Nucleotide-diphospho-sugar transferases superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Nucleotide-diphospho-sugar transferases [ 53447]
• Superfamily: Nucleotide-diphospho-sugar transferases [ 53448] (19)
• Families:
  • Spore coat polysaccharide biosynthesis protein SpsA [ 53449]
  • beta 1,4 galactosyltransferase (b4GalT1) [ 53452]
  • Galactosyltransferase LgtC [ 53458]
  • Glycogenin [ 75273]
  • alpha-1,3-galactosyltransferase-like [ 64131] (3)
  • UDP-glucose pyrophosphorylase [ 53461] (3)
  • glucose-1-phosphate thymidylyltransferase [ 53464] (3)
  • 1,3-glucuronyltransferase [ 53467] (2)
  • N-acetylglucosaminyltransferase I [ 64136]
  • Exostosin [ 89760]
  • Molybdenum cofactor biosynthesis protein MobA [ 53470]
  • Cytidylytransferase [ 68901] (6)
  • Glycolipid 2-alpha-mannosyltransferase [ 102609]
  • Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain [ 117702]
  • MGS-like [ 142691]
  • TTHA0179-like [ 159717]
  • mannose-1-phosphate guanylyl transferase [ 159720]
  • MM2497-like [ 159723]
  • Glycosylating toxin catalytic domain-like [ 159726] (3)

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Superfamily statistics

	Genomes (3,212)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	93,415	665,300	97
Proteins	91,776	652,409	97

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Functional annotation

• General category: Metabolism
• Detailed category: Transferases

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Procollagen-lysine 5-dioxygenase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Mannose-1-phosphate guanylyltransferase	0	2.259	--	DIRECT
Enzyme Commission (EC)	2-C-methyl-D-erythritol 4-phosphate cytidylyltrans	0	2.259	--	DIRECT
Enzyme Commission (EC)	UTP--glucose-1-phosphate uridylyltransferase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Chitin synthase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	0.8117	--	DIRECT
Enzyme Commission (EC)	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synth	0	2.259	--	DIRECT
Enzyme Commission (EC)	2-phospho-L-lactate guanylyltransferase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Phosphorus-oxygen lyases	0	1.606	--	DIRECT
Enzyme Commission (EC)	Glucose-1-phosphate adenylyltransferase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Polypeptide N-acetylgalactosaminyltransferase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabi	0	2.56	--	DIRECT
Enzyme Commission (EC)	UDP-N-acetylglucosamine diphosphorylase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2175	--	DIRECT
Enzyme Commission (EC)	Glucosamine-1-phosphate N-acetyltransferase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Hexosyltransferases	0	1.217	--	DIRECT
Enzyme Commission (EC)	3-deoxy-manno-octulosonate cytidylyltransferase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Hyaluronan synthase	0.000000000004803	2.56	--	DIRECT
Enzyme Commission (EC)	UDP-arabinopyranose mutase	0.000000000006568	2.56	--	DIRECT
Enzyme Commission (EC)	acetylglucosaminyltransferase	0.00000000005383	2.56	--	DIRECT
Enzyme Commission (EC)	N-acetyllactosamine synthase	0.0000000001793	2.56	--	DIRECT
Enzyme Commission (EC)	Galactosylgalactosylxylosylprotein 3-beta-glucuron	0.0000000001793	2.56	--	DIRECT
Enzyme Commission (EC)	N-acetylglucosaminyl-proteoglycan 4-beta-glucurono	0.000000001988	2.56	--	DIRECT
Enzyme Commission (EC)	Beta-N-acetylglucosaminylglycopeptide beta-1,4-gal	0.00000002199	2.56	--	DIRECT
Enzyme Commission (EC)	N-acetyllactosaminide 3-alpha-galactosyltransferas	0.00000002199	2.56	--	DIRECT
Enzyme Commission (EC)	Glucose-1-phosphate thymidylyltransferase	0.00000002209	2.56	--	DIRECT
Enzyme Commission (EC)	Dolichyl-phosphate beta-D-mannosyltransferase	0.0000002428	2.56	--	DIRECT
Enzyme Commission (EC)	Glycogenin glucosyltransferase	0.0000008071	2.56	--	DIRECT
Enzyme Commission (EC)	N-acylneuraminate cytidylyltransferase	0.000002191	2.259	--	DIRECT
Enzyme Commission (EC)	Procollagen galactosyltransferase	0.000002678	2.56	--	DIRECT
Enzyme Commission (EC)	Mannose-6-phosphate isomerase	0.000002993	2.259	--	DIRECT
Enzyme Commission (EC)	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuro	0.000008869	2.56	--	DIRECT
Enzyme Commission (EC)	acetylgalactosaminyltransferase	0.00002941	2.56	--	DIRECT
Enzyme Commission (EC)	Lactosylceramide 4-alpha-galactosyltransferase	0.00002941	2.56	--	DIRECT
Enzyme Commission (EC)	Lactose synthase	0.00002941	2.56	--	DIRECT
Enzyme Commission (EC)	Ceramide glucosyltransferase	0.00002941	2.56	--	DIRECT
Enzyme Commission (EC)	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglu	0.00002941	2.56	--	DIRECT
Enzyme Commission (EC)	acetylglucosaminyltransferase	0.00002941	2.56	--	DIRECT
Enzyme Commission (EC)	Dolichyl-phosphate beta-glucosyltransferase	0.00009768	2.56	--	DIRECT
Enzyme Commission (EC)	UTP-monosaccharide-1-phosphate uridylyltransferase	0.0002111	2.56	--	DIRECT
Enzyme Commission (EC)	Intramolecular transferases (mutases)	1	1.259	--	INHERITED FROM: UDP-arabinopyranose mutase
Enzyme Commission (EC)	Nucleotidyltransferases	0	0.6105	Least Informative	DIRECT
Enzyme Commission (EC)	Isomerases	1	0.5914	Least Informative	INHERITED FROM: UDP-arabinopyranose mutase || Mannose-6-phosphate isomerase
Enzyme Commission (EC)	Lyases	1	0.4169	Least Informative	INHERITED FROM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synth || Phosphorus-oxygen lyases
Enzyme Commission (EC)	Oxidoreductases	1	0.2975	Least Informative	INHERITED FROM: With 2-oxoglutarate as one donor, and incorporatio || Procollagen-lysine 5-dioxygenase
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	0.9165	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0.00000000007521	0.9165	Moderately Informative	DIRECT
Enzyme Commission (EC)	Intramolecular oxidoreductases	1	1.069	Moderately Informative	INHERITED FROM: Mannose-6-phosphate isomerase
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0.8741	1.016	Moderately Informative	INHERITED FROM: Procollagen-lysine 5-dioxygenase || With 2-oxoglutarate as one donor, and incorporatio
Enzyme Commission (EC)	Transferring other groups	1	1.519	Informative	INHERITED FROM: UDP-arabinopyranose mutase
Enzyme Commission (EC)	Interconverting aldoses and ketoses, and related c	1	1.384	Informative	INHERITED FROM: Mannose-6-phosphate isomerase
Enzyme Commission (EC)	Phosphorus-oxygen lyases	1	1.606	Informative	INHERITED FROM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synth
Enzyme Commission (EC)	Cellulose synthase (UDP-forming)	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	With 2-oxoglutarate as one donor, and incorporatio	0.00000001082	1.782	Highly Informative	DIRECT
Enzyme Commission (EC)	Transferases for other substituted phosphate group	0.3125	1.782	Highly Informative	INHERITED FROM: Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabi

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	hereditary multiple exostoses	0.00000009169	2.371	--	DIRECT
Disease Ontology (DO)	exostosis	0.00001116	2.371	--	DIRECT
Disease Ontology (DO)	prostate adenocarcinoma	0.000267	2.371	--	DIRECT
Disease Ontology (DO)	hyperostosis	0.008588	2.371	--	INHERITED FROM: exostosis || hereditary multiple exostoses
Disease Ontology (DO)	prostate carcinoma	0.01681	2.371	--	INHERITED FROM: prostate adenocarcinoma
Disease Ontology (DO)	male reproductive organ cancer	0.05369	1.672	--	INHERITED FROM: prostate adenocarcinoma
Disease Ontology (DO)	musculoskeletal system disease	0.2504	0.9087	--	INHERITED FROM: hereditary multiple exostoses || exostosis
Disease Ontology (DO)	cancer	0.2964	0.3104	--	INHERITED FROM: prostate adenocarcinoma
Disease Ontology (DO)	disease of cellular proliferation	0.3367	0.2812	--	INHERITED FROM: prostate adenocarcinoma
Disease Ontology (DO)	reproductive organ cancer	0.5218	1.33	--	INHERITED FROM: prostate adenocarcinoma
Disease Ontology (DO)	bone disease	0.9179	1.092	--	INHERITED FROM: exostosis || hereditary multiple exostoses
Disease Ontology (DO)	disease of anatomical entity	1	0.2157	--	INHERITED FROM: hereditary multiple exostoses || exostosis
Disease Ontology (DO)	organ system cancer	0.5048	0.5515	Least Informative	INHERITED FROM: prostate adenocarcinoma
Disease Ontology (DO)	connective tissue disease	0.1499	1.009	Moderately Informative	INHERITED FROM: exostosis || hereditary multiple exostoses
Disease Ontology (DO)	prostate cancer	0.04567	1.672	Informative	INHERITED FROM: prostate adenocarcinoma
Disease Ontology (DO)	bone remodeling disease	0.00309	1.894	Highly Informative	INHERITED FROM: hereditary multiple exostoses || exostosis

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
	Variable expressivity	0	0.01931	--	DIRECT
	Phenotypic variability	1	0	--	INHERITED FROM: Variable expressivity
Mode of Inheritance (MI)	Autosomal recessive inheritance	0.00008924	0.1924	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle fiber alpha dystroglycan	0.0000001818	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Type II lissencephaly	0.0000005329	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the calf musculature	0.00004293	2.106	--	DIRECT
Phenotypic Abnormality (PA)	Chorioretinal dysplasia	0.00006363	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal aldolase level	0.0001101	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the curvature of the vertebral column	0.0002723	1.293	--	DIRECT
Phenotypic Abnormality (PA)	Macrogyria	0.0007017	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Hypoplasia of the pons	0.000786	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Optic atrophy	0.0009023	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Retinal dysplasia	0.0009063	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the optic disc	0.002065	2.407	--	INHERITED FROM: Optic atrophy
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.004032	0.4621	--	INHERITED FROM: Abnormality of the curvature of the vertebral column || Macrocephaly
Phenotypic Abnormality (PA)	Abnormality of the pons	0.004081	2.407	--	INHERITED FROM: Hypoplasia of the pons
Phenotypic Abnormality (PA)	Central nervous system cyst	0.006228	2.106	--	INHERITED FROM: Cerebellar cyst
Phenotypic Abnormality (PA)	Increased head circumference	0.006747	1.929	--	INHERITED FROM: Macrocephaly
Phenotypic Abnormality (PA)	Lissencephaly	0.01075	2.407	--	INHERITED FROM: Type II lissencephaly
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.02013	0.472	--	INHERITED FROM: Macrocephaly
Phenotypic Abnormality (PA)	Abnormal fundus morphology	0.02382	1.23	--	INHERITED FROM: Retinal dysplasia || Optic atrophy || Chorioretinal dysplasia
Phenotypic Abnormality (PA)	Abnormal eye morphology	0.02802	0.8155	--	INHERITED FROM: Abnormality of corneal size || Optic atrophy || Retinal dysplasia || Chorioretinal dysplasia
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0.03083	1.009	--	INHERITED FROM: Macrogyria || Type II lissencephaly
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.04405	0.6284	--	INHERITED FROM: Macrogyria || Cerebellar cyst || Hypoplasia of the pons || Type II lissencephaly
Phenotypic Abnormality (PA)	Abnormal chorioretinal morphology	0.06645	2.106	--	INHERITED FROM: Chorioretinal dysplasia
Phenotypic Abnormality (PA)	Cerebellar malformation	0.07133	1.804	--	INHERITED FROM: Cerebellar cyst
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.08188	0.7344	--	INHERITED FROM: Abnormality of the curvature of the vertebral column || Macrocephaly
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.09841	0.2543	--	INHERITED FROM: Cerebellar cyst || Macrogyria || Type II lissencephaly || Hypoplasia of the pons
Phenotypic Abnormality (PA)	Abnormality of the optic nerve	0.1145	1.804	--	INHERITED FROM: Optic atrophy
Phenotypic Abnormality (PA)	Abnormality of the musculature of the limbs	0.1256	1.327	--	INHERITED FROM: Abnormality of the calf musculature
Phenotypic Abnormality (PA)	Abnormality of skull size	0.2056	1.26	--	INHERITED FROM: Macrocephaly
Phenotypic Abnormality (PA)	Abnormality of neuronal migration	0.2698	1.804	--	INHERITED FROM: Type II lissencephaly || Macrogyria
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.2976	0.7731	--	INHERITED FROM: Macrogyria || Cerebellar cyst || Hypoplasia of the pons || Type II lissencephaly
Phenotypic Abnormality (PA)	Abnormality of the cerebral cortex	0.3289	1.804	--	INHERITED FROM: Type II lissencephaly || Macrogyria
Phenotypic Abnormality (PA)	Abnormality of hindbrain morphology	0.4027	1.708	--	INHERITED FROM: Hypoplasia of the pons || Cerebellar cyst
Phenotypic Abnormality (PA)	Intracranial cystic lesion	1	2.106	--	INHERITED FROM: Cerebellar cyst
Phenotypic Abnormality (PA)	Abnormality of the metencephalon	1	1.708	--	INHERITED FROM: Hypoplasia of the pons || Cerebellar cyst
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.00008334	0.6004	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limbs	0.00348	0.6431	Least Informative	INHERITED FROM: Abnormality of the calf musculature
Phenotypic Abnormality (PA)	Abnormality of the head	0.01822	0.4771	Least Informative	INHERITED FROM: Macrocephaly
Phenotypic Abnormality (PA)	Abnormality of the eye	0.212	0.6004	Least Informative	INHERITED FROM: Abnormality of corneal size || Optic atrophy || Retinal dysplasia || Chorioretinal dysplasia
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.3156	0.5677	Least Informative	INHERITED FROM: Cerebellar cyst || Hypoplasia of the pons || Macrogyria || Type II lissencephaly
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.3847	0.5315	Least Informative	INHERITED FROM: Abnormal aldolase level
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.5942	0.472	Least Informative	INHERITED FROM: Macrocephaly || Abnormality of the curvature of the vertebral column
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.0205	0.9152	Moderately Informative	INHERITED FROM: Abnormality of the calf musculature
Phenotypic Abnormality (PA)	Abnormal skull morphology	0.08482	1.009	Moderately Informative	INHERITED FROM: Macrocephaly
Phenotypic Abnormality (PA)	Abnormality of the vertebral column	0.1345	1.064	Moderately Informative	INHERITED FROM: Abnormality of the curvature of the vertebral column
Phenotypic Abnormality (PA)	Abnormal posterior eye segment morphology	0.1893	1.202	Moderately Informative	INHERITED FROM: Optic atrophy || Chorioretinal dysplasia || Retinal dysplasia
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0.2874	0.9916	Moderately Informative	INHERITED FROM: Macrogyria || Type II lissencephaly
Phenotypic Abnormality (PA)	Abnormal anterior eye segment morphology	0.3382	1.176	Moderately Informative	INHERITED FROM: Abnormality of corneal size
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0.4761	0.9294	Moderately Informative	INHERITED FROM: Abnormal muscle fiber alpha dystroglycan || Abnormal muscle fiber protein expression || Abnormality of the calf musculature
Phenotypic Abnormality (PA)	Abnormal muscle fiber morphology	0.05727	1.628	Informative	INHERITED FROM: Abnormal muscle fiber alpha dystroglycan || Abnormal muscle fiber protein expression
Phenotypic Abnormality (PA)	Abnormal cerebellum morphology	0.1321	1.708	Informative	INHERITED FROM: Cerebellar cyst
Phenotypic Abnormality (PA)	Abnormal uvea morphology	0.2294	1.561	Informative	INHERITED FROM: Chorioretinal dysplasia
Phenotypic Abnormality (PA)	Abnormal cornea morphology	0.5816	1.407	Informative	INHERITED FROM: Abnormality of corneal size
Phenotypic Abnormality (PA)	Abnormal retinal morphology	0.7061	1.365	Informative	INHERITED FROM: Retinal dysplasia || Chorioretinal dysplasia
Phenotypic Abnormality (PA)	Macrocephaly	0.00007654	1.929	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of corneal size	0.0004247	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Cerebellar cyst	0.0005611	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle fiber protein expression	0.000995	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature of the lower limbs	0.007805	1.929	Highly Informative	INHERITED FROM: Abnormality of the calf musculature
Phenotypic Abnormality (PA)	Abnormality of brainstem morphology	0.04272	1.929	Highly Informative	INHERITED FROM: Hypoplasia of the pons
Phenotypic Abnormality (PA)	Abnormal cortical gyration	0.08184	1.804	Highly Informative	INHERITED FROM: Macrogyria || Type II lissencephaly
Phenotypic Abnormality (PA)	Abnormal enzyme/coenzyme activity	0.1059	2.106	Highly Informative	INHERITED FROM: Abnormal aldolase level
Phenotypic Abnormality (PA)	Abnormal choroid morphology	0.1125	1.929	Highly Informative	INHERITED FROM: Chorioretinal dysplasia

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	squashed vulva	0.0000001662	2.708	--	DIRECT
Worm Phenotype (WP)	resistant to lectin	0.0000008092	2.708	--	DIRECT
Worm Phenotype (WP)	vulval invagination variant L4	0.000005838	2.407	--	DIRECT
Worm Phenotype (WP)	lectin response variant	0.000009497	2.708	--	DIRECT
Worm Phenotype (WP)	hermaphrodite self sterile	0.00003175	2.708	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0.2518	0.1672	--	INHERITED FROM: hermaphrodite self sterile
Worm Phenotype (WP)	vulva morphology variant	0.3473	1.365	--	INHERITED FROM: squashed vulva || vulval invagination variant L4
Worm Phenotype (WP)	hermaphrodite reproductive system morphology variant	0.3578	1.365	--	INHERITED FROM: vulval invagination variant L4 || squashed vulva
Worm Phenotype (WP)	hermaphrodite sterile	0.6122	0.1685	--	INHERITED FROM: hermaphrodite self sterile
Worm Phenotype (WP)	organ system development variant	0.7523	0.8099	--	INHERITED FROM: squashed vulva || pharyngeal development variant || vulval invagination variant L4
Worm Phenotype (WP)	hermaphrodite fertility variant	0.7966	0.1278	--	INHERITED FROM: hermaphrodite self sterile
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.9173	0.1501	--	INHERITED FROM: lectin response variant || resistant to lectin
Worm Phenotype (WP)	organism physiology variant	0.9403	0.1405	--	INHERITED FROM: lectin response variant || resistant to lectin
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: reproductive system physiology variant || vulval invagination variant L4 || lethal || squashed vulva || development variant || resistant to lectin || lectin response variant || embryonic development variant || embryonic lethal || pharyngeal development variant || fertility variant || hermaphrodite self sterile || organ system physiology variant || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite self sterile
Worm Phenotype (WP)	organ system morphology variant	0.6709	0.7119	Least Informative	INHERITED FROM: squashed vulva || vulval invagination variant L4
Worm Phenotype (WP)	organism environmental stimulus response variant	0.7404	0.5677	Least Informative	INHERITED FROM: resistant to lectin || lectin response variant
Worm Phenotype (WP)	reproductive system morphology variant	0.4313	1.017	Moderately Informative	INHERITED FROM: vulval invagination variant L4 || squashed vulva
Worm Phenotype (WP)	reproductive system development variant	0.5417	1.026	Moderately Informative	INHERITED FROM: squashed vulva || vulval invagination variant L4
Worm Phenotype (WP)	pesticide response variant	0.01105	1.708	Informative	INHERITED FROM: resistant to lectin || lectin response variant
Worm Phenotype (WP)	alimentary system development variant	0.04375	1.666	Informative	INHERITED FROM: pharyngeal development variant
Worm Phenotype (WP)	vulva development variant	0.1396	1.531	Informative	INHERITED FROM: vulval invagination variant L4 || squashed vulva
Worm Phenotype (WP)	pharyngeal development variant	0.0007055	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	pericellular component physiology variant	0.004887	1.929	Highly Informative	INHERITED FROM: resistant to lectin || lectin response variant

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	cell wall morphology	0.00001023	2.17	--	DIRECT
Yeast Phenotype (YP)	cellular morphology	0.5437	1.216	--	INHERITED FROM: chitin deposition || cell wall morphology
Yeast Phenotype (YP)	morphology	0.2241	1.11	Moderately Informative	INHERITED FROM: chitin deposition || cell wall morphology
Yeast Phenotype (YP)	subcellular morphology	0.2443	1.392	Informative	INHERITED FROM: chitin deposition || cell wall morphology
Yeast Phenotype (YP)	chitin deposition	0.000008906	2.17	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.07918	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.2279	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	trichome field	0.000398	2.079	--	DIRECT
Fly Anatomy (FA)	denticle field	0.000398	2.079	--	DIRECT
Fly Anatomy (FA)	anatomical cluster	0.02374	2.079	--	INHERITED FROM: denticle field || denticle belt || trichome field
Fly Anatomy (FA)	cuticle	0.02665	1.266	--	INHERITED FROM: denticle field || denticle belt
Fly Anatomy (FA)	integumentary system	0.2039	0.8617	--	INHERITED FROM: denticle field || denticle belt
Fly Anatomy (FA)	embryonic/larval cuticle	0.2925	1.681	--	INHERITED FROM: denticle belt || denticle field
Fly Anatomy (FA)	anatomical group	0.5549	0.7891	--	INHERITED FROM: trichome field || denticle field || denticle belt
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || denticle field || denticle belt || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || trichome field || multicellular structure || denticle field || denticle belt || organism
Fly Anatomy (FA)	larva	0.687	0.4611	Least Informative	INHERITED FROM: denticle belt || denticle field
Fly Anatomy (FA)	acellular anatomical structure	0.001756	1.176	Moderately Informative	INHERITED FROM: denticle field || denticle belt
Fly Anatomy (FA)	embryonic/larval integumentary system	0.02169	1.426	Informative	INHERITED FROM: denticle belt || denticle field
Fly Anatomy (FA)	denticle belt	0.0003843	2.079	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	pectoral fin fold	0.0000005221	2.439	--	DIRECT
Zebrafish Anatomy (ZA)	fin	0.04528	1.74	--	INHERITED FROM: pectoral fin fold
Zebrafish Anatomy (ZA)	paired fin	0.2906	1.962	--	INHERITED FROM: pectoral fin fold
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: pectoral fin fold || whole organism
Zebrafish Anatomy (ZA)	organism subdivision	0.1752	0.6264	Least Informative	INHERITED FROM: pectoral fin fold
Zebrafish Anatomy (ZA)	multi-tissue structure	0.6586	0.6005	Least Informative	INHERITED FROM: pectoral fin fold
Zebrafish Anatomy (ZA)	surface structure	0.009848	1.536	Informative	INHERITED FROM: pectoral fin fold
Zebrafish Anatomy (ZA)	pectoral fin	0.003349	1.962	Highly Informative	INHERITED FROM: pectoral fin fold

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	vascular system	0.00000002326	1.372	--	DIRECT
Plant ANatomical entity (PAN)	leaf trichome	0.0000002935	2.168	--	DIRECT
Plant ANatomical entity (PAN)	ground tissue cell	0.000001111	1.925	--	DIRECT
Plant ANatomical entity (PAN)	leaf mesophyll	0.000001179	2.168	--	DIRECT
Plant ANatomical entity (PAN)	interfascicular region	0.00000132	2.77	--	DIRECT
Plant ANatomical entity (PAN)	phyllome epidermis	0.000002947	2.168	--	DIRECT
Plant ANatomical entity (PAN)	secondary xylem	0.0003829	2.77	--	DIRECT
Plant ANatomical entity (PAN)	xylem	0.00147	2.293	--	INHERITED FROM: secondary xylem
Plant ANatomical entity (PAN)	chlorenchyma	0.0742	1.867	--	INHERITED FROM: leaf mesophyll
Plant ANatomical entity (PAN)	plant cell	0.12	0.1489	--	INHERITED FROM: ground tissue cell
Plant ANatomical entity (PAN)	phyllome trichome	0.2319	2.168	--	INHERITED FROM: leaf trichome
Plant ANatomical entity (PAN)	collective plant structure	0.2662	0.01577	--	INHERITED FROM: leaf epidermis || interfascicular region || leaf mesophyll || leaf trichome || phyllome epidermis
Plant ANatomical entity (PAN)	multi-tissue plant structure	0.3255	0.2691	--	INHERITED FROM: leaf mesophyll || interfascicular region || leaf epidermis || phyllome epidermis || leaf trichome
Plant ANatomical entity (PAN)	shoot system	0.4366	0.05747	--	INHERITED FROM: interfascicular region || leaf mesophyll || leaf epidermis || leaf trichome || phyllome epidermis
Plant ANatomical entity (PAN)	phyllome	0.4638	0.3809	--	INHERITED FROM: leaf trichome || phyllome epidermis || leaf epidermis || leaf mesophyll
Plant ANatomical entity (PAN)	parenchyma	0.5703	1.729	--	INHERITED FROM: leaf mesophyll
Plant ANatomical entity (PAN)	epidermis	0.6635	0.2464	--	INHERITED FROM: phyllome epidermis || leaf trichome || leaf epidermis || trichome
Plant ANatomical entity (PAN)	plant axis	0.7408	0.3881	--	INHERITED FROM: interfascicular region
Plant ANatomical entity (PAN)	shoot epidermis	0.7729	0.2691	--	INHERITED FROM: leaf epidermis || phyllome epidermis || leaf trichome
Plant ANatomical entity (PAN)	portion of plant tissue	0.8637	0.1892	--	INHERITED FROM: portion of ground tissue || leaf epidermis || ground tissue cell || leaf mesophyll || interfascicular region || trichome || vascular system || portion of vascular tissue || secondary xylem || phyllome epidermis || leaf trichome || phloem
Plant ANatomical entity (PAN)	plant organ	1	0.2816	--	INHERITED FROM: interfascicular region || leaf mesophyll || leaf epidermis || leaf trichome || phyllome epidermis
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: interfascicular region || leaf mesophyll || portion of ground tissue || leaf epidermis || vascular system || trichome || phloem || secondary xylem || ground tissue cell || portion of vascular tissue || leaf trichome || phyllome epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: leaf epidermis || leaf mesophyll || interfascicular region || phyllome epidermis || leaf trichome
Plant ANatomical entity (PAN)	leaf	0.2743	0.5053	Least Informative	INHERITED FROM: leaf epidermis || leaf mesophyll || leaf trichome
Plant ANatomical entity (PAN)	whole plant	0.3275	0.4218	Least Informative	INHERITED FROM: portion of vascular tissue || secondary xylem || vascular system || phloem
Plant ANatomical entity (PAN)	shoot axis	0.7036	0.4735	Least Informative	INHERITED FROM: interfascicular region
Plant ANatomical entity (PAN)	portion of vascular tissue	0.000000000007852	1.594	Informative	DIRECT
Plant ANatomical entity (PAN)	portion of ground tissue	0.00000000154	1.491	Informative	DIRECT
Plant ANatomical entity (PAN)	trichome	0.00000000002195	1.925	Highly Informative	DIRECT
Plant ANatomical entity (PAN)	leaf epidermis	0.000003388	2.168	Highly Informative	DIRECT
Plant ANatomical entity (PAN)	phloem	0.0001899	2.168	Highly Informative	DIRECT
Plant ANatomical entity (PAN)	mesophyll	1	1.867	Highly Informative	INHERITED FROM: leaf mesophyll

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Procollagen-lysine 5-dioxygenase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3035	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	0.8446	--	DIRECT
Enzyme Commission (EC)	Glucosamine-1-phosphate N-acetyltransferase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Cellulose synthase (UDP-forming)	0	2.475	--	DIRECT
Enzyme Commission (EC)	Chitin synthase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Polypeptide N-acetylgalactosaminyltransferase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Mannose-1-phosphate guanylyltransferase	0	2.651	--	DIRECT
Enzyme Commission (EC)	UDP-N-acetylglucosamine diphosphorylase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Glucose-1-phosphate adenylyltransferase	0	2.651	--	DIRECT
Enzyme Commission (EC)	3-deoxy-manno-octulosonate cytidylyltransferase	0	2.952	--	DIRECT
Enzyme Commission (EC)	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Phosphoenolpyruvate guanylyltransferase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Molybdenum cofactor guanylyltransferase	0	2.952	--	DIRECT
Enzyme Commission (EC)	UTP--glucose-1-phosphate uridylyltransferase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Phosphorus-oxygen lyases	0	1.651	--	DIRECT
Enzyme Commission (EC)	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	2.651	--	DIRECT
Enzyme Commission (EC)	UDP-arabinopyranose mutase	0	2.952	--	DIRECT
Enzyme Commission (EC)	UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase	0.00000000000001193	2.952	--	DIRECT
Enzyme Commission (EC)	D-ribitol-5-phosphate cytidylyltransferase	0.00000000000006312	2.952	--	DIRECT
Enzyme Commission (EC)	Hyaluronan synthase	0.00000000001588	2.952	--	DIRECT
Enzyme Commission (EC)	Glucomannan 4-beta-mannosyltransferase	0.00000000004735	2.952	--	DIRECT
Enzyme Commission (EC)	CDP-L-myo-inositol myo-inositolphosphotransferase	0.0000000002552	2.952	--	DIRECT
Enzyme Commission (EC)	acetylglucosaminyltransferase	0.000000000418	2.952	--	DIRECT
Enzyme Commission (EC)	N-acetyllactosamine synthase	0.00000000124	2.952	--	DIRECT
Enzyme Commission (EC)	Glucose-1-phosphate thymidylyltransferase	0.000000001752	2.952	--	DIRECT
Enzyme Commission (EC)	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase	0.000000003675	2.952	--	DIRECT
Enzyme Commission (EC)	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase	0.000000003675	2.952	--	DIRECT
Enzyme Commission (EC)	N-acetyllactosaminide 3-alpha-galactosyltransferase	0.000000003675	2.952	--	DIRECT
Enzyme Commission (EC)	Ceramide glucosyltransferase	0.00000001091	2.952	--	DIRECT
Enzyme Commission (EC)	Procollagen galactosyltransferase	0.00000003236	2.952	--	DIRECT
Enzyme Commission (EC)	Dolichyl-phosphate beta-D-mannosyltransferase	0.00000003236	2.952	--	DIRECT
Enzyme Commission (EC)	8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase	0.00000005486	2.952	--	DIRECT
Enzyme Commission (EC)	Inositol 3-alpha-galactosyltransferase	0.0000000959	2.952	--	DIRECT
Enzyme Commission (EC)	Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase	0.0000000959	2.952	--	DIRECT
Enzyme Commission (EC)	Dolichyl-phosphate beta-glucosyltransferase	0.0000002837	2.952	--	DIRECT
Enzyme Commission (EC)	N-acylneuraminate cytidylyltransferase	0.0000007168	2.475	--	DIRECT
Enzyme Commission (EC)	Glycogenin glucosyltransferase	0.0000008388	2.952	--	DIRECT
Enzyme Commission (EC)	Mannose-6-phosphate isomerase	0.000003423	2.651	--	DIRECT
Enzyme Commission (EC)	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase	0.000007392	2.952	--	DIRECT
Enzyme Commission (EC)	acetylgalactosaminyltransferase	0.00002184	2.952	--	DIRECT
Enzyme Commission (EC)	Glucosylceramide beta-1,4-galactosyltransferase	0.00002184	2.952	--	DIRECT
Enzyme Commission (EC)	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	0.00006505	2.952	--	DIRECT
Enzyme Commission (EC)	Lactose synthase	0.00006505	2.952	--	DIRECT
Enzyme Commission (EC)	acetylglucosaminyltransferase	0.00006505	2.952	--	DIRECT
Enzyme Commission (EC)	Lactosylceramide 4-alpha-galactosyltransferase	0.00006505	2.952	--	DIRECT
Enzyme Commission (EC)	Glucosyl-3-phosphoglycerate synthase	0.00006505	2.952	--	DIRECT
Enzyme Commission (EC)	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	0.0001926	2.952	--	DIRECT
Enzyme Commission (EC)	acetylgalactosaminyltransferase	0.0001926	2.952	--	DIRECT
Enzyme Commission (EC)	Procollagen glucosyltransferase	0.0001926	2.952	--	DIRECT
Enzyme Commission (EC)	UTP-monosaccharide-1-phosphate uridylyltransferase	0.0003039	2.952	--	DIRECT
Enzyme Commission (EC)	acetylgalactosaminyltransferase	0.0005745	2.952	--	DIRECT
Enzyme Commission (EC)	Neolactotriaosylceramide beta-1,4-galactosyltransferase	0.0005745	2.952	--	DIRECT
Enzyme Commission (EC)	Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase	0.0005745	2.952	--	DIRECT
Enzyme Commission (EC)	1L-myo-inositol 1-phosphate cytidylyltransferase	0.0007272	2.952	--	DIRECT
Enzyme Commission (EC)	UDP-N-acetylgalactosamine diphosphorylase	0.0007272	2.952	--	DIRECT
Enzyme Commission (EC)	Transferring other groups	1	1.673	--	INHERITED FROM: UDP-arabinopyranose mutase
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.5453	Least Informative	DIRECT
Enzyme Commission (EC)	Oxidoreductases	1	0.6234	Least Informative	INHERITED FROM: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || Procollagen-lysine 5-dioxygenase
Enzyme Commission (EC)	Lyases	1	0.6918	Least Informative	INHERITED FROM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase || Phosphorus-oxygen lyases
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	1.119	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0	1.204	Moderately Informative	DIRECT
Enzyme Commission (EC)	Nucleotidyltransferases	0	0.9432	Moderately Informative	DIRECT
Enzyme Commission (EC)	Isomerases	1	0.8446	Moderately Informative	INHERITED FROM: Mannose-6-phosphate isomerase || UDP-arabinopyranose mutase
Enzyme Commission (EC)	Hexosyltransferases	0	1.572	Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	1	1.308	Informative	INHERITED FROM: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || Procollagen-lysine 5-dioxygenase
Enzyme Commission (EC)	Pentosyltransferases	1	1.447	Informative	INHERITED FROM: Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase || UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase
Enzyme Commission (EC)	Phosphorus-oxygen lyases	1	1.651	Informative	INHERITED FROM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Enzyme Commission (EC)	Intramolecular oxidoreductases	1	1.35	Informative	INHERITED FROM: Mannose-6-phosphate isomerase
Enzyme Commission (EC)	Intramolecular transferases	1	1.408	Informative	INHERITED FROM: UDP-arabinopyranose mutase
Enzyme Commission (EC)	With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	0.0000004063	2.107	Highly Informative	DIRECT
Enzyme Commission (EC)	Transferases for other substituted phosphate groups	1	2.049	Highly Informative	INHERITED FROM: CDP-L-myo-inositol myo-inositolphosphotransferase
Enzyme Commission (EC)	Interconverting aldoses and ketoses	1	1.776	Highly Informative	INHERITED FROM: Mannose-6-phosphate isomerase

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