Cystathionine synthase-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: PLP-dependent transferase-like [ 53382] (3)
• Superfamily: PLP-dependent transferases [ 53383] (9)
• Family: Cystathionine synthase-like [ 53402] (16)

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Family statistics

	Genomes (3,243)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	20,106	160,083	29
Proteins	20,095	160,021	29

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Cystathionine gamma-synthase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Acting on carbon-carbon bonds	0	1.896	--	DIRECT
Enzyme Commission (EC)	Selenocysteine lyase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Molybdenum cofactor sulfurtransferase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Kynureninase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Cysteine desulfurase	0	2.741	--	DIRECT
Enzyme Commission (EC)	2-aminoethylphosphonate--pyruvate transaminase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Carbon-sulfur lyases	0	1.838	--	DIRECT
Enzyme Commission (EC)	Sulfurtransferases	0	1.741	--	DIRECT
Enzyme Commission (EC)	Serine--pyruvate transaminase	0.00000000006574	2.741	--	DIRECT
Enzyme Commission (EC)	Cystathionine beta-lyase	0.0000000089	2.741	--	DIRECT
Enzyme Commission (EC)	Alanine--glyoxylate transaminase	0.000000009622	2.741	--	DIRECT
Enzyme Commission (EC)	Cystathionine gamma-lyase	0.000002843	2.741	--	DIRECT
Enzyme Commission (EC)	Hydrolases	1	0.01852	--	INHERITED FROM: Acting on carbon-carbon bonds || Kynureninase
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	1	1.185	--	INHERITED FROM: Cystathionine gamma-synthase
Enzyme Commission (EC)	Lyases	0.00005429	0.4956	Least Informative	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	1	1.185	Moderately Informative	INHERITED FROM: Cystathionine gamma-synthase
Enzyme Commission (EC)	Transferring nitrogenous groups	0	1.741	Informative	DIRECT
Enzyme Commission (EC)	Transferring sulfur-containing groups	0	1.511	Informative	DIRECT
Enzyme Commission (EC)	Transaminases (aminotransferases)	0	1.787	Highly Informative	DIRECT
Enzyme Commission (EC)	Carbon-sulfur lyases	1	1.838	Highly Informative	INHERITED FROM: Cystathionine beta-lyase || Selenocysteine lyase || Cystathionine gamma-lyase
Enzyme Commission (EC)	In ketonic substances	1	1.896	Highly Informative	INHERITED FROM: Kynureninase

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.2218	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the kidney	0	1.258	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the urinary system	0	0.8496	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of urine homeostasis	0.02706	1.161	--	INHERITED FROM: Aciduria
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0	0.6051	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0	0.5486	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the upper urinary tract	0	1.12	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the urinary system physiology	0	1.047	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal circulating metabolite concentration	0	0.971	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal renal morphology	0	1.421	Informative	DIRECT
Phenotypic Abnormality (PA)	Aciduria	0.00006569	1.617	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal renal physiology	0.09436	1.462	Informative	INHERITED FROM: Renal insufficiency
Phenotypic Abnormality (PA)	Renal insufficiency	0.0003082	1.985	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	viable	0	0.6613	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: urogenital system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || tissue || anatomical region || trunk region || organism subdivision
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.4584	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: root || collective plant structure || multi-tissue plant structure || plant organ || root system || plant axis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: root system || root
Plant ANatomical entity (PAN)	root	0	0.4679	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || F mature embryo stage || D bilateral stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || D bilateral stage || F mature embryo stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.3205	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.301	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Cystathionine gamma-synthase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Transaminases	0	2.275	--	DIRECT
Enzyme Commission (EC)	2-aminoethylphosphonate--pyruvate transaminase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Sulfurtransferases	0	2.188	--	DIRECT
Enzyme Commission (EC)	Cysteine desulfurase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Molybdenum cofactor sulfurtransferase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Acting on carbon-carbon bonds	0	2.23	--	DIRECT
Enzyme Commission (EC)	Kynureninase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Carbon-sulfur lyases	0	2.275	--	DIRECT
Enzyme Commission (EC)	Selenocysteine lyase	0	3.23	--	DIRECT
Enzyme Commission (EC)	O-acetylhomoserine aminocarboxypropyltransferase	0.0000000000001258	3.23	--	DIRECT
Enzyme Commission (EC)	Serine--pyruvate transaminase	0.000000000007298	3.23	--	DIRECT
Enzyme Commission (EC)	Alanine--glyoxylate transaminase	0.000000009256	3.23	--	DIRECT
Enzyme Commission (EC)	Cysteine-S-conjugate beta-lyase	0.000001006	2.929	--	DIRECT
Enzyme Commission (EC)	Cystathionine gamma-lyase	0.00001436	3.23	--	DIRECT
Enzyme Commission (EC)	Serine--glyoxylate transaminase	0.00002393	3.23	--	DIRECT
Enzyme Commission (EC)	Methionine gamma-lyase	0.00007855	3.23	--	DIRECT
Enzyme Commission (EC)	Homocysteine desulfhydrase	0.0001823	3.23	--	DIRECT
Enzyme Commission (EC)	L-cysteine desulfidase	0.0009677	3.23	--	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	1	1.567	--	INHERITED FROM: Cystathionine gamma-synthase || O-acetylhomoserine aminocarboxypropyltransferase
Enzyme Commission (EC)	Carbon-sulfur lyases	1	2.275	--	INHERITED FROM: Homocysteine desulfhydrase || Cystathionine gamma-lyase || Cysteine-S-conjugate beta-lyase || Selenocysteine lyase || Methionine gamma-lyase || L-cysteine desulfidase
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	1	0.4043	Least Informative	INHERITED FROM: Acting on carbon-carbon bonds || Kynureninase
Enzyme Commission (EC)	Lyases	0.000008414	0.8775	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	0.9987	1.558	Informative	INHERITED FROM: O-acetylhomoserine aminocarboxypropyltransferase || Cystathionine gamma-synthase
Enzyme Commission (EC)	Transferring nitrogenous groups	0	2.23	Highly Informative	DIRECT
Enzyme Commission (EC)	Transferring sulfur-containing groups	0	1.929	Highly Informative	DIRECT
Enzyme Commission (EC)	In ketonic substances	1	2.23	Highly Informative	INHERITED FROM: Kynureninase

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