Gastric lipase family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: alpha/beta-Hydrolases [ 53473]
• Superfamily: alpha/beta-Hydrolases [ 53474] (41)
• Family: Gastric lipase [ 53506]

---

Family statistics

	Genomes (421)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,956	5,160	2
Proteins	1,893	5,012	2

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Sterol esterase	0.000000000000004963	2.741	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	1.21	Moderately Informative	DIRECT
Enzyme Commission (EC)	Triacylglycerol lipase	0.00000003086	1.963	Highly Informative	DIRECT

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	lipid metabolism variant	0.0000001772	1.337	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.5196	0.1444	--	INHERITED FROM: lipid metabolism variant || fat content variant
Worm Phenotype (WP)	organism physiology variant	0.538	0.1342	--	INHERITED FROM: lipid metabolism variant || fat content variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || fat content variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || lipid metabolism variant || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0.02293	0.4899	Least Informative	INHERITED FROM: lipid metabolism variant || fat content variant
Worm Phenotype (WP)	fat content variant	0.0000001215	1.407	Informative	DIRECT

---

Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.6705	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.4893	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence meristem	0	0.6337	--	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || sporophyll || flower || collective plant structure || phyllome || pollen sac || multi-tissue plant structure || microsporophyll || reproductive shoot system || collective leaf structure || shoot system || sporangium || portion of plant tissue || plant organ || portion of meristem tissue || whole plant || inflorescence meristem || inflorescence || microsporangium || corolla || pollen || collective phyllome structure || petal || plant cell || microgametophyte
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: flower || sporophyll || inflorescence meristem || inflorescence || perianth || phyllome || petal || reproductive shoot system || collective phyllome structure || pollen || microsporophyll || pollen sac || corolla || shoot system || collective leaf structure
Plant ANatomical entity (PAN)	microgametophyte	0	0.673	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.6679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0	0.5892	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.46	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.4859	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.4893	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Sterol esterase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Triacylglycerol lipase	0.00000001391	2.385	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	1.539	Informative	DIRECT

---