NADPH-cytochrome p450 reductase-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Ferredoxin reductase-like, C-terminal NADP-linked domain [ 52342]
• Superfamily: Ferredoxin reductase-like, C-terminal NADP-linked domain [ 52343] (5)
• Family: NADPH-cytochrome p450 reductase-like [ 52365] (3)

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Family statistics

	Genomes (716)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	977	5,820	7
Proteins	977	5,819	7

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	NADPH--hemoprotein reductase	0	2.264	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.7	--	DIRECT
Enzyme Commission (EC)	Acting on NADH or NADPH	0.00000000138	1.31	--	DIRECT
Enzyme Commission (EC)	Oxidizing metal ions	0.00000732	1.896	--	DIRECT
Enzyme Commission (EC)	[Methionine synthase] reductase	0.0002989	2.44	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0.000000000001061	1.173	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on a sulfur group of donors	0	1.361	Informative	DIRECT
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation	0.000000000006862	1.741	Informative	DIRECT
Enzyme Commission (EC)	With a heme protein as acceptor	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Nitric-oxide synthase	0	2.042	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.042	Highly Informative	DIRECT
Enzyme Commission (EC)	Sulfite reductase (NADPH)	0	2.042	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT
Disease Ontology (DO)	musculoskeletal system disease	0	0.89	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	malaria	0.000003842	1.735	--	DIRECT
Disease Ontology (DO)	parasitic protozoa infectious disease	0.000009426	1.735	--	DIRECT
Disease Ontology (DO)	nephritis	0.00005874	1.309	--	DIRECT
Disease Ontology (DO)	pre-eclampsia	0.0001412	1.735	--	DIRECT
Disease Ontology (DO)	cognitive disorder	0.0002057	1.151	--	DIRECT
Disease Ontology (DO)	bone disease	0.0002617	1.171	--	DIRECT
Disease Ontology (DO)	bronchial disease	0.0003826	1.133	--	DIRECT
Disease Ontology (DO)	acquired metabolic disease	0.0006975	1.191	--	DIRECT
Disease Ontology (DO)	lung disease	0.0007087	1.258	--	DIRECT
Disease Ontology (DO)	kidney disease	0.0008845	1.066	--	DIRECT
Disease Ontology (DO)	central nervous system disease	0.001214	0.8698	--	INHERITED FROM: Alzheimer's disease || migraine || neurodegenerative disease
Disease Ontology (DO)	hypersensitivity reaction disease	0.005016	0.8505	--	INHERITED FROM: lupus erythematosus
Disease Ontology (DO)	cardiovascular system disease	0.01408	0.7889	--	INHERITED FROM: ischemia || pre-eclampsia
Disease Ontology (DO)	respiratory system disease	0.01623	0.9334	--	INHERITED FROM: upper respiratory tract disease || bronchial disease || asthma || obstructive lung disease || lung disease
Disease Ontology (DO)	immune system disease	0.04421	0.8411	--	INHERITED FROM: lupus erythematosus
Disease Ontology (DO)	brain disease	0.04623	1.258	--	INHERITED FROM: migraine
Disease Ontology (DO)	tauopathy	0.09203	1.61	--	INHERITED FROM: Alzheimer's disease
Disease Ontology (DO)	vascular disease	0.6578	0.832	--	INHERITED FROM: ischemia || pre-eclampsia
Disease Ontology (DO)	nervous system disease	0.04111	0.7279	Least Informative	INHERITED FROM: neurodegenerative disease || Alzheimer's disease || migraine
Disease Ontology (DO)	organ system cancer	0.2245	0.4879	Least Informative	INHERITED FROM: nervous system cancer || autonomic nervous system neoplasm
Disease Ontology (DO)	syndrome	0	1.151	Moderately Informative	DIRECT
Disease Ontology (DO)	nervous system cancer	0.00003222	1.191	Moderately Informative	DIRECT
Disease Ontology (DO)	neurodegenerative disease	0.0003693	1.022	Moderately Informative	DIRECT
Disease Ontology (DO)	disease of mental health	0.001232	1.036	Moderately Informative	INHERITED FROM: cognitive disorder
Disease Ontology (DO)	disease of metabolism	0.001386	0.9817	Moderately Informative	INHERITED FROM: acquired metabolic disease
Disease Ontology (DO)	lower respiratory tract disease	0.00258	0.9947	Moderately Informative	INHERITED FROM: asthma || obstructive lung disease || bronchial disease || lung disease
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.003271	0.8797	Moderately Informative	INHERITED FROM: lupus erythematosus
Disease Ontology (DO)	urinary system disease	0.005606	1.051	Moderately Informative	INHERITED FROM: kidney disease || nephritis
Disease Ontology (DO)	artery disease	0.007272	0.9817	Moderately Informative	INHERITED FROM: pre-eclampsia
Disease Ontology (DO)	disease by infectious agent	0.02079	0.8142	Moderately Informative	INHERITED FROM: malaria || parasitic infectious disease || parasitic protozoa infectious disease
Disease Ontology (DO)	connective tissue disease	0.6249	1.022	Moderately Informative	INHERITED FROM: bone disease
Disease Ontology (DO)	upper respiratory tract disease	0.000006825	1.472	Informative	DIRECT
Disease Ontology (DO)	parasitic infectious disease	0.0000189	1.61	Informative	DIRECT
Disease Ontology (DO)	asthma	0.0003625	1.258	Informative	DIRECT
Disease Ontology (DO)	lupus erythematosus	0.0003826	1.61	Informative	DIRECT
Disease Ontology (DO)	Alzheimer's disease	0.0004961	1.61	Informative	DIRECT
Disease Ontology (DO)	hypertension	0.001636	1.434	Informative	INHERITED FROM: pre-eclampsia
Disease Ontology (DO)	peripheral nervous system neoplasm	0.3758	1.668	Informative	INHERITED FROM: autonomic nervous system neoplasm
Disease Ontology (DO)	migraine	0.000001535	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	ischemia	0.00004585	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	obstructive lung disease	0.00006591	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	autonomic nervous system neoplasm	0.0002962	1.814	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal systemic blood pressure	0.001053	1.86	--	INHERITED FROM: Increased blood pressure
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.1519	0.5179	Least Informative	INHERITED FROM: Increased blood pressure
Phenotypic Abnormality (PA)	Abnormal cardiovascular system physiology	0.02314	0.9309	Moderately Informative	INHERITED FROM: Increased blood pressure
Phenotypic Abnormality (PA)	Increased blood pressure	0.0005644	1.86	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal body weight	0	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal postnatal growth/weight/body size	0	0.8956	--	DIRECT
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0	0.3626	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood homeostasis	0	0.6893	--	DIRECT
Mammalian Phenotype (MP)	abnormal total tissue mass	0	1.188	--	DIRECT
Mammalian Phenotype (MP)	abnormal pyloric sphincter morphology	0.0000000003697	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney thrombosis	0.0000000003697	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal stomach pyloric region morphology	0.000000005697	2.001	--	DIRECT
Mammalian Phenotype (MP)	renal necrosis	0.00000004343	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal urine sodium level	0.0000001603	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood osmolality	0.0000001896	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating alkaline phosphatase level	0.0000003112	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal glomerular capillary morphology	0.0000003299	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney capillary morphology	0.0000003573	1.904	--	DIRECT
Mammalian Phenotype (MP)	visceral vascular congestion	0.0000004182	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal urine osmolality	0.0000006884	1.904	--	DIRECT
Mammalian Phenotype (MP)	vasculature congestion	0.000001855	1.904	--	DIRECT
Mammalian Phenotype (MP)	increased fluid intake	0.000002151	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal capillary morphology	0.000002471	1.904	--	DIRECT
Mammalian Phenotype (MP)	pathological neovascularization	0.000003655	1.649	--	DIRECT
Mammalian Phenotype (MP)	arteriosclerosis	0.000004466	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal fluid intake	0.000005015	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal sodium ion homeostasis	0.000005405	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating LDL cholesterol level	0.000006484	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal osteoclast cell number	0.000006484	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal thrombosis	0.000007207	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal drinking behavior	0.000009376	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal urination	0.00001032	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating cholesterol level	0.00001276	1.524	--	DIRECT
Mammalian Phenotype (MP)	increased systemic arterial blood pressure	0.00001306	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating enzyme level	0.00001399	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal sensitivity to induced morbidity/mortality	0.00001606	1.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal cholesterol level	0.00001943	1.524	--	DIRECT
Mammalian Phenotype (MP)	abnormal osteoclast morphology	0.00002169	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal seizure response to inducing agent	0.00002386	1.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal stomach morphology	0.00002442	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal bone remodeling	0.00002563	1.825	--	DIRECT
Mammalian Phenotype (MP)	increased macrophage cell number	0.00002563	2.001	--	DIRECT
Mammalian Phenotype (MP)	cortical renal glomerulopathies	0.00002685	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal lung morphology	0.00003386	1.205	--	DIRECT
Mammalian Phenotype (MP)	abnormal wound healing	0.00003576	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal prostaglandin level	0.00004394	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal white adipose tissue amount	0.00004648	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal heart rate	0.00004827	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating amino acid level	0.00005367	1.7	--	DIRECT
Mammalian Phenotype (MP)	decreased cardiac muscle contractility	0.00006167	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal female reproductive system physiology	0.00006239	1.223	--	DIRECT
Mammalian Phenotype (MP)	abnormal heart ventricle morphology	0.00006239	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal heart ventricle pressure	0.00006473	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood circulation	0.00009092	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal coronary vessel morphology	0.00009929	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal liver vasculature morphology	0.0001076	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal macrophage cell number	0.0001088	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney blood vessel morphology	0.0001283	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney morphology	0.0001286	1.156	--	DIRECT
Mammalian Phenotype (MP)	increased apoptosis	0.000135	1.241	--	DIRECT
Mammalian Phenotype (MP)	increased cell death	0.0001367	1.241	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney apoptosis	0.0001474	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal respiratory system morphology	0.0001887	1.072	--	DIRECT
Mammalian Phenotype (MP)	kidney degeneration	0.000195	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal renal corpuscle morphology	0.0002218	1.427	--	DIRECT
Mammalian Phenotype (MP)	lethality, incomplete penetrance	0.0002373	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal lung vasculature morphology	0.0002501	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal bone mineral density	0.0002509	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal liver morphology	0.0002981	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal lipid level	0.0003014	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal internal female genitalia morphology	0.0003791	1.281	--	DIRECT
Mammalian Phenotype (MP)	abnormal muscle contractility	0.000387	1.427	--	DIRECT
Mammalian Phenotype (MP)	abnormal female genitalia morphology	0.0004106	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal female reproductive system morphology	0.0004186	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal hepatobiliary system morphology	0.0004226	1.098	--	DIRECT
Mammalian Phenotype (MP)	abnormal macrophage physiology	0.0004434	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal adiponectin level	0.000502	2.001	--	DIRECT
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.000505	0.931	--	DIRECT
Mammalian Phenotype (MP)	increased kidney apoptosis	0.0006416	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal artery morphology	0.0006923	1.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal apoptosis	0.0008205	1.023	--	DIRECT
Mammalian Phenotype (MP)	abnormal fertility/fecundity	0.0009602	1.302	--	DIRECT
Mammalian Phenotype (MP)	muscle phenotype	0.001241	0.8473	--	INHERITED FROM: pyloric sphincter hypertrophy || abnormal muscle morphology || abnormal pyloric sphincter morphology || decreased cardiac muscle contractility || abnormal muscle contractility || impaired muscle contractility
Mammalian Phenotype (MP)	abnormal mononuclear phagocyte morphology	0.001357	1.457	--	INHERITED FROM: abnormal macrophage cell number || abnormal osteoclast cell number || abnormal osteoclast morphology || increased macrophage cell number || abnormal macrophage morphology || increased osteoclast cell number
Mammalian Phenotype (MP)	abnormal skeleton physiology	0.001366	1.302	--	INHERITED FROM: abnormal bone remodeling || abnormal osteoclast physiology || abnormal bone ossification || abnormal bone mineralization
Mammalian Phenotype (MP)	abnormal blood urea nitrogen level	0.001642	1.825	--	INHERITED FROM: increased blood urea nitrogen level
Mammalian Phenotype (MP)	uremia	0.001642	1.825	--	INHERITED FROM: increased circulating creatinine level || increased blood urea nitrogen level
Mammalian Phenotype (MP)	abnormal phagocyte morphology	0.00291	1.281	--	INHERITED FROM: abnormal osteoclast morphology || increased macrophage cell number || abnormal macrophage morphology || abnormal osteoclast cell number || abnormal macrophage cell number || increased osteoclast cell number
Mammalian Phenotype (MP)	reproductive system phenotype	0.003747	0.8397	--	INHERITED FROM: reduced fertility || abnormal fertility/fecundity || abnormal female reproductive system morphology || abnormal internal female genitalia morphology || abnormal female genitalia morphology || abnormal female reproductive system physiology || decreased litter size
Mammalian Phenotype (MP)	abnormal hemostasis	0.003748	1.399	--	INHERITED FROM: abnormal kidney thrombosis || abnormal thrombosis || glomerular capillary thrombosis || abnormal blood coagulation
Mammalian Phenotype (MP)	abnormal adipose tissue morphology	0.003864	1.223	--	INHERITED FROM: abnormal white adipose tissue morphology || increased white adipose tissue amount || abnormal white adipose tissue amount
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.003999	0.825	--	INHERITED FROM: abnormal seizure response to inducing agent
Mammalian Phenotype (MP)	abnormal circulating lipoprotein level	0.004073	1.758	--	INHERITED FROM: increased circulating LDL cholesterol level || abnormal circulating LDL cholesterol level
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.004127	0.7902	--	INHERITED FROM: visceral vascular congestion || abnormal heart ventricle morphology || abnormal coronary vessel morphology || abnormal heart weight || abnormal kidney capillary morphology || liver vascular congestion || abnormal cardiovascular development || abnormal capillary morphology || abnormal lung vasculature morphology || glomerular capillary thrombosis || abnormal coronary artery morphology || pulmonary vascular congestion || perivascular fibrosis || abnormal angiogenesis || arteriosclerosis || abnormal glomerular capillary morphology || abnormal kidney thrombosis || abnormal liver vasculature morphology || abnormal artery morphology || abnormal kidney blood vessel morphology || thick ventricular wall || vasculature congestion
Mammalian Phenotype (MP)	abnormal myeloid leukocyte morphology	0.004827	1.223	--	INHERITED FROM: abnormal macrophage morphology || abnormal osteoclast cell number || abnormal macrophage cell number || abnormal osteoclast morphology || increased macrophage cell number || increased osteoclast cell number
Mammalian Phenotype (MP)	abnormal urine homeostasis	0.005301	1.758	--	INHERITED FROM: abnormal urine sodium level || decreased urine sodium level || decreased urine osmolality || abnormal urine osmolality
Mammalian Phenotype (MP)	abnormal smooth muscle morphology	0.007207	1.825	--	INHERITED FROM: abnormal pyloric sphincter morphology || pyloric sphincter hypertrophy
Mammalian Phenotype (MP)	increased leukocyte cell number	0.00724	1.241	--	INHERITED FROM: increased osteoclast cell number || increased macrophage cell number
Mammalian Phenotype (MP)	abnormal circulating lipid level	0.009902	1.241	--	INHERITED FROM: abnormal circulating LDL cholesterol level || increased circulating LDL cholesterol level || abnormal circulating cholesterol level || abnormal circulating triglyceride level
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0.01408	0.9404	--	INHERITED FROM: abnormal stomach morphology || abnormal pyloric sphincter morphology || abnormal stomach pyloric region morphology || pyloric sphincter hypertrophy || enlarged stomach
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.01828	0.9219	--	INHERITED FROM: abnormal osteoclast physiology || abnormal macrophage physiology
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.01866	0.9219	--	INHERITED FROM: abnormal macrophage physiology || abnormal osteoclast physiology
Mammalian Phenotype (MP)	abnormal litter size	0.01915	1.649	--	INHERITED FROM: decreased litter size
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.01948	0.9219	--	INHERITED FROM: abnormal macrophage physiology || abnormal osteoclast physiology
Mammalian Phenotype (MP)	abnormal circulating protein level	0.01978	1.205	--	INHERITED FROM: abnormal circulating alkaline phosphatase level || abnormal circulating enzyme level || increased circulating alkaline phosphatase level
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.02197	0.8789	--	INHERITED FROM: abnormal macrophage physiology || abnormal osteoclast physiology
Mammalian Phenotype (MP)	abnormal cell physiology	0.0246	0.6209	--	INHERITED FROM: abnormal kidney apoptosis || increased kidney apoptosis || increased apoptosis || increased cell death || abnormal apoptosis || increased renal tubule apoptosis
Mammalian Phenotype (MP)	behavior/neurological phenotype	0.02505	0.8178	--	INHERITED FROM: abnormal seizure response to inducing agent || abnormal behavioral response to xenobiotic || polydipsia || abnormal fluid intake || abnormal drinking behavior || increased fluid intake
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.02527	0.8473	--	INHERITED FROM: abnormal osteoclast morphology || increased osteoclast cell number || increased macrophage cell number || abnormal macrophage morphology || abnormal macrophage cell number || abnormal osteoclast cell number
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.02603	0.8789	--	INHERITED FROM: abnormal osteoclast physiology || abnormal macrophage physiology
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.0269	0.9129	--	INHERITED FROM: increased osteoclast cell number || increased macrophage cell number || abnormal macrophage cell number
Mammalian Phenotype (MP)	abnormal circulating non-HDL cholesterol level	0.03102	1.904	--	INHERITED FROM: abnormal circulating LDL cholesterol level || increased circulating LDL cholesterol level
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.0371	0.8323	--	INHERITED FROM: abnormal bone mineral density || abnormal trabecular bone morphology || abnormal osteoclast cell number || increased bone mineral density || increased osteoclast cell number || abnormal osteoclast morphology || abnormal skeleton development
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.03724	0.8108	--	INHERITED FROM: increased osteoclast cell number || abnormal osteoclast morphology || abnormal macrophage cell number || abnormal osteoclast cell number || increased macrophage cell number || abnormal macrophage morphology
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.03814	0.8038	--	INHERITED FROM: abnormal osteoclast morphology || increased osteoclast cell number || increased macrophage cell number || abnormal macrophage morphology || abnormal macrophage cell number || abnormal osteoclast cell number
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.03943	0.8473	--	INHERITED FROM: increased macrophage cell number || abnormal macrophage cell number || increased osteoclast cell number
Mammalian Phenotype (MP)	skeleton phenotype	0.04423	0.8038	--	INHERITED FROM: increased bone mineral density || abnormal osteoclast cell number || abnormal bone ossification || abnormal osteoclast physiology || abnormal skeleton development || abnormal bone mineralization || abnormal osteoclast morphology || increased osteoclast cell number || abnormal bone mineral density || abnormal trabecular bone morphology || abnormal bone remodeling
Mammalian Phenotype (MP)	preweaning lethality	0.0539	0.7055	--	INHERITED FROM: prenatal lethality, incomplete penetrance
Mammalian Phenotype (MP)	abnormal immune system physiology	0.06482	0.6789	--	INHERITED FROM: abnormal macrophage physiology || abnormal osteoclast physiology
Mammalian Phenotype (MP)	abnormal immune system morphology	0.06525	0.7223	--	INHERITED FROM: abnormal macrophage cell number || abnormal macrophage morphology || abnormal osteoclast cell number || increased macrophage cell number || increased osteoclast cell number || abnormal osteoclast morphology
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.07685	0.7167	--	INHERITED FROM: abnormal macrophage morphology || abnormal macrophage cell number || increased macrophage cell number || abnormal osteoclast cell number || abnormal osteoclast morphology || increased osteoclast cell number
Mammalian Phenotype (MP)	abnormal vascular development	0.08671	1.223	--	INHERITED FROM: abnormal angiogenesis
Mammalian Phenotype (MP)	abnormal survival	0.08671	0.6441	--	INHERITED FROM: lethality, incomplete penetrance || decreased survivor rate || prenatal lethality, incomplete penetrance
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.103	0.6686	--	INHERITED FROM: abnormal macrophage cell number || abnormal macrophage morphology || increased osteoclast cell number || abnormal osteoclast morphology || abnormal osteoclast cell number || increased macrophage cell number
Mammalian Phenotype (MP)	abnormal kidney cortex morphology	0.1228	1.399	--	INHERITED FROM: glomerular capillary thrombosis || abnormal renal glomerulus morphology || glomerulosclerosis || abnormal renal corpuscle morphology || abnormal glomerular capillary morphology || cortical renal glomerulopathies
Mammalian Phenotype (MP)	increased circulating cholesterol level	0.1403	1.758	--	INHERITED FROM: increased circulating LDL cholesterol level
Mammalian Phenotype (MP)	increased sterol level	0.1819	1.758	--	INHERITED FROM: increased circulating LDL cholesterol level
Mammalian Phenotype (MP)	increased cholesterol level	0.1918	1.758	--	INHERITED FROM: increased circulating LDL cholesterol level
Mammalian Phenotype (MP)	abnormal nephron morphology	0.2379	1.261	--	INHERITED FROM: abnormal renal glomerulus morphology || glomerular capillary thrombosis || glomerulosclerosis || abnormal glomerular capillary morphology || abnormal renal tubule morphology || abnormal renal corpuscle morphology || renal tubular necrosis || cortical renal glomerulopathies
Mammalian Phenotype (MP)	abnormal renal/urinary system physiology	0.2399	1.281	--	INHERITED FROM: increased renal tubule apoptosis || decreased urine osmolality || polyuria || increased kidney apoptosis || abnormal kidney apoptosis || abnormal kidney physiology || abnormal urine osmolality || abnormal urination || abnormal urine sodium level || decreased urine sodium level
Mammalian Phenotype (MP)	abnormal circulating creatinine level	0.3372	1.904	--	INHERITED FROM: increased circulating creatinine level
Mammalian Phenotype (MP)	abnormal homeostasis	0	0.4926	Least Informative	DIRECT
Mammalian Phenotype (MP)	growth/size/body region phenotype	0	0.6254	Least Informative	DIRECT
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.01084	0.6737	Least Informative	INHERITED FROM: hypertension || pathological neovascularization || thick ventricular wall || abnormal artery morphology || abnormal liver vasculature morphology || increased systemic arterial systolic blood pressure || abnormal kidney thrombosis || decreased systemic arterial blood pressure || abnormal glomerular capillary morphology || arteriosclerosis || abnormal angiogenesis || glomerular capillary thrombosis || abnormal lung vasculature morphology || liver vascular congestion || abnormal heart weight || abnormal coronary vessel morphology || abnormal heart ventricle morphology || visceral vascular congestion || vasculature congestion || abnormal kidney blood vessel morphology || increased systemic arterial blood pressure || decreased cardiac muscle contractility || abnormal vascular wound healing || abnormal blood circulation || perivascular fibrosis || pulmonary vascular congestion || abnormal coronary artery morphology || abnormal capillary morphology || abnormal vascular endothelial cell physiology || decreased heart rate || abnormal cardiovascular development || congestive heart failure || abnormal kidney capillary morphology || abnormal heart rate || abnormal heart left ventricle pressure || abnormal heart ventricle pressure
Mammalian Phenotype (MP)	nervous system phenotype	0.02909	0.4959	Least Informative	INHERITED FROM: abnormal seizure response to inducing agent
Mammalian Phenotype (MP)	cellular phenotype	0.03869	0.5387	Least Informative	INHERITED FROM: increased apoptosis || abnormal kidney apoptosis || increased kidney apoptosis || increased renal tubule apoptosis || abnormal apoptosis || increased cell death
Mammalian Phenotype (MP)	mortality/aging	0.1099	0.5424	Least Informative	INHERITED FROM: lethality, incomplete penetrance || abnormal sensitivity to induced morbidity/mortality || decreased survivor rate || prenatal lethality, incomplete penetrance || abnormal induced morbidity/mortality
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.144	0.5945	Least Informative	INHERITED FROM: increased osteoclast cell number || abnormal osteoclast morphology || abnormal osteoclast physiology || abnormal macrophage physiology || abnormal osteoclast cell number || increased macrophage cell number || abnormal macrophage cell number || abnormal macrophage morphology
Mammalian Phenotype (MP)	immune system phenotype	0.1514	0.5462	Least Informative	INHERITED FROM: abnormal macrophage physiology || abnormal osteoclast physiology || abnormal osteoclast cell number || increased osteoclast cell number || abnormal macrophage cell number || increased macrophage cell number || abnormal osteoclast morphology || abnormal macrophage morphology
Mammalian Phenotype (MP)	abnormal body size	0	1.001	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal body composition	0	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal induced morbidity/mortality	0.00004442	1.241	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cardiovascular development	0.0001055	1.059	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.0001842	1.047	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal muscle morphology	0.0002656	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	liver/biliary system phenotype	0.0006665	1.012	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal heart morphology	0.001059	0.9597	Moderately Informative	INHERITED FROM: thick ventricular wall || abnormal coronary vessel morphology || abnormal heart weight || abnormal coronary artery morphology || abnormal heart ventricle morphology
Mammalian Phenotype (MP)	respiratory system phenotype	0.001149	0.9404	Moderately Informative	INHERITED FROM: abnormal lung vasculature morphology || abnormal respiratory system morphology || pulmonary vascular congestion || abnormal lung morphology
Mammalian Phenotype (MP)	abnormal cell death	0.001261	0.9904	Moderately Informative	INHERITED FROM: abnormal kidney apoptosis || increased kidney apoptosis || increased cell death || increased apoptosis || increased renal tubule apoptosis || abnormal apoptosis
Mammalian Phenotype (MP)	abnormal reproductive system physiology	0.001668	1.012	Moderately Informative	INHERITED FROM: decreased litter size || abnormal female reproductive system physiology || abnormal fertility/fecundity || reduced fertility
Mammalian Phenotype (MP)	abnormal cardiovascular system physiology	0.002044	0.9499	Moderately Informative	INHERITED FROM: decreased systemic arterial blood pressure || abnormal heart rate || abnormal vascular wound healing || abnormal blood circulation || abnormal heart left ventricle pressure || abnormal heart ventricle pressure || pathological neovascularization || decreased heart rate || abnormal vascular endothelial cell physiology || hypertension || increased systemic arterial blood pressure || decreased cardiac muscle contractility || congestive heart failure || increased systemic arterial systolic blood pressure
Mammalian Phenotype (MP)	abnormal bone structure	0.003157	1.241	Moderately Informative	INHERITED FROM: abnormal bone mineral density || increased osteoclast cell number || abnormal osteoclast morphology || abnormal osteoclast cell number || abnormal trabecular bone morphology || increased bone mineral density
Mammalian Phenotype (MP)	adipose tissue phenotype	0.00413	1.205	Moderately Informative	INHERITED FROM: abnormal white adipose tissue morphology || abnormal white adipose tissue amount || increased white adipose tissue amount
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.005727	1.098	Moderately Informative	INHERITED FROM: abnormal macrophage cell number || increased osteoclast cell number || abnormal osteoclast cell number || increased macrophage cell number || abnormal osteoclast morphology || abnormal macrophage morphology
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.005943	1.098	Moderately Informative	INHERITED FROM: abnormal macrophage physiology || abnormal osteoclast physiology
Mammalian Phenotype (MP)	abnormal digestive system morphology	0.007108	1.023	Moderately Informative	INHERITED FROM: abnormal pyloric sphincter morphology || abnormal stomach morphology || abnormal stomach pyloric region morphology || pyloric sphincter hypertrophy || enlarged stomach
Mammalian Phenotype (MP)	abnormal hormone level	0.007175	1.141	Moderately Informative	INHERITED FROM: abnormal adiponectin level || decreased adiponectin level
Mammalian Phenotype (MP)	prenatal lethality	0.007336	0.9129	Moderately Informative	INHERITED FROM: prenatal lethality, incomplete penetrance
Mammalian Phenotype (MP)	abnormal lipid homeostasis	0.01044	1.141	Moderately Informative	INHERITED FROM: abnormal circulating triglyceride level || abnormal triglyceride level || abnormal cholesterol homeostasis || abnormal sterol level || abnormal cholesterol level || increased prostaglandin level || abnormal prostaglandin level || abnormal circulating LDL cholesterol level || abnormal lipid level || increased circulating LDL cholesterol level || abnormal circulating cholesterol level
Mammalian Phenotype (MP)	abnormal protein level	0.01053	1.112	Moderately Informative	INHERITED FROM: abnormal circulating alkaline phosphatase level || abnormal circulating enzyme level || increased circulating alkaline phosphatase level
Mammalian Phenotype (MP)	increased hematopoietic cell number	0.01125	1.188	Moderately Informative	INHERITED FROM: increased macrophage cell number || increased osteoclast cell number
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.01726	0.9219	Moderately Informative	INHERITED FROM: abnormal macrophage physiology || abnormal osteoclast physiology
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.02504	0.9904	Moderately Informative	INHERITED FROM: abnormal osteoclast cell number || abnormal macrophage cell number || increased osteoclast cell number || abnormal macrophage morphology || abnormal osteoclast morphology || increased macrophage cell number
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.2715	1.023	Moderately Informative	INHERITED FROM: abnormal liver vasculature morphology || abnormal artery morphology || abnormal kidney blood vessel morphology || vasculature congestion || abnormal lung vasculature morphology || abnormal capillary morphology || glomerular capillary thrombosis || visceral vascular congestion || abnormal coronary artery morphology || pulmonary vascular congestion || perivascular fibrosis || abnormal angiogenesis || arteriosclerosis || abnormal glomerular capillary morphology || liver vascular congestion || abnormal kidney thrombosis || abnormal kidney capillary morphology
Mammalian Phenotype (MP)	abnormal reproductive system morphology	0.2965	0.9404	Moderately Informative	INHERITED FROM: abnormal female genitalia morphology || abnormal female reproductive system morphology || abnormal internal female genitalia morphology
Mammalian Phenotype (MP)	abnormal muscle physiology	0.3442	1.085	Moderately Informative	INHERITED FROM: abnormal muscle contractility || impaired muscle contractility || decreased cardiac muscle contractility
Mammalian Phenotype (MP)	abnormal behavior	1	0.855	Moderately Informative	INHERITED FROM: abnormal behavioral response to xenobiotic || abnormal seizure response to inducing agent || abnormal fluid intake || abnormal drinking behavior || increased fluid intake || polydipsia
Mammalian Phenotype (MP)	abnormal circulating triglyceride level	0.000002526	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal triglyceride level	0.00000876	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cholesterol homeostasis	0.00002092	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal sterol level	0.00002113	1.489	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal amino acid level	0.0000387	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal trabecular bone morphology	0.00008785	1.489	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal renal tubule morphology	0.00008785	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal blood coagulation	0.00009204	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal white adipose tissue morphology	0.00009349	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	decreased litter size	0.0001554	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	impaired muscle contractility	0.0001705	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal renal glomerulus morphology	0.0001728	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal bone ossification	0.000282	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal angiogenesis	0.0003277	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal kidney physiology	0.0003715	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal macrophage morphology	0.0004826	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal skeleton development	0.0006105	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal enzyme/coenzyme level	0.0008561	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal behavioral response to xenobiotic	0.0009796	1.489	Informative	DIRECT
Mammalian Phenotype (MP)	seizures	0.001303	1.427	Informative	INHERITED FROM: abnormal seizure response to inducing agent
Mammalian Phenotype (MP)	abnormal innate immunity	0.001485	1.427	Informative	INHERITED FROM: abnormal macrophage physiology || abnormal osteoclast physiology
Mammalian Phenotype (MP)	abnormal lipoprotein level	0.001528	1.7	Informative	INHERITED FROM: increased circulating LDL cholesterol level || abnormal circulating LDL cholesterol level
Mammalian Phenotype (MP)	abnormal adipose tissue amount	0.001566	1.489	Informative	INHERITED FROM: increased white adipose tissue amount || abnormal white adipose tissue amount
Mammalian Phenotype (MP)	abnormal systemic arterial blood pressure	0.004944	1.7	Informative	INHERITED FROM: increased systemic arterial systolic blood pressure || increased systemic arterial blood pressure || hypertension || decreased systemic arterial blood pressure
Mammalian Phenotype (MP)	abnormal cardiac muscle contractility	0.007073	1.7	Informative	INHERITED FROM: decreased cardiac muscle contractility
Mammalian Phenotype (MP)	abnormal heartbeat	0.007346	1.649	Informative	INHERITED FROM: abnormal heart rate || decreased heart rate
Mammalian Phenotype (MP)	abnormal response to injury	0.009061	1.261	Informative	INHERITED FROM: abnormal wound healing || abnormal vascular wound healing
Mammalian Phenotype (MP)	abnormal ion homeostasis	0.01027	1.524	Informative	INHERITED FROM: abnormal urine sodium level || decreased urine sodium level || abnormal sodium ion homeostasis
Mammalian Phenotype (MP)	abnormal gas homeostasis	0.01085	1.649	Informative	INHERITED FROM: abnormal nitric oxide homeostasis
Mammalian Phenotype (MP)	abnormal consumption behavior	0.01196	1.603	Informative	INHERITED FROM: abnormal drinking behavior || increased fluid intake || polydipsia || abnormal fluid intake
Mammalian Phenotype (MP)	abnormal blood vessel physiology	0.0252	1.373	Informative	INHERITED FROM: abnormal vascular endothelial cell physiology || pathological neovascularization || abnormal vascular wound healing
Mammalian Phenotype (MP)	abnormal heart ventricle wall thickness	0.02596	1.7	Informative	INHERITED FROM: thick ventricular wall
Mammalian Phenotype (MP)	abnormal heart size	0.1491	1.603	Informative	INHERITED FROM: abnormal heart weight
Mammalian Phenotype (MP)	pyloric sphincter hypertrophy	0.00000000002349	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	perivascular fibrosis	0.00000000002349	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	glomerular capillary thrombosis	0.0000000001181	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased blood osmolality	0.000000001828	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	enlarged stomach	0.000000007207	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased renal tubule apoptosis	0.000000008961	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	renal tubular necrosis	0.000000008961	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased prostaglandin level	0.000000008961	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased urine sodium level	0.00000002338	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	liver vascular congestion	0.00000003759	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	polydipsia	0.00000005695	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	pulmonary vascular congestion	0.00000006469	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal coronary artery morphology	0.00000008298	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased circulating alkaline phosphatase level	0.0000001226	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased adiponectin level	0.0000001448	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal nitric oxide homeostasis	0.0000001603	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal heart left ventricle pressure	0.0000001945	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased white adipose tissue amount	0.0000003573	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	thick ventricular wall	0.0000004182	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased urine osmolality	0.0000004511	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal vascular endothelial cell physiology	0.0000004511	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	hypertension	0.0000005596	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased circulating LDL cholesterol level	0.000000601	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal vascular wound healing	0.000001012	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased osteoclast cell number	0.000001012	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased systemic arterial systolic blood pressure	0.000001073	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal osteoclast physiology	0.000001137	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	polyuria	0.000001273	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	glomerulosclerosis	0.000001675	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased circulating creatinine level	0.00000205	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased bone mineral density	0.000003655	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased systemic arterial blood pressure	0.0000052	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	prenatal lethality, incomplete penetrance	0.000006972	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased heart rate	0.00001128	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased blood urea nitrogen level	0.00001545	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal bone mineralization	0.00001632	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	reduced fertility	0.00004034	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased survivor rate	0.00004376	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal heart weight	0.0001204	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	congestive heart failure	0.0002777	1.904	Highly Informative	DIRECT

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

---

Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence meristem	0	0.6337	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina base	0	0.6245	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.5171	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.5117	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.4893	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.4728	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.4385	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.4584	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.4282	--	DIRECT
Plant ANatomical entity (PAN)	lamina	0	0.6199	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.6705	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.437	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || root || sporophyll || calyx || inflorescence axis || flower || lamina || collective plant structure || plant embryo || leaf || shoot internode || phyllome || pollen sac || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || megasporophyll || reproductive shoot system || shoot apex || leaf lamina base || branch || collective leaf structure || stem internode || inflorescence branch || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || portion of meristem tissue || stem || whole plant || inflorescence meristem || epidermis || root system || inflorescence || cardinal part of multi-tissue plant structure || gynoecium || vascular leaf || sepal || microsporangium || epidermal cell || leaf lamina || shoot epidermal cell || corolla || pollen || plant axis || collective phyllome structure || petal || plant cell || carpel || seed || shoot epidermis || stamen || shoot axis || microgametophyte || pedicel || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: inflorescence axis || calyx || flower || sporophyll || inflorescence meristem || root system || inflorescence || root || perianth || stem || leaf || phyllome || shoot internode || sepal || vascular leaf || gynoecium || petal || reproductive shoot system || shoot apex || carpel || collective phyllome structure || guard cell || megasporophyll || pollen || microsporophyll || pollen sac || leaf lamina || shoot epidermal cell || corolla || pedicel || androecium || stomatal complex || stamen || stem internode || inflorescence branch || shoot axis || shoot system || leaf lamina base || collective leaf structure || branch || shoot epidermis
Plant ANatomical entity (PAN)	phyllome lamina	1	0.6199	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	organ lamina	1	0.6199	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	shoot apex	0	0.481	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	root	0	0.4679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0	0.4978	Least Informative	DIRECT
Plant ANatomical entity (PAN)	seed	0	0.5189	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0	0.5892	Least Informative	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.437	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.5117	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.4728	Least Informative	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.4893	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.4777	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.4859	Least Informative	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.5153	Least Informative	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.5082	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf lamina	0	0.6199	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.46	Least Informative	DIRECT
Plant ANatomical entity (PAN)	branch	0	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.6679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.673	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3245	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	1	0.3272	--	INHERITED FROM: LP.04 four leaves visible stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || E expanded cotyledon stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || plant embryo stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: E expanded cotyledon stage || sporophyte vegetative stage || C globular stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.3205	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.301	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.3479	Least Informative	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Nitric-oxide synthase (NADPH)	0	2.531	--	DIRECT
Enzyme Commission (EC)	[Methionine synthase] reductase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Acting on NADH or NADPH	0	1.783	--	DIRECT
Enzyme Commission (EC)	With a heme protein as acceptor	0	2.327	--	DIRECT
Enzyme Commission (EC)	NADPH--hemoprotein reductase	0	2.531	--	DIRECT
Enzyme Commission (EC)	Acting on a sulfur group of donors	0	1.783	--	DIRECT
Enzyme Commission (EC)	Assimilatory sulfite reductase (NADPH)	0	2.452	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.00000000000002102	2.452	--	DIRECT
Enzyme Commission (EC)	Unspecific monooxygenase	0.00000000001044	2.628	--	DIRECT
Enzyme Commission (EC)	Oxidizing metal ions	0.00007124	2.275	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0.00000000001229	1.514	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.151	Highly Informative	DIRECT
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation of one atom of oxygen	0.00000000000000255	2.026	Highly Informative	DIRECT
Enzyme Commission (EC)	With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1	2.151	Highly Informative	INHERITED FROM: Unspecific monooxygenase

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