Ribonuclease H family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Ribonuclease H-like motif [ 53066] (7)
• Superfamily: Ribonuclease H-like [ 53098] (14)
• Family: Ribonuclease H [ 53099] (4)

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Family statistics

	Genomes (3,007)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	4,658	62,540	79
Proteins	4,657	62,535	79

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Exoribonuclease H	0	1.7	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	HIV-1 retropepsin	0	1.741	--	DIRECT
Enzyme Commission (EC)	Retroviral ribonuclease H	0.0000000003089	1.7	--	DIRECT
Enzyme Commission (EC)	HIV-2 retropepsin	0.00002181	1.741	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: RNA-directed DNA polymerase || Nucleotidyltransferases || DNA-directed DNA polymerase
Enzyme Commission (EC)	Transferring phosphorous-containing groups	1	0.2728	--	INHERITED FROM: Nucleotidyltransferases || RNA-directed DNA polymerase || DNA-directed DNA polymerase
Enzyme Commission (EC)	Acting on ester bonds	0	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Nucleotidyltransferases	0.000000000001101	0.6958	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	1	0.5709	Least Informative	INHERITED FROM: Aspartic endopeptidases || HIV-2 retropepsin || HIV-1 retropepsin
Enzyme Commission (EC)	Endoribonucleases producing 5'-phosphomonoesters	0	1.361	Informative	DIRECT
Enzyme Commission (EC)	DNA-directed DNA polymerase	0	1.31	Informative	DIRECT
Enzyme Commission (EC)	Aspartic endopeptidases	0	1.662	Informative	DIRECT
Enzyme Commission (EC)	RNA-directed DNA polymerase	0	1.662	Informative	DIRECT
Enzyme Commission (EC)	Exoribonucleases producing 5'-phosphomonoesters	0.000000000000005133	1.486	Informative	DIRECT
Enzyme Commission (EC)	Ribonuclease H	0	2.042	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: phyllome || guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || phyllome || multi-tissue plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || plant organ || whole plant || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Exoribonuclease H	0	2.188	--	DIRECT
Enzyme Commission (EC)	Endoribonucleases producing 5'-phosphomonoesters	0	1.767	--	DIRECT
Enzyme Commission (EC)	Ribonuclease H	0	2.275	--	DIRECT
Enzyme Commission (EC)	HIV-1 retropepsin	0	2.23	--	DIRECT
Enzyme Commission (EC)	HIV-2 retropepsin	0.00001779	2.23	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	1	0.7021	--	INHERITED FROM: Nucleotidyltransferases || DNA-directed DNA polymerase || RNA-directed DNA polymerase
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: DNA-directed DNA polymerase || RNA-directed DNA polymerase || Nucleotidyltransferases
Enzyme Commission (EC)	Acting on ester bonds	0	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Nucleotidyltransferases	0.0000000000000379	1.126	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	1	1.004	Moderately Informative	INHERITED FROM: Aspartic endopeptidases || HIV-1 retropepsin || HIV-2 retropepsin
Enzyme Commission (EC)	Acting on acid anhydrides	1	1.133	Moderately Informative	INHERITED FROM: dUTP diphosphatase
Enzyme Commission (EC)	DNA-directed DNA polymerase	0	1.725	Informative	DIRECT
Enzyme Commission (EC)	In phosphorus-containing anhydrides	0.8443	1.452	Informative	INHERITED FROM: dUTP diphosphatase
Enzyme Commission (EC)	RNA-directed DNA polymerase	0	2.026	Highly Informative	DIRECT
Enzyme Commission (EC)	Aspartic endopeptidases	0	2.116	Highly Informative	DIRECT
Enzyme Commission (EC)	Exoribonucleases producing 5'-phosphomonoesters	0.000000000000004716	1.951	Highly Informative	DIRECT
Enzyme Commission (EC)	Retroviral ribonuclease H	0.000000001182	2.188	Highly Informative	DIRECT
Enzyme Commission (EC)	dUTP diphosphatase	0.000002705	2.188	Highly Informative	DIRECT

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