Acetylcholinesterase-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: alpha/beta-Hydrolases [ 53473]
• Superfamily: alpha/beta-Hydrolases [ 53474] (41)
• Family: Acetylcholinesterase-like [ 53475] (5)

---

Family statistics

	Genomes (629)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,697	13,117	32
Proteins	2,673	13,046	32

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Carboxylesterase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Acetylcholinesterase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Cholinesterase	5.205e-16	2.741	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	1.21	Moderately Informative	DIRECT

---

Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	autism spectrum disorder	0.00005094	1.911	--	DIRECT
Disease Ontology (DO)	pervasive developmental disorder	0.00006318	1.814	--	DIRECT
Disease Ontology (DO)	disease of mental health	0.01355	1.036	Moderately Informative	INHERITED FROM: autistic disorder || pervasive developmental disorder || autism spectrum disorder
Disease Ontology (DO)	developmental disorder of mental health	0.01199	1.61	Informative	INHERITED FROM: pervasive developmental disorder || autism spectrum disorder || autistic disorder
Disease Ontology (DO)	autistic disorder	0.00004582	1.911	Highly Informative	DIRECT

---

Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the endocrine system	0.009261	0.9183	Moderately Informative	INHERITED FROM: Abnormal circulating hormone level
Phenotypic Abnormality (PA)	Abnormal circulating hormone level	0.00008508	1.508	Informative	DIRECT

---

Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal pre-Botzinger complex physiology	0.00000001336	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal autonomic nervous system physiology	0.0000004744	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal synaptic bouton morphology	0.000001044	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal central pattern generator function	0.000001083	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal excitatory postsynaptic current amplitude	0.000002527	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal miniature inhibitory postsynaptic currents	0.000004585	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal excitatory postsynaptic currents	0.0003294	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal parental behavior	0.0006001	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal synapse morphology	0.0009711	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal parasympathetic nervous system physiology	0.01258	2.603	--	INHERITED FROM: abnormal pre-Botzinger complex physiology
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.0615	0.825	--	INHERITED FROM: abnormal miniature inhibitory postsynaptic currents || abnormal autonomic nervous system physiology || abnormal inhibitory postsynaptic currents || decreased excitatory postsynaptic current amplitude || abnormal central pattern generator function || abnormal excitatory postsynaptic currents || abnormal pre-Botzinger complex physiology || abnormal excitatory postsynaptic current amplitude
Mammalian Phenotype (MP)	behavior/neurological phenotype	0.1321	0.8178	--	INHERITED FROM: abnormal parental behavior
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.1792	0.5861	--	INHERITED FROM: abnormal synaptic bouton morphology || abnormal synapse morphology
Mammalian Phenotype (MP)	nervous system phenotype	0.3111	0.4959	Least Informative	INHERITED FROM: abnormal synaptic bouton morphology || abnormal excitatory postsynaptic currents || abnormal synapse morphology || decreased excitatory postsynaptic current amplitude || abnormal excitatory postsynaptic current amplitude || abnormal inhibitory postsynaptic currents || abnormal miniature inhibitory postsynaptic currents || abnormal central pattern generator function || abnormal pre-Botzinger complex physiology || abnormal autonomic nervous system physiology
Mammalian Phenotype (MP)	abnormal synaptic transmission	0.1839	1.156	Moderately Informative	INHERITED FROM: abnormal excitatory postsynaptic currents || abnormal excitatory postsynaptic current amplitude || abnormal inhibitory postsynaptic currents || abnormal miniature inhibitory postsynaptic currents || decreased excitatory postsynaptic current amplitude
Mammalian Phenotype (MP)	abnormal neuron morphology	0.4608	0.8323	Moderately Informative	INHERITED FROM: abnormal synaptic bouton morphology || abnormal synapse morphology
Mammalian Phenotype (MP)	abnormal behavior	1	0.855	Moderately Informative	INHERITED FROM: abnormal parental behavior
Mammalian Phenotype (MP)	abnormal neurite morphology	0.00988	1.649	Informative	INHERITED FROM: abnormal synaptic bouton morphology
Mammalian Phenotype (MP)	abnormal CNS synaptic transmission	0.03213	1.281	Informative	INHERITED FROM: abnormal inhibitory postsynaptic currents || abnormal excitatory postsynaptic current amplitude || abnormal excitatory postsynaptic currents || decreased excitatory postsynaptic current amplitude || abnormal miniature inhibitory postsynaptic currents
Mammalian Phenotype (MP)	decreased excitatory postsynaptic current amplitude	0.000001444	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal inhibitory postsynaptic currents	0.00008723	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal axon morphology	0.001274	2.001	Highly Informative	INHERITED FROM: abnormal synaptic bouton morphology
Mammalian Phenotype (MP)	abnormal social/conspecific interaction	0.01348	1.904	Highly Informative	INHERITED FROM: abnormal parental behavior

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	acetylcholinesterase reduced	0.000004667	2.769	--	DIRECT
Worm Phenotype (WP)	acetylcholinesterase activity variant	0.00001141	2.769	--	DIRECT
Worm Phenotype (WP)	enzyme activity variant	0.00001342	1.99	--	DIRECT
Worm Phenotype (WP)	swimming variant	0.0000826	2.468	--	DIRECT
Worm Phenotype (WP)	basement membrane remodeling variant	0.0001114	1.225	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.2585	0.1444	--	INHERITED FROM: acetylcholinesterase activity variant || enzyme activity reduced || enzyme activity variant || acetylcholinesterase reduced
Worm Phenotype (WP)	organism physiology variant	0.2898	0.1342	--	INHERITED FROM: enzyme activity reduced || acetylcholinesterase activity variant || enzyme activity variant || acetylcholinesterase reduced
Worm Phenotype (WP)	behavior variant	1	0.6859	--	INHERITED FROM: swimming variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: pericellular component development variant || acetylcholinesterase reduced || lethal || basement membrane remodeling variant || development variant || enzyme activity reduced || swimming variant || acetylcholinesterase activity variant || enzyme activity variant || organism development variant
Worm Phenotype (WP)	organism metabolism processing variant	1	0.4899	Least Informative	INHERITED FROM: acetylcholinesterase reduced || acetylcholinesterase activity variant || enzyme activity reduced || enzyme activity variant
Worm Phenotype (WP)	organism behavior variant	1	0.6859	Least Informative	INHERITED FROM: swimming variant
Worm Phenotype (WP)	pericellular component development variant	0.0005584	1.178	Moderately Informative	DIRECT
Worm Phenotype (WP)	movement variant	0.9317	1.02	Moderately Informative	INHERITED FROM: swimming variant
Worm Phenotype (WP)	enzyme activity reduced	0.000007906	1.99	Highly Informative	DIRECT

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0.7832	0.06546	--	INHERITED FROM: electrophoretic variant
Fly Phenotype (FP)	electrophoretic variant	0.0000005575	2.085	Highly Informative	DIRECT

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Carboxylesterase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Acetylcholinesterase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Cholinesterase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Acetylesterase	0.0000007471	3.23	--	DIRECT
Enzyme Commission (EC)	Sterol esterase	0.000133	2.929	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	1.539	Informative	DIRECT

---