Pancreatic lipase, N-terminal domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: alpha/beta-Hydrolases [ 53473]
• Superfamily: alpha/beta-Hydrolases [ 53474] (41)
• Family: Pancreatic lipase, N-terminal domain [ 53577]

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Family statistics

	Genomes (126)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,723	5,118	6
Proteins	1,657	4,948	6

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phospholipase A(1)	0	2.44	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Lipoprotein lipase	1.746e-16	2.741	--	DIRECT
Enzyme Commission (EC)	Galactolipase	0.0000000008604	2.44	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	1.21	Moderately Informative	DIRECT
Enzyme Commission (EC)	Triacylglycerol lipase	0	1.963	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	myocardial infarction	0.000394	1.559	--	DIRECT
Disease Ontology (DO)	arteriosclerotic cardiovascular disease	0.0007483	1.367	--	DIRECT
Disease Ontology (DO)	arteriosclerosis	0.0008198	1.367	--	DIRECT
Disease Ontology (DO)	endocrine system disease	0.001894	1.309	--	INHERITED FROM: pancreas disease || pancreatitis
Disease Ontology (DO)	vascular disease	0.02424	0.832	--	INHERITED FROM: arteriosclerotic cardiovascular disease || coronary artery disease || myocardial infarction || arteriosclerosis || atherosclerosis
Disease Ontology (DO)	disease of anatomical entity	0.0846	0.2414	--	INHERITED FROM: atherosclerosis || arteriosclerosis || coronary artery disease || arteriosclerotic cardiovascular disease || pancreatitis || myocardial infarction || pancreas disease
Disease Ontology (DO)	cardiovascular system disease	0.09461	0.7889	--	INHERITED FROM: atherosclerosis || arteriosclerotic cardiovascular disease || myocardial infarction || coronary artery disease || arteriosclerosis
Disease Ontology (DO)	artery disease	0.01591	0.9817	Moderately Informative	INHERITED FROM: atherosclerosis || arteriosclerosis || coronary artery disease || myocardial infarction || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	pancreas disease	0.00007114	1.668	Informative	DIRECT
Disease Ontology (DO)	atherosclerosis	0.0007402	1.367	Informative	DIRECT
Disease Ontology (DO)	coronary artery disease	0.0007833	1.472	Informative	DIRECT
Disease Ontology (DO)	pancreatitis	0.00001706	2.036	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.2218	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal circulating lipid concentration	0.00006928	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.1364	0.5486	Least Informative	INHERITED FROM: Abnormal circulating lipid concentration
Phenotypic Abnormality (PA)	Abnormal circulating metabolite concentration	0.01646	0.971	Moderately Informative	INHERITED FROM: Abnormal circulating lipid concentration

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	increased triglyceride level	0.000007374	1.758	--	DIRECT
Mammalian Phenotype (MP)	increased circulating HDL cholesterol level	0.00001559	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating phospholipid level	0.00002794	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating LDL cholesterol level	0.00003638	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating lipid level	0.00007456	1.241	--	DIRECT
Mammalian Phenotype (MP)	abnormal cholesterol level	0.0002488	1.524	--	DIRECT
Mammalian Phenotype (MP)	abnormal phospholipid level	0.0003429	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating lipoprotein level	0.004073	1.758	--	INHERITED FROM: increased circulating HDL cholesterol level || abnormal circulating LDL cholesterol level
Mammalian Phenotype (MP)	abnormal circulating non-HDL cholesterol level	0.03102	1.904	--	INHERITED FROM: abnormal circulating LDL cholesterol level
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.03311	0.3626	--	INHERITED FROM: abnormal phospholipid level || abnormal circulating phospholipid level || abnormal lipid homeostasis || increased triglyceride level || abnormal cholesterol level || abnormal circulating LDL cholesterol level || increased circulating HDL cholesterol level || increased circulating triglyceride level || abnormal circulating lipid level
Mammalian Phenotype (MP)	abnormal circulating HDL cholesterol level	0.1153	2.302	--	INHERITED FROM: increased circulating HDL cholesterol level
Mammalian Phenotype (MP)	increased circulating cholesterol level	0.1403	1.758	--	INHERITED FROM: increased circulating HDL cholesterol level
Mammalian Phenotype (MP)	abnormal circulating cholesterol level	0.1514	1.524	--	INHERITED FROM: abnormal circulating LDL cholesterol level || increased circulating HDL cholesterol level
Mammalian Phenotype (MP)	increased sterol level	0.1819	1.758	--	INHERITED FROM: increased circulating HDL cholesterol level
Mammalian Phenotype (MP)	increased cholesterol level	0.1918	1.758	--	INHERITED FROM: increased circulating HDL cholesterol level
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.2756	0.6893	--	INHERITED FROM: increased circulating HDL cholesterol level || abnormal circulating phospholipid level || abnormal circulating LDL cholesterol level || abnormal circulating lipid level || increased circulating triglyceride level
Mammalian Phenotype (MP)	abnormal lipid level	0.7735	1.156	--	INHERITED FROM: increased circulating triglyceride level || abnormal circulating lipid level || increased circulating HDL cholesterol level || abnormal circulating LDL cholesterol level || increased triglyceride level || abnormal phospholipid level || abnormal circulating phospholipid level || abnormal cholesterol level
Mammalian Phenotype (MP)	abnormal homeostasis	0.01706	0.4926	Least Informative	INHERITED FROM: abnormal phospholipid level || abnormal lipid homeostasis || abnormal circulating phospholipid level || increased triglyceride level || abnormal circulating LDL cholesterol level || abnormal cholesterol level || increased circulating HDL cholesterol level || abnormal circulating lipid level || increased circulating triglyceride level
Mammalian Phenotype (MP)	abnormal lipid homeostasis	0.00001065	1.141	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal lipoprotein level	0.003548	1.7	Informative	INHERITED FROM: increased circulating HDL cholesterol level || abnormal circulating LDL cholesterol level
Mammalian Phenotype (MP)	abnormal circulating triglyceride level	0.04846	1.562	Informative	INHERITED FROM: increased circulating triglyceride level
Mammalian Phenotype (MP)	abnormal triglyceride level	0.05733	1.457	Informative	INHERITED FROM: increased circulating triglyceride level || increased triglyceride level
Mammalian Phenotype (MP)	abnormal sterol level	0.1166	1.489	Informative	INHERITED FROM: abnormal circulating LDL cholesterol level || increased circulating HDL cholesterol level || abnormal cholesterol level
Mammalian Phenotype (MP)	abnormal cholesterol homeostasis	0.2222	1.524	Informative	INHERITED FROM: increased circulating HDL cholesterol level || abnormal cholesterol level || abnormal circulating LDL cholesterol level
Mammalian Phenotype (MP)	increased circulating triglyceride level	0.000001476	1.825	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0.3798	0.06546	--	INHERITED FROM: electrophoretic variant
Fly Phenotype (FP)	electrophoretic variant	0.000003427	2.085	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Triacylglycerol lipase	0	2.385	--	DIRECT
Enzyme Commission (EC)	Phospholipase A(1)	0	2.753	--	DIRECT
Enzyme Commission (EC)	Lipoprotein lipase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Galactolipase	0.00000000295	2.753	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	1.539	Informative	DIRECT

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