tRNA-intron endonuclease catalytic domain-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Restriction endonuclease-like [ 52979] (4)
• Superfamily: tRNA-intron endonuclease catalytic domain-like [ 53032]
• Family: tRNA-intron endonuclease catalytic domain-like [ 53033] (3)

---

Family statistics

	Genomes (83)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	97	318	6
Proteins	96	314	4

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	tRNA-intron endonuclease	0	2.44	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Endoribonucleases producing other than 5'-phosphom	0	2.042	Highly Informative	DIRECT

---

Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.2218	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4712	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal skull morphology	0	0.8826	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0	0.533	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the cerebrum	0	1.184	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0	0.6771	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0	0.6631	--	DIRECT
Phenotypic Abnormality (PA)	Decreased head circumference	0	1.348	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0	0.9572	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the eye	0	0.5703	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.513	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.4756	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skull size	0	1.101	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0	0.971	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia involving the central nervous system	0	1.047	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal eye physiology	0	0.7903	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of movement	0	1.064	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Microcephaly	0	1.383	Informative	DIRECT

---

Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphorus-oxygen lyases	0	1.951	--	DIRECT
Enzyme Commission (EC)	tRNA-intron lyase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Lyases	0	0.8775	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphorus-oxygen lyases	1	1.951	Highly Informative	INHERITED FROM: tRNA-intron lyase

---