SUPERFAMILY 1.75 HMM library and genome assignments server

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L domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Family:   L domain [ 52071] (5)

Family statistics
Genomes (120) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,372 4,134 21
Proteins 803 2,534 11

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.001501Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system cancer0Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.00001819Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0003298Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.005838Moderately InformativeInherited
Disease Ontology (DO)large intestine cancer0InformativeDirect
Disease Ontology (DO)hereditary breast ovarian cancer syndrome0.000003598InformativeDirect
Disease Ontology (DO)female reproductive organ cancer0.00005983InformativeDirect
Disease Ontology (DO)lung carcinoma0.0001066InformativeDirect
Disease Ontology (DO)osteosarcoma0.0001548InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.0002052InformativeDirect
Disease Ontology (DO)malignant glioma0.0002989InformativeDirect
Disease Ontology (DO)myeloid leukemia0.002528InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.01394InformativeInherited
Disease Ontology (DO)male reproductive organ cancer0.05145InformativeInherited
Disease Ontology (DO)gastric adenocarcinoma0.000007161Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.00006756Highly InformativeDirect
Disease Ontology (DO)sarcoma0.0001617Highly InformativeDirect
Disease Ontology (DO)acute myeloid leukemia0.0009894Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.000727Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.001471Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.01706Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.04467Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.08953Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.000005872Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.00004055Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal heart morphology0.00004729Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00005335Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.000125Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.0002373Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0005841Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0.0019Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.002529Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2001Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3253Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.5127Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)postnatal lethality0InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0000002794InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.0000347InformativeDirect
Mammalian Phenotype (MP)decreased neuron number0.0001247InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.0001347InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0.000207InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.0004736InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord morphology0.0005899InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0.002123InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.002586InformativeInherited
Mammalian Phenotype (MP)abnormal primary sex determination0.00359InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa physiology0.005554InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.006662InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.009771InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle wall thickness0.009884InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.06127InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.09855InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.1024InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.1312InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.5699InformativeInherited
Mammalian Phenotype (MP)sex reversal0.0000002768Highly InformativeDirect
Mammalian Phenotype (MP)abnormal trigeminal nerve morphology0.000001094Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myelination0.000002586Highly InformativeDirect
Mammalian Phenotype (MP)heart block0.000007464Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular cushion morphology0.00001425Highly InformativeDirect
Mammalian Phenotype (MP)decreased birth weight0.00002181Highly InformativeDirect
Mammalian Phenotype (MP)hyperglycemia0.00004142Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.00005083Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.00006912Highly InformativeDirect
Mammalian Phenotype (MP)abnormal locomotor activation0.0004111Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0004855Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cerebellar layer morphology0.0007094Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0007526Highly InformativeDirect
Mammalian Phenotype (MP)dilated heart0.01007Highly InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic tissue physiology0.02038Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0.06978Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.4566Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.02659Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.03047Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.02742InformativeInherited
Zebrafish Anatomy (ZA)motor neuron0.0002396Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.3291Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4973Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.001729Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.08196Moderately InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.00001805InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00002618InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00008865InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0001191InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0002968InformativeDirect
Xenopus ANatomical entity (XAN)somite0.0009298Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]