Caspase catalytic domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Caspase-like [ 52128]
• Superfamily: Caspase-like [ 52129] (2)
• Family: Caspase catalytic domain [ 52130] (7)

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Family statistics

	Genomes (144)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,571	4,595	37
Proteins	1,553	4,554	37

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Caspase-3	0.00000000003169	2.741	--	DIRECT
Enzyme Commission (EC)	Caspase-1	0.00000002548	2.44	--	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	0.5709	Least Informative	DIRECT
Enzyme Commission (EC)	Cysteine endopeptidases	0	1.326	Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	cancer	0.02677	0.2555	--	INHERITED FROM: melanoma
Disease Ontology (DO)	disease of cellular proliferation	0.03093	0.2322	--	INHERITED FROM: melanoma
Disease Ontology (DO)	disease by infectious agent	0.0004285	0.8142	Moderately Informative	DIRECT
Disease Ontology (DO)	cell type cancer	0.03269	0.9112	Moderately Informative	INHERITED FROM: melanoma
Disease Ontology (DO)	melanoma	0.0001235	2.036	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the skin	0	0.722	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the integument	0	0.6235	Least Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal thymocyte apoptosis	0.00000000000008634	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal thymus physiology	0.00000001246	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal apoptosis	0.00000002847	1.023	--	DIRECT
Mammalian Phenotype (MP)	decreased susceptibility to bacterial infection induced morbidity/mortality	0.000005103	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.000007562	1.112	--	DIRECT
Mammalian Phenotype (MP)	decreased physiological sensitivity to xenobiotic	0.00001622	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased cell death	0.00004813	1.904	--	DIRECT
Mammalian Phenotype (MP)	decreased susceptibility to infection induced morbidity/mortality	0.00005097	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal interleukin-1 secretion	0.00008723	1.825	--	DIRECT
Mammalian Phenotype (MP)	decreased susceptibility to bacterial infection	0.000122	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.0001354	0.8789	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell physiology	0.0001641	0.6209	--	DIRECT
Mammalian Phenotype (MP)	decreased sensitivity to induced morbidity/mortality	0.0001857	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.0002112	0.8789	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system physiology	0.0002311	0.6789	--	DIRECT
Mammalian Phenotype (MP)	decreased T cell apoptosis	0.0002534	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal macrophage apoptosis	0.0002606	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased susceptibility to injury	0.0007068	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal gland physiology	0.001245	1.324	--	INHERITED FROM: abnormal thymus physiology || abnormal thymocyte apoptosis || abnormal endocrine gland physiology
Mammalian Phenotype (MP)	abnormal interleukin level	0.003828	1.562	--	INHERITED FROM: abnormal circulating interleukin-18 level
Mammalian Phenotype (MP)	altered susceptibility to infection induced morbidity/mortality	0.007936	2.302	--	INHERITED FROM: decreased susceptibility to bacterial infection induced morbidity/mortality || decreased susceptibility to infection induced morbidity/mortality
Mammalian Phenotype (MP)	abnormal interleukin secretion	0.0153	1.188	--	INHERITED FROM: abnormal interleukin-1 beta secretion || abnormal interleukin-1 secretion
Mammalian Phenotype (MP)	abnormal circulating protein level	0.02118	1.205	--	INHERITED FROM: abnormal circulating interleukin-18 level
Mammalian Phenotype (MP)	abnormal circulating cytokine level	0.04558	1.373	--	INHERITED FROM: abnormal circulating interleukin-18 level
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.05747	0.9219	--	INHERITED FROM: abnormal leukocyte physiology || decreased T cell apoptosis || abnormal lymphocyte physiology || abnormal thymocyte apoptosis || abnormal T cell apoptosis || abnormal macrophage apoptosis || abnormal T cell physiology
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.06022	0.9219	--	INHERITED FROM: decreased T cell apoptosis || abnormal leukocyte physiology || abnormal T cell physiology || abnormal macrophage apoptosis || abnormal T cell apoptosis || abnormal lymphocyte physiology || abnormal thymocyte apoptosis
Mammalian Phenotype (MP)	abnormal induced cell death	0.06278	1.825	--	INHERITED FROM: decreased sensitivity to induced cell death
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.0664	0.9219	--	INHERITED FROM: decreased T cell apoptosis || abnormal leukocyte physiology || abnormal macrophage apoptosis || abnormal T cell apoptosis || abnormal thymocyte apoptosis || abnormal lymphocyte physiology || abnormal T cell physiology
Mammalian Phenotype (MP)	abnormal cytokine level	0.07861	1.348	--	INHERITED FROM: abnormal circulating interleukin-18 level
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.09565	0.3626	--	INHERITED FROM: abnormal circulating interleukin-18 level || decreased physiological sensitivity to xenobiotic || decreased susceptibility to injury
Mammalian Phenotype (MP)	abnormal intercellular signaling peptide or protein level	0.09669	1.324	--	INHERITED FROM: abnormal circulating interleukin-18 level
Mammalian Phenotype (MP)	abnormal macrophage physiology	0.1348	1.825	--	INHERITED FROM: abnormal macrophage apoptosis
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.1525	0.825	--	INHERITED FROM: abnormal neuron apoptosis || abnormal neuron physiology
Mammalian Phenotype (MP)	abnormal cytokine secretion	0.2627	1.085	--	INHERITED FROM: abnormal interleukin-1 beta secretion || abnormal interleukin-1 secretion
Mammalian Phenotype (MP)	abnormal response to infection	0.3309	1.112	--	INHERITED FROM: decreased susceptibility to bacterial infection induced morbidity/mortality || decreased susceptibility to bacterial infection || decreased susceptibility to infection || decreased susceptibility to infection induced morbidity/mortality
Mammalian Phenotype (MP)	abnormal sensitivity to induced morbidity/mortality	0.5293	1.302	--	INHERITED FROM: decreased sensitivity to induced morbidity/mortality
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.6203	0.6893	--	INHERITED FROM: abnormal circulating interleukin-18 level
Mammalian Phenotype (MP)	cellular phenotype	0.000505	0.5387	Least Informative	DIRECT
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.001349	0.6947	Least Informative	INHERITED FROM: abnormal thymus physiology || abnormal endocrine gland physiology || abnormal thymocyte apoptosis
Mammalian Phenotype (MP)	nervous system phenotype	0.002919	0.4959	Least Informative	INHERITED FROM: abnormal neuron physiology || abnormal neuron apoptosis
Mammalian Phenotype (MP)	immune system phenotype	0.002996	0.5462	Least Informative	INHERITED FROM: abnormal thymus physiology || abnormal interleukin-1 secretion || abnormal T cell physiology || abnormal interleukin-1 beta secretion || abnormal leukocyte physiology || decreased susceptibility to bacterial infection || abnormal circulating interleukin-18 level || abnormal thymocyte apoptosis || abnormal immune organ physiology || abnormal immune system physiology || decreased susceptibility to infection induced morbidity/mortality || decreased susceptibility to bacterial infection induced morbidity/mortality || abnormal T cell apoptosis || abnormal lymphocyte physiology || decreased susceptibility to infection || abnormal macrophage apoptosis || decreased T cell apoptosis
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.01478	0.5945	Least Informative	INHERITED FROM: abnormal blood cell physiology || abnormal thymocyte apoptosis || abnormal thymus physiology || decreased T cell apoptosis || abnormal macrophage apoptosis || abnormal leukocyte physiology || abnormal lymphocyte physiology || abnormal hematopoietic system physiology || abnormal T cell apoptosis || abnormal T cell physiology
Mammalian Phenotype (MP)	mortality/aging	0.0391	0.5424	Least Informative	INHERITED FROM: decreased sensitivity to induced morbidity/mortality || decreased susceptibility to infection induced morbidity/mortality || decreased susceptibility to bacterial infection induced morbidity/mortality
Mammalian Phenotype (MP)	abnormal homeostasis	0.8309	0.4926	Least Informative	INHERITED FROM: abnormal circulating interleukin-18 level
Mammalian Phenotype (MP)	abnormal cell death	0.00000008438	0.9904	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.00007293	0.9219	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal induced morbidity/mortality	0.02069	1.241	Moderately Informative	INHERITED FROM: decreased susceptibility to infection induced morbidity/mortality || decreased susceptibility to bacterial infection induced morbidity/mortality || decreased sensitivity to induced morbidity/mortality
Mammalian Phenotype (MP)	altered susceptibility to infection	0.02192	1.112	Moderately Informative	INHERITED FROM: decreased susceptibility to infection induced morbidity/mortality || decreased susceptibility to infection || decreased susceptibility to bacterial infection || decreased susceptibility to bacterial infection induced morbidity/mortality
Mammalian Phenotype (MP)	abnormal protein level	0.03312	1.112	Moderately Informative	INHERITED FROM: abnormal circulating interleukin-18 level
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.59	1.001	Moderately Informative	INHERITED FROM: abnormal interleukin-1 beta secretion || abnormal interleukin-1 secretion || abnormal circulating interleukin-18 level
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.6036	1.098	Moderately Informative	INHERITED FROM: abnormal macrophage apoptosis
Mammalian Phenotype (MP)	abnormal endocrine gland physiology	0.00000009762	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal T cell physiology	0.0000002155	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal neuron physiology	0.00000508	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal circulating interleukin level	0.002305	1.562	Informative	INHERITED FROM: abnormal circulating interleukin-18 level
Mammalian Phenotype (MP)	altered susceptibility to bacterial infection	0.005876	1.457	Informative	INHERITED FROM: decreased susceptibility to bacterial infection || decreased susceptibility to bacterial infection induced morbidity/mortality
Mammalian Phenotype (MP)	abnormal response to injury	0.05127	1.261	Informative	INHERITED FROM: decreased susceptibility to injury
Mammalian Phenotype (MP)	abnormal innate immunity	0.169	1.427	Informative	INHERITED FROM: abnormal macrophage apoptosis
Mammalian Phenotype (MP)	abnormal circulating interleukin-18 level	0.0000003983	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal immune organ physiology	0.0000006011	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased sensitivity to induced cell death	0.000002315	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal T cell apoptosis	0.000004433	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal interleukin-1 beta secretion	0.00006902	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased apoptosis	0.00009775	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal neuron apoptosis	0.0002783	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased susceptibility to infection	0.0008935	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal physiological response to xenobiotic	0.001934	1.825	Highly Informative	INHERITED FROM: decreased physiological sensitivity to xenobiotic

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	somatic cell death variant	0.0000000000182	2.468	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0.0001668	1.087	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || somatic cell death variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || cell death variant || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || programmed cell death variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	cell physiology variant	0.01484	0.5955	Least Informative	INHERITED FROM: somatic cell death variant || cell death variant || programmed cell death variant
Worm Phenotype (WP)	cell death variant	0.0001985	1.061	Moderately Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	decreased cell death	0.000000197	2.386	--	DIRECT
Fly Phenotype (FP)	cell death defective	0.0005472	1.687	Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	peptidergic neuron	0.0000422	2.389	--	DIRECT
Fly Anatomy (FA)	adult nervous system	0.01942	0.7764	--	INHERITED FROM: peptidergic neuron
Fly Anatomy (FA)	embryonic/larval nervous system	0.1374	0.7171	--	INHERITED FROM: peptidergic neuron
Fly Anatomy (FA)	cell	0.5395	0.4069	--	INHERITED FROM: peptidergic neuron
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || peptidergic neuron || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || peptidergic neuron || organism
Fly Anatomy (FA)	nervous system	0.08479	0.6333	Least Informative	INHERITED FROM: peptidergic neuron
Fly Anatomy (FA)	adult	0.1724	0.4496	Least Informative	INHERITED FROM: peptidergic neuron
Fly Anatomy (FA)	somatic cell	0.4324	0.4861	Least Informative	INHERITED FROM: peptidergic neuron
Fly Anatomy (FA)	larva	0.6524	0.3763	Least Informative	INHERITED FROM: peptidergic neuron
Fly Anatomy (FA)	neuron	0.0773	0.8451	Moderately Informative	INHERITED FROM: peptidergic neuron

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || multi-tissue structure || anatomical cluster || anatomical group || whole organism || compound organ
Zebrafish Anatomy (ZA)	anatomical cluster	0	0.7389	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0	0.5848	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Cysteine endopeptidases	0	1.753	--	DIRECT
Enzyme Commission (EC)	Caspase-3	0.0000000002751	3.23	--	DIRECT
Enzyme Commission (EC)	Caspase-1	0.000000005751	2.929	--	DIRECT
Enzyme Commission (EC)	Caspase-7	0.00003352	3.23	--	DIRECT
Enzyme Commission (EC)	Caspase-8	0.00003352	2.929	--	DIRECT
Enzyme Commission (EC)	Caspase-2	0.0001351	2.929	--	DIRECT
Enzyme Commission (EC)	Caspase-6	0.0005343	3.23	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	1.004	Moderately Informative	DIRECT

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