ALDH-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: ALDH-like [ 53719]
• Superfamily: ALDH-like [ 53720] (2)
• Family: ALDH-like [ 53721] (5)

---

Family statistics

	Genomes (2,955)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	28,849	226,999	19
Proteins	28,779	226,777	19

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Betaine-aldehyde dehydrogenase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Succinylglutamate-semialdehyde dehydrogenase	0	2.741	--	DIRECT
Enzyme Commission (EC)	1-pyrroline-5-carboxylate dehydrogenase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Glutamate-5-semialdehyde dehydrogenase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Aldehyde dehydrogenase (NAD(+))	0.000000000000002408	2.741	--	DIRECT
Enzyme Commission (EC)	Formyltetrahydrofolate dehydrogenase	0.0000000001275	2.264	--	DIRECT
Enzyme Commission (EC)	Methylmalonate-semialdehyde dehydrogenase (acylati	0.0000000118	2.741	--	DIRECT
Enzyme Commission (EC)	Malonate-semialdehyde dehydrogenase (acetylating)	0.00000002269	2.741	--	DIRECT
Enzyme Commission (EC)	Glutamate 5-kinase	0.00001211	2.44	--	DIRECT
Enzyme Commission (EC)	Aminobutyraldehyde dehydrogenase	0.00001505	2.741	--	DIRECT
Enzyme Commission (EC)	Aldehyde dehydrogenase (NAD(P)(+))	0.0002805	2.741	--	DIRECT
Enzyme Commission (EC)	Retinal dehydrogenase	0.0007478	2.741	--	DIRECT
Enzyme Commission (EC)	Phosphotransferases with a carboxyl group as accep	0.7088	1.787	--	INHERITED FROM: Glutamate 5-kinase
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Glutamate 5-kinase
Enzyme Commission (EC)	Transferring phosphorous-containing groups	1	0.2728	--	INHERITED FROM: Glutamate 5-kinase
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0.969	1.279	--	INHERITED FROM: Formyltetrahydrofolate dehydrogenase || 1-pyrroline-5-carboxylate dehydrogenase || With NAD(+) or NADP(+) as acceptor
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0	1.236	Moderately Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.511	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.662	Informative	DIRECT

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || retarded heterochronic variations || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || organism physiology variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || general pace of development variant || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT

---

Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism || compound organ

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	intestine	0.0005312	1.242	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0.189	0.388	--	INHERITED FROM: intestine
Xenopus ANatomical entity (XAN)	anatomical region	0.4518	0.1803	--	INHERITED FROM: intestine
Xenopus ANatomical entity (XAN)	compound organ	0.5503	0.2177	--	INHERITED FROM: intestine
Xenopus ANatomical entity (XAN)	organism subdivision	0.8311	0.1679	--	INHERITED FROM: intestine
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: intestine
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: intestine || anatomical group || multicellular anatomical structure
Xenopus ANatomical entity (XAN)	anatomical cluster	0.01719	0.7159	Least Informative	INHERITED FROM: intestine
Xenopus ANatomical entity (XAN)	trunk	0.1878	0.3894	Least Informative	INHERITED FROM: intestine
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.2209	0.2685	Least Informative	INHERITED FROM: intestine
Xenopus ANatomical entity (XAN)	viscus	0.001524	0.8828	Moderately Informative	INHERITED FROM: intestine
Xenopus ANatomical entity (XAN)	alimentary system	0.004178	0.8739	Moderately Informative	INHERITED FROM: intestine
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.4584	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	pollen	0.000853	0.673	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0.0008569	0.673	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0.0008934	0.6705	--	DIRECT
Plant ANatomical entity (PAN)	whole plant	0.04025	0.3507	--	INHERITED FROM: microgametophyte || pollen
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: root || sporophyll || flower || collective plant structure || phyllome || pollen sac || multi-tissue plant structure || guard cell || reproductive shoot system || shoot system || portion of plant tissue || stomatal complex || plant organ || epidermis || root system || microsporangium || epidermal cell || shoot epidermal cell || pollen || plant axis || collective phyllome structure || plant cell || shoot epidermis || microgametophyte
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: flower || sporophyll || root system || root || phyllome || reproductive shoot system || collective phyllome structure || guard cell || pollen || pollen sac || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	root	0	0.4679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0.000855	0.673	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0.007562	0.6679	Least Informative	INHERITED FROM: pollen || pollen sac || microsporangium
Plant ANatomical entity (PAN)	microsporophyll	0.7803	0.4415	Least Informative	INHERITED FROM: pollen sac || pollen
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Glutamate-5-semialdehyde dehydrogenase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Succinylglutamate-semialdehyde dehydrogenase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Formyltetrahydrofolate dehydrogenase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Aldehyde dehydrogenase (NAD(+))	0.000000000000003275	3.23	--	DIRECT
Enzyme Commission (EC)	Methylmalonate-semialdehyde dehydrogenase (CoA acylating)	0.0000000275	3.23	--	DIRECT
Enzyme Commission (EC)	Proline dehydrogenase	0.0000006287	2.628	--	DIRECT
Enzyme Commission (EC)	L-glutamate gamma-semialdehyde dehydrogenase	0.000001118	2.628	--	DIRECT
Enzyme Commission (EC)	Glutamate 5-kinase	0.00000158	2.929	--	DIRECT
Enzyme Commission (EC)	Aminobutyraldehyde dehydrogenase	0.00001777	3.23	--	DIRECT
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0.00002715	2.385	--	DIRECT
Enzyme Commission (EC)	Retinal dehydrogenase	0.0003894	3.23	--	DIRECT
Enzyme Commission (EC)	Aldehyde dehydrogenase (NAD(P)(+))	0.0009911	3.23	--	DIRECT
Enzyme Commission (EC)	Phosphotransferases with a carboxy group as acceptor	0.5201	2.275	--	INHERITED FROM: Glutamate 5-kinase
Enzyme Commission (EC)	Transferring phosphorus-containing groups	1	0.7021	--	INHERITED FROM: Glutamate 5-kinase
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Glutamate 5-kinase
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0	1.65	Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH group of donors	1	1.686	Informative	INHERITED FROM: Formyltetrahydrofolate dehydrogenase || With a quinone or similar compound as acceptor || Proline dehydrogenase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.054	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	1	1.907	Highly Informative	INHERITED FROM: Formyltetrahydrofolate dehydrogenase

---