Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: TK C-terminal domain-like [ 52921]
• Superfamily: TK C-terminal domain-like [ 52922] (3)
• Family: Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain [ 52926] (4)

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Family statistics

	Genomes (1,563)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,467	15,436	8
Proteins	2,466	15,436	8

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	1-deoxy-D-xylulose-5-phosphate synthase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Transferring aldehyde or ketone residues	0	1.787	--	DIRECT
Enzyme Commission (EC)	Pyruvate dehydrogenase (acetyl-transferring)	0.00003115	2.139	--	DIRECT
Enzyme Commission (EC)	Transketolases and transaldolases	1	1.787	--	INHERITED FROM: 1-deoxy-D-xylulose-5-phosphate synthase
Enzyme Commission (EC)	Oxidoreductases	1	0.3212	Least Informative	INHERITED FROM: With a disulfide as acceptor || Pyruvate dehydrogenase (acetyl-transferring) || Acting on the aldehyde or oxo group of donors
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0	1.236	Moderately Informative	DIRECT
Enzyme Commission (EC)	With a disulfide as acceptor	0	1.963	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.2218	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle tone	0	0.8942	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.6915	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.5433	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Muscular hypotonia	0	1.031	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Generalized hypotonia	0	1.508	Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.773	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || organism metabolism processing variant || retarded heterochronic variations || reproductive system physiology variant || transgene expression variant || gene expression variant || organism homeostasis metabolism variant || lethal || larval development variant || organism physiology variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || general pace of development variant || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || level of transgene expression variant || fertility reduced || transgene expression increased
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	level of transgene expression variant	0	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	transgene expression increased	0	1.426	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	cell	0	0.8608	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	egg	0	1.202	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.7579	--	DIRECT
Xenopus ANatomical entity (XAN)	gamete	0	1.202	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: testis || alimentary system || liver and biliary system || liver || urogenital system || nervous system || egg || genital system || male genitalia || central nervous system || pancreas || gamete
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || liver || head region || genital system || egg || nervous system || alimentary system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || ectoderm || compound organ || trunk || tissue || anatomical region || germ cell || liver and biliary system || solid compound organ || central nervous system || male genitalia || gamete || trunk region || pancreas || anatomical cluster || viscus || male organism || organism subdivision || cell || head || primary germ layer
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0	0.9357	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	germ cell	0	1.08	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.8739	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.7647	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.8828	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	liver and biliary system	0	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	solid compound organ	0	1.334	Informative	DIRECT
Xenopus ANatomical entity (XAN)	liver	0	1.786	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	pancreas	0.00007575	1.911	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6447	--	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7127	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	unspecified stage	0	1.131	Moderately Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.5171	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.4728	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || sporophyll || calyx || flower || collective plant structure || plant embryo || phyllome || multi-tissue plant structure || microsporophyll || reproductive shoot system || shoot system || plant organ || stem || whole plant || sepal || plant axis || collective phyllome structure || stamen || shoot axis || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: calyx || flower || sporophyll || perianth || stem || phyllome || sepal || reproductive shoot system || collective phyllome structure || microsporophyll || androecium || stamen || shoot axis || shoot system
Plant ANatomical entity (PAN)	plant embryo	0	0.4978	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.4728	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.4777	Least Informative	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.5153	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: flowering stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || flowering stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	With a disulfide as acceptor	0	2.385	--	DIRECT
Enzyme Commission (EC)	Transferring aldehyde or ketonic groups	0	2.151	--	DIRECT
Enzyme Commission (EC)	1-deoxy-D-xylulose-5-phosphate synthase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Pyruvate dehydrogenase (acetyl-transferring)	0.00001147	2.628	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0.5817	0.7328	Least Informative	INHERITED FROM: Acting on the aldehyde or oxo group of donors || Pyruvate dehydrogenase (acetyl-transferring) || With a disulfide as acceptor
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0	1.65	Informative	DIRECT
Enzyme Commission (EC)	Transketolases and transaldolases	1	2.151	Highly Informative	INHERITED FROM: 1-deoxy-D-xylulose-5-phosphate synthase

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