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Home > SCOP hierarchy > Aspartate/ornithine carbamoyltransferase superfamily

Aspartate/ornithine carbamoyltransferase superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Alpha and beta proteins (a/b) [ 51349] (147)
Fold:	ATC-like [ 53670] (2)
Superfamily:	Aspartate/ornithine carbamoyltransferase [ 53671]
Families:	Aspartate/ornithine carbamoyltransferase [ 53672] (3)

Superfamily statistics

	Genomes (2,984)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,463	49,247	28
Proteins	6,444	49,148	28

Functional annotation

General category	Metabolism
Detailed category	Amino acids metabolism and transport

Document: Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring one-carbon groups	0	Least Informative	Direct
Enzyme Commission (EC)	Ligases	1	Least Informative	Inherited
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Carbon--nitrogen ligases with glutamine as amido-N	0.5347	Informative	Inherited
Enzyme Commission (EC)	Carboxyl- and carbamoyltransferases	0	Highly Informative	Direct
Enzyme Commission (EC)	Carbamoyl-phosphate synthase (glutamine-hydrolyzin	0.0008941	Highly Informative	Direct

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	1	Least Informative	Inherited
Enzyme Commission (EC)	Transferring one-carbon groups	0	Moderately Informative	Direct
Enzyme Commission (EC)	Ligases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptide bonds	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Carbon--nitrogen ligases with glutamine as amido-N-donor	0.5942	Informative	Inherited
Enzyme Commission (EC)	Carboxy- and carbamoyltransferases	0	Highly Informative	Direct
Enzyme Commission (EC)	Carbamoyl-phosphate synthase (glutamine-hydrolyzing)	0.00002024	Highly Informative	Direct
Enzyme Commission (EC)	Dihydroorotase	0.0002891	Highly Informative	Direct

Document: EC annotation of SCOP domains

InterPro annotation

Cross references IPR006130 SSF53671 Protein matches

Abstract
This family contains two related enzymes:

Aspartate carbamoyltransferase (ATCase) catalyzes the conversion of aspartate and carbamoyl phosphate to carbamoylaspartate, the second step in the de novo biosynthesis of pyrimidine nucleotides [ PubMed 3015959]. In prokaryotes ATCase consists of two subunits: a catalytic chain (gene pyrB) and a regulatory chain (gene pyrI), while in eukaryotes it is a domain in a multi- functional enzyme (called URA2 in yeast, rudimentary in Drosophila, and CAD in mammals [ PubMed 8098212]) that also catalyzes other steps of the biosynthesis of pyrimidines.

Ornithine carbamoyltransferase (OTCase) catalyzes the conversion of ornithine and carbamoyl phosphate to citrulline. In mammals this enzyme participates in the urea cycle [ PubMed 2662961] and is located in the mitochondrial matrix. In prokaryotes and eukaryotic microorganisms it is involved in the biosynthesis of arginine. In some bacterial species it is also involved in the degradation of arginine [ PubMed 3109911] (the arginine deaminase pathway).

It has been shown [ PubMed 6379651] that these two enzymes are evolutionary related. The predicted secondary structure of both enzymes are similar and there are some regions of sequence similarities. One of these regions includes three residues which have been shown, by crystallographic studies [ PubMed 6377306], to be implicated in binding the phosphoryl group of carbamoyl phosphate.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Aspartate/ornithine carbamoyltransferase domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 57 hidden Markov models representing the Aspartate/ornithine carbamoyltransferase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) · Internal database links ]