Crotonase-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: ClpP/crotonase [ 52095]
• Superfamily: ClpP/crotonase [ 52096] (4)
• Family: Crotonase-like [ 52103] (13)

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Family statistics

	Genomes (2,208)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	12,103	100,042	23
Proteins	12,090	100,004	23

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	3-hydroxyisobutyryl-CoA hydrolase	0	2.741	--	DIRECT
Enzyme Commission (EC)	3-hydroxybutyryl-CoA epimerase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0	0.935	--	DIRECT
Enzyme Commission (EC)	Carbon-oxygen lyases	0	0.8221	--	DIRECT
Enzyme Commission (EC)	Ethylmalonyl-CoA decarboxylase	0	2.741	--	DIRECT
Enzyme Commission (EC)	3-hydroxyacyl-CoA dehydrogenase	0	2.264	--	DIRECT
Enzyme Commission (EC)	1,4-dihydroxy-2-naphthoyl-CoA synthase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Dodecenoyl-CoA isomerase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Methylmalonyl-CoA decarboxylase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Acting on hydroxy acids and derivatives	0	2.264	--	DIRECT
Enzyme Commission (EC)	Enoyl-CoA hydratase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Carbon-carbon lyases	1	0.9151	--	INHERITED FROM: 1,4-dihydroxy-2-naphthoyl-CoA synthase || Methylmalonyl-CoA decarboxylase || Oxo-acid-lyases || Ethylmalonyl-CoA decarboxylase
Enzyme Commission (EC)	Hydrolases	1	0.01852	--	INHERITED FROM: 3-hydroxyisobutyryl-CoA hydrolase || Thiolester hydrolases
Enzyme Commission (EC)	Acyltransferases	0.9759	0.8778	--	INHERITED FROM: Histone acetyltransferase
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Histone acetyltransferase
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Lyases	0	0.4956	Least Informative	DIRECT
Enzyme Commission (EC)	Isomerases	0	0.6881	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.6802	0.5107	Least Informative	INHERITED FROM: Thiolester hydrolases || 3-hydroxyisobutyryl-CoA hydrolase
Enzyme Commission (EC)	Hydro-lyases	0	0.9853	Moderately Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	0.9853	Moderately Informative	DIRECT
Enzyme Commission (EC)	Intramolecular oxidoreductases	0.00000000000002709	1.118	Moderately Informative	DIRECT
Enzyme Commission (EC)	Carboxy-lyases	1	1.06	Moderately Informative	INHERITED FROM: Ethylmalonyl-CoA decarboxylase || Methylmalonyl-CoA decarboxylase
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.825	1.001	Moderately Informative	INHERITED FROM: Histone acetyltransferase
Enzyme Commission (EC)	Racemases and epimerases	0	1.379	Informative	DIRECT
Enzyme Commission (EC)	Thiolester hydrolases	3.476e-16	1.595	Informative	DIRECT
Enzyme Commission (EC)	Oxo-acid-lyases	0.00000000009976	1.741	Informative	DIRECT
Enzyme Commission (EC)	Histone acetyltransferase	0.0000001221	1.627	Informative	DIRECT
Enzyme Commission (EC)	Transposing C==C bonds	0	1.838	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the mitochondrion	0.0001713	1.985	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of acid-base homeostasis	0.0002089	1.258	--	DIRECT
Phenotypic Abnormality (PA)	Aminoaciduria	0.0002461	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the basal ganglia	0.0002911	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal cellular phenotype	0.008748	1.462	--	INHERITED FROM: Abnormality of the mitochondrion || Abnormality of mitochondrial metabolism
Phenotypic Abnormality (PA)	Abnormality of urine homeostasis	0.02706	1.161	--	INHERITED FROM: Aminoaciduria || Aciduria
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0.2113	0.9572	--	INHERITED FROM: Abnormality of the basal ganglia
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.4052	0.6631	--	INHERITED FROM: Abnormality of the basal ganglia
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.4948	0.533	--	INHERITED FROM: Abnormality of the basal ganglia
Phenotypic Abnormality (PA)	Abnormality of the urinary system	0.7368	0.8496	--	INHERITED FROM: Aminoaciduria || Aciduria
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.8858	0.2371	--	INHERITED FROM: Abnormality of the basal ganglia
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.05109	0.6051	Least Informative	INHERITED FROM: Aminoaciduria || Aciduria
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.2002	0.5486	Least Informative	INHERITED FROM: Abnormality of the mitochondrion || Aciduria || Acidosis || Abnormality of acid-base homeostasis || Abnormality of mitochondrial metabolism || Aminoaciduria
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.59	0.4756	Least Informative	INHERITED FROM: Abnormality of the basal ganglia
Phenotypic Abnormality (PA)	Abnormal homeostasis	0.04462	0.7903	Moderately Informative	INHERITED FROM: Acidosis || Abnormality of acid-base homeostasis
Phenotypic Abnormality (PA)	Abnormality of the urinary system physiology	0.06696	1.047	Moderately Informative	INHERITED FROM: Aminoaciduria || Aciduria
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0.2031	0.971	Moderately Informative	INHERITED FROM: Abnormality of the basal ganglia
Phenotypic Abnormality (PA)	Acidosis	0.0001369	1.383	Informative	DIRECT
Phenotypic Abnormality (PA)	Aciduria	0.0006886	1.617	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal cellular physiology	0.0105	1.462	Informative	INHERITED FROM: Abnormality of the mitochondrion || Abnormality of mitochondrial metabolism
Phenotypic Abnormality (PA)	Abnormality of the cerebral subcortex	0.04163	1.508	Informative	INHERITED FROM: Abnormality of the basal ganglia
Phenotypic Abnormality (PA)	Abnormality of mitochondrial metabolism	0.00008135	1.985	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal lipid level	0.001762	1.156	--	INHERITED FROM: abnormal fatty acid level
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.1477	0.3626	--	INHERITED FROM: abnormal fatty acid level
Mammalian Phenotype (MP)	abnormal homeostasis	0.1033	0.4926	Least Informative	INHERITED FROM: abnormal fatty acid level
Mammalian Phenotype (MP)	abnormal lipid homeostasis	0.002167	1.141	Moderately Informative	INHERITED FROM: abnormal fatty acid level
Mammalian Phenotype (MP)	abnormal fatty acid level	0.00001431	2.126	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	lipid metabolism variant	0.00001128	1.337	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.3191	0.1444	--	INHERITED FROM: lipid metabolism variant || fat content variant
Worm Phenotype (WP)	organism physiology variant	0.3387	0.1342	--	INHERITED FROM: lipid metabolism variant || fat content variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || fat content variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || lipid metabolism variant || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0.02343	0.4899	Least Informative	INHERITED FROM: lipid metabolism variant || fat content variant
Worm Phenotype (WP)	fat content variant	0.0000009996	1.407	Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: alimentary system || liver and biliary system || urogenital system || genital system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || genital system || alimentary system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || liver and biliary system || trunk region || anatomical cluster || viscus || organism subdivision
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.8739	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.8828	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	liver and biliary system	0.000286	1.689	Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.4728	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || calyx || flower || collective plant structure || phyllome || multi-tissue plant structure || reproductive shoot system || shoot system || plant organ || sepal || plant axis || collective phyllome structure || shoot axis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: calyx || flower || perianth || phyllome || sepal || reproductive shoot system || collective phyllome structure || shoot axis || shoot system
Plant ANatomical entity (PAN)	sepal	0	0.4728	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || corolla development stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0	1.372	--	DIRECT
Enzyme Commission (EC)	3-hydroxyacyl-CoA dehydrogenase	0	2.753	--	DIRECT
Enzyme Commission (EC)	3-hydroxyisobutyryl-CoA hydrolase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Ethylmalonyl-CoA decarboxylase	0	3.23	--	DIRECT
Enzyme Commission (EC)	1,4-dihydroxy-2-naphthoyl-CoA synthase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Carbon-oxygen lyases	0	1.208	--	DIRECT
Enzyme Commission (EC)	Crotonobetainyl-CoA hydratase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Enoyl-CoA hydratase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Acting on hydroxy acids and derivatives	0	2.753	--	DIRECT
Enzyme Commission (EC)	3-hydroxybutyryl-CoA epimerase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Delta(3)-Delta(2)-enoyl-CoA isomerase	0	2.628	--	DIRECT
Enzyme Commission (EC)	4-chlorobenzoyl-CoA dehalogenase	0.0000000000514	3.23	--	DIRECT
Enzyme Commission (EC)	6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase	0.0000001992	3.23	--	DIRECT
Enzyme Commission (EC)	Methylglutaconyl-CoA hydratase	0.0000005462	3.23	--	DIRECT
Enzyme Commission (EC)	Acting on halide bonds	0.0000008191	2.753	--	DIRECT
Enzyme Commission (EC)	Short-chain-enoyl-CoA hydratase	0.000006222	3.23	--	DIRECT
Enzyme Commission (EC)	Itaconyl-CoA hydratase	0.000006222	3.23	--	DIRECT
Enzyme Commission (EC)	Long-chain-3-hydroxyacyl-CoA dehydrogenase	0.00001073	2.929	--	DIRECT
Enzyme Commission (EC)	Acting on carbon-carbon bonds	0.00001348	2.23	--	DIRECT
Enzyme Commission (EC)	In C-halide compounds	1	2.753	--	INHERITED FROM: 4-chlorobenzoyl-CoA dehalogenase
Enzyme Commission (EC)	Carbon-carbon lyases	1	1.305	--	INHERITED FROM: Ethylmalonyl-CoA decarboxylase || 1,4-dihydroxy-2-naphthoyl-CoA synthase || Oxo-acid-lyases
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Histone acetyltransferase
Enzyme Commission (EC)	Hydrolases	1	0.4043	Least Informative	INHERITED FROM: Acting on carbon-carbon bonds || 4-chlorobenzoyl-CoA dehalogenase || Acting on halide bonds || 3-hydroxyisobutyryl-CoA hydrolase || Thiolester hydrolases || 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase
Enzyme Commission (EC)	Lyases	0	0.8775	Moderately Informative	DIRECT
Enzyme Commission (EC)	Isomerases	0	1.026	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.8383	0.8756	Moderately Informative	INHERITED FROM: Thiolester hydrolases || 3-hydroxyisobutyryl-CoA hydrolase
Enzyme Commission (EC)	Acyltransferases	1	1.034	Moderately Informative	INHERITED FROM: Histone acetyltransferase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.437	Informative	DIRECT
Enzyme Commission (EC)	Hydro-lyases	0	1.385	Informative	DIRECT
Enzyme Commission (EC)	Racemases and epimerases	0	1.711	Informative	DIRECT
Enzyme Commission (EC)	Intramolecular oxidoreductases	3.693e-16	1.505	Informative	DIRECT
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	1	1.321	Informative	INHERITED FROM: Histone acetyltransferase
Enzyme Commission (EC)	Carboxy-lyases	1	1.474	Informative	INHERITED FROM: Ethylmalonyl-CoA decarboxylase
Enzyme Commission (EC)	Transposing C=C bonds	0	2.116	Highly Informative	DIRECT
Enzyme Commission (EC)	Thiolester hydrolases	0.000000000000001646	1.951	Highly Informative	DIRECT
Enzyme Commission (EC)	Oxo-acid-lyases	0.000000004185	2.084	Highly Informative	DIRECT
Enzyme Commission (EC)	Histone acetyltransferase	0.0001387	1.951	Highly Informative	DIRECT
Enzyme Commission (EC)	In ketonic substances	1	2.23	Highly Informative	INHERITED FROM: 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Post-translational modification	Lyase	0	0.7782	Moderately Informative	DIRECT

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