Cofactor-dependent phosphoglycerate mutase family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Phosphoglycerate mutase-like [ 53253]
• Superfamily: Phosphoglycerate mutase-like [ 53254] (3)
• Family: Cofactor-dependent phosphoglycerate mutase [ 53255] (3)

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Family statistics

	Genomes (1,904)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,603	14,559	11
Proteins	2,602	14,543	11

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphoglycerate mutase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Bisphosphoglycerate phosphatase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Fructose-2,6-bisphosphate 2-phosphatase	0.0000000008211	2.264	--	DIRECT
Enzyme Commission (EC)	Bisphosphoglycerate mutase	0.000000169	2.741	--	DIRECT
Enzyme Commission (EC)	Hydrolases	1	0.01852	--	INHERITED FROM: Phosphoric monoester hydrolases || Fructose-2,6-bisphosphate 2-phosphatase || Bisphosphoglycerate phosphatase
Enzyme Commission (EC)	Isomerases	0	0.6881	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.08912	0.5107	Least Informative	INHERITED FROM: Fructose-2,6-bisphosphate 2-phosphatase || Phosphoric monoester hydrolases || Bisphosphoglycerate phosphatase
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0.0000000002092	0.9703	Moderately Informative	DIRECT
Enzyme Commission (EC)	Intramolecular transferases (mutases)	0	1.399	Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases (phosphomutases)	0	1.838	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: nervous system || brain || central nervous system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: head region || brain || nervous system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || central nervous system || trunk region || anatomical cluster || organism subdivision || head
Xenopus ANatomical entity (XAN)	nervous system	0	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.7859	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6447	--	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7127	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.4584	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: root || collective plant structure || multi-tissue plant structure || plant organ || root system || plant axis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: root system || root
Plant ANatomical entity (PAN)	root	0	0.4679	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || E expanded cotyledon stage || F mature embryo stage || D bilateral stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: E expanded cotyledon stage || sporophyte vegetative stage || C globular stage || D bilateral stage || F mature embryo stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.3205	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.301	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)	0	3.23	--	DIRECT
Enzyme Commission (EC)	Fructose-2,6-bisphosphate 2-phosphatase	0.0000000000005256	2.753	--	DIRECT
Enzyme Commission (EC)	Bisphosphoglycerate mutase	0.00000006957	3.23	--	DIRECT
Enzyme Commission (EC)	Hydrolases	1	0.4043	Least Informative	INHERITED FROM: Fructose-2,6-bisphosphate 2-phosphatase
Enzyme Commission (EC)	Isomerases	0	1.026	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.986	0.8756	Moderately Informative	INHERITED FROM: Fructose-2,6-bisphosphate 2-phosphatase
Enzyme Commission (EC)	Intramolecular transferases	0	1.606	Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0.001857	1.338	Informative	INHERITED FROM: Fructose-2,6-bisphosphate 2-phosphatase
Enzyme Commission (EC)	Phosphotransferases (phosphomutases)	0	2.23	Highly Informative	DIRECT

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