Transferrin family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Periplasmic binding protein-like II [ 53849]
• Superfamily: Periplasmic binding protein-like II [ 53850] (3)
• Family: Transferrin [ 53888] (3)

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Family statistics

	Genomes (136)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	770	2,490	87
Proteins	439	1,486	63

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT
Disease Ontology (DO)	central nervous system disease	0	0.8698	--	DIRECT
Disease Ontology (DO)	tauopathy	0	1.61	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	nervous system disease	0	0.7279	Least Informative	DIRECT
Disease Ontology (DO)	cell type cancer	0	0.9112	Moderately Informative	DIRECT
Disease Ontology (DO)	neurodegenerative disease	0	1.022	Moderately Informative	DIRECT
Disease Ontology (DO)	Alzheimer's disease	0	1.61	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	intestine	0	1.242	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: alimentary system || urogenital system || intestine || nervous system || brain || genital system || central nervous system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || head region || genital system || brain || intestine || nervous system || alimentary system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || central nervous system || trunk region || anatomical cluster || viscus || organism subdivision || head
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.8828	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.8739	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.7859	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	unspecified stage	0	1.131	Moderately Informative	DIRECT

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