Formyltransferase superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Formyltransferase [ 53327]
• Superfamily: Formyltransferase [ 53328]
• Families: Formyltransferase [ 53329] (4)

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Superfamily statistics

	Genomes (3,091)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	8,852	69,564	13
Proteins	8,824	69,465	13

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Functional annotation

• General category: Metabolism
• Detailed category: Transferases

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic	0	2.259	--	DIRECT
Enzyme Commission (EC)	Methionyl-tRNA formyltransferase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Formyltetrahydrofolate deformylase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.00000006079	0.8787	--	DIRECT
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptid	1	0.8195	--	INHERITED FROM: Formyltetrahydrofolate deformylase
Enzyme Commission (EC)	Hydrolases	1	0.04271	--	INHERITED FROM: Formyltetrahydrofolate deformylase
Enzyme Commission (EC)	Transferring one-carbon groups	0	0.7211	Least Informative	DIRECT
Enzyme Commission (EC)	Ligases	1	0.6568	Least Informative	INHERITED FROM: Phosphoribosylamine--glycine ligase || Phosphoribosylformylglycinamidine cyclo-ligase
Enzyme Commission (EC)	Oxidoreductases	1	0.2975	Least Informative	INHERITED FROM: Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic || With NAD(+) or NADP(+) as acceptor || Formyltetrahydrofolate dehydrogenase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.000000003085	0.9471	Moderately Informative	DIRECT
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	0.9067	Moderately Informative	INHERITED FROM: Phosphoribosylamine--glycine ligase || Phosphoribosylformylglycinamidine cyclo-ligase
Enzyme Commission (EC)	In linear amides	0.9421	1.083	Moderately Informative	INHERITED FROM: Formyltetrahydrofolate deformylase
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0.06006	1.198	Moderately Informative	INHERITED FROM: Formyltetrahydrofolate dehydrogenase
Enzyme Commission (EC)	Hydroxymethyl-, formyl- and related transferases	0	1.356	Informative	DIRECT
Enzyme Commission (EC)	Other carbon--nitrogen ligases	0.9519	1.329	Informative	INHERITED FROM: Phosphoribosylamine--glycine ligase
Enzyme Commission (EC)	Cyclo-ligases	0.006156	1.657	Informative	INHERITED FROM: Phosphoribosylformylglycinamidine cyclo-ligase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.03395	1.414	Informative	INHERITED FROM: Formyltetrahydrofolate dehydrogenase
Enzyme Commission (EC)	UDP-4-amino-4-deoxy-L-arabinose formyltransferase	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Formyltetrahydrofolate dehydrogenase	0	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphoribosylamine--glycine ligase	0.00000004785	1.782	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphoribosylglycinamide formyltransferase	0.0000001658	1.782	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphoribosylformylglycinamidine cyclo-ligase	0.0003963	1.782	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || anatomical region || organism subdivision
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.3033	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5946	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6715	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5693	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1968	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.2036	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2833	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.4754	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.4754	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || LP.12 twelve leaves visible stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || LP.06 six leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: LP.12 twelve leaves visible stage || E expanded cotyledon stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || C globular stage || leaf production stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.478	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.353	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.4088	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3937	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.3729	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.5666	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.5603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.513	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.4338	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.5243	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating)	0	2.651	--	DIRECT
Enzyme Commission (EC)	Formyltetrahydrofolate dehydrogenase	0	2.35	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3035	--	DIRECT
Enzyme Commission (EC)	UDP-4-amino-4-deoxy-L-arabinose formyltransferase	0	2.475	--	DIRECT
Enzyme Commission (EC)	Methionyl-tRNA formyltransferase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Formyltetrahydrofolate deformylase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Phosphoribosylformylglycinamidine cyclo-ligase	0.0002098	2.253	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.02193	1.721	--	INHERITED FROM: Formyltetrahydrofolate dehydrogenase
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	1.181	--	INHERITED FROM: Phosphoribosylformylglycinamidine cyclo-ligase || Phosphoribosylamine--glycine ligase
Enzyme Commission (EC)	Oxidoreductases	1	0.6234	Least Informative	INHERITED FROM: Formyltetrahydrofolate dehydrogenase || With NAD(+) or NADP(+) as acceptor || Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating)
Enzyme Commission (EC)	Hydrolases	1	0.3541	Least Informative	INHERITED FROM: Formyltetrahydrofolate deformylase
Enzyme Commission (EC)	Transferring one-carbon groups	0	1.054	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.000000001517	1.228	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptide bonds	1	1.094	Moderately Informative	INHERITED FROM: Formyltetrahydrofolate deformylase
Enzyme Commission (EC)	Ligases	1	0.9606	Moderately Informative	INHERITED FROM: Phosphoribosylamine--glycine ligase || Phosphoribosylformylglycinamidine cyclo-ligase
Enzyme Commission (EC)	Hydroxymethyl-, formyl- and related transferases	0	1.721	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.00000000006703	1.329	Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0.04377	1.505	Informative	INHERITED FROM: Formyltetrahydrofolate dehydrogenase
Enzyme Commission (EC)	In linear amides	1	1.372	Informative	INHERITED FROM: Formyltetrahydrofolate deformylase
Enzyme Commission (EC)	Other carbon--nitrogen ligases	1	1.505	Informative	INHERITED FROM: Phosphoribosylamine--glycine ligase
Enzyme Commission (EC)	Phosphoribosylamine--glycine ligase	0.00000002355	2.174	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphoribosylglycinamide formyltransferase	0.00000008648	2.174	Highly Informative	DIRECT
Enzyme Commission (EC)	Cyclo-ligases	0.004039	1.998	Highly Informative	INHERITED FROM: Phosphoribosylformylglycinamidine cyclo-ligase

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InterPro annotation

• Cross references: IPR002376 SSF53328 Protein matches
• Abstract: A number of formyl transferases belong to this group. Methionyl-tRNA formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP. Formyltetrahydrofolate dehydrogenase produces formate from formyl- tetrahydrofolate. This is the N-terminal domain of these enzymes and is found upstream of the C-terminal domain .

  The trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase catalyses the second, third and fifth steps in de novo purine biosynthesis. The glycinamide ribonucleotide transformylase belongs to this group.

InterPro database

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