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  Home > SCOP hierarchy > Class I aminoacyl-tRNA synthetases (RS), catalytic domain family


Class I aminoacyl-tRNA synthetases (RS), catalytic domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Adenine nucleotide alpha hydrolase-like [ 52373] (3)
Superfamily:   Nucleotidylyl transferase [ 52374] (5)
Family:   Class I aminoacyl-tRNA synthetases (RS), catalytic domain [ 52375] (12)

Family statistics
Genomes (3,260) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 36,686 262,938 45
Proteins 36,637 262,773 45

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Methionine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.0001752Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.02776Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.041Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.06654Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3918Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.5012Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.00006529Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.0002524Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skull size0.02748Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental delay0.06569Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.07358Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.6092Moderately InformativeInherited
Phenotypic Abnormality (PA)Acidosis0.000001481InformativeDirect
Phenotypic Abnormality (PA)Abnormal liver morphology0.07426InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral subcortex0.5936InformativeInherited
Phenotypic Abnormality (PA)Hepatic steatosis0.00006111Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplasia of the corpus callosum0.0003438Highly InformativeDirect
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the cerebrum0.01892Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.3169Least InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0000004513Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00006776Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.001318Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.01104Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.05006Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.001121Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.00976Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.04806Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.07226Moderately InformativeInherited
Worm Phenotype (WP)cell cycle variant0.1586Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.4468Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.9024Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.9808Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)avoids bacterial lawn0.00000004633InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0000005893InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.0002563InformativeDirect
Worm Phenotype (WP)hermaphrodite physiology variant0.001468InformativeInherited
Worm Phenotype (WP)germ cell physiology variant0.003298InformativeInherited
Worm Phenotype (WP)endocytic transport defect0.004534InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.00621InformativeInherited
Worm Phenotype (WP)chemical resistant0.03853InformativeInherited
Worm Phenotype (WP)cell differentiation variant0.0000000000001924Highly InformativeDirect
Worm Phenotype (WP)hypoxia response variant0.0000000000003298Highly InformativeDirect
Worm Phenotype (WP)pleiotropic defects severe early emb0.000000003979Highly InformativeDirect
Worm Phenotype (WP)oocyte number decreased0.0002503Highly InformativeDirect
Worm Phenotype (WP)paraquat response variant0.0005019Highly InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.07086Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0.9321Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.0481Moderately InformativeInherited
Yeast Phenotype (YP)heat sensitivity0.0008536InformativeDirect
Yeast Phenotype (YP)respiratory metabolism0.005023InformativeInherited
Yeast Phenotype (YP)mitochondrial genome maintenance0.0003635Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)decreased cell size0.00005501Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.000037InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-oxygen bonds0InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amine) ligases (amide synthases)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.
   
Superfamily level     Family level

Alignments of sequences to 114 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Nucleotidylyl transferase domain.
   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.