28-residue LRR family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
• Superfamily: RNI-like [ 52047] (3)
• Family: 28-residue LRR [ 52048] (2)

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Family statistics

	Genomes (130)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,754	3,594	8
Proteins	1,665	3,422	5

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	allergic rhinitis	0.0001988	1.668	--	DIRECT
Disease Ontology (DO)	nasal cavity disease	0.0002166	1.668	--	DIRECT
Disease Ontology (DO)	nose disease	0.0002543	1.668	--	DIRECT
Disease Ontology (DO)	intestinal disease	0.00136	1.399	--	INHERITED FROM: inflammatory bowel disease || Crohn's disease
Disease Ontology (DO)	respiratory system disease	0.01791	0.9334	--	INHERITED FROM: nose disease || nasal cavity disease || allergic rhinitis
Disease Ontology (DO)	disease of anatomical entity	0.5091	0.2414	--	INHERITED FROM: Crohn's disease || nasal cavity disease || allergic rhinitis || nose disease || inflammatory bowel disease
Disease Ontology (DO)	rhinitis	1	1.668	--	INHERITED FROM: allergic rhinitis
Disease Ontology (DO)	gastrointestinal system disease	0.06306	0.8797	Moderately Informative	INHERITED FROM: inflammatory bowel disease || Crohn's disease
Disease Ontology (DO)	inflammatory bowel disease	0.000797	1.472	Informative	DIRECT
Disease Ontology (DO)	upper respiratory tract disease	0.004181	1.472	Informative	INHERITED FROM: allergic rhinitis || nose disease || nasal cavity disease
Disease Ontology (DO)	Crohn's disease	0.0001178	1.911	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Aphthous ulcer	0.0000006675	1.86	--	DIRECT
Phenotypic Abnormality (PA)	Retrobulbar optic neuritis	0.000002398	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Red eye	0.00002186	1.86	--	DIRECT
Phenotypic Abnormality (PA)	Optic neuritis	0.00002334	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Colitis	0.00004148	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal conjunctiva morphology	0.0001016	1.86	--	DIRECT
Phenotypic Abnormality (PA)	Lymphadenopathy	0.0005968	1.559	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal large intestine morphology	0.0006886	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal spleen morphology	0.001866	1.348	--	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Abnormality of the spleen	0.00242	1.316	--	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Abnormality of the vasculature of the eye	0.002524	1.763	--	INHERITED FROM: Conjunctivitis || Red eye
Phenotypic Abnormality (PA)	Abnormality of temperature regulation	0.003154	1.348	--	INHERITED FROM: Fever
Phenotypic Abnormality (PA)	Abnormal oral mucosa morphology	0.003623	1.258	--	INHERITED FROM: Recurrent aphthous stomatitis || Stomatitis || Aphthous ulcer
Phenotypic Abnormality (PA)	Abnormal leukocyte count	0.004217	1.559	--	INHERITED FROM: Leukocytosis
Phenotypic Abnormality (PA)	Visceromegaly	0.007376	1.462	--	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Gastrointestinal inflammation	0.009095	2.462	--	INHERITED FROM: Colitis
Phenotypic Abnormality (PA)	Inflammation of the large intestine	0.01821	2.462	--	INHERITED FROM: Colitis
Phenotypic Abnormality (PA)	Abnormal cellular immune system morphology	0.01881	1.462	--	INHERITED FROM: Leukocytosis
Phenotypic Abnormality (PA)	Abnormality of abdomen morphology	0.03782	1.462	--	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Abnormality of vision	0.06263	1.258	--	INHERITED FROM: Photophobia
Phenotypic Abnormality (PA)	Constitutional symptom	0.1128	1.258	--	INHERITED FROM: Arthralgia || Myalgia
Phenotypic Abnormality (PA)	Abnormal immune system morphology	0.1129	1.421	--	INHERITED FROM: Leukocytosis
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.1263	0.7381	--	INHERITED FROM: Stomatitis || Recurrent aphthous stomatitis || Aphthous ulcer
Phenotypic Abnormality (PA)	Abnormal posterior eye segment morphology	0.1393	1.421	--	INHERITED FROM: Optic neuritis || Retrobulbar optic neuritis
Phenotypic Abnormality (PA)	Abnormal inflammatory response	0.1722	1.161	--	INHERITED FROM: Recurrent aphthous stomatitis || Conjunctivitis || Optic neuritis || Retrobulbar optic neuritis || Uveitis || Colitis || Stomatitis
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.1998	0.7142	--	INHERITED FROM: Splenomegaly || Conjunctivitis || Lymphadenopathy || Red eye
Phenotypic Abnormality (PA)	Abnormality of the ocular adnexa	0.2029	1.082	--	INHERITED FROM: Conjunctivitis || Abnormal conjunctiva morphology
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.2542	0.7065	--	INHERITED FROM: Aphthous ulcer || Recurrent aphthous stomatitis || Stomatitis
Phenotypic Abnormality (PA)	Abnormality of the optic nerve	0.2685	1.763	--	INHERITED FROM: Optic neuritis || Retrobulbar optic neuritis
Phenotypic Abnormality (PA)	Abnormality of the head	0.3	0.4538	--	INHERITED FROM: Abnormal conjunctiva morphology || Conjunctivitis || Aphthous ulcer || Stomatitis || Recurrent aphthous stomatitis
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.3093	0.4454	--	INHERITED FROM: Conjunctivitis || Abnormal conjunctiva morphology || Aphthous ulcer || Recurrent aphthous stomatitis || Stomatitis
Phenotypic Abnormality (PA)	Abnormality of the orbital region	0.3463	1.082	--	INHERITED FROM: Abnormal conjunctiva morphology || Conjunctivitis
Phenotypic Abnormality (PA)	Morphological abnormality of the gastrointestinal tract	0.3593	1.184	--	INHERITED FROM: Abnormal large intestine morphology || Colitis
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.3685	0.2371	--	INHERITED FROM: Photophobia
Phenotypic Abnormality (PA)	Abnormal eye morphology	0.3922	0.7812	--	INHERITED FROM: Optic neuritis || Retrobulbar optic neuritis || Uveitis || Conjunctivitis || Red eye
Phenotypic Abnormality (PA)	Unusual infection	0.7228	1.184	--	INHERITED FROM: Unusual infection by anatomical site
Phenotypic Abnormality (PA)	Increased inflammatory response	1	1.207	--	INHERITED FROM: Colitis || Stomatitis || Conjunctivitis || Optic neuritis || Recurrent aphthous stomatitis || Retrobulbar optic neuritis || Uveitis
Phenotypic Abnormality (PA)	Abnormality of the immune system	0.03201	0.7464	Least Informative	INHERITED FROM: Recurrent aphthous stomatitis || Stomatitis || Retrobulbar optic neuritis || Uveitis || Lymphadenopathy || Conjunctivitis || Leukocytosis || Optic neuritis || Unusual infection by anatomical site || Splenomegaly || Colitis
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.06842	0.5759	Least Informative	INHERITED FROM: Abnormal large intestine morphology || Colitis || Splenomegaly
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.1203	0.5486	Least Informative	INHERITED FROM: Abnormal C-reactive protein level || Abnormal erythrocyte sedimentation rate || Fever
Phenotypic Abnormality (PA)	Abnormality of the face	0.2095	0.533	Least Informative	INHERITED FROM: Aphthous ulcer || Conjunctivitis || Abnormal conjunctiva morphology || Recurrent aphthous stomatitis || Stomatitis
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.2538	0.3869	Least Informative	INHERITED FROM: Photophobia
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.31	0.5179	Least Informative	INHERITED FROM: Lymphadenopathy || Conjunctivitis || Red eye || Splenomegaly
Phenotypic Abnormality (PA)	Abnormality of the eye	0.4578	0.5703	Least Informative	INHERITED FROM: Optic neuritis || Retrobulbar optic neuritis || Uveitis || Photophobia || Conjunctivitis || Red eye
Phenotypic Abnormality (PA)	Abnormality of immune system physiology	0.008808	0.8942	Moderately Informative	INHERITED FROM: Optic neuritis || Colitis || Unusual infection by anatomical site || Stomatitis || Recurrent aphthous stomatitis || Uveitis || Retrobulbar optic neuritis || Conjunctivitis
Phenotypic Abnormality (PA)	Abnormality of the lymphatic system	0.01656	1.184	Moderately Informative	INHERITED FROM: Splenomegaly || Lymphadenopathy
Phenotypic Abnormality (PA)	Abnormal homeostasis	0.09923	0.7903	Moderately Informative	INHERITED FROM: Fever
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.09926	0.9183	Moderately Informative	INHERITED FROM: Leukocytosis
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0.1752	0.9572	Moderately Informative	INHERITED FROM: Colitis
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0.1948	1.082	Moderately Informative	INHERITED FROM: Conjunctivitis || Abnormal conjunctiva morphology
Phenotypic Abnormality (PA)	Abnormality of the abdominal organs	0.2015	1.031	Moderately Informative	INHERITED FROM: Splenomegaly
Phenotypic Abnormality (PA)	Behavioral abnormality	0.2194	1.082	Moderately Informative	INHERITED FROM: Photophobia
Phenotypic Abnormality (PA)	Abnormal eye physiology	0.2257	0.7903	Moderately Informative	INHERITED FROM: Conjunctivitis || Uveitis || Photophobia
Phenotypic Abnormality (PA)	Abnormal circulating metabolite concentration	0.322	0.971	Moderately Informative	INHERITED FROM: Abnormal C-reactive protein level
Phenotypic Abnormality (PA)	Abnormality of digestive system morphology	0.3509	1.184	Moderately Informative	INHERITED FROM: Colitis || Abnormal large intestine morphology
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.3991	1.031	Moderately Informative	INHERITED FROM: Colitis || Abnormal large intestine morphology
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.8289	Moderately Informative	INHERITED FROM: Aphthous ulcer || Recurrent aphthous stomatitis || Stomatitis
Phenotypic Abnormality (PA)	Fever	0.0001932	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Stomatitis	0.0002	1.617	Informative	DIRECT
Phenotypic Abnormality (PA)	Unusual infection by anatomical site	0.0004564	1.559	Informative	DIRECT
Phenotypic Abnormality (PA)	Splenomegaly	0.0006682	1.462	Informative	DIRECT
Phenotypic Abnormality (PA)	Inflammatory abnormality of the eye	0.00154	1.617	Informative	INHERITED FROM: Conjunctivitis || Uveitis
Phenotypic Abnormality (PA)	Abnormal uvea morphology	0.001866	1.559	Informative	INHERITED FROM: Uveitis
Phenotypic Abnormality (PA)	Abnormal circulating protein level	0.01056	1.508	Informative	INHERITED FROM: Abnormal C-reactive protein level
Phenotypic Abnormality (PA)	Abnormality of the lymph nodes	0.0296	1.508	Informative	INHERITED FROM: Lymphadenopathy
Phenotypic Abnormality (PA)	Pain	0.03576	1.383	Informative	INHERITED FROM: Arthralgia || Myalgia
Phenotypic Abnormality (PA)	Abnormal intestine morphology	0.0383	1.421	Informative	INHERITED FROM: Abnormal large intestine morphology || Colitis
Phenotypic Abnormality (PA)	Abnormal leukocyte morphology	0.04894	1.508	Informative	INHERITED FROM: Leukocytosis
Phenotypic Abnormality (PA)	Functional abnormality of the gastrointestinal tract	0.06574	1.421	Informative	INHERITED FROM: Colitis
Phenotypic Abnormality (PA)	Abnormal fundus morphology	0.1379	1.421	Informative	INHERITED FROM: Retrobulbar optic neuritis || Optic neuritis
Phenotypic Abnormality (PA)	Recurrent aphthous stomatitis	0.0000006675	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Conjunctivitis	0.00002186	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Leukocytosis	0.00006132	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Uveitis	0.00006384	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal erythrocyte sedimentation rate	0.0001229	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Myalgia	0.0001582	1.763	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Arthralgia	0.0002442	1.763	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal C-reactive protein level	0.0004726	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Photophobia	0.0006514	1.985	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal interleukin secretion	0.00002599	1.188	--	DIRECT
Mammalian Phenotype (MP)	abnormal susceptibility to induced colitis	0.00005703	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal sarcomere morphology	0.00006224	2.603	--	DIRECT
Mammalian Phenotype (MP)	colitis	0.0002321	1.758	--	DIRECT
Mammalian Phenotype (MP)	large intestinal inflammation	0.0002903	1.649	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.0007249	0.9219	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.0007599	0.9219	--	DIRECT
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.0008485	0.9219	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.001157	0.8789	--	INHERITED FROM: abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal intestine physiology	0.00244	1.603	--	INHERITED FROM: large intestinal inflammation || colitis || abnormal susceptibility to induced colitis
Mammalian Phenotype (MP)	abnormal circulating protein level	0.006668	1.205	--	INHERITED FROM: abnormal circulating interleukin level
Mammalian Phenotype (MP)	intestinal inflammation	0.01073	1.649	--	INHERITED FROM: colitis || large intestinal inflammation || abnormal susceptibility to induced colitis
Mammalian Phenotype (MP)	increased inflammatory response	0.0135	1.059	--	INHERITED FROM: abnormal susceptibility to induced colitis || large intestinal inflammation || colitis
Mammalian Phenotype (MP)	abnormal intercellular signaling peptide or protein level	0.01513	1.324	--	INHERITED FROM: abnormal circulating interleukin level
Mammalian Phenotype (MP)	abnormal interleukin-1 secretion	0.01871	1.825	--	INHERITED FROM: abnormal interleukin-1 beta secretion
Mammalian Phenotype (MP)	abnormal circulating cytokine level	0.02966	1.373	--	INHERITED FROM: abnormal circulating interleukin level
Mammalian Phenotype (MP)	abnormal muscle fiber morphology	0.03119	1.825	--	INHERITED FROM: abnormal sarcomere morphology
Mammalian Phenotype (MP)	abnormal cytokine level	0.07883	1.348	--	INHERITED FROM: abnormal circulating interleukin level
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.09091	0.8789	--	INHERITED FROM: abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal immune system physiology	0.1038	0.6789	--	INHERITED FROM: abnormal cell-mediated immunity || abnormal circulating interleukin level || abnormal interleukin secretion || colitis || abnormal susceptibility to induced colitis || abnormal adaptive immunity || abnormal immune serum protein physiology || abnormal immune cell physiology || large intestinal inflammation || abnormal interleukin-1 beta secretion || abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal cytokine secretion	0.1825	1.085	--	INHERITED FROM: abnormal interleukin secretion || abnormal interleukin-1 beta secretion
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0.1913	0.9404	--	INHERITED FROM: colitis || abnormal susceptibility to induced colitis || large intestinal inflammation
Mammalian Phenotype (MP)	abnormal interleukin level	0.2189	1.562	--	INHERITED FROM: abnormal circulating interleukin level
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.3709	0.3626	--	INHERITED FROM: abnormal circulating interleukin level
Mammalian Phenotype (MP)	muscle phenotype	0.4023	0.8473	--	INHERITED FROM: abnormal sarcomere morphology
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.6712	0.6893	--	INHERITED FROM: abnormal circulating interleukin level
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.002726	0.5945	Least Informative	INHERITED FROM: abnormal leukocyte physiology
Mammalian Phenotype (MP)	immune system phenotype	0.03939	0.5462	Least Informative	INHERITED FROM: abnormal immune cell physiology || abnormal interleukin-1 beta secretion || abnormal leukocyte physiology || colitis || abnormal interleukin secretion || abnormal cell-mediated immunity || large intestinal inflammation || abnormal susceptibility to induced colitis || abnormal circulating interleukin level || abnormal adaptive immunity || abnormal immune serum protein physiology
Mammalian Phenotype (MP)	abnormal homeostasis	0.2222	0.4926	Least Informative	INHERITED FROM: abnormal circulating interleukin level
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.00008938	1.001	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.0006265	0.9219	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal protein level	0.002653	1.112	Moderately Informative	INHERITED FROM: abnormal circulating interleukin level
Mammalian Phenotype (MP)	abnormal muscle morphology	0.2038	1.112	Moderately Informative	INHERITED FROM: abnormal sarcomere morphology
Mammalian Phenotype (MP)	abnormal inflammatory response	0.3	1.023	Moderately Informative	INHERITED FROM: large intestinal inflammation || abnormal susceptibility to induced colitis || colitis
Mammalian Phenotype (MP)	abnormal circulating interleukin level	0.00009444	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal digestive system physiology	0.02514	1.399	Informative	INHERITED FROM: colitis || abnormal susceptibility to induced colitis || large intestinal inflammation
Mammalian Phenotype (MP)	abnormal interleukin-1 beta secretion	0.00001188	1.825	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.6547	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.6514	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: cell || anatomical system || anatomical group || whole organism
Zebrafish Anatomy (ZA)	cell	0	0.6388	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	epaxial muscle	0.0001209	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	skeletal muscle	0.06526	1.61	--	INHERITED FROM: epaxial muscle
Xenopus ANatomical entity (XAN)	muscular system	0.07698	1.263	--	INHERITED FROM: epaxial muscle
Xenopus ANatomical entity (XAN)	trunk region	0.3411	0.388	--	INHERITED FROM: epaxial muscle || trunk musculature
Xenopus ANatomical entity (XAN)	anatomical region	0.5627	0.1803	--	INHERITED FROM: epaxial muscle || trunk musculature
Xenopus ANatomical entity (XAN)	organism subdivision	0.6165	0.1679	--	INHERITED FROM: epaxial muscle || trunk musculature
Xenopus ANatomical entity (XAN)	anatomical group	0.6655	0.1408	--	INHERITED FROM: trunk musculature || epaxial muscle
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.787	0.1131	--	INHERITED FROM: epaxial muscle || trunk musculature
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: epaxial muscle
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: epaxial muscle || trunk musculature
Xenopus ANatomical entity (XAN)	trunk	0.34	0.3894	Least Informative	INHERITED FROM: epaxial muscle || trunk musculature
Xenopus ANatomical entity (XAN)	anatomical cluster	0.5484	0.7159	Least Informative	INHERITED FROM: epaxial muscle || trunk musculature
Xenopus ANatomical entity (XAN)	tissue	0.8798	0.4672	Least Informative	INHERITED FROM: epaxial muscle
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.2675	1.087	Moderately Informative	INHERITED FROM: epaxial muscle
Xenopus ANatomical entity (XAN)	muscle	0.08246	1.45	Informative	INHERITED FROM: epaxial muscle
Xenopus ANatomical entity (XAN)	trunk musculature	0.0004291	2.166	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage 15	0.000004231	2.785	--	DIRECT
Xenopus DEvelopment stage (XDE)	embryonic stage	0.009234	1.006	Moderately Informative	INHERITED FROM: neurula stage || NF stage 15
Xenopus DEvelopment stage (XDE)	neurula stage	0.0001472	2.183	Highly Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || E expanded cotyledon stage || F mature embryo stage || D bilateral stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: E expanded cotyledon stage || sporophyte vegetative stage || D bilateral stage || F mature embryo stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.3205	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.301	Least Informative	DIRECT

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