Thioredoxin-like superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Thioredoxin fold [ 52832] (2)
• Superfamily: Thioredoxin-like [ 52833] (23)
• Families:
  • Thioltransferase [ 52834] (15)
  • PDI-like [ 52849] (2)
  • Calsequestrin [ 52855]
  • DsbA-like [ 100953] (3)
  • Glutathione S-transferase (GST), N-terminal domain [ 52862] (18)
  • Phosducin [ 52888]
  • ERP29 N domain-like [ 52892] (2)
  • spliceosomal protein U5-15Kd [ 52895]
  • SH3BGR (SH3-binding, glutamic acid-rich protein-like) [ 102446]
  • KaiB-like [ 102449] (2)
  • DsbC/DsbG C-terminal domain-like [ 52898] (2)
  • Glutathione peroxidase-like [ 52901] (28)
  • Thioredoxin-like 2Fe-2S ferredoxin [ 52918]
  • ArsC-like [ 69518] (3)
  • Txnl5-like [ 110612]
  • YuzD-like [ 117605]
  • YKR049C-like [ 142395]
  • Atu2684-like [ 142398]
  • HyaE-like [ 142401]
  • NQO2-like [ 142405]
  • Mitochondrial ribosomal protein L51/S25/CI-B8 domain [ 142408]
  • Selenoprotein W-related [ 142411] (3)
  • UAS domain [ 159589]

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Superfamily statistics

	Genomes (3,255)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	135,619	814,729	301
Proteins	123,030	771,535	292

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Functional annotation

• General category: Metabolism
• Detailed category: Redox

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on a peroxide as acceptor	0	1.481	--	DIRECT
Enzyme Commission (EC)	Transposing S-S bonds	0	2.259	--	DIRECT
Enzyme Commission (EC)	Maleylacetoacetate isomerase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Glutathione dehydrogenase (ascorbate)	0	2.259	--	DIRECT
Enzyme Commission (EC)	Carbon-halide lyases	0	2.259	--	DIRECT
Enzyme Commission (EC)	Peroxiredoxin	0	2.259	--	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	0	1.041	--	DIRECT
Enzyme Commission (EC)	Acting on phosphorus or arsenic in donors	0	2.259	--	DIRECT
Enzyme Commission (EC)	Glutathione peroxidase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Thiol oxidase	0	2.259	--	DIRECT
Enzyme Commission (EC)	With disulfide as acceptor	0	2.259	--	DIRECT
Enzyme Commission (EC)	Thyroxine 5'-deiodinase	0	2.56	--	DIRECT
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0.0000000001859	2.259	--	DIRECT
Enzyme Commission (EC)	Thyroxine 5-deiodinase	0.000000007156	2.56	--	DIRECT
Enzyme Commission (EC)	Phospholipid-hydroperoxide glutathione peroxidase	0.0000001444	2.56	--	DIRECT
Enzyme Commission (EC)	NADH dehydrogenase	0.0000004867	1.657	--	DIRECT
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0.00006168	1.384	--	DIRECT
Enzyme Commission (EC)	Prostamide/prostaglandin F(2-alpha) synthase	0.000155	2.56	--	DIRECT
Enzyme Commission (EC)	Cis-trans-isomerases	0.6323	1.414	--	INHERITED FROM: Maleylacetoacetate isomerase
Enzyme Commission (EC)	Cis-trans Isomerases	1	1.414	--	INHERITED FROM: Maleylacetoacetate isomerase
Enzyme Commission (EC)	Transferring phosphorous-containing groups	1	0.2175	--	INHERITED FROM: Protein-histidine kinases
Enzyme Commission (EC)	Transferases	0.8861	0	--	INHERITED FROM: Glutathione transferase || Transferring alkyl or aryl groups, other than meth || Protein-histidine kinases
Enzyme Commission (EC)	Sole sub-subclass for oxidoreductases that do not	1	2.083	--	INHERITED FROM: Thyroxine 5-deiodinase || Thyroxine 5'-deiodinase
Enzyme Commission (EC)	With oxygen as acceptor	0.001107	1.782	--	INHERITED FROM: Thiol oxidase
Enzyme Commission (EC)	Oxidoreductases	0	0.2975	Least Informative	DIRECT
Enzyme Commission (EC)	Isomerases	0.000000004463	0.5914	Least Informative	DIRECT
Enzyme Commission (EC)	Lyases	1	0.4169	Least Informative	INHERITED FROM: Carbon-halide lyases
Enzyme Commission (EC)	Acting on a sulfur group of donors	0	1.198	Moderately Informative	DIRECT
Enzyme Commission (EC)	Intramolecular oxidoreductases	0	1.069	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	1	1.041	Moderately Informative	INHERITED FROM: Glutathione transferase
Enzyme Commission (EC)	Acting on NADH or NADPH	0.7939	1.145	Moderately Informative	INHERITED FROM: With other acceptors || NADH dehydrogenase || With a quinone or similar compound as acceptor || NADH:ubiquinone reductase (H(+)-translocating)
Enzyme Commission (EC)	Peroxidases	0	1.481	Informative	DIRECT
Enzyme Commission (EC)	NADH:ubiquinone reductase (H(+)-translocating)	0.00000000009784	1.56	Informative	DIRECT
Enzyme Commission (EC)	With other acceptors	0.0000000001562	1.384	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.00000731	1.519	Informative	DIRECT
Enzyme Commission (EC)	Protein-histidine kinases	0.0002113	1.481	Informative	DIRECT
Enzyme Commission (EC)	Protein-disulfide reductase	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Glutathione transferase	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Other oxidoreductases	0.000000001046	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	Other intramolecular oxidoreductases	0.000004643	1.861	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	Pick's disease	0.0000028	2.371	--	DIRECT
Disease Ontology (DO)	oligodendroglioma	0.0002092	2.371	--	DIRECT
Disease Ontology (DO)	normocytic anemia	0.007605	1.894	--	INHERITED FROM: congenital hemolytic anemia
Disease Ontology (DO)	anemia	0.06191	1.769	--	INHERITED FROM: congenital hemolytic anemia
Disease Ontology (DO)	disease of anatomical entity	0.2512	0.2157	--	INHERITED FROM: congenital hemolytic anemia || Pick's disease
Disease Ontology (DO)	cancer	0.2677	0.3104	--	INHERITED FROM: oligodendroglioma
Disease Ontology (DO)	disease of cellular proliferation	0.3207	0.2812	--	INHERITED FROM: oligodendroglioma
Disease Ontology (DO)	central nervous system disease	0.8336	0.8526	--	INHERITED FROM: Pick's disease
Disease Ontology (DO)	hemolytic anemia	1	2.07	--	INHERITED FROM: congenital hemolytic anemia
Disease Ontology (DO)	nervous system disease	0.05115	0.6635	Least Informative	INHERITED FROM: Pick's disease
Disease Ontology (DO)	neurodegenerative disease	0.05096	0.9909	Moderately Informative	INHERITED FROM: Pick's disease
Disease Ontology (DO)	hematopoietic system disease	0.4432	0.9397	Moderately Informative	INHERITED FROM: congenital hemolytic anemia
Disease Ontology (DO)	cell type cancer	0.6005	1.009	Moderately Informative	INHERITED FROM: oligodendroglioma
Disease Ontology (DO)	malignant glioma	0.7874	1.526	Informative	INHERITED FROM: oligodendroglioma
Disease Ontology (DO)	congenital hemolytic anemia	0.00002639	2.07	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal CSF lactate level	0.0001332	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebrospinal fluid	0.0007226	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal CSF metabolite level	0.04229	2.407	--	INHERITED FROM: Abnormal CSF lactate level
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.2703	0.6284	--	INHERITED FROM: Abnormal CSF lactate level || Abnormality of the cerebrospinal fluid
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.5371	0.2543	--	INHERITED FROM: Abnormal CSF lactate level || Abnormality of the cerebrospinal fluid
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.4215	0.5677	Least Informative	INHERITED FROM: Abnormal CSF lactate level || Abnormality of the cerebrospinal fluid

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal peroxidase activity	0.00002308	2.508	--	DIRECT
Mammalian Phenotype (MP)	increased cellular sensitivity to oxidative stress	0.00005198	2.508	--	DIRECT
Mammalian Phenotype (MP)	increased thyroxine level	0.000246	2.508	--	DIRECT
Mammalian Phenotype (MP)	increased circulating thyroxine level	0.000246	2.508	--	DIRECT
Mammalian Phenotype (MP)	increased circulating levels of thyroid hormone	0.0009563	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating thyroxine level	0.01141	2.508	--	INHERITED FROM: increased circulating thyroxine level
Mammalian Phenotype (MP)	abnormal thyroxine level	0.0116	2.508	--	INHERITED FROM: increased circulating thyroxine level || increased thyroxine level
Mammalian Phenotype (MP)	abnormal induced cell death	0.0373	1.809	--	INHERITED FROM: increased cellular sensitivity to oxidative stress
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.1215	0.3617	--	INHERITED FROM: abnormal peroxidase activity || increased circulating levels of thyroid hormone || increased thyroxine level || increased circulating thyroxine level
Mammalian Phenotype (MP)	abnormal cell physiology	0.2289	0.6214	--	INHERITED FROM: abnormal redox activity || increased cellular sensitivity to oxidative stress
Mammalian Phenotype (MP)	abnormal circulating hormone level	0.2788	1.128	--	INHERITED FROM: increased circulating levels of thyroid hormone || increased circulating thyroxine level
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.9745	0.7085	--	INHERITED FROM: increased circulating thyroxine level || increased circulating levels of thyroid hormone
Mammalian Phenotype (MP)	cellular phenotype	0.2231	0.5301	Least Informative	INHERITED FROM: increased cellular sensitivity to oxidative stress || abnormal redox activity
Mammalian Phenotype (MP)	abnormal homeostasis	0.6213	0.495	Least Informative	INHERITED FROM: increased circulating levels of thyroid hormone || increased thyroxine level || increased circulating thyroxine level
Mammalian Phenotype (MP)	abnormal metabolism	0.0324	1.093	Moderately Informative	INHERITED FROM: abnormal peroxidase activity
Mammalian Phenotype (MP)	abnormal hormone level	0.3384	1.076	Moderately Informative	INHERITED FROM: increased thyroxine level || increased circulating levels of thyroid hormone || increased circulating thyroxine level
Mammalian Phenotype (MP)	abnormal cell death	0.5971	1.045	Moderately Informative	INHERITED FROM: increased cellular sensitivity to oxidative stress
Mammalian Phenotype (MP)	abnormal enzyme/coenzyme activity	0.2331	1.605	Informative	INHERITED FROM: abnormal peroxidase activity
Mammalian Phenotype (MP)	abnormal redox activity	0.000000005496	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal thyroid hormone level	0.03376	2.207	Highly Informative	INHERITED FROM: increased thyroxine level || increased circulating levels of thyroid hormone || increased circulating thyroxine level
Mammalian Phenotype (MP)	increased sensitivity to induced cell death	0.2562	2.031	Highly Informative	INHERITED FROM: increased cellular sensitivity to oxidative stress

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	enzyme activity variant	0	1.929	--	DIRECT
Worm Phenotype (WP)	organism electrophilic stress hypersensitive	0	2.407	--	DIRECT
Worm Phenotype (WP)	organism heat hypersensitive	0.00002474	2.407	--	DIRECT
Worm Phenotype (WP)	pseudocoelom morphology variant	0.00002682	2.407	--	DIRECT
Worm Phenotype (WP)	organism toxic chemical response variant	0.0001581	1.929	--	DIRECT
Worm Phenotype (WP)	organism oxidative stress response variant	0.1486	1.862	--	INHERITED FROM: paraquat response variant
Worm Phenotype (WP)	organism morphology variant	0.4407	0.2011	--	INHERITED FROM: pseudocoelom morphology variant
Worm Phenotype (WP)	chemical response variant	0.6485	0.8045	--	INHERITED FROM: paraquat response variant || organism toxic chemical response variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.8606	0.1501	--	INHERITED FROM: enzyme activity reduced || organism stress response variant || enzyme activity variant || organism heat hypersensitive || organism toxic chemical response variant || paraquat response variant || metal response variant || organism electrophilic stress hypersensitive
Worm Phenotype (WP)	organism physiology variant	0.9067	0.1405	--	INHERITED FROM: enzyme activity reduced || organism heat hypersensitive || organism toxic chemical response variant || enzyme activity variant || organism stress response variant || paraquat response variant || organism electrophilic stress hypersensitive || metal response variant
Worm Phenotype (WP)	morphology variant	0.9607	0.06117	--	INHERITED FROM: pseudocoelom morphology variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: paraquat response variant || organism stress response variant || development variant || metal response variant || enzyme activity reduced || enzyme activity variant || organism toxic chemical response variant || organism heat hypersensitive || organism electrophilic stress hypersensitive
Worm Phenotype (WP)	organism environmental stimulus response variant	0.007297	0.5677	Least Informative	INHERITED FROM: paraquat response variant || organism electrophilic stress hypersensitive || organism toxic chemical response variant || organism heat hypersensitive || organism stress response variant || metal response variant
Worm Phenotype (WP)	organism metabolism processing variant	0.1617	0.4572	Least Informative	INHERITED FROM: enzyme activity reduced || enzyme activity variant
Worm Phenotype (WP)	organism stress response variant	0.00004031	0.8325	Moderately Informative	DIRECT
Worm Phenotype (WP)	body region morphology variant	0.8311	1.045	Moderately Informative	INHERITED FROM: pseudocoelom morphology variant
Worm Phenotype (WP)	metal response variant	0.0004862	1.628	Informative	DIRECT
Worm Phenotype (WP)	pesticide response variant	0.001861	1.708	Informative	INHERITED FROM: paraquat response variant
Worm Phenotype (WP)	pericellular component morphology variant	0.007821	1.666	Informative	INHERITED FROM: pseudocoelom morphology variant
Worm Phenotype (WP)	organism temperature response variant	0.7424	1.477	Informative	INHERITED FROM: organism heat hypersensitive
Worm Phenotype (WP)	enzyme activity reduced	0	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	paraquat response variant	0.000008375	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	organism heat response variant	0.2002	2.106	Highly Informative	INHERITED FROM: organism heat hypersensitive

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	bone element	0.00001815	1.761	--	DIRECT
Xenopus ANatomical entity (XAN)	skeletal tissue	0.00002263	1.72	--	DIRECT
Xenopus ANatomical entity (XAN)	skeleton	0.0001672	1.647	--	DIRECT
Xenopus ANatomical entity (XAN)	tail region	0.0004037	1.284	--	DIRECT
Xenopus ANatomical entity (XAN)	early proximal tubule	0.0005675	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	proximal tubule	0.004294	2.062	--	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	skeletal element	0.006832	1.682	--	INHERITED FROM: bone tissue || bone element || skeletal tissue
Xenopus ANatomical entity (XAN)	pronephric nephron	0.01285	1.983	--	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	anatomical cluster	0.1396	0.7974	--	INHERITED FROM: bone tissue || skeletal tissue || skeleton || bone element
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.2907	0.1217	--	INHERITED FROM: tail || bone tissue || skeletal tissue || bone element || early proximal tubule || connective tissue
Xenopus ANatomical entity (XAN)	anatomical region	0.4299	0.193	--	INHERITED FROM: tail region || early proximal tubule || tail
Xenopus ANatomical entity (XAN)	pronephric kidney	0.4855	1.858	--	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	anatomical group	0.4893	0.1442	--	INHERITED FROM: bone tissue || bone element || skeleton || skeletal tissue || dermal system || early proximal tubule
Xenopus ANatomical entity (XAN)	kidney	0.4962	1.615	--	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	trunk region	0.5113	0.4287	--	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	coelom	0.5341	1.682	--	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	embryonic kidney	0.5759	1.72	--	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	organism subdivision	0.6274	0.1871	--	INHERITED FROM: early proximal tubule || tail
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: bone tissue || skeleton || bone element || skeletal tissue || dermal system || early proximal tubule
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: tail region || bone tissue || tail || early proximal tubule || dermal system || connective tissue || skeletal tissue || bone element || skeleton
Xenopus ANatomical entity (XAN)	compound organ	1	0.24	--	INHERITED FROM: bone tissue || skeletal tissue || early proximal tubule || bone element
Xenopus ANatomical entity (XAN)	tissue	0.02091	0.5011	Least Informative	INHERITED FROM: early proximal tubule || connective tissue || bone tissue || skeletal tissue
Xenopus ANatomical entity (XAN)	embryo	0.06617	0.6341	Least Informative	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	urogenital system	0.143	0.5011	Least Informative	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	trunk	0.5315	0.4308	Least Informative	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.8457	0.3033	Least Informative	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.003579	1.118	Moderately Informative	INHERITED FROM: skeleton || bone element || skeletal tissue || bone tissue
Xenopus ANatomical entity (XAN)	multi-tissue structure	1	1.071	Moderately Informative	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	dermal system	0.0001221	1.647	Informative	DIRECT
Xenopus ANatomical entity (XAN)	tail	0.0003762	1.399	Informative	DIRECT
Xenopus ANatomical entity (XAN)	connective tissue	0.0004079	1.72	Informative	DIRECT
Xenopus ANatomical entity (XAN)	skeletal system	0.001377	1.531	Informative	INHERITED FROM: skeletal tissue || bone element || skeleton || bone tissue
Xenopus ANatomical entity (XAN)	solid compound organ	0.001716	1.399	Informative	INHERITED FROM: bone tissue || skeletal tissue || bone element
Xenopus ANatomical entity (XAN)	anatomical space	0.433	1.482	Informative	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	urinary system	0.5247	1.531	Informative	INHERITED FROM: early proximal tubule
Xenopus ANatomical entity (XAN)	bone tissue	0.00001662	1.807	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	pronephric tubule	0.0193	1.983	Highly Informative	INHERITED FROM: early proximal tubule
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0.08284	0.6715	--	INHERITED FROM: NF stage 66
Xenopus DEvelopment stage (XDE)	tadpole stage	0.6859	0.5946	--	INHERITED FROM: NF stage 66
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0.0003785	0.5693	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0.3196	0.7597	Moderately Informative	INHERITED FROM: NF stage 66
Xenopus DEvelopment stage (XDE)	NF stage 66	0.0003607	1.384	Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	androecium	0.0000009111	0.594	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0.000006337	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0.00003349	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0.00007421	0.7448	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0.0001857	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0.0002529	0.4713	--	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0.0003844	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	stem	0.0004501	0.577	--	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0.0004975	0.5246	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0.000681	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0.0007491	0.6087	--	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0.0008119	0.6463	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0.001819	0.51	--	INHERITED FROM: shoot internode
Plant ANatomical entity (PAN)	epidermal cell	0.002211	0.2569	--	INHERITED FROM: guard cell
Plant ANatomical entity (PAN)	plant axis	0.008206	0.3881	--	INHERITED FROM: shoot internode || stem
Plant ANatomical entity (PAN)	gynoecium	0.01266	0.6058	--	INHERITED FROM: carpel
Plant ANatomical entity (PAN)	phyllome	0.02232	0.3809	--	INHERITED FROM: vascular leaf || sporophyll || carpel || pollen
Plant ANatomical entity (PAN)	shoot system	0.02374	0.05747	--	INHERITED FROM: vascular leaf || shoot internode || stem || sporophyll || shoot epidermis || stomatal complex || androecium || pollen || guard cell || carpel
Plant ANatomical entity (PAN)	collective plant structure	0.07	0.01577	--	INHERITED FROM: shoot internode || vascular leaf || sporophyll || stem || stomatal complex || androecium || shoot epidermis || guard cell || carpel || pollen
Plant ANatomical entity (PAN)	epidermis	0.1135	0.2464	--	INHERITED FROM: shoot epidermis || stomatal complex || guard cell
Plant ANatomical entity (PAN)	multi-tissue plant structure	0.1441	0.2691	--	INHERITED FROM: stem || cardinal part of multi-tissue plant structure || sporophyll || vascular leaf || microsporangium || shoot internode || pollen || carpel || sporangium
Plant ANatomical entity (PAN)	reproductive shoot system	0.1881	0.4141	--	INHERITED FROM: androecium || carpel
Plant ANatomical entity (PAN)	shoot epidermal cell	0.3029	0.276	--	INHERITED FROM: guard cell
Plant ANatomical entity (PAN)	vascular system	0.4018	1.372	--	INHERITED FROM: phloem
Plant ANatomical entity (PAN)	pollen sac	0.4027	0.7531	--	INHERITED FROM: pollen
Plant ANatomical entity (PAN)	plant organ	0.5591	0.2816	--	INHERITED FROM: stem || sporophyll || vascular leaf || shoot internode || microsporangium || pollen || carpel || sporangium
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: sporophyll || shoot internode || guard cell || phloem || sporangium || portion of plant tissue || stomatal complex || stem || cardinal part of multi-tissue plant structure || vascular leaf || microsporangium || pollen || plant cell || carpel || shoot epidermis || microgametophyte || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: sporophyll || stem || shoot internode || vascular leaf || carpel || guard cell || pollen || androecium || stomatal complex || shoot epidermis
Plant ANatomical entity (PAN)	guard cell	0.000006185	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0.0002144	0.7407	Least Informative	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0.0009131	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0.001677	0.4648	Least Informative	INHERITED FROM: androecium || carpel
Plant ANatomical entity (PAN)	shoot axis	0.006762	0.4735	Least Informative	INHERITED FROM: stem || shoot internode
Plant ANatomical entity (PAN)	flower	0.02103	0.4337	Least Informative	INHERITED FROM: androecium || carpel
Plant ANatomical entity (PAN)	leaf	0.05835	0.5053	Least Informative	INHERITED FROM: vascular leaf
Plant ANatomical entity (PAN)	whole plant	0.09809	0.4218	Least Informative	INHERITED FROM: microgametophyte || pollen || phloem
Plant ANatomical entity (PAN)	microsporophyll	0.1702	0.5029	Least Informative	INHERITED FROM: pollen
Plant ANatomical entity (PAN)	megasporophyll	0.6222	0.6087	Least Informative	INHERITED FROM: carpel
Plant ANatomical entity (PAN)	pollen	0.0001963	0.7531	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	portion of vascular tissue	0.1448	1.594	Informative	INHERITED FROM: phloem
Plant ANatomical entity (PAN)	phloem	0.0005478	2.168	Highly Informative	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	0.0002952	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0.0002984	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0.2661	0.2036	--	INHERITED FROM: leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	whole plant development stage	0.2744	0.1968	--	INHERITED FROM: 1 main shoot growth stage || leaf production stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: leaf production stage || 1 main shoot growth stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Peroxidases	0	1.721	--	DIRECT
Enzyme Commission (EC)	Peroxiredoxin	0	2.651	--	DIRECT
Enzyme Commission (EC)	Glutathione peroxidase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Acting on phosphorus or arsenic in donors	0	2.35	--	DIRECT
Enzyme Commission (EC)	With disulfide as acceptor	0	2.35	--	DIRECT
Enzyme Commission (EC)	Catalyzing the reaction X-H + Y-H = 'X-Y'	0	2.253	--	DIRECT
Enzyme Commission (EC)	Protein-disulfide reductase	0	2.475	--	DIRECT
Enzyme Commission (EC)	Thiol oxidase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	0	1.318	--	DIRECT
Enzyme Commission (EC)	Glutathione transferase	0	2.35	--	DIRECT
Enzyme Commission (EC)	Carbon-halide lyases	0	2.651	--	DIRECT
Enzyme Commission (EC)	Maleylacetoacetate isomerase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Transposing S-S bonds	0	2.475	--	DIRECT
Enzyme Commission (EC)	With other acceptors	2.574e-16	2.952	--	DIRECT
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0.000000000000421	2.253	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0.000000000005614	1.838	--	DIRECT
Enzyme Commission (EC)	Protein-disulfide reductase (glutathione)	0.000000001169	2.952	--	DIRECT
Enzyme Commission (EC)	Adenylyl-sulfate reductase (glutathione)	0.00000003329	2.952	--	DIRECT
Enzyme Commission (EC)	Other isomerases	0.00000004281	2.952	--	DIRECT
Enzyme Commission (EC)	Hydron translocation or charge separation linked to oxidoreductase reactions	0.00000008423	1.651	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.000001532	2.651	--	DIRECT
Enzyme Commission (EC)	Phospholipid-hydroperoxide glutathione peroxidase	0.000002538	2.952	--	DIRECT
Enzyme Commission (EC)	Phospholipase A(2)	0.000292	2.253	--	DIRECT
Enzyme Commission (EC)	Prostamide/prostaglandin F(2-alpha) synthase	0.0003904	2.952	--	DIRECT
Enzyme Commission (EC)	Methylarsonate reductase	0.0005388	2.651	--	DIRECT
Enzyme Commission (EC)	Glutathione dehydrogenase (ascorbate)	0.0006867	2.952	--	DIRECT
Enzyme Commission (EC)	Cis-trans-isomerases	0.5169	1.806	--	INHERITED FROM: Maleylacetoacetate isomerase
Enzyme Commission (EC)	With a disulfide as acceptor	1	2.35	--	INHERITED FROM: Adenylyl-sulfate reductase (glutathione) || Protein-disulfide reductase (glutathione)
Enzyme Commission (EC)	Transferases	1	0.3035	--	INHERITED FROM: Glutathione transferase || Transferring alkyl or aryl groups, other than methyl groups || Protein-histidine kinases
Enzyme Commission (EC)	Acting on ester bonds	1	0.7559	--	INHERITED FROM: Phospholipase A(2)
Enzyme Commission (EC)	Cis-trans isomerases	1	1.806	--	INHERITED FROM: Maleylacetoacetate isomerase
Enzyme Commission (EC)	Translocases	1	1.339	--	INHERITED FROM: Hydron translocation or charge separation linked to oxidoreductase reactions || NADH:ubiquinone reductase (H(+)-translocating)
Enzyme Commission (EC)	Oxidoreductases	0	0.6234	Least Informative	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	1	0.5453	Least Informative	INHERITED FROM: Protein-histidine kinases
Enzyme Commission (EC)	Hydrolases	1	0.3541	Least Informative	INHERITED FROM: Phospholipase A(2)
Enzyme Commission (EC)	Lyases	1	0.6918	Least Informative	INHERITED FROM: Carbon-halide lyases
Enzyme Commission (EC)	Isomerases	0.0000000002674	0.8446	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on a peroxide as acceptor	0	1.697	Informative	DIRECT
Enzyme Commission (EC)	Acting on a sulfur group of donors	0	1.489	Informative	DIRECT
Enzyme Commission (EC)	Intramolecular oxidoreductases	0	1.35	Informative	DIRECT
Enzyme Commission (EC)	Catalysing the translocation of hydrons	0.4992	1.505	Informative	INHERITED FROM: NADH:ubiquinone reductase (H(+)-translocating) || Hydron translocation or charge separation linked to oxidoreductase reactions
Enzyme Commission (EC)	Acting on NADH or NADPH	0.5049	1.59	Informative	INHERITED FROM: With other acceptors || NADH dehydrogenase
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	1	1.329	Informative	INHERITED FROM: Glutathione transferase
Enzyme Commission (EC)	Carboxylic ester hydrolases	1	1.408	Informative	INHERITED FROM: Phospholipase A(2)
Enzyme Commission (EC)	NADH dehydrogenase	0.0000000000002563	1.873	Highly Informative	DIRECT
Enzyme Commission (EC)	NADH:ubiquinone reductase (H(+)-translocating)	0.00000000005714	1.952	Highly Informative	DIRECT
Enzyme Commission (EC)	Other intramolecular oxidoreductases	0.000001947	1.998	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.000003547	1.91	Highly Informative	DIRECT
Enzyme Commission (EC)	Protein-histidine kinases	0.0004443	1.873	Highly Informative	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0.01674	2.049	Highly Informative	INHERITED FROM: Thiol oxidase
Enzyme Commission (EC)	Acting on hydrogen as donors	0.1713	2.049	Highly Informative	INHERITED FROM: With NAD(+) or NADP(+) as acceptor

---

UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Biological process	Biological rhythms	0.00000000001775	1.204	Moderately Informative	DIRECT
Post-translational modification	Transferase	0.000000000000009803	0.9853	Moderately Informative	DIRECT
Post-translational modification	Eye lens protein	1.415e-16	1.462	Informative	DIRECT

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InterPro annotation

• Cross references: IPR012336 SSF52833 Protein matches
• Abstract:

  Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2), where a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system, the NADP/thioredoxin system, and the glutathione/glutaredoxin system [15862094]. Several of these disulphide proteins share a common structure, consisting of a three-layer alpha/beta/alpha core. Proteins that contain this thioredoxin fold include: 2Fe-2S ferredoxin, thioltransferase, phosducin, glutathione peroxidase-like enzymes, arsenate reductase, disulphide bond isomerase DsbC (C-terminal domain), disulphide bond facilitator DsbA (contains an alpha-helical insertion), glutathione S-transferase (N-terminal domain), Endoplasmic reticulum protein ERP29 (N-terminal domain), spliceosomal protein U5-15Kd, circadian oscillation regulator KaiB, protein disulphide isomerase PDI (contains two tandem repeats of this fold), and calsequestrin (contains three tandem repeats of this fold).

  This entry differs from the thioredoxin fold protein, the classification of this fold is in the glutathione S-transferase enzymes, where this entry defines two regions containing this fold, and the thioredoxin fold protein defines only the N-terminal as containing this fold.

InterPro database

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