L-arabinose binding protein-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Periplasmic binding protein-like I [ 53821]
• Superfamily: Periplasmic binding protein-like I [ 53822]
• Family: L-arabinose binding protein-like [ 53823] (16)

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Family statistics

	Genomes (2,078)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	19,101	146,758	47
Proteins	19,049	146,595	47

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphorus-oxygen lyases	0	1.838	--	DIRECT
Enzyme Commission (EC)	Phosphorus-oxygen lyases	1	1.838	--	INHERITED FROM: Guanylate cyclase
Enzyme Commission (EC)	Lyases	0	0.4956	Least Informative	DIRECT
Enzyme Commission (EC)	Guanylate cyclase	0	2.139	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	temporal lobe epilepsy	0.000000009829	2.212	--	DIRECT
Disease Ontology (DO)	motor neuron disease	0.0001755	1.911	--	DIRECT
Disease Ontology (DO)	autism spectrum disorder	0.0004947	1.911	--	DIRECT
Disease Ontology (DO)	cognitive disorder	0.01885	1.151	--	INHERITED FROM: bipolar disorder || schizophrenia
Disease Ontology (DO)	brain disease	0.04352	1.258	--	INHERITED FROM: temporal lobe epilepsy || epilepsy
Disease Ontology (DO)	pervasive developmental disorder	0.06091	1.814	--	INHERITED FROM: autism spectrum disorder || autistic disorder
Disease Ontology (DO)	mood disorder	0.1801	1.814	--	INHERITED FROM: bipolar disorder
Disease Ontology (DO)	disease of anatomical entity	0.1924	0.2414	--	INHERITED FROM: amyotrophic lateral sclerosis || nervous system disease || motor neuron disease || epilepsy || temporal lobe epilepsy
Disease Ontology (DO)	psychotic disorder	0.227	1.399	--	INHERITED FROM: schizophrenia
Disease Ontology (DO)	central nervous system disease	0.2274	0.8698	--	INHERITED FROM: temporal lobe epilepsy || amyotrophic lateral sclerosis || epilepsy || motor neuron disease
Disease Ontology (DO)	nervous system disease	0.00007305	0.7279	Least Informative	DIRECT
Disease Ontology (DO)	disease of mental health	0.00000000767	1.036	Moderately Informative	DIRECT
Disease Ontology (DO)	neurodegenerative disease	0.7314	1.022	Moderately Informative	INHERITED FROM: motor neuron disease || amyotrophic lateral sclerosis
Disease Ontology (DO)	schizophrenia	0.000000009329	1.399	Informative	DIRECT
Disease Ontology (DO)	epilepsy	0.0000002468	1.668	Informative	DIRECT
Disease Ontology (DO)	developmental disorder of mental health	0.4588	1.61	Informative	INHERITED FROM: autism spectrum disorder || autistic disorder
Disease Ontology (DO)	amyotrophic lateral sclerosis	0.000000969	2.036	Highly Informative	DIRECT
Disease Ontology (DO)	bipolar disorder	0.00016	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	autistic disorder	0.0004377	1.911	Highly Informative	DIRECT
Disease Ontology (DO)	focal epilepsy	0.007013	1.911	Highly Informative	INHERITED FROM: temporal lobe epilepsy

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Absent speech	0.000246	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Hypsarrhythmia	0.00048	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Upper motor neuron dysfunction	0.000998	1.286	--	DIRECT
Phenotypic Abnormality (PA)	EEG with generalized epileptiform discharges	0.001549	1.559	--	INHERITED FROM: Hypsarrhythmia
Phenotypic Abnormality (PA)	EEG abnormality	0.00368	1.559	--	INHERITED FROM: Hypsarrhythmia
Phenotypic Abnormality (PA)	Abnormality of central nervous system electrophysiology	0.004634	1.559	--	INHERITED FROM: Hypsarrhythmia
Phenotypic Abnormality (PA)	Interictal EEG abnormality	0.1128	1.559	--	INHERITED FROM: Hypsarrhythmia
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0.1194	0.7381	--	INHERITED FROM: Absent speech
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.4575	0.2371	--	INHERITED FROM: Absent speech || Hypsarrhythmia || Epileptic encephalopathy || Upper motor neuron dysfunction
Phenotypic Abnormality (PA)	Interictal epileptiform activity	1	1.559	--	INHERITED FROM: Hypsarrhythmia
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.3133	0.3869	Least Informative	INHERITED FROM: Upper motor neuron dysfunction || Epileptic encephalopathy || Absent speech || Hypsarrhythmia
Phenotypic Abnormality (PA)	Abnormality of central motor function	0.01548	1.047	Moderately Informative	INHERITED FROM: Upper motor neuron dysfunction
Phenotypic Abnormality (PA)	Neurodevelopmental delay	0.02641	0.9853	Moderately Informative	INHERITED FROM: Absent speech
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0.0411	0.8092	Moderately Informative	INHERITED FROM: Absent speech
Phenotypic Abnormality (PA)	Encephalopathy	0.004136	1.684	Informative	INHERITED FROM: Epileptic encephalopathy
Phenotypic Abnormality (PA)	Abnormal nervous system electrophysiology	0.01163	1.462	Informative	INHERITED FROM: Hypsarrhythmia
Phenotypic Abnormality (PA)	Neurological speech impairment	0.01864	1.508	Informative	INHERITED FROM: Absent speech
Phenotypic Abnormality (PA)	Epileptic encephalopathy	0.0001008	1.763	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Delayed speech and language development	0.01233	1.86	Highly Informative	INHERITED FROM: Absent speech

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	absence of NMDA-mediated synaptic currents	0.00000009326	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal pain threshold	0.00001737	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal taste sensitivity	0.00002066	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal inhibitory postsynaptic potential	0.0001779	2.603	--	DIRECT
Mammalian Phenotype (MP)	behavior/neurological phenotype	0.0004915	0.8178	--	DIRECT
Mammalian Phenotype (MP)	abnormal cognition	0.0006085	1.399	--	DIRECT
Mammalian Phenotype (MP)	abnormal locomotor behavior	0.0009035	1.649	--	DIRECT
Mammalian Phenotype (MP)	abnormal gustatory system physiology	0.001946	2.603	--	INHERITED FROM: abnormal taste sensitivity
Mammalian Phenotype (MP)	abnormal touch/ nociception	0.002596	1.649	--	INHERITED FROM: abnormal pain threshold
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.00838	0.825	--	INHERITED FROM: absence of NMDA-mediated synaptic currents || abnormal synaptic transmission || abnormal glutamate-mediated receptor currents || abnormal nervous system electrophysiology || abnormal long term depression || abnormal inhibitory postsynaptic potential
Mammalian Phenotype (MP)	abnormal fear/anxiety-related behavior	0.05273	1.825	--	INHERITED FROM: decreased fear-related response
Mammalian Phenotype (MP)	abnormal synaptic depression	0.09211	1.825	--	INHERITED FROM: abnormal long term depression
Mammalian Phenotype (MP)	abnormal fear-related response	0.09923	2.126	--	INHERITED FROM: decreased fear-related response
Mammalian Phenotype (MP)	integument phenotype	0.1086	0.797	--	INHERITED FROM: abnormal pain threshold
Mammalian Phenotype (MP)	abnormal motor capabilities/coordination/movement	0.4301	1.205	--	INHERITED FROM: abnormal locomotor behavior
Mammalian Phenotype (MP)	abnormal NMDA-mediated synaptic currents	0.8051	2.126	--	INHERITED FROM: absence of NMDA-mediated synaptic currents
Mammalian Phenotype (MP)	nervous system phenotype	0.0000006887	0.4959	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal synaptic transmission	0.0001358	1.156	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal behavior	1	0.855	Moderately Informative	INHERITED FROM: decreased fear-related response || abnormal learning/memory/conditioning || abnormal behavioral response to xenobiotic || abnormal locomotor behavior || abnormal sensory capabilities/reflexes/nociception || abnormal pain threshold || abnormal cognition || abnormal emotion/affect behavior
Mammalian Phenotype (MP)	abnormal learning/memory/conditioning	0.000002084	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal nervous system electrophysiology	0.00006902	1.7	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal behavioral response to xenobiotic	0.0001535	1.489	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal sensory capabilities/reflexes/nociception	0.0001855	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal emotion/affect behavior	0.0009092	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal voluntary movement	0.1403	1.489	Informative	INHERITED FROM: abnormal locomotor behavior
Mammalian Phenotype (MP)	abnormal CNS synaptic transmission	0.1749	1.281	Informative	INHERITED FROM: abnormal inhibitory postsynaptic potential || abnormal long term depression || absence of NMDA-mediated synaptic currents || abnormal glutamate-mediated receptor currents
Mammalian Phenotype (MP)	abnormal long term depression	0.0000005396	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased fear-related response	0.00005299	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal glutamate-mediated receptor currents	0.0002543	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	taste/olfaction phenotype	0.004791	2.001	Highly Informative	INHERITED FROM: abnormal taste sensitivity

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	bromide chemotaxis defective	0	2.468	--	DIRECT
Worm Phenotype (WP)	iodide chemotaxis defective	0	2.468	--	DIRECT
Worm Phenotype (WP)	lithium chemotaxis defective	0	2.468	--	DIRECT
Worm Phenotype (WP)	magnesium chemotaxis defective	0	2.468	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	bromide chemotaxis variant	0	2.468	--	DIRECT
Worm Phenotype (WP)	iodide chemotaxis variant	0	2.468	--	DIRECT
Worm Phenotype (WP)	chemotaxis variant	0.000000000000009374	1.513	--	DIRECT
Worm Phenotype (WP)	chemosensory behavior variant	0.000000001576	1.49	--	DIRECT
Worm Phenotype (WP)	alkaline pH chemotaxis variant	0.000000008373	2.292	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.000000523	0.6859	--	DIRECT
Worm Phenotype (WP)	thermosensory behavior variant	0.000009583	1.866	--	DIRECT
Worm Phenotype (WP)	cation positive chemotaxis defective	0.00003746	2.468	--	DIRECT
Worm Phenotype (WP)	anion positive chemotaxis defective	0.00005875	2.468	--	DIRECT
Worm Phenotype (WP)	cation positive chemotaxis variant	0.000292	2.468	--	DIRECT
Worm Phenotype (WP)	anion positive chemotaxis variant	0.0004394	2.468	--	DIRECT
Worm Phenotype (WP)	pharyngeal pumping reduced	0.0006962	2.468	--	DIRECT
Worm Phenotype (WP)	aqueous chemosensory response variant	0.001639	1.814	--	INHERITED FROM: alkaline pH chemotaxis variant || iodide chemotaxis variant || anion positive chemotaxis variant || bromide chemotaxis defective || bromide chemotaxis variant || iodide chemotaxis defective || magnesium chemotaxis defective || cation positive chemotaxis variant || cation positive chemotaxis defective || anion positive chemotaxis defective || lithium chemotaxis defective || aqueous positive chemotaxis variant
Worm Phenotype (WP)	positive chemotaxis variant	0.0125	1.689	--	INHERITED FROM: bromide chemotaxis variant || cation positive chemotaxis defective || cation positive chemotaxis variant || iodide chemotaxis defective || magnesium chemotaxis defective || anion positive chemotaxis defective || alkaline pH chemotaxis variant || iodide chemotaxis variant || bromide chemotaxis defective || anion positive chemotaxis variant || aqueous positive chemotaxis variant || lithium chemotaxis defective
Worm Phenotype (WP)	organism physiology variant	0.05747	0.1342	--	INHERITED FROM: bromide chemotaxis variant || organism environmental stimulus response variant || magnesium chemotaxis defective || thermosensory behavior variant || lithium chemotaxis defective || anion positive chemotaxis variant || anion positive chemotaxis defective || thermotaxis variant || chemotaxis variant || iodide chemotaxis variant || chemosensory response variant || iodide chemotaxis defective || bromide chemotaxis defective || cation positive chemotaxis variant || alkaline pH chemotaxis variant || organism temperature response variant || aqueous positive chemotaxis variant || cation positive chemotaxis defective
Worm Phenotype (WP)	eating variant	0.1398	1.769	--	INHERITED FROM: pharyngeal pumping reduced
Worm Phenotype (WP)	aqueous positive chemotaxis defective	0.1545	2.07	--	INHERITED FROM: lithium chemotaxis defective || bromide chemotaxis defective || cation positive chemotaxis defective || iodide chemotaxis defective || magnesium chemotaxis defective || anion positive chemotaxis defective
Worm Phenotype (WP)	feeding behavior variant	0.2186	1.25	--	INHERITED FROM: pharyngeal pumping reduced
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.9585	0.1444	--	INHERITED FROM: anion positive chemotaxis variant || anion positive chemotaxis defective || lithium chemotaxis defective || magnesium chemotaxis defective || thermosensory behavior variant || organism environmental stimulus response variant || bromide chemotaxis variant || iodide chemotaxis defective || chemosensory response variant || chemotaxis variant || iodide chemotaxis variant || thermotaxis variant || alkaline pH chemotaxis variant || bromide chemotaxis defective || cation positive chemotaxis variant || aqueous positive chemotaxis variant || cation positive chemotaxis defective || organism temperature response variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: bromide chemotaxis defective || hermaphrodite fertility variant || reproductive system physiology variant || anion positive chemotaxis variant || iodide chemotaxis variant || alkaline pH chemotaxis variant || lethal || magnesium chemotaxis defective || bromide chemotaxis variant || chemosensory behavior variant || anion positive chemotaxis defective || thermotaxis variant || cation positive chemotaxis variant || development variant || organism temperature response variant || hermaphrodite sterile || organism environmental stimulus response variant || hermaphrodite fertility reduced || chemotaxis variant || embryonic development variant || embryonic lethal || iodide chemotaxis defective || chemosensory response variant || fertility variant || behavior variant || pharyngeal pumping reduced || cation positive chemotaxis defective || aqueous positive chemotaxis variant || thermosensory behavior variant || organ system physiology variant || organism behavior variant || maternal sterile || social behavior variant || lithium chemotaxis defective || organism development variant || fertility reduced
Worm Phenotype (WP)	pharyngeal pumping variant	1	1.99	--	INHERITED FROM: pharyngeal pumping reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism environmental stimulus response variant	0.00000007622	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0.0000004797	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	chemical response variant	0.01619	0.9053	Moderately Informative	INHERITED FROM: alkaline pH chemotaxis variant || lithium chemotaxis defective || anion positive chemotaxis defective || anion positive chemotaxis variant || bromide chemotaxis variant || magnesium chemotaxis defective || cation positive chemotaxis variant || bromide chemotaxis defective || chemosensory response variant || iodide chemotaxis defective || cation positive chemotaxis defective || aqueous positive chemotaxis variant || iodide chemotaxis variant || chemotaxis variant
Worm Phenotype (WP)	organism stress response variant	1	0.9693	Moderately Informative	INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant
Worm Phenotype (WP)	chemosensory response variant	0.00000003467	1.49	Informative	DIRECT
Worm Phenotype (WP)	organism temperature response variant	0.00003803	1.593	Informative	DIRECT
Worm Phenotype (WP)	thermotaxis variant	0.00000004318	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	social behavior variant	0.000221	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	aqueous positive chemotaxis variant	0.0007321	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	positive chemotaxis defective	0.203	1.99	Highly Informative	INHERITED FROM: bromide chemotaxis defective || anion positive chemotaxis defective || iodide chemotaxis defective || magnesium chemotaxis defective || cation positive chemotaxis defective || lithium chemotaxis defective
Worm Phenotype (WP)	pharyngeal pumping rate variant	0.4222	1.99	Highly Informative	INHERITED FROM: pharyngeal pumping reduced

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	neurophysiology defective	0.0004345	1.541	Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	embryonic/larval nervous system	0	0.7171	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || nervous system || peripheral nervous system || embryonic/larval nervous system || larva || organ system subdivision || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || organ system subdivision || larva || embryonic/larval nervous system || organism || nervous system || peripheral nervous system
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.6333	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	peripheral nervous system	0	0.8978	Moderately Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	late tailbud stage	0.009951	1.638	--	INHERITED FROM: NF stage 35 and 36
Xenopus DEvelopment stage (XDE)	embryonic stage	0.001633	1.006	Moderately Informative	INHERITED FROM: NF stage 35 and 36
Xenopus DEvelopment stage (XDE)	tailbud stage	0.4252	1.554	Informative	INHERITED FROM: NF stage 35 and 36
Xenopus DEvelopment stage (XDE)	NF stage 35 and 36	0.000005531	2.086	Highly Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphorus-oxygen lyases	0	1.951	--	DIRECT
Enzyme Commission (EC)	Guanylate cyclase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Lyases	0	0.8775	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphorus-oxygen lyases	1	1.951	Highly Informative	INHERITED FROM: Guanylate cyclase

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