Resolvase-like superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Resolvase-like [ 53040] (2)
• Superfamily: Resolvase-like [ 53041]
• Families: gamma,delta resolvase, catalytic domain [ 53042]

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Superfamily statistics

	Genomes (1,709)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,076	61,042	5
Proteins	6,073	61,021	5

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Functional annotation

• General category: Information
• Detailed category: DNA replication/repair

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InterPro annotation

• Cross references: IPR006119 SSF53041 Protein matches
• Abstract:

  Site-specific recombination plays an important role in DNA rearrangement in prokaryotic organisms. Two types of site-specific recombination are known to occur:

  1. Recombination between inverted repeats resulting in the reversal of a DNA segment.
  2. Recombination between repeat sequences on two DNA molecules resulting in their cointegration, or between repeats on one DNA molecule resulting in the excision of a DNA fragment.

  Site-specific recombination is characterised by a strand exchange mechanism that requires no DNA synthesis or high energy cofactor; the phosphodiester bond energy is conserved in a phospho-protein linkage during strand cleavage and re-ligation.

  Two unrelated families of recombinases are currently known [3011407]. The first, called the 'phage integrase' family, groups a number of bacterial phage and yeast plasmid enzymes. The second [2896291], called the 'resolvase' family, groups enzymes which share the following structural characteristics: an N-terminal catalytic and dimerization domain that contains a conserved serine residue involved in the transient covalent attachment to DNA, and a C-terminal helix-turn-helix DNA-binding domain .

InterPro database

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