Tubulin nucleotide-binding domain-like superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Tubulin nucleotide-binding domain-like [ 52489]
• Superfamily: Tubulin nucleotide-binding domain-like [ 52490]
• Families: Tubulin, GTPase domain [ 52491] (3)

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Superfamily statistics

	Genomes (3,030)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	10,893	76,293	19
Proteins	10,801	76,009	19

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Functional annotation

• General category: Processes_IC
• Detailed category: Cell motility

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	psychotic disorder	0.0008835	1.292	--	DIRECT
Disease Ontology (DO)	cognitive disorder	0.002623	1.092	--	INHERITED FROM: psychotic disorder || schizophrenia
Disease Ontology (DO)	disease of mental health	0.01653	1.009	Moderately Informative	INHERITED FROM: schizophrenia || psychotic disorder
Disease Ontology (DO)	schizophrenia	0.0008681	1.292	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
	Variable expressivity	0	0.01931	--	DIRECT
	Phenotypic variability	1	0	--	INHERITED FROM: Variable expressivity
Mode of Inheritance (MI)	Autosomal dominant inheritance	0.0000589	0.5798	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the brainstem	0.000004983	2.106	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of neuronal migration	0.0001648	1.804	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebral cortex	0.0004787	1.804	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0.057	1.009	--	INHERITED FROM: Abnormal cortical gyration || Abnormality of the cerebral cortex
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.5164	0.6284	--	INHERITED FROM: Abnormality of the cerebral cortex || Abnormality of brainstem morphology || Abnormality of neuronal migration || Aplasia/Hypoplasia of the brainstem || Abnormal cortical gyration
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.5313	0.7731	--	INHERITED FROM: Aplasia/Hypoplasia of the brainstem || Abnormality of the cerebral cortex || Abnormal cortical gyration || Abnormality of brainstem morphology
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.6189	0.2543	--	INHERITED FROM: Abnormality of the cerebral cortex || Abnormality of neuronal migration || Aplasia/Hypoplasia of the brainstem || Abnormality of brainstem morphology || Abnormal cortical gyration
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.1654	0.5677	Least Informative	INHERITED FROM: Abnormality of brainstem morphology || Abnormality of the cerebral cortex || Abnormal cortical gyration || Abnormality of neuronal migration || Aplasia/Hypoplasia of the brainstem
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia involving the central nervous system	0.03981	1.128	Moderately Informative	INHERITED FROM: Aplasia/Hypoplasia of the brainstem
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0.06181	0.9916	Moderately Informative	INHERITED FROM: Abnormal cortical gyration || Abnormality of the cerebral cortex
Phenotypic Abnormality (PA)	Abnormality of brainstem morphology	0.00001081	1.929	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal cortical gyration	0.00002925	1.804	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.7938	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6038	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	pronuclear migration defective early emb	0.0000000000003467	2.23	--	DIRECT
Worm Phenotype (WP)	transgene subcellular localization variant	0.0000000000008598	1.23	--	DIRECT
Worm Phenotype (WP)	pronuclear nuclear appearance defective early emb	0.00000000002054	2.009	--	DIRECT
Worm Phenotype (WP)	pronuclear nuclear appearance variant emb	0.00000000002054	2.009	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.00000000006412	1.074	--	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0.00000000008535	1.064	--	DIRECT
Worm Phenotype (WP)	microtubule organization biogenesis variant	0.000000003124	1.753	--	DIRECT
Worm Phenotype (WP)	vulva location variant	0.0000000343	2.407	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0.00000005751	0.7833	--	DIRECT
Worm Phenotype (WP)	embryonic polarity variant	0.0000003839	2.407	--	DIRECT
Worm Phenotype (WP)	recycling endosome localization variant	0.0000006218	1.753	--	DIRECT
Worm Phenotype (WP)	neuronal outgrowth variant	0.000003798	1.407	--	DIRECT
Worm Phenotype (WP)	embryonic cell physiology variant	0.000006175	1.628	--	DIRECT
Worm Phenotype (WP)	breaks in alae	0.00000698	2.23	--	DIRECT
Worm Phenotype (WP)	presynaptic region morphology variant	0.00001215	2.407	--	DIRECT
Worm Phenotype (WP)	locomotion variant	0.00009304	1.045	--	DIRECT
Worm Phenotype (WP)	organ system development variant	0.0001803	0.8099	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.0002005	0.632	--	DIRECT
Worm Phenotype (WP)	cuticle morphology variant	0.0002082	1.753	--	DIRECT
Worm Phenotype (WP)	nose touch variant	0.0002539	2.407	--	DIRECT
Worm Phenotype (WP)	axon morphology variant	0.0005713	1.708	--	DIRECT
Worm Phenotype (WP)	spindle assembly defective	0.0007439	2.407	--	DIRECT
Worm Phenotype (WP)	amphid phasmid neuron morphology variant	0.001082	1.862	--	INHERITED FROM: dye filling defect
Worm Phenotype (WP)	cell migration variant	0.001871	1.327	--	INHERITED FROM: distal tip cell migration variant
Worm Phenotype (WP)	spindle variant	0.005021	1.862	--	INHERITED FROM: mitotic spindle defective early emb || spindle assembly defective
Worm Phenotype (WP)	spindle defective early emb	0.005688	1.862	--	INHERITED FROM: mitotic spindle defective early emb
Worm Phenotype (WP)	copulation variant	0.006179	1.594	--	INHERITED FROM: vulva location variant || post hermaphrodite contact variant || male mating variant
Worm Phenotype (WP)	sexually dimorphic behavior variant	0.006283	1.594	--	INHERITED FROM: vulva location variant || post hermaphrodite contact variant || male mating variant
Worm Phenotype (WP)	gonad development variant	0.007503	1.407	--	INHERITED FROM: male somatic gonad development variant || male gonad development variant
Worm Phenotype (WP)	cytokinesis variant	0.01206	1.666	--	INHERITED FROM: cytokinesis variant emb
Worm Phenotype (WP)	somatic gonad morphology variant	0.02366	1.804	--	INHERITED FROM: gonad arm morphology variant
Worm Phenotype (WP)	response to bacteria variant	0.0428	1.26	--	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	endosome localization variant	0.04925	1.753	--	INHERITED FROM: RAB-11 recycling endosome localization variant || recycling endosome localization variant
Worm Phenotype (WP)	activity level variant	0.07699	1.346	--	INHERITED FROM: sluggish
Worm Phenotype (WP)	neurite morphology variant	0.09281	1.628	--	INHERITED FROM: axon morphology variant
Worm Phenotype (WP)	gonad morphology variant	0.2237	1.245	--	INHERITED FROM: gonad arm morphology variant
Worm Phenotype (WP)	organelle organization biogenesis variant	0.3618	1.23	--	INHERITED FROM: mitotic spindle defective early emb || cytoskeleton organization biogenesis variant || microtubule organization biogenesis variant || spindle assembly defective
Worm Phenotype (WP)	amphid phasmid sensillum morphology variant	0.445	1.708	--	INHERITED FROM: dye filling defect
Worm Phenotype (WP)	chemical response variant	0.5684	0.8045	--	INHERITED FROM: nicotine response variant
Worm Phenotype (WP)	cell type morphology variant	0.8286	0.8211	--	INHERITED FROM: axon morphology variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || organism metabolism processing variant || protein protein interaction variant || pronuclear nuclear appearance defective early emb || distal tip cell migration variant || reproductive system physiology variant || transgene expression variant || male mating variant || gene expression variant || early embryonic lethal || embryonic cell organization biogenesis variant || organ system development variant || organism homeostasis metabolism variant || nose touch variant || sluggish || avoids bacterial lawn || lethal || miRNA expression variant || vulva location variant || protein interaction variant || organism physiology variant || transgene subcellular localization variant || cytokinesis variant emb || embryonic cell physiology variant || mitotic spindle defective early emb || male gonad development variant || touch resistant || spindle assembly defective || development variant || pronucleus centrosomes defective early emb || exploded through vulva || pronuclear migration defective early emb || mechanosensation variant || male somatic gonad development variant || cell physiology variant || organism environmental stimulus response variant || dead eggs laid || nicotine response variant || pronuclear nuclear appearance variant emb || axon outgrowth variant || embryonic development variant || embryonic polarity variant || embryonic lethal || fertility variant || behavior variant || post hermaphrodite contact variant || protein aggregation variant || microtubule organization biogenesis variant || neuronal outgrowth variant || organ system physiology variant || organism behavior variant || mitosis variant || organism development variant || locomotion variant || fertility reduced
Worm Phenotype (WP)	male behavior variant	1	1.594	--	INHERITED FROM: male mating variant || post hermaphrodite contact variant || vulva location variant
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4572	Least Informative	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.0000006634	0.7119	Least Informative	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.0000008514	0.6905	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0.0001858	0.632	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.0003201	0.5677	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.0008904	0.5344	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.006088	0.632	Least Informative	INHERITED FROM: axon outgrowth variant || distal tip cell migration variant || neuronal outgrowth variant
Worm Phenotype (WP)	early embryonic lethal	0.0000165	1.106	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein interaction variant	0.00002785	1.035	Moderately Informative	DIRECT
Worm Phenotype (WP)	neuron development variant	0.003833	1.245	Moderately Informative	INHERITED FROM: neuronal outgrowth variant || axon outgrowth variant
Worm Phenotype (WP)	pattern of transgene expression variant	0.01362	1.017	Moderately Informative	INHERITED FROM: transgene subcellular localization variant
Worm Phenotype (WP)	cell organization biogenesis variant	0.02302	1.106	Moderately Informative	INHERITED FROM: mitotic spindle defective early emb || pronuclear migration defective early emb || pronuclear nuclear appearance variant emb || pronuclear nuclear appearance defective early emb || embryonic cell organization biogenesis variant || cytoskeleton organization biogenesis variant || microtubule organization biogenesis variant || pronucleus centrosomes defective early emb || spindle assembly defective
Worm Phenotype (WP)	nervous system morphology variant	0.04674	1.216	Moderately Informative	INHERITED FROM: dye filling defect || axon morphology variant || presynaptic region morphology variant
Worm Phenotype (WP)	movement variant	0.0769	1.026	Moderately Informative	INHERITED FROM: sluggish || locomotion variant
Worm Phenotype (WP)	drug response variant	0.08201	1.017	Moderately Informative	INHERITED FROM: nicotine response variant
Worm Phenotype (WP)	cell division variant	0.08251	1	Moderately Informative	INHERITED FROM: mitosis variant || mitotic spindle defective early emb || cytokinesis variant emb || spindle assembly defective
Worm Phenotype (WP)	feeding behavior variant	0.1367	1.176	Moderately Informative	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	reproductive system morphology variant	0.8294	1.017	Moderately Informative	INHERITED FROM: gonad arm morphology variant
Worm Phenotype (WP)	reproductive system development variant	0.9044	1.026	Moderately Informative	INHERITED FROM: male gonad development variant || male somatic gonad development variant
Worm Phenotype (WP)	cytoskeleton organization biogenesis variant	0.00000001242	1.561	Informative	DIRECT
Worm Phenotype (WP)	embryonic cell organization biogenesis variant	0.00000003618	1.628	Informative	DIRECT
Worm Phenotype (WP)	nicotine response variant	0.000000104	1.708	Informative	DIRECT
Worm Phenotype (WP)	axon outgrowth variant	0.000003112	1.407	Informative	DIRECT
Worm Phenotype (WP)	cytokinesis variant emb	0.00008709	1.666	Informative	DIRECT
Worm Phenotype (WP)	male mating variant	0.0001089	1.594	Informative	DIRECT
Worm Phenotype (WP)	mechanosensation variant	0.0001623	1.708	Informative	DIRECT
Worm Phenotype (WP)	pericellular component morphology variant	0.000345	1.666	Informative	DIRECT
Worm Phenotype (WP)	male gonad development variant	0.0003537	1.708	Informative	DIRECT
Worm Phenotype (WP)	avoids bacterial lawn	0.0004853	1.327	Informative	DIRECT
Worm Phenotype (WP)	mitosis variant	0.0006027	1.708	Informative	DIRECT
Worm Phenotype (WP)	cell component localization variant	0.003445	1.365	Informative	INHERITED FROM: recycling endosome localization variant || RAB-11 recycling endosome localization variant
Worm Phenotype (WP)	somatic gonad development variant	0.003884	1.531	Informative	INHERITED FROM: male somatic gonad development variant
Worm Phenotype (WP)	neuron morphology variant	0.004657	1.594	Informative	INHERITED FROM: axon morphology variant
Worm Phenotype (WP)	epithelial system development variant	0.04874	1.561	Informative	INHERITED FROM: exploded through vulva
Worm Phenotype (WP)	RNA expression variant	0.2578	1.407	Informative	INHERITED FROM: miRNA expression variant
Worm Phenotype (WP)	sensillum morphology variant	0.5786	1.477	Informative	INHERITED FROM: dye filling defect
Worm Phenotype (WP)	egg laying variant	0.6171	1.452	Informative	INHERITED FROM: dead eggs laid
Worm Phenotype (WP)	locomotion reduced	0.663	1.452	Informative	INHERITED FROM: sluggish
Worm Phenotype (WP)	pronucleus centrosomes defective early emb	0.00000000001367	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	touch resistant	0.000000001954	2.23	Highly Informative	DIRECT
Worm Phenotype (WP)	distal tip cell migration variant	0.00000000269	2.23	Highly Informative	DIRECT
Worm Phenotype (WP)	RAB-11 recycling endosome localization variant	0.0000006011	1.753	Highly Informative	DIRECT
Worm Phenotype (WP)	post hermaphrodite contact variant	0.0000006443	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	mitotic spindle defective early emb	0.0000008642	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	dead eggs laid	0.00001418	2.23	Highly Informative	DIRECT
Worm Phenotype (WP)	sluggish	0.00002089	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	miRNA expression variant	0.0000251	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	alae morphology variant	0.00004075	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	exploded through vulva	0.00008135	1.753	Highly Informative	DIRECT
Worm Phenotype (WP)	male somatic gonad development variant	0.0002367	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	gonad arm morphology variant	0.0004042	1.804	Highly Informative	DIRECT
Worm Phenotype (WP)	dye filling defect	0.000812	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	synapse morphology variant	0.006688	1.929	Highly Informative	INHERITED FROM: presynaptic region morphology variant

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.2018	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5905	Least Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0.5552	0.05522	--	INHERITED FROM: cell cycle defective
Fly Phenotype (FP)	fertile	0.07092	0.981	Moderately Informative	INHERITED FROM: male fertile
Fly Phenotype (FP)	wild-type	0.0002104	1.525	Informative	DIRECT
Fly Phenotype (FP)	cell cycle defective	0.0002723	1.604	Informative	DIRECT
Fly Phenotype (FP)	male fertile	0.000004319	1.826	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	spermatid cyst	0.0000534	2.079	--	DIRECT
Fly Anatomy (FA)	reproductive system	0.003375	1.101	--	INHERITED FROM: spermatid || spermatid cyst
Fly Anatomy (FA)	germline cyst	0.006025	1.339	--	INHERITED FROM: spermatid || spermatid cyst
Fly Anatomy (FA)	male organism	0.00705	1.535	--	INHERITED FROM: spermatid cyst || spermatid
Fly Anatomy (FA)	male germline cyst	0.02715	2.079	--	INHERITED FROM: spermatid cyst || spermatid
Fly Anatomy (FA)	adipose system	0.03848	1.681	--	INHERITED FROM: fat cell
Fly Anatomy (FA)	male germline cell	0.06052	1.903	--	INHERITED FROM: spermatid
Fly Anatomy (FA)	developing material anatomical entity	0.06149	0.8487	--	INHERITED FROM: type II neuroblast || type I neuroblast
Fly Anatomy (FA)	testis	0.07246	1.602	--	INHERITED FROM: spermatid cyst || spermatid
Fly Anatomy (FA)	male reproductive system	0.07693	1.602	--	INHERITED FROM: spermatid || spermatid cyst
Fly Anatomy (FA)	somatic stem cell	0.2976	1.339	--	INHERITED FROM: type II neuroblast || type I neuroblast
Fly Anatomy (FA)	organ system	0.4397	0.2279	--	INHERITED FROM: spermatid cyst || fat cell || spermatid
Fly Anatomy (FA)	portion of tissue	0.7015	0.7782	--	INHERITED FROM: fat cell
Fly Anatomy (FA)	organism	0.7881	0.07918	--	INHERITED FROM: spermatid cyst || spermatid || fat cell
Fly Anatomy (FA)	multicellular structure	0.9336	0.009143	--	INHERITED FROM: spermatid || fat cell || spermatid cyst
Fly Anatomy (FA)	somatic cell	0.9533	0.5607	--	INHERITED FROM: type II neuroblast || fat cell || type I neuroblast
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: type II neuroblast || cell || fat cell || spermatid || type I neuroblast || spermatid cyst
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: spermatid cyst || type I neuroblast || fat cell || spermatid || cell || type II neuroblast
Fly Anatomy (FA)	cell	0	0.4937	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0.03451	0.7081	Least Informative	INHERITED FROM: spermatid || spermatid cyst
Fly Anatomy (FA)	gonad	0.002821	1.101	Moderately Informative	INHERITED FROM: spermatid || spermatid cyst
Fly Anatomy (FA)	somatic precursor cell	0.03199	1.079	Moderately Informative	INHERITED FROM: type II neuroblast || type I neuroblast
Fly Anatomy (FA)	stem cell	0.1804	1.204	Moderately Informative	INHERITED FROM: type I neuroblast || type II neuroblast
Fly Anatomy (FA)	germline cell	0.003592	1.38	Informative	INHERITED FROM: spermatid
Fly Anatomy (FA)	male-specific anatomical entity	0.00705	1.535	Informative	INHERITED FROM: spermatid || spermatid cyst
Fly Anatomy (FA)	neuroblast	0.03067	1.426	Informative	INHERITED FROM: type I neuroblast || type II neuroblast
Fly Anatomy (FA)	fat body	0.03848	1.681	Informative	INHERITED FROM: fat cell
Fly Anatomy (FA)	fat cell	0.000006377	1.903	Highly Informative	DIRECT
Fly Anatomy (FA)	spermatid	0.0000403	2.079	Highly Informative	DIRECT
Fly Anatomy (FA)	type I neuroblast	0.0001141	1.903	Highly Informative	DIRECT
Fly Anatomy (FA)	type II neuroblast	0.0003795	1.903	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.2245	--	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5472	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || sensory system || anatomical group || whole organism || organism subdivision || compound organ || cavitated compound organ || nervous system
Zebrafish Anatomy (ZA)	nervous system	0	0.6911	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	compound organ	0	0.4571	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	organism subdivision	0	0.6264	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	sensory system	0	1.097	Moderately Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	ciliated cell	0.0000000000000571	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	epidermal cell	0.000000000000134	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	epidermis	0.000005113	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	vagus nerve	0.00002423	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	glossopharyngeal nerve	0.00006717	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	intersomitic neuron	0.00007552	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	facial nerve	0.0000847	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	gastrocoel roof plate	0.0001147	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	non-neural ectoderm	0.0001301	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	spinal neuron	0.0002069	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	trigeminal nerve	0.0002239	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	nerve	0.005081	1.916	--	INHERITED FROM: facial nerve || trigeminal nerve || glossopharyngeal nerve || vagus nerve
Xenopus ANatomical entity (XAN)	cephalic nerve	0.005425	1.916	--	INHERITED FROM: facial nerve || trigeminal nerve || glossopharyngeal nerve || vagus nerve
Xenopus ANatomical entity (XAN)	cell	0.00672	0.7974	--	INHERITED FROM: epidermal cell || epithelial cell || spinal neuron || cell part || intersomitic neuron || ciliated cell || neuron
Xenopus ANatomical entity (XAN)	central nervous system	0.02779	0.6506	--	INHERITED FROM: spinal neuron
Xenopus ANatomical entity (XAN)	skin	0.0461	1.72	--	INHERITED FROM: epidermal cell || epidermis
Xenopus ANatomical entity (XAN)	primary germ layer	0.09272	0.7237	--	INHERITED FROM: epidermal cell || non-neural ectoderm || gastrocoel roof plate || epidermis
Xenopus ANatomical entity (XAN)	compound organ	0.2949	0.24	--	INHERITED FROM: spinal neuron
Xenopus ANatomical entity (XAN)	head region	0.305	0.5108	--	INHERITED FROM: glossopharyngeal nerve || facial nerve || vagus nerve || trigeminal nerve
Xenopus ANatomical entity (XAN)	anatomical region	0.4128	0.193	--	INHERITED FROM: intersomitic neuron || glossopharyngeal nerve || trigeminal nerve || facial nerve || vagus nerve || vegetal hemisphere
Xenopus ANatomical entity (XAN)	organism subdivision	0.4773	0.1871	--	INHERITED FROM: epidermis || glossopharyngeal nerve || trigeminal nerve || facial nerve || vagus nerve || epidermal cell
Xenopus ANatomical entity (XAN)	anatomical group	0.5343	0.1442	--	INHERITED FROM: epidermal cell || trigeminal nerve || spinal neuron || facial nerve || vagus nerve || neuron || glossopharyngeal nerve || dermal system || epidermis || intersomitic neuron
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.673	0.1217	--	INHERITED FROM: trigeminal nerve || epidermal cell || gastrocoel roof plate || epithelial cell || spinal neuron || vagus nerve || facial nerve || multi-tissue structure || glossopharyngeal nerve || non-neural ectoderm || epidermis || epithelium
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: epidermal cell || trigeminal nerve || spinal neuron || facial nerve || vagus nerve || glossopharyngeal nerve || neuron || dermal system || epidermis || intersomitic neuron
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: gastrocoel roof plate || epithelial cell || spinal neuron || ciliated cell || cell part || trigeminal nerve || epidermal cell || vegetal hemisphere || epidermis || dermal system || epithelium || intersomitic neuron || vagus nerve || facial nerve || multi-tissue structure || glossopharyngeal nerve || neuron || non-neural ectoderm
Xenopus ANatomical entity (XAN)	nervous system	0.0306	0.6341	Least Informative	INHERITED FROM: intersomitic neuron || glossopharyngeal nerve || neuron || vagus nerve || facial nerve || spinal neuron || trigeminal nerve
Xenopus ANatomical entity (XAN)	embryo	0.1348	0.6341	Least Informative	INHERITED FROM: vegetal hemisphere || epidermal cell || epidermis || gastrocoel roof plate || non-neural ectoderm
Xenopus ANatomical entity (XAN)	tissue	0.2599	0.5011	Least Informative	INHERITED FROM: epidermis || epithelial cell || gastrocoel roof plate || epithelium || trigeminal nerve || facial nerve || vagus nerve || epidermal cell || glossopharyngeal nerve || non-neural ectoderm
Xenopus ANatomical entity (XAN)	head	0.2753	0.5108	Least Informative	INHERITED FROM: facial nerve || vagus nerve || trigeminal nerve || glossopharyngeal nerve
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.7799	0.3033	Least Informative	INHERITED FROM: spinal neuron
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.00004642	1.071	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0.01048	0.9688	Moderately Informative	INHERITED FROM: epidermis || non-neural ectoderm || epidermal cell
Xenopus ANatomical entity (XAN)	sensory system	0.04522	1.17	Moderately Informative	INHERITED FROM: glossopharyngeal nerve || vagus nerve || facial nerve
Xenopus ANatomical entity (XAN)	epithelium	0.000001176	1.615	Informative	DIRECT
Xenopus ANatomical entity (XAN)	dermal system	0.0001633	1.647	Informative	DIRECT
Xenopus ANatomical entity (XAN)	surface structure	0.001213	1.419	Informative	INHERITED FROM: epidermal cell || epidermis
Xenopus ANatomical entity (XAN)	peripheral nervous system	0.07834	1.682	Informative	INHERITED FROM: glossopharyngeal nerve || trigeminal nerve || facial nerve || vagus nerve
Xenopus ANatomical entity (XAN)	anatomical space	0.1238	1.482	Informative	INHERITED FROM: gastrocoel roof plate
Xenopus ANatomical entity (XAN)	endoderm	0.141	1.615	Informative	INHERITED FROM: gastrocoel roof plate
Xenopus ANatomical entity (XAN)	spinal cord	0.1968	1.506	Informative	INHERITED FROM: spinal neuron
Xenopus ANatomical entity (XAN)	cell part	0.00000000000001081	2.062	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	epithelial cell	0.0000000001045	2.159	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	neuron	0.000000002385	1.761	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	vegetal hemisphere	0.0001975	2.062	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	gustatory system	0.001214	1.983	Highly Informative	INHERITED FROM: vagus nerve || glossopharyngeal nerve || facial nerve
Xenopus ANatomical entity (XAN)	archenteron	0.001738	2.062	Highly Informative	INHERITED FROM: gastrocoel roof plate
Xenopus ANatomical entity (XAN)	intersomitic region	0.01107	1.983	Highly Informative	INHERITED FROM: intersomitic neuron
Xenopus ANatomical entity (XAN)	cranial nerve	1	1.983	Highly Informative	INHERITED FROM: vagus nerve || glossopharyngeal nerve || trigeminal nerve || facial nerve
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	vascular system	0.005347	1.372	--	INHERITED FROM: portion of vascular tissue
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || portion of vascular tissue || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	whole plant	0.1936	0.4218	Least Informative	INHERITED FROM: portion of vascular tissue
Plant ANatomical entity (PAN)	portion of vascular tissue	0.0006374	1.594	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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InterPro annotation

• Cross references: IPR003008 SSF52490 Protein matches
• Abstract:

  This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.

InterPro database

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