Translational machinery components superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Ribonuclease H-like motif [ 53066] (7)
• Superfamily: Translational machinery components [ 53137] (2)
• Families:
  • Ribosomal protein L18 and S11 [ 53138] (2)
  • ERF1/Dom34 middle domain-like [ 53143] (3)

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Superfamily statistics

	Genomes (3,247)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	10,604	65,177	25
Proteins	10,580	65,104	25

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Functional annotation

• General category: Information
• Detailed category: Translation

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.4022	--	DIRECT
Worm Phenotype (WP)	slow growth	0	0.5903	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.5373	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	rachis narrow	0.00001078	1.708	--	DIRECT
Worm Phenotype (WP)	meiotic progression prophase variant	0.00004323	1.327	--	DIRECT
Worm Phenotype (WP)	meiotic progression during oogenesis variant	0.00007791	1.293	--	DIRECT
Worm Phenotype (WP)	germ cell compartment morphology variant	0.0001079	1.31	--	DIRECT
Worm Phenotype (WP)	oogenesis variant	0.000215	1.189	--	DIRECT
Worm Phenotype (WP)	meiosis variant	0.000504	1.176	--	DIRECT
Worm Phenotype (WP)	gonad morphology variant	0.0005299	1.245	--	DIRECT
Worm Phenotype (WP)	gametogenesis variant	0.004491	0.9517	--	INHERITED FROM: germ cell differentiation variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || oogenesis variant || pachytene region organization variant || meiotic progression during oogenesis variant || meiosis variant || diplotene progression during oogenesis variant || oocyte number decreased
Worm Phenotype (WP)	cell type morphology variant	0.01305	0.8211	--	INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || meiotic progression during oogenesis variant || retarded heterochronic variations || reproductive system physiology variant || metabolic pathway variant || diplotene progression during oogenesis variant || early embryonic lethal || oogenesis variant || organism homeostasis metabolism variant || oocyte number decreased || lethal || organism physiology variant || meiosis variant || germ cell differentiation variant || slow growth || development variant || developmental timing variant || cell physiology variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || general pace of development variant || fertility variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced || pachytene region organization variant
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	general pace of development variant	0	0.5708	Least Informative	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.5373	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.0007457	0.5344	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.01161	0.4572	Least Informative	INHERITED FROM: metabolic pathway variant
Worm Phenotype (WP)	organ system morphology variant	0.03365	0.7119	Least Informative	INHERITED FROM: rachis morphology variant || gonad morphology variant || rachis narrow || pachytene region organization variant
Worm Phenotype (WP)	cell morphology variant	0.036	0.6905	Least Informative	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || oocyte morphology variant || germ cell compartment expansion variant
Worm Phenotype (WP)	cell development variant	0.04511	0.632	Least Informative	INHERITED FROM: germ cell differentiation variant || meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || meiosis variant || oocyte number decreased || pachytene progression during oogenesis variant || meiotic progression prophase variant || oogenesis variant || pachytene region organization variant
Worm Phenotype (WP)	germ cell differentiation variant	0.0007614	1.128	Moderately Informative	DIRECT
Worm Phenotype (WP)	metabolic pathway variant	0.0008494	1.117	Moderately Informative	DIRECT
Worm Phenotype (WP)	early embryonic lethal	0.0009702	1.106	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell morphology variant	0.00184	1.064	Moderately Informative	INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant
Worm Phenotype (WP)	germ cell development variant	0.004202	0.9752	Moderately Informative	INHERITED FROM: meiotic progression during oogenesis variant || pachytene region organization variant || oocyte number decreased || meiosis variant || diplotene progression during oogenesis variant || oogenesis variant || pachytene progression during oogenesis variant || meiotic progression prophase variant
Worm Phenotype (WP)	reproductive system morphology variant	0.005541	1.017	Moderately Informative	INHERITED FROM: rachis narrow || pachytene region organization variant || rachis morphology variant || gonad morphology variant
Worm Phenotype (WP)	cell cycle variant	0.04283	1.164	Moderately Informative	INHERITED FROM: diplotene progression during oogenesis variant || meiosis variant || pachytene region organization variant || meiotic progression prophase variant || pachytene progression during oogenesis variant
Worm Phenotype (WP)	cell division variant	0.1344	1	Moderately Informative	INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || pachytene region organization variant || meiosis variant || diplotene progression during oogenesis variant
Worm Phenotype (WP)	pachytene progression during oogenesis variant	0.00001221	1.429	Informative	DIRECT
Worm Phenotype (WP)	diplotene progression during oogenesis variant	0.00001285	1.666	Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment expansion variant	0.00004715	1.407	Informative	DIRECT
Worm Phenotype (WP)	rachis morphology variant	0.00005133	1.531	Informative	DIRECT
Worm Phenotype (WP)	oocyte morphology variant	0.0002328	1.276	Informative	DIRECT
Worm Phenotype (WP)	pachytene region organization variant	0.00000752	1.753	Highly Informative	DIRECT
Worm Phenotype (WP)	oocyte number decreased	0.000014	1.804	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.2018	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.05522	--	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.2245	--	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5472	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: cell || anatomical system || anatomical cluster || pericardial region || anatomical group || whole organism || organism subdivision || compound organ || cavitated compound organ || head || nervous system
Zebrafish Anatomy (ZA)	nervous system	0	0.6911	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	compound organ	0	0.4571	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	organism subdivision	0	0.6264	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cell	0	0.7491	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	head	0	1.008	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	anatomical cluster	0	0.883	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	pericardial region	0	1.661	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	genital system	0	0.5909	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	cell	0	0.7974	--	DIRECT
Xenopus ANatomical entity (XAN)	egg	0	1.17	--	DIRECT
Xenopus ANatomical entity (XAN)	gamete	0	1.17	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0.1643	0.7974	--	INHERITED FROM: pancreas
Xenopus ANatomical entity (XAN)	trunk region	0.4371	0.4287	--	INHERITED FROM: pancreas
Xenopus ANatomical entity (XAN)	anatomical region	0.853	0.193	--	INHERITED FROM: pancreas
Xenopus ANatomical entity (XAN)	compound organ	0.9143	0.24	--	INHERITED FROM: pancreas
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: urogenital system || egg || genital system || pancreas || gamete
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: urogenital system || genital system || egg || anatomical group || multicellular anatomical structure || germ cell || gamete || pancreas || cell
Xenopus ANatomical entity (XAN)	organism subdivision	1	0.1871	--	INHERITED FROM: pancreas
Xenopus ANatomical entity (XAN)	urogenital system	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0.4364	0.4308	Least Informative	INHERITED FROM: pancreas
Xenopus ANatomical entity (XAN)	germ cell	0	1.013	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0.0736	0.9618	Moderately Informative	INHERITED FROM: pancreas
Xenopus ANatomical entity (XAN)	alimentary system	0.1039	0.955	Moderately Informative	INHERITED FROM: pancreas
Xenopus ANatomical entity (XAN)	pancreas	0.0007864	1.807	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: plant cell
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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