Actin/HSP70 family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Ribonuclease H-like motif [ 53066] (7)
• Superfamily: Actin-like ATPase domain [ 53067] (14)
• Family: Actin/HSP70 [ 53068] (7)

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Family statistics

	Genomes (3,168)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	35,399	196,835	106
Proteins	19,445	110,209	53

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal peristalsis	0.0000004454	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Transient ischemic attack	0.00004013	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limb bone	0.0001822	0.9572	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of finger	0.0003013	1.258	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.0003531	0.8289	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system morphology	0.0003691	0.8391	--	DIRECT
Phenotypic Abnormality (PA)	Highly arched eyebrow	0.0004456	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the ureter	0.0006998	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Short neck	0.0008043	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.008418	0.6771	--	INHERITED FROM: Short neck
Phenotypic Abnormality (PA)	Abnormality of the neck	0.02129	1.763	--	INHERITED FROM: Short neck
Phenotypic Abnormality (PA)	Abnormal cerebral artery morphology	0.02328	1.985	--	INHERITED FROM: Transient ischemic attack || Cerebral ischemia
Phenotypic Abnormality (PA)	Abnormal eyebrow morphology	0.03082	1.763	--	INHERITED FROM: Highly arched eyebrow
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.03868	0.4712	--	INHERITED FROM: Abnormal appendicular skeleton morphology || Abnormality of limb bone || Abnormality of limb bone morphology || Abnormality of finger || Short neck
Phenotypic Abnormality (PA)	Abnormality of the head	0.04279	0.4538	--	INHERITED FROM: Highly arched eyebrow
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.04503	0.4454	--	INHERITED FROM: Highly arched eyebrow || Short neck
Phenotypic Abnormality (PA)	Abnormal ureter morphology	0.06943	2.161	--	INHERITED FROM: Hydroureter
Phenotypic Abnormality (PA)	Arterial stenosis	0.06987	1.86	--	INHERITED FROM: Cerebral ischemia || Transient ischemic attack
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.1406	0.9183	--	INHERITED FROM: Abnormality of finger
Phenotypic Abnormality (PA)	Abnormality of the ocular adnexa	0.1483	1.082	--	INHERITED FROM: Highly arched eyebrow
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.1616	0.2371	--	INHERITED FROM: Stroke || Transient ischemic attack || Cerebral ischemia
Phenotypic Abnormality (PA)	Abnormality of the urinary system	0.3069	0.8496	--	INHERITED FROM: Abnormality of the ureter || Hydroureter
Phenotypic Abnormality (PA)	Abnormal digit morphology	0.4702	1.14	--	INHERITED FROM: Abnormality of finger
Phenotypic Abnormality (PA)	Abnormality of the orbital region	0.483	1.082	--	INHERITED FROM: Highly arched eyebrow
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.5786	0.533	--	INHERITED FROM: Stroke || Cerebral ischemia || Transient ischemic attack
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.5975	0.6631	--	INHERITED FROM: Cerebral ischemia || Stroke || Transient ischemic attack
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.8399	0.7142	--	INHERITED FROM: Stroke || Transient ischemic attack || Cerebral ischemia
Phenotypic Abnormality (PA)	Abnormal hair morphology	0.9232	1.207	--	INHERITED FROM: Highly arched eyebrow
Phenotypic Abnormality (PA)	Gastrointestinal dysmotility	1	2.462	--	INHERITED FROM: Abnormal peristalsis
Phenotypic Abnormality (PA)	Abnormality of limbs	0.00249	0.6429	Least Informative	INHERITED FROM: Abnormality of limb bone || Abnormality of limb bone morphology || Abnormality of finger
Phenotypic Abnormality (PA)	Abnormality of the integument	0.01218	0.6235	Least Informative	INHERITED FROM: Highly arched eyebrow
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.01305	0.5179	Least Informative	INHERITED FROM: Abnormality of cardiovascular system morphology || Transient ischemic attack || Cerebral ischemia || Stroke
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.02054	0.5759	Least Informative	INHERITED FROM: Abnormal peristalsis
Phenotypic Abnormality (PA)	Abnormality of the face	0.02385	0.533	Least Informative	INHERITED FROM: Highly arched eyebrow
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.02623	0.4756	Least Informative	INHERITED FROM: Stroke || Transient ischemic attack || Cerebral ischemia
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.02999	0.513	Least Informative	INHERITED FROM: Short neck || Abnormality of finger || Abnormality of limb bone morphology || Abnormal appendicular skeleton morphology
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.1762	0.6051	Least Informative	INHERITED FROM: Abnormality of the ureter || Hydroureter
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0.0001822	0.9572	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the hand	0.001548	1.031	Moderately Informative	INHERITED FROM: Abnormality of finger
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.04548	1.031	Moderately Informative	INHERITED FROM: Abnormal peristalsis
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0.1419	1.082	Moderately Informative	INHERITED FROM: Highly arched eyebrow
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0.1752	0.9572	Moderately Informative	INHERITED FROM: Abnormal peristalsis
Phenotypic Abnormality (PA)	Abnormal vascular morphology	0.2208	1.207	Moderately Informative	INHERITED FROM: Transient ischemic attack || Cerebral ischemia
Phenotypic Abnormality (PA)	Abnormality of the upper urinary tract	0.2643	1.12	Moderately Informative	INHERITED FROM: Hydroureter || Abnormality of the ureter
Phenotypic Abnormality (PA)	Abnormality of skin adnexa morphology	0.2679	1.184	Moderately Informative	INHERITED FROM: Highly arched eyebrow
Phenotypic Abnormality (PA)	Abnormality of the vertebral column	0.3538	1.031	Moderately Informative	INHERITED FROM: Short neck
Phenotypic Abnormality (PA)	Abnormal systemic arterial morphology	0.004764	1.421	Informative	INHERITED FROM: Transient ischemic attack || Cerebral ischemia
Phenotypic Abnormality (PA)	Abnormality of the cerebral vasculature	0.0204	1.462	Informative	INHERITED FROM: Stroke || Transient ischemic attack || Cerebral ischemia
Phenotypic Abnormality (PA)	Functional abnormality of the gastrointestinal tract	0.1289	1.421	Informative	INHERITED FROM: Abnormal peristalsis
Phenotypic Abnormality (PA)	Hydroureter	0.00003239	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Cerebral ischemia	0.0005144	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Stroke	0.0008807	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal gastrointestinal motility	0.001834	2.161	Highly Informative	INHERITED FROM: Abnormal peristalsis
Phenotypic Abnormality (PA)	Abnormality of the cervical spine	0.00808	1.86	Highly Informative	INHERITED FROM: Short neck

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.2459	0.825	--	INHERITED FROM: altered response to CNS ischemic injury
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.7111	0.3626	--	INHERITED FROM: altered response to CNS ischemic injury
Mammalian Phenotype (MP)	nervous system phenotype	0.4384	0.4959	Least Informative	INHERITED FROM: altered response to CNS ischemic injury
Mammalian Phenotype (MP)	abnormal response to injury	0.03728	1.261	Informative	INHERITED FROM: altered response to CNS ischemic injury
Mammalian Phenotype (MP)	altered response to CNS ischemic injury	0.0006055	2.001	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0.0000000002053	0.773	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.0000000004025	1.087	--	DIRECT
Worm Phenotype (WP)	germ cell morphology variant	0.000000001719	1.156	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.000000003485	0.6859	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.000000004572	0.6256	--	DIRECT
Worm Phenotype (WP)	receptor mediated endocytosis defective	0.0000001032	1.689	--	DIRECT
Worm Phenotype (WP)	oocyte physiology variant	0.0000001487	1.593	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic physiology variant	0.0000008472	1.426	--	DIRECT
Worm Phenotype (WP)	reduced brood size	0.000001259	1.593	--	DIRECT
Worm Phenotype (WP)	endocytic transport variant	0.000002846	1.354	--	DIRECT
Worm Phenotype (WP)	dead eggs laid	0.000004941	2.292	--	DIRECT
Worm Phenotype (WP)	mitochondria alignment variant	0.000009092	1.623	--	DIRECT
Worm Phenotype (WP)	body wall muscle myosin organization defective	0.00001735	2.468	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.00001777	0.7516	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.00002224	0.7558	--	DIRECT
Worm Phenotype (WP)	protein interaction variant	0.00002474	1.078	--	DIRECT
Worm Phenotype (WP)	germ cell compartment nuclei number variant	0.00003121	1.814	--	DIRECT
Worm Phenotype (WP)	L1 larval development variant	0.00009547	2.292	--	DIRECT
Worm Phenotype (WP)	cadmium response variant	0.0007069	1.814	--	DIRECT
Worm Phenotype (WP)	protruding vulva	0.0008226	1.623	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0.001082	1.306	--	INHERITED FROM: muscle cell attachment variant
Worm Phenotype (WP)	striated muscle morphology variant	0.001362	1.407	--	INHERITED FROM: body wall muscle myosin organization defective || body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	response to bacteria variant	0.002412	1.426	--	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	body wall muscle thick filament variant	0.003092	2.292	--	INHERITED FROM: body wall muscle myosin organization defective
Worm Phenotype (WP)	vesicle trafficking variant	0.006628	1.354	--	INHERITED FROM: receptor mediated endocytosis defective || endocytic transport defect || endocytic transport variant
Worm Phenotype (WP)	cytokinesis variant	0.008086	1.689	--	INHERITED FROM: cytokinesis variant emb || cleavage furrow defective early emb
Worm Phenotype (WP)	mitochondria spacing variant	0.008165	1.623	--	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	gametogenesis variant	0.08077	1.013	--	INHERITED FROM: germ cell development variant
Worm Phenotype (WP)	germ cell cytoplasmic morphology variant	0.09718	1.866	--	INHERITED FROM: cytoplasmic processing body variant
Worm Phenotype (WP)	cell component morphology variant	0.09827	0.8392	--	INHERITED FROM: cytoplasmic processing body variant || germline nuclear positioning variant || mitochondria alignment variant
Worm Phenotype (WP)	muscle system morphology variant	0.1175	1.407	--	INHERITED FROM: body wall muscle myosin organization defective || body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	postembryonic development variant	0.1183	0.269	--	INHERITED FROM: L1 larval development variant
Worm Phenotype (WP)	organelle organization biogenesis variant	0.125	1.306	--	INHERITED FROM: germline nuclear positioning variant
Worm Phenotype (WP)	feeding behavior variant	0.1463	1.25	--	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	larval development variant	0.1707	0.4322	--	INHERITED FROM: L1 larval development variant
Worm Phenotype (WP)	muscle cell morphology variant	0.2649	1.337	--	INHERITED FROM: body wall muscle myosin organization defective || body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	cytokinesis defective early emb	0.5291	1.866	--	INHERITED FROM: cleavage furrow defective early emb
Worm Phenotype (WP)	cleavage furrow defective	0.5795	2.07	--	INHERITED FROM: cleavage furrow defective early emb
Worm Phenotype (WP)	hermaphrodite reproductive system morphology variant	0.7193	1.426	--	INHERITED FROM: protruding vulva
Worm Phenotype (WP)	germ cell compartment morphology variant	0.8535	1.354	--	INHERITED FROM: germ cell compartment nuclei number variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || organism metabolism processing variant || protein protein interaction variant || reproductive system physiology variant || transgene expression variant || gene expression variant || endocytic transport variant || organism homeostasis metabolism variant || avoids bacterial lawn || lethal || protein interaction variant || germ cell physiology variant || organism physiology variant || cytokinesis variant emb || germ cell development variant || oocyte physiology variant || sexually dimorphic physiology variant || endocytic transport defect || development variant || cleavage furrow defective early emb || cell physiology variant || reduced brood size || muscle cell attachment variant || dead eggs laid || cadmium response variant || brood size variant || embryonic development variant || embryonic lethal || germline nuclear positioning variant || fertility variant || behavior variant || protein expression reduced || protein aggregation variant || L1 larval development variant || organ system physiology variant || organism behavior variant || organism development variant || hermaphrodite physiology variant || receptor mediated endocytosis defective || cell development variant
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.446	--	INHERITED FROM: body wall muscle sarcomere morphology variant || body wall muscle myosin organization defective
Worm Phenotype (WP)	organism behavior variant	0.000000003194	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.000001319	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.000002135	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.0009519	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.001188	0.6614	Least Informative	INHERITED FROM: cadmium response variant || avoids bacterial lawn
Worm Phenotype (WP)	protein protein interaction variant	0.0000000005833	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0.0006059	1.013	Moderately Informative	DIRECT
Worm Phenotype (WP)	early embryonic lethal	0.00148	1.178	Moderately Informative	INHERITED FROM: cleavage furrow defective early emb
Worm Phenotype (WP)	cell division variant	0.007866	1.036	Moderately Informative	INHERITED FROM: cleavage furrow defective early emb || cytokinesis variant emb
Worm Phenotype (WP)	cell type morphology variant	0.03364	0.8878	Moderately Informative	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || body wall muscle myosin organization defective || body wall muscle sarcomere morphology variant || germ cell compartment nuclei number variant
Worm Phenotype (WP)	reproductive system morphology variant	0.05722	1.078	Moderately Informative	INHERITED FROM: protruding vulva
Worm Phenotype (WP)	protein expression variant	0.097	1.125	Moderately Informative	INHERITED FROM: protein expression reduced
Worm Phenotype (WP)	cell organization biogenesis variant	0.2298	1.135	Moderately Informative	INHERITED FROM: germline nuclear positioning variant
Worm Phenotype (WP)	hermaphrodite physiology variant	0.0000002484	1.446	Informative	DIRECT
Worm Phenotype (WP)	cytokinesis variant emb	0.000000762	1.689	Informative	DIRECT
Worm Phenotype (WP)	germ cell physiology variant	0.000001436	1.49	Informative	DIRECT
Worm Phenotype (WP)	endocytic transport defect	0.000002352	1.407	Informative	DIRECT
Worm Phenotype (WP)	brood size variant	0.000004163	1.538	Informative	DIRECT
Worm Phenotype (WP)	avoids bacterial lawn	0.00001151	1.49	Informative	DIRECT
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0.0009634	1.446	Informative	DIRECT
Worm Phenotype (WP)	vulva morphology variant	0.001801	1.426	Informative	INHERITED FROM: protruding vulva
Worm Phenotype (WP)	cell component localization variant	0.003879	1.388	Informative	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	muscle cell physiology variant	0.02525	1.426	Informative	INHERITED FROM: muscle cell attachment variant
Worm Phenotype (WP)	metal response variant	0.03573	1.655	Informative	INHERITED FROM: cadmium response variant
Worm Phenotype (WP)	nuclear positioning variant	0.05375	1.623	Informative	INHERITED FROM: germline nuclear positioning variant
Worm Phenotype (WP)	level of protein expression variant	0.06638	1.689	Informative	INHERITED FROM: protein expression reduced
Worm Phenotype (WP)	mitochondria morphology variant	0.08371	1.513	Informative	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	egg laying variant	0.6387	1.513	Informative	INHERITED FROM: dead eggs laid
Worm Phenotype (WP)	protein expression reduced	0.00002964	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	muscle cell attachment variant	0.0000923	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	cytoplasmic processing body variant	0.0004342	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	germline nuclear positioning variant	0.0004342	1.769	Highly Informative	DIRECT
Worm Phenotype (WP)	cleavage furrow defective early emb	0.0007903	2.07	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	actin cytoskeleton morphology	0.000636	2.444	--	DIRECT
Yeast Phenotype (YP)	cytoskeleton morphology	0.002324	2.444	--	INHERITED FROM: actin cytoskeleton morphology
Yeast Phenotype (YP)	cellular morphology	0.1738	1.24	--	INHERITED FROM: actin cytoskeleton morphology
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT
Yeast Phenotype (YP)	morphology	0.05343	1.143	Moderately Informative	INHERITED FROM: actin cytoskeleton morphology
Yeast Phenotype (YP)	subcellular morphology	0.6388	1.541	Informative	INHERITED FROM: actin cytoskeleton morphology
Yeast Phenotype (YP)	freeze-thaw resistance	0.0009183	1.967	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical group || whole organism || compound organ || cavitated compound organ
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5123	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	skeletal muscle	0.000001278	1.61	--	DIRECT
Xenopus ANatomical entity (XAN)	head somite	0.000002072	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	jaw muscle	0.000009044	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	myocyte	0.00003505	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	muscular system	0.00004581	1.263	--	DIRECT
Xenopus ANatomical entity (XAN)	cranial muscle	0.00004851	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	heart	0.000511	1.689	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk somite	0.0006645	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	cell	0.01706	0.8608	--	INHERITED FROM: myocyte
Xenopus ANatomical entity (XAN)	head region	0.127	0.4759	--	INHERITED FROM: head mesoderm || jaw muscle || head somite || cranial muscle
Xenopus ANatomical entity (XAN)	primary germ layer	0.2376	0.6748	--	INHERITED FROM: head somite || trunk somite || head mesoderm
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: muscular system || muscle || myocyte || trunk somite || jaw muscle || cranial muscle || head somite || skeletal muscle || pancreas || heart
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: tail region || jaw muscle || trunk somite || muscle || myocyte || anatomical group || cavitated compound organ || multicellular anatomical structure || muscular system || head mesoderm || compound organ || tail || trunk || anatomical region || skeletal muscle || heart || trunk region || pancreas || head somite || organism subdivision || cranial muscle
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0.003839	0.7159	Least Informative	INHERITED FROM: heart || pancreas
Xenopus ANatomical entity (XAN)	tissue	0.01593	0.4672	Least Informative	INHERITED FROM: skeletal muscle || jaw muscle || trunk somite || myocyte || muscle || cranial muscle || head somite || head mesoderm
Xenopus ANatomical entity (XAN)	embryo	0.02457	0.5979	Least Informative	INHERITED FROM: head somite || trunk somite || head mesoderm
Xenopus ANatomical entity (XAN)	head	0.1045	0.4777	Least Informative	INHERITED FROM: cranial muscle || head mesoderm || jaw muscle
Xenopus ANatomical entity (XAN)	tail region	0.0004921	1.242	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.003875	1.087	Moderately Informative	INHERITED FROM: cranial muscle || muscular system || head somite || muscle || myocyte || skeletal muscle || trunk somite || jaw muscle
Xenopus ANatomical entity (XAN)	alimentary system	0.03457	0.8739	Moderately Informative	INHERITED FROM: pancreas
Xenopus ANatomical entity (XAN)	viscus	0.08928	0.8828	Moderately Informative	INHERITED FROM: pancreas || heart
Xenopus ANatomical entity (XAN)	muscle	0.00007672	1.45	Informative	DIRECT
Xenopus ANatomical entity (XAN)	tail	0.0006269	1.334	Informative	DIRECT
Xenopus ANatomical entity (XAN)	cardiovascular system	0.003011	1.586	Informative	INHERITED FROM: heart
Xenopus ANatomical entity (XAN)	mesoderm	0.005196	1.285	Informative	INHERITED FROM: head mesoderm || head somite || trunk somite
Xenopus ANatomical entity (XAN)	pancreas	0.00009275	1.911	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	head mesoderm	0.0007881	2.087	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	somite	0.002278	1.824	Highly Informative	INHERITED FROM: trunk somite || head somite

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	parenchyma	0.0005994	1.787	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0.02723	0.1621	--	INHERITED FROM: trichome || parenchyma
Plant ANatomical entity (PAN)	plant cell	0.06646	0.1228	--	INHERITED FROM: pollen tube cell
Plant ANatomical entity (PAN)	epidermis	0.5047	0.2046	--	INHERITED FROM: trichome
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || trichome || shoot system || parenchyma || pollen tube cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant ANatomical entity (PAN)	pollen tube cell	0.0001219	1.454	Informative	DIRECT
Plant ANatomical entity (PAN)	portion of ground tissue	0.01783	1.579	Informative	INHERITED FROM: parenchyma
Plant ANatomical entity (PAN)	trichome	0.0002303	1.947	Highly Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	1	0.1547	--	INHERITED FROM: seedling development stage
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	1	0.1593	--	INHERITED FROM: seedling development stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: seedling development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: seedling development stage
Plant structure DEvelopment stage (PDE)	seedling development stage	0.0000008126	1.721	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	seed development stage	0.000006498	1.304	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Non-chaperonin molecular chaperone ATPase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Adenosinetriphosphatase	0.000000000004035	2.531	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0	1.133	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on ATP; involved in cellular and subcellular movement	0.00000002089	1.385	Informative	DIRECT
Enzyme Commission (EC)	In phosphorus-containing anhydrides	1	1.452	Informative	INHERITED FROM: Adenosinetriphosphatase

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