Rhodanese/Cell cycle control phosphatase superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Rhodanese/Cell cycle control phosphatase [ 52820]
• Superfamily: Rhodanese/Cell cycle control phosphatase [ 52821] (4)
• Families:
  • Cell cycle control phosphatase, catalytic domain [ 52822] (4)
  • Single-domain sulfurtransferase [ 69509] (3)
  • Multidomain sulfurtransferase (rhodanese) [ 52827] (4)
  • Ubiquitin carboxyl-terminal hydrolase 8, USP8 [ 117586]

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Superfamily statistics

	Genomes (3,030)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	24,655	169,647	30
Proteins	20,265	134,551	20

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Functional annotation

• General category: Processes_IC
• Detailed category: Cell cycle, Apoptosis

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring sulfur-containing groups	0	1.384	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Thiosulfate sulfurtransferase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Ubiquitinyl hydrolase 1	0.00000000002769	1.238	--	DIRECT
Enzyme Commission (EC)	3-mercaptopyruvate sulfurtransferase	0.00000005651	2.56	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.1113	0.04271	--	INHERITED FROM: Phosphoric monoester hydrolases || Acting on ester bonds || Protein-tyrosine-phosphatase || Omega peptidases || Phosphoprotein phosphatase || Ubiquitinyl hydrolase 1
Enzyme Commission (EC)	Acting on ester bonds	0	0.4665	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0.4896	0.5513	Least Informative	INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0	0.9165	Moderately Informative	DIRECT
Enzyme Commission (EC)	Omega peptidases	0.000000001076	1.145	Moderately Informative	DIRECT
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0	1.414	Informative	DIRECT
Enzyme Commission (EC)	Sulfurtransferases	0	1.56	Informative	DIRECT
Enzyme Commission (EC)	Phosphoprotein phosphatase	0.00002524	1.56	Informative	DIRECT
Enzyme Commission (EC)	tRNA sulfurtransferase	0	2.083	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.1924	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.472	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.5614	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2543	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4621	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the foot	0	1.106	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0	0.6284	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.7631	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal eye morphology	0	0.8155	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0	0.7731	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4771	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the eye	0	0.6004	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.6004	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.472	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.4022	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.5677	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limbs	0	0.6431	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0	0.9152	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle tone	0	1.045	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0	0.8268	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal eye physiology	0	0.8751	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of movement	0	1.045	Moderately Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal enterocyte differentiation	0.00000001269	2.508	--	DIRECT
Mammalian Phenotype (MP)	decreased small intestine length	0.00000006079	2.508	--	DIRECT
Mammalian Phenotype (MP)	decreased small intestinal villus height	0.0000002816	2.508	--	DIRECT
Mammalian Phenotype (MP)	decreased small intestinal villus size	0.00000367	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal small intestinal crypt cell proliferation	0.00000447	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal intestine development	0.000006391	2.508	--	DIRECT
Mammalian Phenotype (MP)	decreased intestine length	0.000007492	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal small intestinal crypt cell physiology	0.00002027	2.508	--	DIRECT
Mammalian Phenotype (MP)	increased enterocyte apoptosis	0.00009573	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal enterocyte apoptosis	0.000161	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal small intestinal villus morphology	0.0003189	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal small intestine crypts of Lieberkuhn morphology	0.0003338	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal intestinal epithelium physiology	0.0007933	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal intestinal mucosa morphology	0.00769	1.73	--	INHERITED FROM: abnormal small intestine crypts of Lieberkuhn morphology
Mammalian Phenotype (MP)	abnormal intestinal epithelium morphology	0.0113	1.663	--	INHERITED FROM: abnormal small intestine crypts of Lieberkuhn morphology
Mammalian Phenotype (MP)	abnormal exocrine gland morphology	0.05857	1.253	--	INHERITED FROM: abnormal small intestine crypts of Lieberkuhn morphology
Mammalian Phenotype (MP)	abnormal digestive system physiology	0.1091	1.304	--	INHERITED FROM: abnormal intestinal epithelium physiology || increased enterocyte apoptosis || abnormal small intestinal crypt cell physiology || abnormal small intestinal crypt cell proliferation || abnormal enterocyte apoptosis || abnormal enterocyte physiology
Mammalian Phenotype (MP)	increased cell death	0.2864	1.304	--	INHERITED FROM: increased enterocyte apoptosis
Mammalian Phenotype (MP)	abnormal cell proliferation	0.3085	1.332	--	INHERITED FROM: abnormal small intestinal crypt cell proliferation
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.3851	0.8003	--	INHERITED FROM: abnormal small intestine crypts of Lieberkuhn morphology
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0.4152	0.9281	--	INHERITED FROM: abnormal small intestinal crypt cell physiology || abnormal small intestine crypts of Lieberkuhn morphology || abnormal small intestinal crypt cell proliferation || increased enterocyte apoptosis || abnormal small intestinal villus morphology || decreased small intestine length || abnormal enterocyte physiology || abnormal intestinal epithelium physiology || decreased small intestinal villus size || abnormal enterocyte differentiation || abnormal intestine development || abnormal enterocyte apoptosis || decreased small intestinal villus height || abnormal digestive system development || decreased intestine length
Mammalian Phenotype (MP)	abnormal cell physiology	0.5407	0.6214	--	INHERITED FROM: abnormal small intestinal crypt cell proliferation || abnormal enterocyte differentiation || abnormal enterocyte apoptosis || increased enterocyte apoptosis
Mammalian Phenotype (MP)	abnormal apoptosis	0.6324	1.076	--	INHERITED FROM: abnormal enterocyte apoptosis || increased enterocyte apoptosis
Mammalian Phenotype (MP)	cellular phenotype	0.3445	0.5301	Least Informative	INHERITED FROM: increased enterocyte apoptosis || abnormal small intestinal crypt cell proliferation || abnormal enterocyte apoptosis || abnormal enterocyte differentiation
Mammalian Phenotype (MP)	abnormal cell death	0.02133	1.045	Moderately Informative	INHERITED FROM: abnormal enterocyte apoptosis || increased enterocyte apoptosis
Mammalian Phenotype (MP)	abnormal digestive system morphology	0.2824	1.031	Moderately Informative	INHERITED FROM: decreased small intestine length || abnormal small intestine crypts of Lieberkuhn morphology || abnormal intestine development || abnormal enterocyte differentiation || decreased small intestinal villus size || abnormal small intestinal villus morphology || decreased intestine length || abnormal digestive system development || decreased small intestinal villus height
Mammalian Phenotype (MP)	abnormal gland morphology	0.3261	0.8644	Moderately Informative	INHERITED FROM: abnormal small intestine crypts of Lieberkuhn morphology
Mammalian Phenotype (MP)	abnormal intestine physiology	0.02026	1.554	Informative	INHERITED FROM: abnormal enterocyte apoptosis || abnormal small intestinal crypt cell physiology || abnormal small intestinal crypt cell proliferation || abnormal enterocyte physiology || abnormal intestinal epithelium physiology || increased enterocyte apoptosis
Mammalian Phenotype (MP)	abnormal intestine morphology	0.05665	1.508	Informative	INHERITED FROM: abnormal small intestine crypts of Lieberkuhn morphology || decreased small intestinal villus height || decreased intestine length || abnormal small intestinal villus morphology || abnormal enterocyte differentiation || decreased small intestinal villus size || abnormal intestine development || decreased small intestine length
Mammalian Phenotype (MP)	abnormal cell differentiation	0.1754	1.466	Informative	INHERITED FROM: abnormal enterocyte differentiation
Mammalian Phenotype (MP)	increased apoptosis	0.1889	1.304	Informative	INHERITED FROM: increased enterocyte apoptosis
Mammalian Phenotype (MP)	abnormal enterocyte physiology	0.0002744	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal digestive system development	0.0007404	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal small intestine morphology	0.006307	2.207	Highly Informative	INHERITED FROM: abnormal small intestine crypts of Lieberkuhn morphology || decreased small intestinal villus height || decreased small intestine length || abnormal small intestinal villus morphology || decreased small intestinal villus size
Mammalian Phenotype (MP)	abnormal crypts of Lieberkuhn morphology	0.01606	2.031	Highly Informative	INHERITED FROM: abnormal small intestine crypts of Lieberkuhn morphology

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.07918	--	DIRECT
Fly Anatomy (FA)	tagma	0	0.6478	--	DIRECT
Fly Anatomy (FA)	adult sense organ	0	1.266	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.2279	--	DIRECT
Fly Anatomy (FA)	sense organ	0	1.101	--	DIRECT
Fly Anatomy (FA)	external sensory organ	0	1.15	--	DIRECT
Fly Anatomy (FA)	anatomical group	0	0.7891	--	DIRECT
Fly Anatomy (FA)	non-connected functional system	0	0.9652	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.5607	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: external sensory organ || organism || adult || somatic cell || adult sense organ || cell || adult tagma || sense organ || tagma || organ system subdivision || organ system || organism subdivision || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: anatomical group || organ system || organism subdivision || multicellular structure || sensory system || adult tagma || non-connected functional system || tagma || sense organ || organ system subdivision || adult sense organ || cell || somatic cell || adult || external sensory organ || organism
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.632	--	INHERITED FROM: tagma || adult tagma
Fly Anatomy (FA)	adult	0	0.5607	Least Informative	DIRECT
Fly Anatomy (FA)	cell	0	0.4937	Least Informative	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.6243	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.5673	Least Informative	DIRECT
Fly Anatomy (FA)	adult tagma	0	0.7674	Moderately Informative	DIRECT
Fly Anatomy (FA)	sensory system	0	0.9652	Moderately Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.2245	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism || organism subdivision
Zebrafish Anatomy (ZA)	organism subdivision	0	0.6264	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1968	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.2036	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2833	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.4754	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.4754	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || E expanded cotyledon stage || LP.12 twelve leaves visible stage || F mature embryo stage || D bilateral stage || LP.06 six leaves visible stage || plant embryo stage || leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: LP.12 twelve leaves visible stage || E expanded cotyledon stage || LP.06 six leaves visible stage || sporophyte vegetative stage || leaf production stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.478	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.353	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.4088	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.3729	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.5666	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.5243	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0.3035	--	DIRECT
Enzyme Commission (EC)	Thiosulfate sulfurtransferase	0	2.952	--	DIRECT
Enzyme Commission (EC)	tRNA uracil 4-sulfurtransferase	0	2.475	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.7559	--	DIRECT
Enzyme Commission (EC)	Ubiquitinyl hydrolase 1	0.00000000007513	1.59	--	DIRECT
Enzyme Commission (EC)	Arsenate reductase (glutaredoxin)	0.0000000001264	2.952	--	DIRECT
Enzyme Commission (EC)	3-mercaptopyruvate sulfurtransferase	0.000000004559	2.952	--	DIRECT
Enzyme Commission (EC)	With disulfide as acceptor	0.00000006805	2.35	--	DIRECT
Enzyme Commission (EC)	Acting on phosphorus or arsenic in donors	0.0000001015	2.35	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.01218	0.3541	Least Informative	INHERITED FROM: Phosphoric monoester hydrolases || Acting on ester bonds || Omega peptidases || Ubiquitinyl hydrolase 1 || Protein-serine/threonine phosphatase || Protein-tyrosine-phosphatase
Enzyme Commission (EC)	Oxidoreductases	1	0.6234	Least Informative	INHERITED FROM: Acting on phosphorus or arsenic in donors || Arsenate reductase (glutaredoxin) || With disulfide as acceptor
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0	1.174	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0.6086	0.8949	Moderately Informative	INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1
Enzyme Commission (EC)	Transferring sulfur-containing groups	0	1.748	Informative	DIRECT
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0	1.63	Informative	DIRECT
Enzyme Commission (EC)	Omega peptidases	0.000000002413	1.447	Informative	DIRECT
Enzyme Commission (EC)	Sulfurtransferases	0	1.952	Highly Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine phosphatase	0.000002651	1.91	Highly Informative	DIRECT

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InterPro annotation

• Cross references: IPR001763 SSF52821 Protein matches
• Abstract:

  Rhodanese, a sulphurtransferase involved in cyanide detoxification (see ) shares evolutionary relationship with a large family of proteins [9733650], including

  • Cdc25 phosphatase catalytic domain.
  • non-catalytic domains of eukaryotic dual-specificity MAPK-phosphatases.
  • non-catalytic domains of yeast PTP-type MAPK-phosphatases.
  • non-catalytic domains of yeast Ubp4, Ubp5, Ubp7.
  • non-catalytic domains of mammalian Ubp-Y.
  • Drosophila heat shock protein HSP-67BB.
  • several bacterial cold-shock and phage shock proteins.
  • plant senescence associated proteins.
  • catalytic and non-catalytic domains of rhodanese (see ).

  Rhodanese has an internal duplication. This domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases [8702871].

InterPro database

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