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Toll/Interleukin receptor TIR domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Toll/Interleukin receptor TIR domain [ 52200]
Family:   Toll/Interleukin receptor TIR domain [ 52201] (2)

Family statistics
Genomes (113) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 715 3,153 4
Proteins 713 3,146 4

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.8873Least InformativeInherited
Disease Ontology (DO)organ system cancer0.8942Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.0000001884Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.004173Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01185Moderately InformativeInherited
Disease Ontology (DO)integumentary system disease0.04135Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.1382Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.291Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.6578Moderately InformativeInherited
Disease Ontology (DO)asthma0.00000000000142InformativeDirect
Disease Ontology (DO)liver disease0.00004433InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.0001612InformativeDirect
Disease Ontology (DO)parasitic infectious disease0.0008321InformativeDirect
Disease Ontology (DO)lymphoma0.01181InformativeInherited
Disease Ontology (DO)upper respiratory tract disease0.07061InformativeInherited
Disease Ontology (DO)interstitial lung disease0.1883InformativeInherited
Disease Ontology (DO)myopathy1InformativeInherited
Disease Ontology (DO)opportunistic mycosis0.000000000009155Highly InformativeDirect
Disease Ontology (DO)dermatomyositis0.000001628Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0000498Highly InformativeDirect
Disease Ontology (DO)meningitis0.0000797Highly InformativeDirect
Disease Ontology (DO)mature T-cell and NK-cell lymphoma0.0002839Highly InformativeDirect
Disease Ontology (DO)atopic dermatitis0.0004491Highly InformativeDirect
Disease Ontology (DO)irritable bowel syndrome0.0004996Highly InformativeDirect
Disease Ontology (DO)parasitic helminthiasis infectious disease0.007357Highly InformativeInherited
Disease Ontology (DO)hepatitis0.09934Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.00000001187Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.000004075Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.3178Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.4101Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.5106Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7126Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.7866Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.000000006235Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000005805Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00005346Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0002278Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.03061Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.06963Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1055Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.131Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1672Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.2192Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.2714Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.2864Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.3246Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.3438Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.3879Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.5373Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.0000000006435InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0001011InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0001571InformativeDirect
Mammalian Phenotype (MP)abnormal innate immunity0.0005761InformativeDirect
Mammalian Phenotype (MP)abnormal fat pad morphology0.0005836InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell number0.002258InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.004855InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.006468InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.07355InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.08932InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1449InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.1525InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.1806InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme level0.1943InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.1966InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.3606InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.6838InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin level0.7066InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.7596InformativeInherited
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.9189InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.000002427Highly InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to induced colitis0.000004575Highly InformativeDirect
Mammalian Phenotype (MP)increased mature B cell number0.00009422Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.0001434Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.000159Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion0.000159Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to kidney reperfusion injury0.0002311Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.0005716Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.0006916Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0.02103Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neuron apoptosis0.02186Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat cell morphology0.03788Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.04091Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immune organ physiology0.1954Highly InformativeInherited
Mammalian Phenotype (MP)decreased acute inflammation0.733Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.0907Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1721Least InformativeInherited
Fly Anatomy (FA)nervous system0.295Least InformativeInherited
Fly Anatomy (FA)ganglion0.02037Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.04089Moderately InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.0006916InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.225Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)neurula stage0.0003252Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Toll/Interleukin receptor TIR domain domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]