RecA protein-like (ATPase-domain) family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: P-loop containing nucleoside triphosphate hydrolases [ 52539]
• Superfamily: P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
• Family: RecA protein-like (ATPase-domain) [ 52670] (17)

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Family statistics

	Genomes (3,253)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	22,810	220,760	43
Proteins	22,637	219,710	41

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	H(+)-transporting two-sector ATPase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0	0.7283	Least Informative	DIRECT
Enzyme Commission (EC)	In phosphorous-containing anhydrides	1	1.098	Moderately Informative	INHERITED FROM: Nucleoside-triphosphatase
Enzyme Commission (EC)	Nucleoside-triphosphatase	0	1.595	Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides; catalyzing transmembran	0	1.662	Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	autosomal dominant disease	0.0001712	1.399	--	DIRECT
Disease Ontology (DO)	autosomal genetic disease	0.002562	1.133	--	INHERITED FROM: hereditary breast ovarian cancer syndrome || autosomal dominant disease
Disease Ontology (DO)	monogenic disease	0.00315	1.115	--	INHERITED FROM: autosomal dominant disease || hereditary breast ovarian cancer syndrome
Disease Ontology (DO)	genetic disease	0.005723	1.066	Moderately Informative	INHERITED FROM: hereditary breast ovarian cancer syndrome || autosomal dominant disease
Disease Ontology (DO)	hereditary breast ovarian cancer syndrome	0.00002391	1.513	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Triphalangeal thumb	0.0000004875	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Pyridoxine-responsive sideroblastic anemia	0.000000504	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Absent testis	0.000000504	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Primary peritoneal carcinoma	0.000001018	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Small intestinal stenosis	0.000001382	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Duodenal stenosis	0.000001382	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Clubbing of toes	0.000003069	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Sideroblastic anemia	0.0000048	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Bicornuate uterus	0.00001436	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the preputium	0.00001854	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal prostate morphology	0.0000369	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Meckel diverticulum	0.00007058	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Hypoplasia of the ulna	0.00007058	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Multiple cafe-au-lait spots	0.00007058	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal ileum morphology	0.0000938	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Dolichocephaly	0.00009686	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Neoplasm of the breast	0.00009876	1.985	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of thumb phalanx	0.0001016	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal carotid artery morphology	0.0001025	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the ulna	0.0001025	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the duodenum	0.0001212	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Myelodysplasia	0.0001427	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Tracheoesophageal fistula	0.0001539	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Forearm undergrowth	0.0001539	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal shape of the palpebral fissure	0.0001801	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal forearm bone morphology	0.0002689	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Toe syndactyly	0.0003128	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the autonomic nervous system	0.0003128	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Arteriovenous malformation	0.0003157	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the peripheral nervous system	0.0003238	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Recurrent urinary tract infections	0.0003432	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the radius	0.0003432	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Oligohydramnios	0.0003644	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of chromosome stability	0.000365	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the fallopian tube	0.000385	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal ureter morphology	0.0005083	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Clubbing	0.0005124	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Hip dislocation	0.0006149	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia affecting the anterior segment of the eye	0.0007507	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal uterus morphology	0.0007507	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Anal atresia	0.0007863	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal spermatogenesis	0.0008564	1.985	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal morphology of ulna	0.0008643	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Cardiomyopathy	0.0009594	1.559	--	DIRECT
Phenotypic Abnormality (PA)	Lower extremity joint dislocation	0.001236	1.617	--	INHERITED FROM: Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of male internal genitalia	0.001588	2.161	--	INHERITED FROM: Abnormal prostate morphology || Prostate neoplasm
Phenotypic Abnormality (PA)	Abnormality of the synovia	0.001726	1.508	--	INHERITED FROM: Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of the choanae	0.001741	2.161	--	INHERITED FROM: Choanal atresia
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the testes	0.002505	2.462	--	INHERITED FROM: Absent testis
Phenotypic Abnormality (PA)	Functional abnormality of male internal genitalia	0.002654	1.985	--	INHERITED FROM: Azoospermia || Abnormal spermatogenesis
Phenotypic Abnormality (PA)	Abnormality of female internal genitalia	0.003212	1.258	--	INHERITED FROM: Abnormality of the fallopian tube || Abnormal uterus morphology || Bicornuate uterus
Phenotypic Abnormality (PA)	Abnormal breast morphology	0.003876	1.763	--	INHERITED FROM: Breast carcinoma || Neoplasm of the breast
Phenotypic Abnormality (PA)	Abnormality of the breast	0.004013	1.763	--	INHERITED FROM: Breast carcinoma || Neoplasm of the breast
Phenotypic Abnormality (PA)	Upper limb undergrowth	0.004217	2.462	--	INHERITED FROM: Hypoplasia of the ulna || Forearm undergrowth
Phenotypic Abnormality (PA)	Abnormal soft palate morphology	0.005079	2.161	--	INHERITED FROM: Abnormality of the uvula
Phenotypic Abnormality (PA)	Abnormality of forearm bone	0.005455	1.86	--	INHERITED FROM: Forearm undergrowth || Aplasia/Hypoplasia of the radius || Aplasia/Hypoplasia of the ulna || Hypoplasia of the ulna || Abnormal forearm bone morphology || Abnormal morphology of ulna
Phenotypic Abnormality (PA)	Abnormality of the hip bone	0.007328	1.508	--	INHERITED FROM: Hip dislocation
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving forearm bones	0.009181	2.462	--	INHERITED FROM: Forearm undergrowth || Aplasia/Hypoplasia of the ulna || Aplasia/Hypoplasia of the radius || Hypoplasia of the ulna
Phenotypic Abnormality (PA)	Abnormal tracheobronchial morphology	0.01058	1.763	--	INHERITED FROM: Tracheoesophageal fistula
Phenotypic Abnormality (PA)	Abnormal cellular phenotype	0.01083	1.462	--	INHERITED FROM: Abnormality of chromosome stability
Phenotypic Abnormality (PA)	Abnormality of the testis size	0.01312	2.462	--	INHERITED FROM: Absent testis
Phenotypic Abnormality (PA)	Abnormality of the ureter	0.01421	1.763	--	INHERITED FROM: Hydroureter || Abnormal ureter morphology
Phenotypic Abnormality (PA)	Abnormality of the forearm	0.01634	1.86	--	INHERITED FROM: Forearm undergrowth || Abnormal morphology of ulna || Aplasia/Hypoplasia of the ulna || Aplasia/Hypoplasia of the radius || Hypoplasia of the ulna || Abnormal forearm bone morphology
Phenotypic Abnormality (PA)	Abnormality of the foot	0.01856	1.082	--	INHERITED FROM: Toe syndactyly || Clubbing of toes
Phenotypic Abnormality (PA)	Abnormality of pelvic girdle bone morphology	0.02311	1.462	--	INHERITED FROM: Hip dislocation
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the upper limbs	0.02552	1.559	--	INHERITED FROM: Forearm undergrowth || Hypoplasia of the ulna || Aplasia/Hypoplasia of the radius || Aplasia/Hypoplasia of the ulna
Phenotypic Abnormality (PA)	Abnormality of the calvaria	0.0304	1.286	--	INHERITED FROM: Dolichocephaly
Phenotypic Abnormality (PA)	Short long bone	0.03576	2.462	--	INHERITED FROM: Forearm undergrowth || Hypoplasia of the ulna
Phenotypic Abnormality (PA)	Aplasia/hypoplasia of the extremities	0.04309	1.462	--	INHERITED FROM: Aplasia/Hypoplasia of the radius || Aplasia/Hypoplasia of the ulna || Forearm undergrowth || Hypoplasia of the ulna
Phenotypic Abnormality (PA)	Limb undergrowth	0.04514	2.462	--	INHERITED FROM: Forearm undergrowth || Hypoplasia of the ulna
Phenotypic Abnormality (PA)	Abnormal eyelid morphology	0.04653	1.232	--	INHERITED FROM: Abnormal shape of the palpebral fissure
Phenotypic Abnormality (PA)	Neoplasm of the gastrointestinal tract	0.05149	1.763	--	INHERITED FROM: Primary peritoneal carcinoma
Phenotypic Abnormality (PA)	Abnormality of lower limb joint	0.05734	1.348	--	INHERITED FROM: Hip dislocation
Phenotypic Abnormality (PA)	Abnormal male reproductive system physiology	0.05894	1.985	--	INHERITED FROM: Azoospermia || Abnormal spermatogenesis
Phenotypic Abnormality (PA)	Abnormal testis morphology	0.06581	1.559	--	INHERITED FROM: Absent testis
Phenotypic Abnormality (PA)	Abnormal upper limb bone morphology	0.06649	1.86	--	INHERITED FROM: Abnormal morphology of ulna || Abnormal forearm bone morphology || Aplasia/Hypoplasia of the ulna || Aplasia/Hypoplasia of the radius || Forearm undergrowth || Hypoplasia of the ulna
Phenotypic Abnormality (PA)	Abnormality of the genital system	0.0685	0.9309	--	INHERITED FROM: Abnormality of the preputium || Decreased fertility in males || Abnormal uterus morphology || Abnormal prostate morphology || Abnormality of the fallopian tube || Bicornuate uterus || Prostate neoplasm || Absent testis || Abnormal spermatogenesis || Azoospermia
Phenotypic Abnormality (PA)	Decreased fertility	0.07008	2.161	--	INHERITED FROM: Decreased fertility in males
Phenotypic Abnormality (PA)	Abnormality of the ocular adnexa	0.08291	1.082	--	INHERITED FROM: Abnormal shape of the palpebral fissure
Phenotypic Abnormality (PA)	Abnormality of the orbital region	0.09038	1.082	--	INHERITED FROM: Abnormal shape of the palpebral fissure
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system morphology	0.09661	0.8391	--	INHERITED FROM: Cardiomyopathy || Abnormal carotid artery morphology || Arteriovenous malformation
Phenotypic Abnormality (PA)	Abnormality of finger	0.1012	1.258	--	INHERITED FROM: Abnormality of thumb phalanx || Triphalangeal thumb || Triangular shaped phalanges of the hand
Phenotypic Abnormality (PA)	Abnormal internal genitalia	0.1171	1.232	--	INHERITED FROM: Prostate neoplasm || Abnormality of the fallopian tube || Bicornuate uterus || Abnormal prostate morphology || Abnormal uterus morphology
Phenotypic Abnormality (PA)	Abnormality of the female genitalia	0.124	1.207	--	INHERITED FROM: Abnormality of the fallopian tube || Bicornuate uterus || Abnormal uterus morphology
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.1263	0.7381	--	INHERITED FROM: Abnormality of the uvula || High palate
Phenotypic Abnormality (PA)	Abnormal erythrocyte morphology	0.1336	1.684	--	INHERITED FROM: Sideroblastic anemia || Pyridoxine-responsive sideroblastic anemia
Phenotypic Abnormality (PA)	Abnormal skull morphology	0.1467	0.8826	--	INHERITED FROM: Dolichocephaly
Phenotypic Abnormality (PA)	Unusual infection	0.1512	1.184	--	INHERITED FROM: Recurrent urinary tract infections
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.1527	0.7142	--	INHERITED FROM: Abnormal carotid artery morphology || Arteriovenous malformation
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving the skeleton	0.1576	1.383	--	INHERITED FROM: Hypoplasia of the ulna || Forearm undergrowth || Aplasia/Hypoplasia of the ulna || Aplasia/Hypoplasia of the radius
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.1591	0.7065	--	INHERITED FROM: High palate || Abnormality of the uvula
Phenotypic Abnormality (PA)	Abnormal digit morphology	0.1732	1.14	--	INHERITED FROM: Clubbing || Toe syndactyly || Abnormality of thumb phalanx || Triphalangeal thumb || Triangular shaped phalanges of the hand || Clubbing of toes
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.1973	0.8289	--	INHERITED FROM: Abnormal forearm bone morphology || Triangular shaped phalanges of the hand || Aplasia/Hypoplasia of the radius || Forearm undergrowth || Hypoplasia of the ulna || Toe syndactyly || Aplasia/Hypoplasia of the ulna || Clubbing of toes || Abnormal morphology of ulna || Triphalangeal thumb || Abnormality of thumb phalanx || Hip dislocation || Clubbing
Phenotypic Abnormality (PA)	Abnormality of the respiratory system	0.2006	0.9183	--	INHERITED FROM: Tracheoesophageal fistula
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.2286	0.9183	--	INHERITED FROM: Aplasia/Hypoplasia of the ulna || Hypoplasia of the ulna || Aplasia/Hypoplasia of the radius || Forearm undergrowth || Abnormality of thumb phalanx || Abnormal morphology of ulna || Triphalangeal thumb || Triangular shaped phalanges of the hand || Abnormal forearm bone morphology
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.2673	0.7722	--	INHERITED FROM: Hyperpigmentation of the skin || Multiple cafe-au-lait spots
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.2829	0.4712	--	INHERITED FROM: Forearm undergrowth || Aplasia/Hypoplasia of the radius || Aplasia/Hypoplasia of the ulna || Toe syndactyly || Hypoplasia of the ulna || Abnormal forearm bone morphology || Triangular shaped phalanges of the hand || Abnormality of thumb phalanx || Hip dislocation || Clubbing || Dolichocephaly || Clubbing of toes || Triphalangeal thumb || Abnormal morphology of ulna
Phenotypic Abnormality (PA)	Abnormality of limb bone	0.2883	0.9572	--	INHERITED FROM: Clubbing || Abnormality of thumb phalanx || Abnormal morphology of ulna || Triphalangeal thumb || Clubbing of toes || Aplasia/Hypoplasia of the ulna || Hypoplasia of the ulna || Toe syndactyly || Aplasia/Hypoplasia of the radius || Forearm undergrowth || Triangular shaped phalanges of the hand || Abnormal forearm bone morphology
Phenotypic Abnormality (PA)	Morphological abnormality of the gastrointestinal tract	0.2927	1.184	--	INHERITED FROM: Small intestinal stenosis || Anal atresia || Abnormal ileum morphology || Abnormality of the duodenum || Tracheoesophageal fistula || Duodenal stenosis || Meckel diverticulum
Phenotypic Abnormality (PA)	Abnormal eye morphology	0.2946	0.7812	--	INHERITED FROM: Aplasia/Hypoplasia affecting the anterior segment of the eye
Phenotypic Abnormality (PA)	Abnormality of the head	0.3	0.4538	--	INHERITED FROM: Abnormal shape of the palpebral fissure || High palate || Dolichocephaly || Abnormality of the uvula || Choanal atresia
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.3093	0.4454	--	INHERITED FROM: Abnormal shape of the palpebral fissure || Dolichocephaly || High palate || Abnormality of the uvula || Choanal atresia
Phenotypic Abnormality (PA)	Abnormality of the skin	0.3311	0.722	--	INHERITED FROM: Hyperpigmentation of the skin || Multiple cafe-au-lait spots
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.4048	0.6771	--	INHERITED FROM: Dolichocephaly
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.633	0.2371	--	INHERITED FROM: Abnormality of the autonomic nervous system || Abnormality of the peripheral nervous system
Phenotypic Abnormality (PA)	Abnormal external genitalia	0.6532	1.421	--	INHERITED FROM: Abnormality of the preputium || Absent testis
Phenotypic Abnormality (PA)	Abnormality of the male genitalia	0.6706	1.421	--	INHERITED FROM: Prostate neoplasm || Absent testis || Abnormality of the preputium || Abnormal prostate morphology
Phenotypic Abnormality (PA)	Abnormality of the urinary system	0.7765	0.8496	--	INHERITED FROM: Recurrent urinary tract infections || Hydroureter || Abnormal ureter morphology
Phenotypic Abnormality (PA)	Neoplasm by anatomical site	0.8164	1.184	--	INHERITED FROM: Neoplasm of the breast || Myelodysplasia || Breast carcinoma || Primary peritoneal carcinoma
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.03804	0.6051	Least Informative	INHERITED FROM: Bicornuate uterus || Prostate neoplasm || Recurrent urinary tract infections || Azoospermia || Decreased fertility in males || Absent testis || Abnormal spermatogenesis || Abnormal ureter morphology || Abnormality of the preputium || Abnormal uterus morphology || Abnormal prostate morphology || Hydroureter || Abnormality of the fallopian tube
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.1203	0.5486	Least Informative	INHERITED FROM: Abnormality of chromosome stability
Phenotypic Abnormality (PA)	Abnormality of limbs	0.1384	0.6429	Least Informative	INHERITED FROM: Toe syndactyly || Hypoplasia of the ulna || Aplasia/Hypoplasia of the ulna || Forearm undergrowth || Aplasia/Hypoplasia of the radius || Triangular shaped phalanges of the hand || Abnormal forearm bone morphology || Hip dislocation || Clubbing || Abnormality of thumb phalanx || Triphalangeal thumb || Abnormal morphology of ulna || Clubbing of toes
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.1431	0.5179	Least Informative	INHERITED FROM: Cardiomyopathy || Abnormal carotid artery morphology || Arteriovenous malformation
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.1912	0.5759	Least Informative	INHERITED FROM: Primary peritoneal carcinoma || Tracheoesophageal fistula || Duodenal stenosis || Anal atresia || Abnormality of the duodenum || Meckel diverticulum || Small intestinal stenosis || Abnormal ileum morphology
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.2423	0.513	Least Informative	INHERITED FROM: Clubbing of toes || Abnormal morphology of ulna || Triphalangeal thumb || Abnormality of thumb phalanx || Dolichocephaly || Clubbing || Hip dislocation || Abnormal forearm bone morphology || Triangular shaped phalanges of the hand || Aplasia/Hypoplasia of the radius || Forearm undergrowth || Aplasia/Hypoplasia of the ulna || Hypoplasia of the ulna || Toe syndactyly
Phenotypic Abnormality (PA)	Abnormality of the eye	0.245	0.5703	Least Informative	INHERITED FROM: Aplasia/Hypoplasia affecting the anterior segment of the eye
Phenotypic Abnormality (PA)	Abnormality of the immune system	0.4324	0.7464	Least Informative	INHERITED FROM: Recurrent urinary tract infections
Phenotypic Abnormality (PA)	Abnormality of the integument	0.5142	0.6235	Least Informative	INHERITED FROM: Multiple cafe-au-lait spots || Hyperpigmentation of the skin
Phenotypic Abnormality (PA)	Abnormality of the face	0.6524	0.533	Least Informative	INHERITED FROM: Abnormality of the uvula || Abnormal shape of the palpebral fissure || Choanal atresia || High palate
Phenotypic Abnormality (PA)	Abnormal reproductive system morphology	0.005807	1.031	Moderately Informative	INHERITED FROM: Abnormality of the preputium || Abnormal prostate morphology || Abnormal uterus morphology || Abnormality of the fallopian tube || Bicornuate uterus || Prostate neoplasm || Absent testis
Phenotypic Abnormality (PA)	Neoplasm	0.006439	1.14	Moderately Informative	INHERITED FROM: Neoplasm of the breast || Myelodysplasia || Breast carcinoma || Primary peritoneal carcinoma
Phenotypic Abnormality (PA)	Abnormal anterior eye segment morphology	0.01428	1.12	Moderately Informative	INHERITED FROM: Aplasia/Hypoplasia affecting the anterior segment of the eye
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.04132	0.9309	Moderately Informative	INHERITED FROM: Toe syndactyly || Hip dislocation || Clubbing of toes
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.06784	1.031	Moderately Informative	INHERITED FROM: Meckel diverticulum || Anal atresia || Abnormal ileum morphology || Abnormality of the duodenum || Tracheoesophageal fistula || Duodenal stenosis || Small intestinal stenosis || Primary peritoneal carcinoma
Phenotypic Abnormality (PA)	Localized skin lesion	0.07499	1.161	Moderately Informative	INHERITED FROM: Multiple cafe-au-lait spots
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0.07845	1.082	Moderately Informative	INHERITED FROM: Abnormal shape of the palpebral fissure
Phenotypic Abnormality (PA)	Abnormality of digestive system morphology	0.0827	1.184	Moderately Informative	INHERITED FROM: Anal atresia || Abnormal ileum morphology || Small intestinal stenosis || Abnormality of the duodenum || Tracheoesophageal fistula || Duodenal stenosis || Meckel diverticulum
Phenotypic Abnormality (PA)	Abnormality of the urinary system physiology	0.1388	1.047	Moderately Informative	INHERITED FROM: Recurrent urinary tract infections
Phenotypic Abnormality (PA)	Abnormal vascular morphology	0.1418	1.207	Moderately Informative	INHERITED FROM: Abnormal carotid artery morphology || Arteriovenous malformation
Phenotypic Abnormality (PA)	Abnormal joint morphology	0.1703	1.101	Moderately Informative	INHERITED FROM: Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.2319	0.9183	Moderately Informative	INHERITED FROM: Sideroblastic anemia || Pyridoxine-responsive sideroblastic anemia || Myelodysplasia
Phenotypic Abnormality (PA)	Abnormal respiratory system morphology	0.233	1.064	Moderately Informative	INHERITED FROM: Tracheoesophageal fistula
Phenotypic Abnormality (PA)	Abnormality of the upper urinary tract	0.2643	1.12	Moderately Informative	INHERITED FROM: Hydroureter || Abnormal ureter morphology
Phenotypic Abnormality (PA)	Abnormal heart morphology	0.3741	0.9183	Moderately Informative	INHERITED FROM: Cardiomyopathy
Phenotypic Abnormality (PA)	Abnormality of immune system physiology	0.5144	0.8942	Moderately Informative	INHERITED FROM: Recurrent urinary tract infections
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0.7493	0.9572	Moderately Informative	INHERITED FROM: Forearm undergrowth || Aplasia/Hypoplasia of the radius || Aplasia/Hypoplasia of the ulna || Toe syndactyly || Hypoplasia of the ulna || Abnormal forearm bone morphology || Triangular shaped phalanges of the hand || Abnormality of thumb phalanx || Clubbing || Clubbing of toes || Triphalangeal thumb || Abnormal morphology of ulna
Phenotypic Abnormality (PA)	Abnormality of the hand	0.7754	1.031	Moderately Informative	INHERITED FROM: Triangular shaped phalanges of the hand || Triphalangeal thumb || Abnormality of thumb phalanx
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.8289	Moderately Informative	INHERITED FROM: High palate || Abnormality of the uvula
Phenotypic Abnormality (PA)	Abnormal myocardium morphology	0.001368	1.508	Informative	INHERITED FROM: Cardiomyopathy
Phenotypic Abnormality (PA)	Abnormality of the hip joint	0.001516	1.508	Informative	INHERITED FROM: Hip dislocation
Phenotypic Abnormality (PA)	Joint dislocation	0.00415	1.508	Informative	INHERITED FROM: Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of the palpebral fissures	0.006591	1.559	Informative	INHERITED FROM: Abnormal shape of the palpebral fissure
Phenotypic Abnormality (PA)	Abnormal palate morphology	0.006612	1.348	Informative	INHERITED FROM: Abnormality of the uvula || High palate
Phenotypic Abnormality (PA)	Abnormality of skin pigmentation	0.007817	1.559	Informative	INHERITED FROM: Hyperpigmentation of the skin
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the extremities	0.01898	1.508	Informative	INHERITED FROM: Aplasia/Hypoplasia of the radius || Aplasia/Hypoplasia of the ulna || Forearm undergrowth || Hypoplasia of the ulna
Phenotypic Abnormality (PA)	Abnormal finger phalanx morphology	0.02001	1.508	Informative	INHERITED FROM: Triphalangeal thumb || Triangular shaped phalanges of the hand || Abnormality of thumb phalanx
Phenotypic Abnormality (PA)	Abnormal cellular physiology	0.02404	1.462	Informative	INHERITED FROM: Abnormality of chromosome stability
Phenotypic Abnormality (PA)	Abnormality of long bone morphology	0.03699	1.462	Informative	INHERITED FROM: Forearm undergrowth || Hypoplasia of the ulna || Abnormal morphology of ulna
Phenotypic Abnormality (PA)	Anorectal anomaly	0.04846	1.684	Informative	INHERITED FROM: Anal atresia
Phenotypic Abnormality (PA)	Abnormality of prenatal development or birth	0.05172	1.286	Informative	INHERITED FROM: Oligohydramnios
Phenotypic Abnormality (PA)	Abnormality of the upper respiratory tract	0.05959	1.508	Informative	INHERITED FROM: Tracheoesophageal fistula
Phenotypic Abnormality (PA)	Abnormality of toe	0.08009	1.617	Informative	INHERITED FROM: Toe syndactyly || Clubbing of toes
Phenotypic Abnormality (PA)	Anemia	0.08408	1.684	Informative	INHERITED FROM: Pyridoxine-responsive sideroblastic anemia || Sideroblastic anemia
Phenotypic Abnormality (PA)	Recurrent infections	0.1275	1.383	Informative	INHERITED FROM: Recurrent urinary tract infections
Phenotypic Abnormality (PA)	Abnormality of the nose	0.1385	1.258	Informative	INHERITED FROM: Choanal atresia
Phenotypic Abnormality (PA)	Abnormality of the uterus	0.1462	1.684	Informative	INHERITED FROM: Bicornuate uterus || Abnormal uterus morphology
Phenotypic Abnormality (PA)	Abnormality of reproductive system physiology	0.1894	1.508	Informative	INHERITED FROM: Azoospermia || Decreased fertility in males || Abnormal spermatogenesis
Phenotypic Abnormality (PA)	Abnormal intestine morphology	0.2066	1.421	Informative	INHERITED FROM: Small intestinal stenosis || Abnormal ileum morphology || Abnormality of the duodenum || Meckel diverticulum || Duodenal stenosis
Phenotypic Abnormality (PA)	Abnormal systemic arterial morphology	0.2166	1.421	Informative	INHERITED FROM: Abnormal carotid artery morphology
Phenotypic Abnormality (PA)	Abnormality of calvarial morphology	0.5545	1.508	Informative	INHERITED FROM: Dolichocephaly
Phenotypic Abnormality (PA)	Abnormality of male external genitalia	0.9691	1.462	Informative	INHERITED FROM: Absent testis || Abnormality of the preputium
Phenotypic Abnormality (PA)	Breast carcinoma	0.000004586	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Prostate neoplasm	0.00001436	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the uvula	0.00004924	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Hydroureter	0.00005196	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Triangular shaped phalanges of the hand	0.0001274	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Decreased fertility in males	0.0001539	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	High palate	0.0004219	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Azoospermia	0.0006248	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Choanal atresia	0.0006881	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Hyperpigmentation of the skin	0.0007444	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal trachea morphology	0.001332	1.985	Highly Informative	INHERITED FROM: Tracheoesophageal fistula
Phenotypic Abnormality (PA)	Anemia of inadequate production	0.001709	2.161	Highly Informative	INHERITED FROM: Sideroblastic anemia || Pyridoxine-responsive sideroblastic anemia
Phenotypic Abnormality (PA)	Abnormal thumb morphology	0.001804	1.86	Highly Informative	INHERITED FROM: Triphalangeal thumb || Abnormality of thumb phalanx
Phenotypic Abnormality (PA)	Abnormality of the ulna	0.001834	2.161	Highly Informative	INHERITED FROM: Aplasia/Hypoplasia of the ulna || Hypoplasia of the ulna || Abnormal morphology of ulna
Phenotypic Abnormality (PA)	Abnormality of the anus	0.002435	1.985	Highly Informative	INHERITED FROM: Anal atresia
Phenotypic Abnormality (PA)	Cafe-au-lait spot	0.002523	1.985	Highly Informative	INHERITED FROM: Multiple cafe-au-lait spots
Phenotypic Abnormality (PA)	Syndactyly	0.002524	2.161	Highly Informative	INHERITED FROM: Toe syndactyly
Phenotypic Abnormality (PA)	Abnormality of the radius	0.004521	1.86	Highly Informative	INHERITED FROM: Aplasia/Hypoplasia of the radius
Phenotypic Abnormality (PA)	Abnormality of the phalanges of the toes	0.01486	1.86	Highly Informative	INHERITED FROM: Clubbing of toes
Phenotypic Abnormality (PA)	Abnormal esophagus morphology	0.0197	2.161	Highly Informative	INHERITED FROM: Tracheoesophageal fistula
Phenotypic Abnormality (PA)	Abnormality of the penis	0.02713	1.86	Highly Informative	INHERITED FROM: Abnormality of the preputium
Phenotypic Abnormality (PA)	Hematological neoplasm	0.03626	2.161	Highly Informative	INHERITED FROM: Myelodysplasia
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia affecting the eye	0.04501	1.86	Highly Informative	INHERITED FROM: Aplasia/Hypoplasia affecting the anterior segment of the eye
Phenotypic Abnormality (PA)	Abnormality of the small intestine	0.04648	2.161	Highly Informative	INHERITED FROM: Meckel diverticulum || Small intestinal stenosis || Abnormal ileum morphology || Abnormality of the duodenum || Duodenal stenosis
Phenotypic Abnormality (PA)	Abnormality of the amniotic fluid	0.07679	2.161	Highly Informative	INHERITED FROM: Oligohydramnios
Phenotypic Abnormality (PA)	Ocular anterior segment dysgenesis	0.07725	2.161	Highly Informative	INHERITED FROM: Aplasia/Hypoplasia affecting the anterior segment of the eye

---

Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	embryonic lethality	0.00005436	1.126	--	DIRECT
Mammalian Phenotype (MP)	preweaning lethality	0.02655	0.7055	--	INHERITED FROM: embryonic lethality || prenatal lethality
Mammalian Phenotype (MP)	abnormal survival	0.06065	0.6441	--	INHERITED FROM: prenatal lethality || embryonic lethality
Mammalian Phenotype (MP)	mortality/aging	0.09015	0.5424	Least Informative	INHERITED FROM: embryonic lethality || prenatal lethality
Mammalian Phenotype (MP)	prenatal lethality	0.0005902	0.9129	Moderately Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.773	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	meiosis variant	0.0000003156	1.263	--	DIRECT
Worm Phenotype (WP)	recycling endosome morphology variant	0.0000003614	1.727	--	DIRECT
Worm Phenotype (WP)	endosome morphology variant	0.000000436	1.727	--	DIRECT
Worm Phenotype (WP)	vesicle morphology variant	0.0000006626	1.689	--	DIRECT
Worm Phenotype (WP)	apoptosis variant	0.000001094	1.125	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0.000001576	1.087	--	DIRECT
Worm Phenotype (WP)	accumulated cell corpses	0.000001633	1.371	--	DIRECT
Worm Phenotype (WP)	meiotic progression during oogenesis variant	0.00000269	1.321	--	DIRECT
Worm Phenotype (WP)	germ cell compartment morphology variant	0.000003814	1.354	--	DIRECT
Worm Phenotype (WP)	recycling endosome localization variant	0.000007544	1.769	--	DIRECT
Worm Phenotype (WP)	endosome localization variant	0.000007948	1.769	--	DIRECT
Worm Phenotype (WP)	gametogenesis variant	0.000008982	1.013	--	DIRECT
Worm Phenotype (WP)	gonad morphology variant	0.00002804	1.306	--	DIRECT
Worm Phenotype (WP)	somatic gonad development variant	0.00008121	1.655	--	DIRECT
Worm Phenotype (WP)	transgene subcellular localization variant	0.000106	1.125	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0.0001119	0.8392	--	DIRECT
Worm Phenotype (WP)	germ cell morphology variant	0.0001347	1.156	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.0002035	1.087	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.0003856	0.7558	--	DIRECT
Worm Phenotype (WP)	reproductive system development variant	0.001734	1.156	--	INHERITED FROM: oocyte septum formation variant || gonad development variant || somatic gonad development variant
Worm Phenotype (WP)	behavior variant	0.002063	0.6859	--	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	organ system morphology variant	0.006408	0.7516	--	INHERITED FROM: diplotene region organization variant || reproductive system morphology variant || gonad morphology variant
Worm Phenotype (WP)	protein interaction variant	0.0126	1.078	--	INHERITED FROM: protein protein interaction variant || protein aggregation variant
Worm Phenotype (WP)	response to bacteria variant	0.01559	1.426	--	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	feeding behavior variant	0.02204	1.25	--	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	oogenesis variant	0.03711	1.237	--	INHERITED FROM: meiotic progression during oogenesis variant || diplotene region organization variant || diplotene progression during oogenesis variant
Worm Phenotype (WP)	meiotic progression prophase variant	0.06172	1.407	--	INHERITED FROM: diplotene region organization variant || diplotene progression during oogenesis variant
Worm Phenotype (WP)	cell corpse number variant	0.06235	1.306	--	INHERITED FROM: accumulated cell corpses || accumulated germline cell corpses
Worm Phenotype (WP)	germ cell compartment nuclei number variant	0.08056	1.814	--	INHERITED FROM: germ cell compartment anucleate
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || meiotic progression during oogenesis variant || organism metabolism processing variant || somatic gonad development variant || protein protein interaction variant || vesicle morphology variant || reproductive system physiology variant || transgene expression variant || diplotene progression during oogenesis variant || gene expression variant || organism homeostasis metabolism variant || apoptosis variant || avoids bacterial lawn || lethal || diplotene region organization variant || chromosome condensation variant || organism physiology variant || transgene subcellular localization variant || meiosis variant || germ cell development variant || cell division variant || oocyte septum formation variant || development variant || accumulated germline cell corpses || hermaphrodite sterile || organism environmental stimulus response variant || hermaphrodite fertility reduced || cell death variant || accumulated cell corpses || embryonic development variant || embryonic lethal || vesicle organization variant || fertility variant || protein aggregation variant || gametogenesis variant || recycling endosome morphology variant || cell cycle variant || gonad development variant || organ system physiology variant || maternal sterile || endosome morphology variant || organism development variant || programmed cell death variant || fertility reduced || transgene expression increased || cell development variant
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.0004937	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.00149	0.5955	Least Informative	INHERITED FROM: apoptosis variant || meiosis variant || diplotene progression during oogenesis variant || cell division variant || cell death variant || accumulated cell corpses || programmed cell death variant || cell cycle variant || accumulated germline cell corpses || chromosome condensation variant || diplotene region organization variant
Worm Phenotype (WP)	organism behavior variant	0.002015	0.6859	Least Informative	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	cell cycle variant	0.0000006955	1.225	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell organization biogenesis variant	0.000001355	1.135	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell death variant	0.000002052	1.061	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell division variant	0.000005847	1.036	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0.000008097	1.013	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0.0002287	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system morphology variant	0.0005927	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	organ system development variant	0.0135	0.9113	Moderately Informative	INHERITED FROM: somatic gonad development variant || oocyte septum formation variant || gonad development variant
Worm Phenotype (WP)	germ cell differentiation variant	0.1634	1.167	Moderately Informative	INHERITED FROM: diplotene region organization variant || diplotene progression during oogenesis variant || meiotic progression during oogenesis variant
Worm Phenotype (WP)	pattern of transgene expression variant	0.2067	0.9833	Moderately Informative	INHERITED FROM: transgene subcellular localization variant
Worm Phenotype (WP)	level of transgene expression variant	0.2436	1.125	Moderately Informative	INHERITED FROM: transgene expression increased
Worm Phenotype (WP)	cell type morphology variant	0.3699	0.8878	Moderately Informative	INHERITED FROM: germ cell morphology variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment anucleate
Worm Phenotype (WP)	diplotene progression during oogenesis variant	0.0000002755	1.655	Informative	DIRECT
Worm Phenotype (WP)	accumulated germline cell corpses	0.0000006487	1.513	Informative	DIRECT
Worm Phenotype (WP)	vesicle organization variant	0.0000007662	1.655	Informative	DIRECT
Worm Phenotype (WP)	oocyte morphology variant	0.000009896	1.292	Informative	DIRECT
Worm Phenotype (WP)	avoids bacterial lawn	0.0001123	1.49	Informative	DIRECT
Worm Phenotype (WP)	transgene expression increased	0.0001491	1.426	Informative	DIRECT
Worm Phenotype (WP)	gonad development variant	0.0001659	1.538	Informative	DIRECT
Worm Phenotype (WP)	cell component localization variant	0.008241	1.388	Informative	INHERITED FROM: endosome localization variant || recycling endosome localization variant || RAB-11 recycling endosome localization variant
Worm Phenotype (WP)	mitosis variant	0.02767	1.689	Informative	INHERITED FROM: chromosome condensation variant
Worm Phenotype (WP)	meiotic chromosome organization variant	0.3283	1.623	Informative	INHERITED FROM: chromosome condensation variant
Worm Phenotype (WP)	diplotene region organization variant	0.00000003146	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment anucleate	0.0000007712	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	oocyte septum formation variant	0.000002187	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	RAB-11 recycling endosome localization variant	0.000007345	1.769	Highly Informative	DIRECT
Worm Phenotype (WP)	chromosome condensation variant	0.000007744	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	lysosome-related organelle morphology variant	0.0001375	1.924	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5867	Least Informative	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0.6505	0.3202	Least Informative	INHERITED FROM: oxidative stress resistance || alkaline pH resistance
Yeast Phenotype (YP)	development	0	1.143	Moderately Informative	DIRECT
Yeast Phenotype (YP)	oxidative stress resistance	0.000196	1.666	Informative	DIRECT
Yeast Phenotype (YP)	desiccation resistance	0.0004088	1.666	Informative	DIRECT
Yeast Phenotype (YP)	sexual cycle	0.01197	1.745	Informative	INHERITED FROM: sporulation
Yeast Phenotype (YP)	sporulation	0.00001857	1.967	Highly Informative	DIRECT
Yeast Phenotype (YP)	alkaline pH resistance	0.00007058	1.967	Highly Informative	DIRECT
Yeast Phenotype (YP)	starvation resistance	0.0003333	1.967	Highly Informative	DIRECT
Yeast Phenotype (YP)	resistance to enzymatic treatment	0.0003885	2.143	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	cell cycle defective	0.0008224	1.541	Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	presumptive oocyte	0.000000002276	2.389	--	DIRECT
Fly Anatomy (FA)	karyosome	0.0000004802	2.389	--	DIRECT
Fly Anatomy (FA)	oocyte nucleus	0.000008694	2.389	--	DIRECT
Fly Anatomy (FA)	nurse cell	0.0001254	2.389	--	DIRECT
Fly Anatomy (FA)	chorionic specialization	0.0002095	2.088	--	DIRECT
Fly Anatomy (FA)	chorion	0.0002169	2.088	--	DIRECT
Fly Anatomy (FA)	gamete	0.001113	1.912	--	INHERITED FROM: oocyte
Fly Anatomy (FA)	germarium	0.003105	1.69	--	INHERITED FROM: presumptive oocyte
Fly Anatomy (FA)	egg chamber	0.01291	1.69	--	INHERITED FROM: nurse cell || oocyte
Fly Anatomy (FA)	ovary	0.02461	1.31	--	INHERITED FROM: presumptive oocyte || nurse cell || oocyte
Fly Anatomy (FA)	female reproductive system	0.02567	1.31	--	INHERITED FROM: oocyte || presumptive oocyte || nurse cell
Fly Anatomy (FA)	female organism	0.0311	1.213	--	INHERITED FROM: oocyte || nurse cell || presumptive oocyte
Fly Anatomy (FA)	reproductive system	0.07882	1.047	--	INHERITED FROM: oocyte || nurse cell || presumptive oocyte
Fly Anatomy (FA)	germline cyst	0.1235	1.389	--	INHERITED FROM: oocyte || nurse cell
Fly Anatomy (FA)	cell	0.2733	0.4069	--	INHERITED FROM: female germline cell || nurse cell || presumptive oocyte || oocyte
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: chorionic specialization || organism || female germline cell || karyosome || nurse cell || oocyte || chorion || multi-tissue structure || oocyte nucleus || presumptive oocyte || dorsal appendage || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || oocyte nucleus || presumptive oocyte || dorsal appendage || multi-tissue structure || chorion || oocyte || female germline cell || karyosome || nurse cell || chorionic specialization || organism
Fly Anatomy (FA)	multi-tissue structure	0	0.6038	Least Informative	DIRECT
Fly Anatomy (FA)	female-specific anatomical entity	0.02694	1.213	Moderately Informative	INHERITED FROM: nurse cell || oocyte || presumptive oocyte
Fly Anatomy (FA)	gonad	0.05123	1.047	Moderately Informative	INHERITED FROM: oocyte || nurse cell || presumptive oocyte
Fly Anatomy (FA)	acellular anatomical structure	0.06263	1.134	Moderately Informative	INHERITED FROM: chorionic specialization || chorion || dorsal appendage
Fly Anatomy (FA)	egg	0.002764	1.69	Informative	INHERITED FROM: chorion || dorsal appendage || chorionic specialization
Fly Anatomy (FA)	female germline cyst	0.01358	1.486	Informative	INHERITED FROM: nurse cell || oocyte
Fly Anatomy (FA)	germline cell	0.01752	1.389	Informative	INHERITED FROM: nurse cell || presumptive oocyte || female germline cell || oocyte
Fly Anatomy (FA)	ovariole	0.02162	1.31	Informative	INHERITED FROM: oocyte || nurse cell || presumptive oocyte
Fly Anatomy (FA)	cell component	0.02511	1.544	Informative	INHERITED FROM: oocyte nucleus || karyosome
Fly Anatomy (FA)	dorsal appendage	0.0001888	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	female germline cell	0.0002554	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	oocyte	0.0005305	1.912	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system || plant cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	seed development stage	0.00024	1.304	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Catalysing the translocation of hydrons	0	1.832	--	DIRECT
Enzyme Commission (EC)	Hydron translocation linked to the hydrolysis of a nucleoside triphosphate	0	2.385	--	DIRECT
Enzyme Commission (EC)	H(+)-transporting two-sector ATPase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Na(+)-transporting two-sector ATPase	0.00000000005685	2.753	--	DIRECT
Enzyme Commission (EC)	Adenosylcobinamide kinase	0.000000001977	3.23	--	DIRECT
Enzyme Commission (EC)	Adenosylcobinamide-phosphate guanylyltransferase	0.000000001977	3.23	--	DIRECT
Enzyme Commission (EC)	Corrinoid adenosyltransferase	0.0000001736	2.929	--	DIRECT
Enzyme Commission (EC)	Linked to the hydrolysis of a nucleoside triphosphate	0.3028	2.275	--	INHERITED FROM: Na(+)-transporting two-sector ATPase
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	1	1.567	--	INHERITED FROM: Corrinoid adenosyltransferase
Enzyme Commission (EC)	Transferring phosphorus-containing groups	1	0.7021	--	INHERITED FROM: Adenosylcobinamide-phosphate guanylyltransferase || Adenosylcobinamide kinase
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Adenosylcobinamide kinase || Corrinoid adenosyltransferase || Adenosylcobinamide-phosphate guanylyltransferase
Enzyme Commission (EC)	Hydrolases	1	0.4043	Least Informative	INHERITED FROM: Nucleoside-triphosphate phosphatase
Enzyme Commission (EC)	Acting on acid anhydrides	0.6588	1.133	Moderately Informative	INHERITED FROM: Nucleoside-triphosphate phosphatase
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	1	1.238	Moderately Informative	INHERITED FROM: Adenosylcobinamide kinase
Enzyme Commission (EC)	Nucleotidyltransferases	1	1.126	Moderately Informative	INHERITED FROM: Adenosylcobinamide-phosphate guanylyltransferase
Enzyme Commission (EC)	Translocases	0	1.628	Informative	DIRECT
Enzyme Commission (EC)	In phosphorus-containing anhydrides	0.05161	1.452	Informative	INHERITED FROM: Nucleoside-triphosphate phosphatase
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	1	1.558	Informative	INHERITED FROM: Corrinoid adenosyltransferase
Enzyme Commission (EC)	Nucleoside-triphosphate phosphatase	0	2.054	Highly Informative	DIRECT
Enzyme Commission (EC)	Catalysing the translocation of inorganic cations	1	2.116	Highly Informative	INHERITED FROM: Na(+)-transporting two-sector ATPase

---