RanGAP1), N-terminal domain [ 52052]
	Cyclin A/CDK2-associated p19, Skp2 [ 52055]

Superfamily statistics

	Genomes (829)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	64,634	154,498	12
Proteins	58,396	140,599	9

Functional annotation

General category	Processes_EC
Detailed category	Cell adhesion

Document: Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	0.4543	Least Informative	Inherited
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0.0000000175	Moderately Informative	Direct
Enzyme Commission (EC)	With 2-oxoglutarate as one donor, and incorporatio	0.000000000000002328	Highly Informative	Direct

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	nervous system disease	0.5466	Least Informative	Inherited
Disease Ontology (DO)	gastrointestinal system disease	0.003291	Moderately Informative	Inherited
Disease Ontology (DO)	sensory system disease	0.1283	Moderately Informative	Inherited
Disease Ontology (DO)	syndrome	0.2369	Moderately Informative	Inherited
Disease Ontology (DO)	connective tissue disease	0.4104	Moderately Informative	Inherited
Disease Ontology (DO)	lower respiratory tract disease	0.8563	Moderately Informative	Inherited
Disease Ontology (DO)	inflammatory bowel disease	0.00001202	Informative	Direct
Disease Ontology (DO)	allergic rhinitis	0.00002502	Informative	Direct
Disease Ontology (DO)	periodontal disease	0.001355	Informative	Inherited
Disease Ontology (DO)	hypersensitivity reaction type IV disease	0.003206	Informative	Inherited
Disease Ontology (DO)	irritable bowel syndrome	0.000007774	Highly Informative	Direct
Disease Ontology (DO)	uveitis	0.00007208	Highly Informative	Direct
Disease Ontology (DO)	sarcoidosis	0.0001679	Highly Informative	Direct

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.1562	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.2724	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the head	0.2953	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the integument	0.4814	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.4973	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the eye	0.5496	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.6943	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.03883	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0.11	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal anterior eye segment morphology	0.1138	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of immune system physiology	0.1727	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.2192	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0.307	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.3554	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal posterior eye segment morphology	0.3623	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal eye physiology	0.3973	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system morphology	0.4559	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.6836	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Unusual CNS infection	0.0004469	Informative	Direct
Phenotypic Abnormality (PA)	Inflammatory abnormality of the eye	0.0026	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the vasculature of the eye	0.007526	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of temperature regulation	0.007722	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal oral mucosa morphology	0.01341	Informative	Inherited
Phenotypic Abnormality (PA)	Functional abnormality of the gastrointestinal tract	0.01502	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal uvea morphology	0.03597	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal leukocyte morphology	0.03766	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal intestine morphology	0.1273	Informative	Inherited
Phenotypic Abnormality (PA)	Localized skin lesion	0.1795	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal cornea morphology	0.2494	Informative	Inherited
Phenotypic Abnormality (PA)	Constitutional symptom	0.273	Informative	Inherited
Phenotypic Abnormality (PA)	Recurrent aphthous stomatitis	0.0000005167	Highly Informative	Direct
Phenotypic Abnormality (PA)	Retrobulbar optic neuritis	0.0000005286	Highly Informative	Direct
Phenotypic Abnormality (PA)	Vasculitis	0.0001788	Highly Informative	Direct
Phenotypic Abnormality (PA)	Meningitis	0.0002058	Highly Informative	Direct
Phenotypic Abnormality (PA)	Papule	0.0002909	Highly Informative	Direct
Phenotypic Abnormality (PA)	Keratoconjunctivitis sicca	0.0003128	Highly Informative	Direct
Phenotypic Abnormality (PA)	Uveitis	0.0003385	Highly Informative	Direct
Phenotypic Abnormality (PA)	Myalgia	0.00044	Highly Informative	Direct
Phenotypic Abnormality (PA)	Arthralgia	0.0005156	Highly Informative	Direct
Phenotypic Abnormality (PA)	Abnormal erythrocyte sedimentation rate	0.0009539	Highly Informative	Direct
Phenotypic Abnormality (PA)	Inflammation of the large intestine	0.008917	Highly Informative	Inherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)

	MP term	FDR (all)	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	immune system phenotype	0.06225	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.000509	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal inflammatory response	0.107	Moderately Informative	Inherited
Mammalian Phenotype (MP)	increased susceptibility to infection	0.0009813	Informative	Direct
Mammalian Phenotype (MP)	abnormal intestine physiology	0.004255	Informative	Inherited
Mammalian Phenotype (MP)	abnormal interleukin secretion	0.1835	Informative	Inherited
Mammalian Phenotype (MP)	abnormal interleukin-1 beta secretion	0.000001698	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal susceptibility to induced colitis	0.00001459	Highly Informative	Direct
Mammalian Phenotype (MP)	decreased interleukin-12b secretion	0.00007789	Highly Informative	Direct

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)

	WP term	FDR (all)	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	organism metabolism processing variant	1	Least Informative	Inherited
Worm Phenotype (WP)	protein interaction variant	0.6893	Moderately Informative	Inherited
Worm Phenotype (WP)	resistant to protein aggregation induced paralysis	0.0001987	Highly Informative	Direct

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical direction	0.2688	Informative	Inherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)

	AP term	FDR (all)	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	microsporophyll	1	Least Informative	Inherited
Plant ANatomical entity (PAN)	flower	1	Least Informative	Inherited
Plant ANatomical entity (PAN)	collective phyllome structure	1	Least Informative	Inherited
Plant ANatomical entity (PAN)	sporangium	1	Least Informative	Inherited
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	1	Least Informative	Inherited
Plant ANatomical entity (PAN)	anther	0.00008398	Highly Informative	Direct

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	Least Informative	Direct
Enzyme Commission (EC)	Oxidoreductases	0.8363	Least Informative	Inherited
Enzyme Commission (EC)	Lyases	0.9011	Least Informative	Inherited
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0	Informative	Direct
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0.000001618	Informative	Direct
Enzyme Commission (EC)	Protein-tyrosine kinases	0.001086	Informative	Inherited
Enzyme Commission (EC)	Phosphorus-oxygen lyases	1	Informative	Inherited
Enzyme Commission (EC)	With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	0.0000000000003127	Highly Informative	Direct
Enzyme Commission (EC)	Receptor protein-tyrosine kinase	0.000000006007	Highly Informative	Direct
Enzyme Commission (EC)	Adenylate cyclase	0.000003125	Highly Informative	Direct

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a RNI-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the RNI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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RNI-like superfamily